Clinical trials: Nicotinamide
Cardiovascular Diseases, Heart Diseases
Diet, Exercise, Niacin, and Fenofibrate to Reduce Heart Disease Risk Factors in Individuals With HIV Lipodystrophy or Dyslipidemia
This study will evaluate the efficacy of diet and exercise (DE), with and without niacin and fenofibrate, in reducing the cardiovascular risk of patients with HIV lipodystrophy or dyslipidemia.
- Conditions
- Cardiovascular Diseases, Heart Diseases, HIV Infections, Hyperlipidemia
- Trial name
- HeartPositive (NCT00246376)
- Testing
- Diet, Exercise, Niacin
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- Baylor College of Medicine
Acute Kidney Injury
NAD Supplementation to Reduce the Incidence of Cardiac Surgery Associated Acute Kidney Injury
The purpose of this single-center, randomized, double-blinded placebo-controlled pilot trial is to demonstrate feasibility and help design a larger trial to assess the effectiveness of nicotinamide (NAM) supplementation in…
- Trial name
- NCT07739290
- Testing
- Nicotinamide (NAM)
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
NAD
Method Optimization for the Quantification of the NAD
Method optimization for the quantification of the NAD metabolome in human whole blood, and evaluation of baseline inter and intra-subject variability.
- Trial name
- NCT05561712
- Testing
- Laboratory method validation
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Huntington Disease
The NAD-HD Study: A Study to Investigate Efficacy and Safety of Nicotinamide Riboside Compared With Placebo in Huntington's Disease
The goal of this clinical trial is to learn if oral supplement of nicotinamide riboside (NR), a form of vitamin B3, slows disease progression in adults with Huntington's disease.
- Trial name
- NAD-HD (NCT06853743)
- Testing
- Nicotinamide Riboside (NR)
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Aging
Evaluate the Efficacy and Safety of Uthever NMN(Nicotinamide Mononucleotide, a Form of Vitamin B3)
This will be a multi-center, two arm study in 66 healthy adults. Subjects will complete a screening visit (V1, Day -7) to determine eligibility for the study based on Inclusion \& Exclusion Criteria, patient history and safety…
- Trial name
- NMN (NCT04228640)
- Testing
- NMN
- Where
- 2 sites in India
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- EffePharm LTD
Dyslipidemia
An Investigational Drug Study Evaluating a Novel Approach to Treat Dyslipidemia (0524A-032)
This is a 3-week trial in normal healthy or lipid clinic patients studying a novel approach to treating dyslipidemia.
- Trial name
- NCT00111891
- Testing
- niacin (+) laropiprant
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Health Adult Subjects
Effects of NR Supplementation on Metabolic Flexibility in Zone 2 Training
Zone 2 training, a low-intensity endurance exercise performed at approximately 66-80% of VO₂max or near the first ventilatory threshold, has gained popularity for improving aerobic capacity, fat metabolism, and mitochondrial…
- Trial name
- NCT07344636
- Testing
- Nicotinamide Riboside (NR)
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ZHANG Jiaqi
Actinic Keratoses
Comparison of Nicotinamide Treatments for Actinic Keratosis
In this study, the investigators aimed to evaluate the effect of oral nicotinamide compared to topical nicotinamide in the presence of actinic keratoses on the face.
- Trial name
- NCT07049068
- Testing
- Oral Nicotinamide, topical nicotinamide
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Federal University of Rio Grande do Sul
Hyperphosphatemia
Nicotinic Acid in Hemodialysis Patients With Hyperphosphatemia
With calcium carbonate as the positive control drug, to observe the effectiveness and safety of nicotinic acid in hemodialysis patients with hyperphosphatemia
- Trial name
- NAHPH (NCT02836184)
- Testing
- Nicotinic Acids, Calcium Carbonate
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Jiujiang No.1 People's Hospital
Cardiac Surgery
Nicotinamide Mononucleotide in Patients Undergoing Cardiac Surgery
The investigators will perform a phase 2a, randomized, double-blind, placebo-controlled clinical trial in adult patients undergoing elective cardiac surgery to investigate the effects of oral nicotinamide mononucleotide (NMN)…
- Trial name
- NCT07013591
- Testing
- MIB-626
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Brigham and Women's Hospital
Aging
To Evaluate the Efficacy and Safety of NMN as an Anti-ageing Supplement in Middle Aged and Older (40-65 Years) Adults
It will be a two-part study. Part I will be six arms; randomized, double blind, parallel design, placebo-controlled dose ranging study. Part II will be open-label single dose study at the highest dose.
- Trial name
- NCT04823260
- Testing
- Nicotinamide Mononucleotide
- Where
- 2 sites in India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Abinopharm, Inc
Leber Hereditary Optic Neuropathy (LHON), Leber's Hereditary Optic Neuropathy (LHON)
Pilot Study of the Efficacy of Nicotinamide (Vitamin B3) in Leber's Hereditary Optic Neuropathy
Leber Hereditary Optic Neuropathy (LHON) is a rare genetic disease that causes sudden and severe vision loss, usually in young adults.
- Conditions
- Leber Hereditary Optic Neuropathy (LHON), Leber's Hereditary Optic Neuropathy (LHON), Mitochondrial Disease, Optic Nerve Disease
- Trial name
- NICOLHON (NCT07258667)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Angers
Parkinson Disease
N-DOSE: A Dose Optimization Trial of Nicotinamide Riboside in Parkinson's Disease
N-DOSE is a double-blinded placebo-controlled randomized trial aiming to determine the optimal biological dose (OBD) of nicotinamide riboside (NR), in individuals with Parkinson's disease (PD).
- Trial name
- NCT05589766
- Testing
- Nicotinamide Riboside
- Where
- Norway
- Volunteers
- 81 people
- Sponsor
- Haukeland University Hospital
Larynx Carcinoma
Randomized Trial of ARCON in Larynx Cancer
TITLE: A multicentre, randomised, phase III clinical trial comparing accelerated radiotherapy with accelerated radiotherapy plus carbogen and nicotinamide (ARCON) in clinical stage T2-4 laryngeal carcinoma.
- Trial name
- NCT00147732
- Testing
- Accelerated radiotherapy, ARCON
- Where
- 7 sites in Netherlands, United Kingdom
- Volunteers
- 345 people
- Sponsor
- Radboud University Medical Center
Skin Care
A Study to Assess the Local Cutaneous and Ocular Tolerance of Three Developmental Facial Skin-care Formulations.
This study aims to determine the local cutaneous and ocular tolerance of 3 developmental skin-care products; a serum, a lotion, and a cream in healthy female subjects with clinically evaluated sensitive facial skin for 21 days.
- Trial name
- NCT04557371
- Testing
- Serum, Lotion, Cream
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hyperlipidemia
A Study Of Nutraceutical Drinks For Cholesterol (Evaluating Effectiveness and Tolerability)
Great controversy exists about the feasibility and safety of a product that can be employed for self-directed cholesterol reduction.
- Trial name
- NCT01152073
- Testing
- Second Formulation, Third Formulation
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Healthy Drink Discoveries, Inc.
Flushing
Effect of MK0524A on Flushing Caused by Niacin (0524A-056)
The primary objective of the study is to assess the effects of MK0524A in reducing flushing associated with niacin.
- Trial name
- NCT00533611
- Testing
- MK0524A, /Duration of Treatment : 4 Weeks, Comparator : niacin /Duration of Treatment : 1 Weeks
- Volunteers
- 330 people
- Sponsor
- Merck Sharp & Dohme LLC
Healthy Elderly Volunteers
Effects of Vitamin B3 Derivative Nicotinamide Riboside (NR) in Bone, Skeletal Muscle and Metabolic Functions in Aging
Researchers are trying to determine if the vitamin B3 derivative Nicotinamide Riboside (NR) has any effects in bone, skeletal muscle, and metabolic functions and structure in aging.
- Trial name
- NCT03818802
- Testing
- Nicotinamide Riboside
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Peripheral Arterial Disease
Effects of Niacin on Good Cholesterol in People With Peripheral Arterial Disease
Atherosclerosis is a disorder in the body that is characterized by cholesterol plaque formation in various arteries, causing narrowing of the artery and a limitation in blood flow.
- Trial name
- NCT01391377
- Testing
- Niacin/Laropiprant combination, Sugar pill
- Where
- Australia
- Volunteers
- 7 people
- Sponsor
- Bayside Health
Parkinson's Disease
NAD Supplementation in Parkinson's Disease
The goal of this clinical trial is to learn whether Nicotinamide Riboside, a form of Vitamin B3 also known as NR, can improve blood vessel health in the brain, memory, and physical function in eligible study participants.
- Trial name
- NCT07703137
- Testing
- Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma