Clinical trials: Nicotinamide
Polycystic Kidney Disease
Uncontrolled, Open Label, Pilot and Feasibility Study of Niacinamide in Polycystic Kidney Disease
The goal of this pilot study is to evaluate the feasibility of administering niacinamide to patients with autosomal dominant polycystic kidney disease, to develop methods to assess the biological efficacy of niacinamide, and to…
- Trial name
- NIAC-PKD1 (NCT02140814)
- Testing
- Niacinamide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Alan Yu, MB, BChir
Peripheral Artery Disease
Nicotinamide Riboside With and Without Resveratrol to Improve Functioning in Peripheral Artery Disease
NICE is a randomized clinical trial that will examine the effects of nicotinamide riboside (NR) both with and without resveratrol to test whether, among people with PAD, NR significantly improves walking performance more than…
- Trial name
- NICE (NCT03743636)
- Testing
- Nicotinamide riboside, Resveratrol
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Northwestern University
Metabolic Syndrome
Olive Oil and Nampt on Postprandial Inflammation and Atherosclerosis in the Setting of Metabolic Syndrome
The metabolic syndrome may be defined as the constellation of cardiovascular disease (CVD) risk factors that comprises obesity, type 2 diabetes, dyslipidemia, and hypertension.
- Trial name
- OLNAMS (NCT02061267)
- Testing
- Niacin, Saturated meal, Monounsaturated meal
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Glaucoma
The Glaucoma Nicotinamide Trial
The Glaucoma Nicotinamide Trial (TGNT) is a prospective, randomized, placebo-controlled double-masked clinical trial composed of two cohorts; The Swedish Glaucoma Nicotinamide Trial (SGNT) and the Vitamin B3 In Glaucoma Study…
- Trial name
- TGNT (NCT05275738)
- Testing
- Nicotinamide
- Where
- 2 sites in Sweden
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Umeå University
Friedreich Ataxia
Study of the Efficacy and Safety of Nicotinamide in Patients With Friedreich Ataxia
Friedreich ataxia is the most frequent early-onset autosomal recessive hereditary ataxia. It is caused by a pathological expansion of a GAA repeat in the first intron of the frataxin gene (FXN) and results in decreased levels of…
- Trial name
- NICOFA (NCT03761511)
- Testing
- Nicotinamide
- Where
- 7 sites in Austria, France and 4 more
- Sponsor
- RWTH Aachen University
Healthy Volunteers
Pharmacodynamics and Tolerance of Nicotinamide Mononucleotide (NMN, 400mg/Day) in Healthy Adults
The purpose of this study is to evaluate the physiological and/or biological actions of nicotinamide mononucleotide (NMN-C) in healthy adults receiving a repeated-dose over the course of 28 days by studying the tolerance and…
- Trial name
- NCT04862338
- Testing
- Nicotinamide mononucleotide (NMN-C)
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Seneque SA
Healthy Aging
Evaluate the Safety, Tolerability, and Efficacy of UthPeak NMNH (Reduced β-Nicotinamide Mononucleotide Calcium Salt) in Healthy Adult Participants
This randomized, double-blind, placebo-controlled trial evaluated the effects of 90-day NMNH-Ca supplementation on blood NAD⁺ levels, blood phenotypic age, physical function, BMI, and health-related quality of life in healthy…
- Trial name
- NCT06889740
- Testing
- NMNH-Ca
- Where
- 2 sites in India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- EffePharm LTD
Type 2 Diabetes Mellitus, Obesity
Effects of Niacin on Intramyocellular Fatty Acid Trafficking in Upper Body Obesity and Type 2 Diabetes Mellitus
Muscle insulin resistance is a hallmark of upper body obesity (UBO) and Type 2 diabetes (T2DM). It is unknown whether muscle free fatty acid (FFA) availability or intramyocellular fatty acid trafficking is responsible for the…
- Trial name
- NCT03867500
- Testing
- Niacin, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
PCOS
Role of Nesfatin-1 and Nicotinamide in Infertile Women With Polycystic Ovary Syndrome
evaluation of the potential role of circulating Nesfatin-1 and Nicotinamide in patients with polycystic ovary syndrome. and detection the correlation between Nesfatin-1 and body mass index (BMI), Waist hip ratio (WHR), blood…
- Trial name
- NCT03870035
- Volunteers
- 56 people
- Sponsor
- Assiut University
Periodontitis Stage I, Periodontal Diseases
Effect of Adjunctive Use of Vitamin B3 and B9 on Myeloperoxidase Level in the GCF of Patients With Stage I and II Periodontitis
this study addresses the effect of the vitamin B3 and vitamin B9 on the periodontal healing at the sites of periodontal destruction due to periodontitis and evaluate its added effect to the conventional non-surgical periodontal…
- Conditions
- Periodontitis Stage I, Periodontal Diseases, Periodontal Inflammation, Periodontal Attachment Loss
- Trial name
- NCT05435378
- Testing
- Vitamin B3 100 MG Oral Tablet, vitamin B9, full mouth non surgical periodontal treatment
- Volunteers
- 30 people
- Sponsor
- Cairo University
Skin Cancer, Cutaneous Squamous Cell Carcinoma (CSCC)
A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients
A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Organ Transplant Recipients This study is designed to evaluate whether a topical 5% niacinamide cream can help prevent skin cancer in organ…
- Conditions
- Skin Cancer, Cutaneous Squamous Cell Carcinoma (CSCC), Actinic Keratosis (AK), Organ Transplant Recipient
- Trial name
- NCT07286318
- Testing
- Topical niacinamide 5% cream, Sunscreen
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Marissa Lobl
Chronic Kidney Disease
Niacin and Endothelial Function in Early CKD
The purpose of this study is to obtain information on whether raising levels of HDL-cholesterol (the "good" cholesterol) can improve how blood vessels work in kidney disease.
- Trial name
- NCT00852969
- Testing
- Niacin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tufts Medical Center
Oxidative Stress, Physical Activity
Effect of the Combination of Pterostilbene Cocrystal With Silybin and Nicotinamide Riboside on Exercise-Induced Oxidative Stress
This study aims to evaluate the effects of the dietary supplement ccPT-SIL-NR, which contains pterostilbene (ccPT), silybin (SIL), and nicotinamide riboside (NR), on oxidative stress markers after a high-intensity exercise…
- Conditions
- Oxidative Stress, Physical Activity, Antioxidant Effect
- Trial name
- PT-SILAOX (NCT07024966)
- Testing
- Pterostilbene-silybin-nicotinamide riboside, Control Group
- Where
- Spain
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Healthy Aging
IV Administration of ChromaDex's Niagen® as Compared to NAD+
This is a 2-part study evaluating the effects of IV administration of NR on healthy adult populations. Study 1 involved all four arms with 37 people.
- Trial name
- NCT06382688
- Testing
- NAD+ (nicotinamide adenine dinucleotide) IV, Niagen® (nicotinamide riboside) IV, Niagen® (nicotinamide riboside) oral
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute
Migraine Prophylaxis
Effect of Nicotinic Acid as Add on Therapy in Patients Receiving β Blocker for Prophylaxis of Moderate to Severe Migraine
This is a prospective single center, randomized, double-blind, 3 arm placebo-controlled study in subjects with migraine headache requiring prophylactic treatment.
- Trial name
- NCT05846373
- Testing
- Nicotinic Acid 500 MG Extended Release Oral Tablet, Nicotinic Acid 1000 MG Extended Release Oral Tablet
- Where
- Bangladesh
- Volunteers
- 58 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh