Clinical trials: Nicotine
Growth Failure, Congenital Heart Disease
A Study to Evaluate the Effects of a New Formula on the Growth, Safety and Tolerance of Infants With Growth Failure
This study is a prospective, open-label, multi-site, growth, safety and tolerance study to evaluate a NF (New Formula). A minimum of 45 evaluable infants with confirmed growth failure will be enrolled.
- Trial name
- NCT03563391
- Testing
- New Infant Formula
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Nutricia North America
Tobacco Use
Pharmacokinetics and Comparative Bioavailability of Nicotine From Two Variants of NP2, NP2-4mg and NP2-6mg, Compared to Nicotine Lozenge 4mg (Loz-4mg) and Nicotine Gum 4mg (Gum-4mg)
This is a multi-center, randomized, controlled, partially blinded study to assess the pharmacokinetics and comparative bioavailability of nicotine from two variants of NP2 (4 and 6 mg) in comparison with Loz-4mg and Gum-4mg in…
- Trial name
- NCT06171490
- Testing
- NP2-4mg, NP2-6 mg, Loz-4mg
- Where
- 2 sites in Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Tobacco Dependence
Comparative Pharmacokinetic Study of New Oral Nicotine Replacement Therapy Products.
Comparative pharmacokinetic study of new oral nicotine replacement therapy products.
- Trial name
- NCT01227720
- Testing
- Experimental Nicotine Replacement Therapy (NRT) 2 mg, Experimental Nicotine Replacement Therapy (NRT), Marketed Nicotine Lozenge
- Where
- 2 sites in Sweden
- Volunteers
- 104 people
- Sponsor
- McNeil AB
Smoking
Functional Magnetic Resonance Imaging (fMRI) Investigation of Nicotine Withdrawal Symptoms
A single center, double blind, randomized, placebo controlled, two-treatments, two-period crossover study conducted in adult smokers.
- Trial name
- NCT00657020
- Testing
- Nicotine
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Smoking
CSD170303: Study to Assess Nicotine Uptake in Smokers From Electronic Cigarettes
To determine the rate and amount of nicotine uptake with 10-minute ad libitum use of four different marketed electronic cigarettes.
- Trial name
- NCT03234010
- Testing
- FT21092, FT21093, FT21096
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking Cessation, Tobacco Use Cessation
Safety and Effectiveness of NicVAX in Treating Nicotine Dependent Individuals
Nicotine is highly addictive and many individuals are unable to quit smoking even with treatment. The purpose of this study is to determine the effectiveness of various doses of NicVAX in treating nicotine dependent individuals.
- Trial name
- NCT00218413
- Testing
- NicVAX
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Nabi Biopharmaceuticals
Schizophrenia
First Time in Human Study With GSK1018921
GSK1018921 is a new drug under development for the treatment of schizophrenia. GSK1018921 differs from other available drugs in its mode of action and it is assumed that it may have an effect in the treatment of so-called…
- Trial name
- NCT00527020
- Testing
- GSK1018921, Nicotine Lozenges
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Nicotine Use Disorder
Study to Assess PK, PD, Nicotine Extraction, Palatability, Subjective Effects of Nicotine Pouches - Daily Nicotine Users
This is an explorative, open-label, randomised, 3-way cross-over study to assess pharmacokinetics (PK), pharmacodynamics (PD), safety and tolerability, nicotine extraction, palatability and subjective effects after single use of…
- Trial name
- NCT06170138
- Testing
- Test product 1 - Test product 2 - Comparator product
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Amplicon AB
Cigarette Smoking Behavior
Effect of Flavored on!® Nicotine Pouch Products on Smoking Behaviors: a SMART Study
The goal of this clinical trial is to learn about the role of flavored on!® nicotine pouch products (the research products), an oral tobacco-leaf-free product, in the replacement of cigarettes with the use of the research…
- Trial name
- NCT06072547
- Testing
- Access to all varieties of on! 4mg nicotine pouches (Berry, Citrus, Cinnamon, Wintergreen, Mint, Coffee, and Original), Access to Original on! 4mg nicotine pouches, Non-Flavored then complete flavor on! nicotine pouches
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Altria Client Services LLC
Tobacco Use
A Study to Evaluate Changes in Smokers Using Oral Tobacco-derived Nicotine Products.
