Clinical trials: Nicotinamide
Cystic Fibrosis
Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis
The purpose of this research study is to examine if the use of antioxidant supplements impacts exercise intolerance in people with CF.
- Trial name
- NCT04166396
- Testing
- Resveratrol, NR
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Coronary Heart Disease
Niacin/Laropiprant and Endothelial Function
Primary objective: To evaluate the impact of 12 weeks' administration of extended release niacin/laropiprant (ERN/LRPT) compared to placebo added to statin therapy on endothelial dependant dilatation of the arterial wall assessed…
- Trial name
- NCT01126073
- Testing
- Niacin/laropiprant
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Visual Field Defect, Peripheral, Glaucoma, Open-Angle
Nutritional Supplements and Performance During Visual Field Testing (B3 Vitamin)
This study seeks to test whether these over-the-counter nutritional supplements have an impact on patients' performance during visual field testing.
- Trial name
- NCT03797469
- Testing
- Vitamin B3, Pyruvate
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Columbia University
Glaucoma
Nicotinamide and Glaucoma
The investigators will include different subgroups of open-angle glaucoma and healthy controls. The participants will attend two visits with two weeks apart.
- Trial name
- NCT05916066
- Testing
- Nicotinamide
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Umeå University
Premature Birth of Newborn
Skin Maturation in Premature Infants
The skin barrier lipids will be lower in premature infants than in full term infants and will become normal over 3-4 months after birth.
- Trial name
- NCT01619228
- Where
- 2 sites in United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Safety Issues, Pharmacokinetic
Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes
A double-blind, randomised, placebo-controlled, single-ascending and multiple-ascending dose trial to evaluate the safety and pharmacokinetics of oral controlled-ileal-release nicotinic acid (CIR-NA) compared to immediate-release…
- Trial name
- NCT06378125
- Testing
- controlled-ileal-release nicotinic acid (SAD/ MAD/MD) single- and multiple-ascending dose (SAD/MAD) or multiple dose (MD), immediate-release nicotinic acid (SAD)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Dyslipidemias
Nicotinic Acid Composition of HDL and Arterial Endothelium Function in Premature Coronary Heart Disease and High HDL
Patients with premature ischemic heart disease (PIHD) and elevated levels of HDL-C present an altered composition of high-density lipoproteins (HDL) which is associated with a loss of their anti-atherogenic effects and of their…
- Trial name
- 11MSP011 (NCT01450410)
- Testing
- Nicotinic acid
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Xavier Pinto Sala
Healthy Adult
Nicotinamide Adenine Dinucleotide Responses to a Nutritional Supplement
The objective of this study is to evaluate nicotinamide adenine dinucleotide (NAD+) in response to a proprietary nutritional supplement in generally healthy adults, compared to placebo.
- Trial name
- NCT07428889
- Testing
- Proprietary Nutritional Supplement
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Shaklee Corporation
Healthy
A Study of 99mTc-3PRGD2 Injection in Healthy Volunteers
The study drug 99mTc-3PRGD2 of this study is a new radioactive diagnostic preparation for clinical use as a nuclear medicine molecular probe for tumor SPECT/CT imaging.
- Trial name
- NCT03974685
- Testing
- 99mTc niacinamide polyethylene glycol bicyclic RGD peptide (99mTc-3PRGD2)
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- RDO Pharm.
Vacterl Association, Congenital Malformation
Genetic Variants in Nicotinamide Adenine Dinucleotide (NAD) Synthesis Pathway
Researchers are trying to identify versions of genes as well as factors in subjects blood associated with certain types of congenital malformations(CMs).
- Trial name
- NCT03799705
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Mayo Clinic
Hypercholesterolemia
To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With Type IIa or Type IIb Hyperlipidemia (0653A-091)(COMPLETED)
To evaluate the efficacy and safety of ezetimibe/simvastatin and niacin in patients with high cholesterol.
- Trial name
- NCT00271817
- Testing
- Comparator: ezetimibe/simvastatin + niacin (ER), Comparator: niacin (ER) tablet, Comparator: ezetimibe (+) simvastatin
- Volunteers
- 1,220 people
- Sponsor
- Organon and Co
Flushing, Hyperlipidemias
Effects of Psyllium on Niacin Tolerability
The purpose of this study is to determine whether psyllium is effective in reducing flushing due to niacin and also to measure the effect of niacin on cholesterol levels.
- Conditions
- Flushing, Hyperlipidemias, Dyslipidemias
- Trial name
- NCT03370848
- Testing
- Psyllium, Aspirin
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- VA Greater Los Angeles Healthcare System
Aging
Nicotinamide Adenine Dinucleotide and Skeletal Muscle Metabolic Phenotype
This study is designed to assess the physiological consequences of elevating Nicotinamide Adenine Dinucleotide (NAD+) availability using Nicotinamide Riboside (NR) supplementation in skeletal muscle tissue, and examine its effect…
- Trial name
- NADMet (NCT02950441)
- Testing
- Nicotinamide Riboside
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Amyotrophic Lateral Sclerosis
The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS.
Amyotrophic lateral sclerosis (ALS) is a serious rapidly progressive disease of the nervous system. The average survival from the time of diagnosis is 3 years. Apart from Riluzole, there is no effective treatment.
- Trial name
- NCT04562831
- Testing
- EH301 (Nicotinamide Riboside/Pterostilbene)
- Where
- 9 sites in Norway
- Volunteers
- 380 people
- Sponsor
- Haukeland University Hospital
Cognitive Impairment, Sleep Quality
Benefits of Nicotinamide Riboside Upon Cognition and Sleep
Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor.
- Trial name
- NCT05500170
- Testing
- Nicotinamide riboside
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Premature Ovarian Insufficiency
sFlt- 1, PIGF, and Niacin Levels in Women With Premature Ovarian Insufficiency
Aim: To evaluate serum soluble fms-like tyrosine kinase-1, proangiogenic protein placental growth factor, and niacin levels in women with premature ovarian insufficiency (POI) and to compare the results with those of healthy…
- Trial name
- POİ&niacin (NCT04641624)
- Testing
- ultrasound assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Dyslipidemia
MK0524A Bioequivalence Study (0524A-059)
This study will evaluate the definitive bioequivalence of tablets of MK0524A (1000 mg Extended Release (ER) Niacin/ 20 mg laropiprant) from two sources.
- Trial name
- NCT00944645
- Testing
- niacin (+) laropiprant (Source 1), Comparator: niacin (+) laropiprant (Source 2)
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Melasma
Comparison of 30% Metformin and 2% Nicotinamide Lotion With Kligman Formula in the Treatment of Melasma
Comparison of 30% Metformin and 2% Nicotinamide lotion with kligman formula in the treatment of Melasma
- Trial name
- NCT05790577
- Testing
- Metformin and Nicotinamide vs Kligman Formula
- Where
- Pakistan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ishtiaq Ahmed
Coronary Artery Disease, Dyslipidemia
The Impact of Tredaptive on Flow-Mediated Dilation in Cardiac Patients
Laropiprant (LRP; Merck \& Co., Inc, Whitehouse Station, NJ, USA) is a potent, once-daily, highly selective PGD2-receptor (DP1) antagonist.
- Trial name
- NCT01052311
- Testing
- Tredaptive (1 g extended release niacin+ 20 mg laropiprant), Tredaptive
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Sheba Medical Center
Chronic Kidney Disease, Sarcopenia
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease
Chronic kidney disease is associated with the loss of skeletal muscle mass and function. This process detrimentally impacts mobility, functional independence, and quality of life.
- Conditions
- Chronic Kidney Disease, Sarcopenia, Frailty
- Trial name
- CoNR (NCT03579693)
- Testing
- CoQ10, Nicotinamide riboside
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Washington