Clinical trials: Nicotinamide
Hypercholesterolemia, Flushing
Alternative Options to Minimize Niacin-Induced Flushing
Niacin (Vitamin B3) is known to effectively and safely treat hypercholesterolemia. However, use of niacin is limited due to incidents of flushing which limits its acceptability.
- Trial name
- NCT00895193
- Testing
- Apple pectin, Aspirin 325 mg
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Patrick Moriarty, MD, FACP, FACC
Obesity, Short Stature
Free Fatty Acids, Body Weight, and Growth Hormones Secretion in Children
Background: Overweight and obese children and adults often have lower levels of growth hormone in the blood. Regulation of growth hormone may be tied to weight and free fatty acids in the blood.
- Conditions
- Obesity, Short Stature, Growth Hormone Deficiency
- Trial name
- NCT01237041
- Testing
- Niacin First, Dose-Establishing Study 1 Niacin 250mg, Dose-Establishing Study 1 Niacin 500mg
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Delayed Graft Function
Graft Acute Kidney Injury: Vitamin B3 to Facilitate Renal Recovery In the Early Life of a Transplant
Delayed graft function occurs in more than 20% of kidney transplantations. It is an episode of post-ischemic acute kidney injury with long-term consequences on the allograft's function.
- Trial name
- GABRIEL (NCT05513807)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hyperlipidemia
Biosynthesis of PGD2 in Vivo
The investigator would like to see if aspirin could block niacin-induced flushing by analyzing blood and urine after taking aspirin. Phase I: Subjects were assigned to either placebo or aspirin groups.
- Trial name
- NCT01275300
- Testing
- Aspirin, Niacin
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cognition Disorders in Old Age, Mild Cognitive Impairment
Crossover Trial for Nicotinamide Riboside in Subjective Cognitive Decline and Mild Cognitive Impairment
In this research study we want to learn more about whether taking Niagen, a daily supplement containing a form of Vitamin B3, will improve cognitive function, mood, and daily activity in people with Subjective Cognitive Decline…
- Conditions
- Cognition Disorders in Old Age, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT04078178
- Testing
- Niagen
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Steven E Arnold, MD
Chemotherapy-induced Peripheral Neuropathy, Breast Cancer Metastatic
NR in Chemo-induced Peripheral Neuropathy
The purpose of this single-arm phase II trial is to determine whether nicotinamide riboside (NIAGEN®) prevents the progression of peripheral sensory neuropathy in patients receiving infusions of paclitaxel or nab-paclitaxel for…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Breast Cancer Metastatic, Platinum-resistant Recurrent Ovarian Cancer, Head and Neck Cancer Stage IV
- Trial name
- NCT03642990
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Donna Hammond, PhD
Alzheimer Disease (AD)
N-AD: Orally Administered Nicotinamide Riboside Over Two Years as a Potential Disease Modifying Treatment for Alzheimer's Disease
The goal of this clinical trial is to learn if orally administered nicotinamide riboside works to slow the progression of early Alzheimer disease in adults. It will also learn about the safety of drug nicotinamide riboside.
- Trial name
- N-AD (NCT07741071)
- Testing
- Nicotinamide Riboside (NR), Palacebo
- Where
- 2 sites in Norway
- Volunteers
- 270 people
- Sponsor
- Haukeland University Hospital
Hypercholesterolemia
Evaluation of the Safety & Efficacy of a Combination of Niacin ER & Simvastatin in Patients With Dyslipidemia (OCEANS)
The purpose of this 24 week study is to compare the effectiveness and safety of different doses of Niacin ER/Simvastatin (NS) in subjects with elevated fat levels in their blood (dyslipidemia).
- Trial name
- NCT00080275
- Testing
- Niacin Extended-Release and simvastatin Tablets
- Volunteers
- 600 people
- Sponsor
- Kos Pharmaceuticals
Healthy Volunteers
The Genetics of Evoked Responses to Niacin and Endotoxemia: The GENE Study
The purpose of this study is to determine genetic factors that affect responses to niacin therapy and endotoxemia in healthy volunteers.
- Trial name
- GENE (NCT00953667)
- Testing
- Immediate Release Niacin, Extended Release Niacin, Endotoxin
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivors of Childhood Cancer
This trial studies the effect of exercise and nicotinamide riboside on muscle health and insulin resistance in adult survivors of childhood cancer with prediabetes (elevated blood sugar level that is not high enough to be…
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Prediabetes
- Trial name
- NCT05023993
- Testing
- Exercise Intervention, Nicotinamide Riboside
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Acute Kidney Injury
Pharmacokinetics, Pharmacodynamics and Safety of Basis in Acute Kidney Injury Study
This study will determine the pharmacokinetics, pharmacodynamics and safety of escalating doses of Basis following twice daily oral administration in patients with acute kidney injury (AKI).
- Trial name
- BAKIS (NCT03176628)
- Testing
- Basis
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Atherosclerosis
Comparative Study of the Effect of Ezetimibe Versus Extended-Release Niacin on Atherosclerosis
Recent evidence on the use of statin therapy indicates the potential for ultra-low levels of low-density lipoprotein (LDL-C) to provide greater protection from recurrent coronary heart disease (CHD) events.
- Trial name
- NCT00397657
- Testing
- extended release niacin, ezetimibe
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Walter Reed Army Medical Center
Elevated Lipoprotein(a) Levels
Evaluation of the Effect of NICOtinic Acid (Niacin) on Elevated Lipoprotein(a) Levels (NICOLa Study)
Lipoprotein (Lp)(a) has been associated with increased risk of cardiovascular disease. Niacin has been shown to lower Lp(a) in patients with normal or moderately elevated levels.
- Trial name
- NICOLa (NCT00633698)
- Testing
- Nicotinic acid (niacin)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Charite University, Berlin, Germany
Hypertriglyceridemia
Effect of AMR101 (Ethyl Icosapentate) on Triglyceride (Tg) Levels in Patients on Statins With High Tg Levels (≥ 200 and < 500 mg/dL)
The primary objective is to determine the efficacy of AMR101 (ethyl icosapentate) compared to placebo in lowering high fasting triglyceride levels in patients with high risk for cardiovascular disease and fasting triglyceride…
- Trial name
- ANCHOR (NCT01047501)
- Testing
- AMR101 (ethyl icosapentate) - 4 g/day, AMR101 (ethyl icosapentate) - 2 g/day
- Where
- 80 sites in United States
- Volunteers
- 702 people
- Sponsor
- Amarin Pharma Inc.
Covid19, Lymphopenia
Nicotinamide-based Supportive Therapy in Lymphopenia for Patients With COVID-19
The mechanism of peripheral blood lymphocyte decline in COVID-19 patients is not yet clear. However, one theory demonstrated that in the whole progression of COVID-19, the extensive activation of poly-ADP-ribose polymerase (PARP)…
- Trial name
- NCT04910230
- Testing
- nicotinamide
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Qiang Hu
Acute Kidney Injury, Cardiac Valve Disease
Impact of Nicotinamide Riboside (NR) on Kidney Function in Patients Undergoing Cardiac Surgery
Acute kidney injury (AKI) associated with cardiac surgery is the most important complication in adult patients undergoing open heart surgery and is associated with increased mortality and morbidity.
- Trial name
- AKI-RCT (NCT06521307)
- Testing
- Nicotinamide riboside
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Non Alcoholic Fatty Liver Disease
Nicotinamide in Non-Alcoholic Fatty Liver Disease Patients
The purpose of the study is to evaluate the efficacy and safety of Niacinamide supplementation on clinical outcome of fatty liver patients having type II DM through measurement of the following before and after Niacinamide…
- Trial name
- NCT03850886
- Testing
- Niacinamide Oral Tablet, Antidiabetic
- Where
- Egypt
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Parkinson's Disease
Low Dose Niacin (Vitamin B3) for Parkinson's Disease
(1) To examine the blood, urine and spinal fluid of persons with Parkinson's to look for evidence of inflammation and; (2) whether 18 months of vitamin B3(niacin or niacinamide) supplementation may reduce the inflammation and/or…
- Trial name
- NAPS (NCT03808961)
- Testing
- Niacin, Niacinamide
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- VA Office of Research and Development
Hand-Foot Skin Reaction (HFSR)
A Study to Investigate Nicotinic Acid on VEGFR Inhibitor-Associated Hand-Foot Skin Reactions
Hand-Foot Skin Reaction (HFSR) is a common adverse event induced by Vascular Endothelial Growth Receptor Inhibitor (VEGFRi) in cancer patients.
- Trial name
- NCT04242927
- Testing
- Nicotinic acid +Routine care, Routine care
- Where
- China
- Volunteers
- 36 people
- Sponsor
- First People's Hospital of Hangzhou
Multiple Sclerosis, Progressive Multiple Sclerosis
Nicotinamide Riboside Supplementation In Progressive Multiple Sclerosis
The purpose of this study is to assess the safety and efficacy of Nicotinamide riboside (NR) for treatment of patients with progressive multiple sclerosis.
- Trial name
- Norseman (NCT05740722)
- Testing
- Nicotinamid riboside
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Haukeland University Hospital