Clinical trials: Nicotine
Cigarette Smoking
Concurrent Nicotine Patch / Denicotinized Cigarette Therapy for Smoking Cessation II
The main goals of the study are to assess benefits of higher doses of the nicotine patch prior to smoking cessation for high- and low-dependent smokers, and to investigate the potential relationship between genetic factors and…
- Trial name
- CON NIC II (NCT00734617)
- Testing
- Nicotine Patch
- Where
- United States
- Volunteers
- 479 people, healthy volunteers welcome
- Sponsor
- Duke University
Cigarette Smoking, Nicotine Vaping
Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type
This study will investigate the relative appeal (abuse liability) of novel tobacco products, how the appeal is modulated by relative price, user type, and how novel products may substitute for one another.
- Trial name
- NCT05177848
- Testing
- All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Nicotine vaping products at 2x market price
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Virginia Polytechnic Institute and State University
Smoking Cessation
Facilitating Smoking Cessation With Reduced Nicotine Cigarettes
STUDY 1: INTERVENTION DEVELOPMENT The purpose of this study is to determine the best way to help people stop smoking by using very low nicotine content (VLNC) cigarettes.
- Trial name
- NCT02796391
- Testing
- Very Low Nicotine Content (VLNC) Cigarettes, One on One Counseling
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Smoking Cessation
Providing Free Nicotine Patches to Quitline Smokers
The California Smokers' Helpline will conduct a 3 X 2 (nicotine patch by counseling condition) randomized trial to test the provision of nicotine patches to help smokers calling a telephone quitline.
- Trial name
- NCT01736085
- Testing
- Telephone counseling, Voucher, Nicotine patches
- Where
- United States
- Volunteers
- 3,706 people
- Sponsor
- University of California, San Diego
Smoking Cessation
Combining Varenicline and Bupropion for Smoking Cessation
The goal of this clinical research study is learn if the combination of Chantix (varenicline) and Zyban (bupropion) is more effective at helping people to quit smoking than varenicline when given alone.
- Trial name
- NCT00943618
- Testing
- Varenicline, Bupropion, Counseling/Phone Calls
- Where
- United States
- Volunteers
- 641 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Smoking Cessation, Smoking
A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers
The overall purpose of this research is two-fold. First, the two smoking cessation medication treatments with the strongest evidence of effectiveness have never been directly compared.
- Conditions
- Smoking Cessation, Smoking, Nicotine Dependence
- Trial name
- NHLBI-RO1 (NCT01553084)
- Testing
- Varenicline, Nicotine lozenge, Nicotine Patch
- Where
- 2 sites in United States
- Volunteers
- 1,086 people
- Sponsor
- University of Wisconsin, Madison
Pulmonary Function; Newborn, Abnormal, Infant Wheeze
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function
Vitamin C supplementation (500 mg per day) given to pregnant women who can not quit smoking will improve the pulmonary function tests in their offspring measured at 3 months of age.
- Conditions
- Pulmonary Function; Newborn, Abnormal, Infant Wheeze, In-utero Nicotine, Second Hand Smoke
- Trial name
- VCSIP (NCT01723696)
- Testing
- Vitamin C +prenatal vitamin
- Where
- 2 sites in United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Tobacco Use
A Study to Assess Changes in Cigarette Consumption During a Switch to Very Low Nicotine Cigarettes
This study evaluates the impact of switching from usual brand cigarettes to very low nicotine cigarettes on cigarette consumption, smoking behavior, and biomarkers of exposure.
- Trial name
- NCT03571724
- Testing
- Non-Menthol Very Low Nicotine Cigarettes, Menthol Very Low Nicotine Cigarettes, Subject's UB non-mentholated filtered cigarettes
- Where
- 2 sites in United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- 22nd Century Group, Inc.
Healthy Volunteers
A Study to Evaluate Nicotine Uptake and Biomarkers in Smokers Using mybluTM Electronic Cigarettes
This study evaluates the overall performance of the currently-marketed MybluTM e-cigarette device and pods, as assessed by nicotine uptake, exposure to smoke constituents, safety and consumer satisfaction, over 8 days.
- Trial name
- NCT04430634
- Testing
- Myblu variant A, Myblu variant B, Myblu variant C
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fontem US LLC
Smoking
Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 (THS 2.2)
The primary objective of this clinical study is to evaluate the pharmacokinetic (PK) profile (rate and amount of nicotine absorbed) following a single use of the THS 2.2 compared to the PK profiles from a single use of a…
- Trial name
- NCT01967732
- Testing
- THS 2.2, CC, NNS
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Nicotine Dependence
Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of Nicotine
Unfortunately, the investigators still need to assess and identify novel ways to help people quit smoking. Differences between people in terms of how fast they metabolize nicotine influences response to transdermal nicotine…
- Trial name
- HDP (NCT00956943)
- Testing
- Nicoderm CQ transdermal nicotine
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tobacco Use Disorder
Effect of Ramelteon on Smoking Abstinence
This is a randomized, double-blind, placebo-controlled crossover study to test whether a medication called ramelteon (Brand Name: Remeron) will help smokers quit and whether it reduces sleep problems that smokers experience…
- Trial name
- RAP (NCT02560324)
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Pennsylvania
Schizophrenia
Nicotine Effects on Endophenotypes of Schizophrenia
The purpose of this study is to test the effects of nicotine on cognition with the following schizophrenia endophenotypes: prepulse inhibition, antisaccades, the continuous performance test, spatial working memory and a verbal…
- Trial name
- NCT01315002
- Testing
- Transdermal nicotine patch
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Nicotine Addiction, E-Cig Use
Sex Differences in E-cig Perception: Study 1
The primary objective is to examine the influence of sex on sensory effects, appeal, and reinforcing value of nicotine containing e-cigs in popular flavor components; sweet and cooling.
- Conditions
- Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
- Trial name
- NCT05432830
- Testing
- E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yale University
Malnutrition, Wasting
Nutritional Impact of Moringa Oleifera Leaf Supplementation in Mothers and Children
Studies to date on the effects of Moringa oleifera in diabetes and anemia and animal studies that examine the utility of moringa for increased milk and litter yield are of small scale, however high-quality large-scale placebo or…
- Conditions
- Malnutrition, Wasting, Growth Failure
- Trial name
- NCT04587271
- Testing
- Moringa oleifera (high dose), Moringa oleifera (low dose)
- Where
- 2 sites in Kenya
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Suzanna L Attia
Nicotine Addiction
Nicotine Reinforcement and Aversion in Young Adult Light Smokers
The proposed study will examine the threshold for nicotine self-administration (NSA) using five different nicotine doses in young adult male and female non-dependent smokers (light and intermittent smokers or LITS).
- Trial name
- NCT01495819
- Testing
- Saline, Nicotine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Smoking Cessation
Telephone Counseling and the Distribution of Nicotine Patches to Smokers
The primary purpose of this study is to determine the effects of distributing free nicotine replacement therapy (NRT) to tobacco quitline callers directly. Specifically, this study aims to: 1.
- Trial name
- NCT00851357
- Testing
- Nicotine Patch, Telephone Counseling, Self-Help Materials
- Where
- United States
- Volunteers
- 4,200 people
- Sponsor
- University of California, San Diego
Tobacco Use Disorder, Schizophrenia
Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia
The objective of this study is to investigate the relative contributions of nicotine replacement and sensorimotor replacement (i.e., smoking denicotinized cigarettes) on abstinence-induced smoking urges, withdrawal-related…
- Trial name
- NCT01213524
- Testing
- sensorimotor replacement, 42 mg transdermal nicotine replacement, usual brand smoking
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Brown University
Smoking, Nicotine Dependence
A Trial of E-cigarettes in Current Cigarette Smokers
The purpose of this study is to examine cigarette smokers' use of electronic cigarettes (e-cigarettes), and how use of e-cigarettes affects short term smoking behavior.
- Conditions
- Smoking, Nicotine Dependence, Nicotine Dependence, Other Tobacco Product
- Trial name
- NCT02357173
- Testing
- electronic cigarette, cigarette group
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Medical University of South Carolina
Nicotine Dependence
Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms
The proposed work will advance the understanding and effectiveness of tobacco dependence treatment and result in more smokers quitting successfully.
- Trial name
- NCT00332644
- Testing
- nicotine patch, nicotine lozenge, nicotine patch + nicotine lozenge
- Where
- 2 sites in United States
- Volunteers
- 1,504 people
- Sponsor
- University of Wisconsin, Madison