The purpose of this study is to evaluate changes in exposure to selected harmful and potentially harmful constituents (HPHC) by measuring biomarkers in adult smokers who partially or completely switch from smoking cigarettes to…
- Trial name
- NCT03692078
- Testing
- OTDN product 1, OTDN product 2, Tobacco Cessation
- Where
- 2 sites in United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Altria Client Services LLC
Opioid Use Disorder
The Feasibility of VR for OUD
This study aims to evaluate feasibility of a virtual reality software device and measure the effects of the intervention on OUD patient mood, tension and cravings, as well as the effect of treatment on patient retention to their…
- Trial name
- NCT06255119
- Testing
- 3D Therapy Thrive
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- 3D Therapy, LLC
Vaping Cessation
Phase 3 Trial Evaluating the Efficacy and Safety of Cytisinicline for Vaping Cessation in Adults Using Nicotine-Containing E Cigarettes
This will be a multi-center, double-blind, randomized, placebo-controlled, Phase 3 study conducted in male or female adults who are daily nicotine e-cigarette users only.
- Trial name
- ORCA-V2 (NCT07392125)
- Testing
- Cytisinicline, Behavioral Support
- Volunteers
- 800 people
- Sponsor
- Achieve Life Sciences
NO VAPE + 12 Weeks of Standard CBT, Sham NO VAPE + 12 Weeks Standard CBT
Trial of Novel, On-Demand Virtual Reality to Amplify Practice Efficacy (NO VAPE) Added to Cognitive Behavioral Therapy for Nicotine Vaping Cessation
3. General Description of Study Design The proposed study will evaluate the effect of adding a VR app with CBT-embedded content to a 12-session individual CBT treatment program.
- Trial name
- NO VAPE (NCT07223879)
- Testing
- NO VAPE VR app with CBT-embedded content with a 12-session individual CBT treatment program
- Volunteers
- 90 people
- Sponsor
- Charles River Analytics
Schizophrenia, Cognition Disorders
The Effect of Nicotine on Arousal, Cognition and Social Cognition in Young and Elderly Healthy Subjects.
This study in young and elderly healthy subjects will investigate the effect of nicotine on arousal, cognitive task and social cognition after acute dose administration.
- Trial name
- NCT01181934
- Testing
- A643 (nicotine)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Smoking Cessation
Provoked Craving Relief Study by NRT
This study is designed to assess the ability of the mint nicotine mouth strip to relieve provoked cigarette craving in light smokers compared to nicotine lozenge and nicotine gum.
- Trial name
- NRT (NCT01476202)
- Testing
- nicotine
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tobacco Dependence
Multiple-dose Nicotine Pharmacokinetics With Three Oral Nicotine Replacement Products
Multiple-dose nicotine pharmacokinetics with three oral nicotine replacement products. A study in healthy smokers.
- Trial name
- NCT01321931
- Testing
- Nicotine
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- McNeil AB
Healthy Volunteers, Smoking
A Nicotine Pharmacokinetics and Smoking Behaviour Study Examining Cigarette Ingredients
This study will compare nicotine delivery and smoking behaviour in healthy subjects using several combustible cigarette prototypes containing different ingredients which are commonly used in the European Union.
- Trial name
- NCT03272295
- Testing
- Reference cigarette, Cigarette with carob bean extract, Cigarette with cocoa powder
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- British American Tobacco (Investments) Limited
Healthy Volunteers
Nicotine Pharmacokinetic Study of Heated Tobacco and Heated Herbal Products
This is a randomised, cross-over, open-label, confinement study conducted in 25 adult male or female smokers of combustible cigarettes (CCs).
- Trial name
- NCT06093659
- Testing
- Heated tobacco product with heated tobacco sticks (Product A), Heated tobacco product with heated tobacco sticks (Product B), Heated herbal product with nicotine-infused heated herbal sticks (Product C)
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Imperial Brands PLC
Smoking Cessation
An Open Label Study That Compares Varenicline to Transdermal Nicotine Patch for Smoking Cessation
Open-label comparison of standard 12-week regimen of varenicline with standard 10-week regimen of transdermal nicotine patch for smoking cessation.
- Trial name
- NCT00143325
- Testing
- varenicline (CP-526,555)
- Where
- 22 sites in United States, Belgium and 3 more
- Volunteers
- 730 people
- Sponsor
- Pfizer
Smoking
CSD170301: An Unblinded, Parallel, Randomized Study to Assess Nicotine Uptake in Smokers From Four Different Electronic Cigarettes
To determine the rate and amount of nicotine uptake with 10-minute ad libitum use of four different marketed electronic cigarettes.
- Trial name
- NCT03105804
- Testing
- FT21039, FT21041, FT21044
- Where
- 2 sites in United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- RAI Services Company