Clinical trials: Nicotine
Cigarette Smoking, Nicotine Dependence
Smokers' Response to Nicotine Dependence Genotyping
Innovative strategies to reduce adult smoking prevalence include using genetic information to motivate cessation and, ultimately, to tailor cessation pharmacotherapy.
- Trial name
- NCT01780038
- Testing
- Receipt of Genetic Results, No results given
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Nicotine Dependence
Nicotine Vaccination and Nicotinic Receptor Occupancy
This is a molecular imaging research study designed to examine how much nicotine gets into the brain before and after vaccination with NicVAX, a nicotine vaccine developed by Nabi Biopharmaceuticals.
- Trial name
- NCT00996034
- Testing
- NicVAX, [123I]5-IA-85380, Nicotine bitartrate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Addiction
tDCS Effects on Resisting Smoking: Dose Ranging Study
Behaviors such as tobacco use, unhealthy diet, and sedentary behavior have far-reaching health implications. These modifiable behaviors account for a substantial proportion of deaths from cancer, cardiovascular disease and…
- Trial name
- RDR (NCT02624284)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking Cessation
Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening
To compare the effectiveness of four interventions to promote sustained, biochemically confirmed smoking abstinence for 6 months among underserved smokers referred for lung cancer screening at four large U.S. health systems.
- Trial name
- NCT04798664
- Testing
- Removal of Financial Barriers, Financial Incentives, Mobile Health Application
- Where
- 5 sites in United States
- Volunteers
- 3,228 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Nicotine Dependence
Study Two on the Effectiveness of Mindfulness Training for Smokers
The MTS2 study enrollment goal is N=240 adult smokers randomized to study treatments. The study design includes two randomized arms to compare matched intensive interventions and a third non-randomized option for participants who…
- Trial name
- MTS2 (NCT01299909)
- Testing
- Integrated Training for Smokers, Mindfulness Training for Smokers, Quitline
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Wisconsin, Madison
Tobacco Use
Study to Evaluate Changes in Smokers Using on!® Nicotine Pouches
The purpose of this study is to generate evidence regarding the extent of reduction in exposure to selected HPHCs in adult smokers switching to on!® NPs.
- Trial name
- NCT05664672
- Testing
- OTDN Product 1, OTDN Product 2, OTDN Product 3
- Where
- 3 sites in United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Altria Client Services LLC
Nicotine Dependence
Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction
The purpose of this study is to investigate the effect of gemfibrozil on nicotine reinforcement and cue-elicited craving. Other objectives of this study include screening for the ability of gemfibrozil to aid smoking abstinence…
- Trial name
- NCT01876810
- Testing
- Gemfibrozil
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Centre for Addiction and Mental Health
Alcoholism, Nicotine Dependence
Varenicline and Alcohol in Inpatient Addictions Program (IAP)
The overall hypothesis of this line of research is that varenicline will decrease alcohol consumption and tobacco use and will increase alcohol and tobacco abstinence rates.
- Trial name
- NCT01169610
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Nicotine Dependence, Cigarettes
Penn State TXT2Quit Study
This study is evaluating the feasibility and short term smoking cessation outcomes of an automated smoking cessation intervention delivered via mobile phone text messaging as an adjunct to Varenicline in a primary care setting.
- Trial name
- NCT02367391
- Testing
- Motivational Text Messages, Control
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Smoking
Efficacy and Safety Study of Nicotine Mint Lozenge (2mg and 4mg) in Smoking Cessation
A multi-center, randomized, double-blind, placebo-controlled, 4-arm clinical study to evaluate efficacy and safety of nicotine lozenge (2mg and 4mg) in smoking cessation in adult cigarette smokers who are motivated to quit…
- Trial name
- NCT00985985
- Testing
- Nicotine
- Volunteers
- 723 people
- Sponsor
- GlaxoSmithKline
Marijuana Dependence
Nicotine Patch for Marijuana Withdrawal
The purpose of this 3-year trial is to test the efficacy of transdermal nicotine patch versus placebo patch on marijuana withdrawal symptoms in cannabis-dependent individuals, using a randomized, double-blind, and…
- Trial name
- NMW (NCT01400243)
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Southern Illinois University Carbondale
Tobacco Dependence
Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders
The overall aim of this project is to evaluate the effect of progressive nicotine reduction in cigarettes on smoking behavior, toxin exposure and psychiatric symptoms in smokers with comorbid mood and/or anxiety disorders.
- Trial name
- NCT01928758
- Testing
- Reduced Nicotine Content Cigarettes, Usual Nicotine Content Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Breast Cancer, Chemotherapeutic Agent Toxicity
Nicotine Patches in Reducing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine For Metastatic Breast Cancer
RATIONALE: Nicotine patches may reduce hand-foot syndrome in patients receiving capecitabine for metastatic breast cancer. It is not yet known which nicotine patch regimen may be more effective in reducing hand-foot syndrome.
- Conditions
- Breast Cancer, Chemotherapeutic Agent Toxicity, Palmar-plantar Erythrodysesthesia
- Trial name
- NCT00751101
- Testing
- Nicotine patch
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Smoking Cessation, Smoking, Cigarette
AXS-05 Phase II Trial on Smoking Behavior
This research study is designed with the purpose of evaluating a new drug, combination Dextromethorphan-Bupropion (AXS-05), for its effects on smoking behavior.
- Conditions
- Smoking Cessation, Smoking, Cigarette, Nicotine Dependence
- Trial name
- NCT03471767
- Testing
- AXS-05, Bupropion SR
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- James Davis
Oxygen Deficiency, Desaturation of Blood
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Use in Pediatric Procedures
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT03430206
- Testing
- High-flow nasal cannula
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Stanford University
Nicotine Dependence, Healthy
Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm
A research study designed to examine amphetamine-induced dopamine release using the PET imaging agent [11C]PHNO in tobacco smokers while currently smoking and during acute withdrawal and in nonsmokers.
- Trial name
- phno_amth (NCT01699607)
- Testing
- Amphetamine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Dependence
Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes
The overall goal of this study is to determine if switching to very low nicotine content cigarettes changes the function of brain circuitry involved in incentive salience and executive control among dependent smokers.
- Trial name
- NCT03612960
- Testing
- Very low nicotine content cigarettes, Normal nicotine content cigarettes
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Milton S. Hershey Medical Center
Smoking Cessation, Schizophrenia
Trial of Nicotine Nasal Spray as an Aid for Smoking Cessation in Schizophrenia
This R01 grant describes a randomized, double-blind, placebo-controlled trial of nicotine nasal spray (NNS) as an aid for smoking cessation in 60 individuals with schizophrenia.
- Trial name
- NCT01010477
- Testing
- Nicotine Nasal Spray, Behavioral counseling
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Rutgers, The State University of New Jersey
Alcohol Dependence, Alcohol Drinking
Role of Proinflammatory Signaling in Alcohol Craving
Background: Drinking too much alcohol can injure cells in the body. Inflammation is the body s reaction to injured cells. Studies show that inflammation can cause cravings for alcohol.
- Conditions
- Alcohol Dependence, Alcohol Drinking, Stress, Alcohol-Related Disorders
- Trial name
- NCT01631630
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Smokeless Tobacco Use
A Pilot Study Evaluating Nicotine Lozenges and Self Help
The investigators are hypothesizing that by offering both self-help materials and mailed nicotine lozenges we will be able to help increase tobacco abstinence rates among ST users, as well as decrease tobacco withdrawal.
- Trial name
- NCT00888459
- Testing
- nicotine replacement therapy
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic