Clinical trials: Nicotine
Bipolar Disorder, Schizophrenia
Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness
Approximately 60 chronic smokers with bipolar disorder, schizophrenia or schizoaffective disorder who are motivated to try to quit smoking will be randomized to receive smoking cessation treatment with the FDA-approved…
- Conditions
- Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Nicotine Dependence
- Trial name
- NCT04011280
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of California, San Diego
Nicotine Dependence
The Interaction of Flavor With Nicotine Form in Adult Smokers
This study seeks to elucidate the impact of e-cigarette flavor on subjective effects and nicotine exposure from e-cigarettes containing different forms of nicotine.
- Trial name
- NCT04262817
- Testing
- Nicotine form, E-cigarette experimental flavor
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Dependence
Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use
The goal of this research is to understand the potential impact of two new FDA strategies to ensure the availability of safer Alternative Nicotine Delivery Systems (ANDS) and to reduce the nicotine content in combustible…
- Trial name
- NCT04084210
- Testing
- Juul Electronic cigarette, Very Low Nicotine Cigarettes, Active Nicotine Patch
- Where
- 2 sites in United States
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Nicotine Dependence, Symptoms of Anxiety
Integrated Treatment for Smoking Cessation & Anxiety in People With HIV
During the 1-year formative phase of a study to develop an integrated treatment for quitting smoking for anxiety-vulnerable HIV+ smokers.
- Conditions
- Nicotine Dependence, Symptoms of Anxiety, HIV
- Trial name
- Project Quit (NCT01393301)
- Testing
- Integrated cognitive-behavioral therapy for smoking cessation and anxiety, Control
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Massachusetts General Hospital
Nicotine Dependence
Imaging Extrastriatal Dopamine Release in Tobacco Smokers and Nonsmokers
The goal is to examine sex differences in amphetamine-induced dopamine release in tobacco smokers and nonsmokers.
- Trial name
- NCT02348385
- Testing
- Amphetamine
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Dependence
Testing an Organizational Change Model to Address Smoking in Mental Healthcare
Despite an overall reduction in US smoking rates from >50% in the 1960s to about 20% by 2000, the rate of smoking among persons with a serious mental illness (SMI) remains 2-3 times greater than in the general population.
- Trial name
- NCT02849652
- Testing
- ATTOC Intervention, UC Intervention
- Where
- United States
- Volunteers
- 832 people
- Sponsor
- University of Pennsylvania
Nicotine Dependence, Cigarettes
The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products
This study plans to investigate whether using electronic cigarettes (e-cigarettes) or skin patches containing nicotine affects switching from smoking conventional combustible (burning) cigarettes.
- Trial name
- ENDS-Switch (NCT03492463)
- Testing
- Nicotine patch, E-cigarettes, Non-nicotine e-cigarettes
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Duke University
Smoking Cessation, Nicotine Addiction
Circuitry-Guided Smoking Cessation in Schizophrenia
In a double-blinded, randomized, parallel controlled design, patients with schizophrenia spectrum disorder will be exposed to active or sham repetitive transcranial magentic stimulation (TMS) which was guided by functional…
- Conditions
- Smoking Cessation, Nicotine Addiction, Schizophrenia
- Trial name
- NCT03281629
- Testing
- Active TMS stimulation
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Maryland, Baltimore
Smoking Cessation, Smoking, Cigarette
AXS-05 Phase II Trial on Smoking Behavior
This research study is designed with the purpose of evaluating a new drug, combination Dextromethorphan-Bupropion (AXS-05), for its effects on smoking behavior.
- Conditions
- Smoking Cessation, Smoking, Cigarette, Nicotine Dependence
- Trial name
- NCT03471767
- Testing
- AXS-05, Bupropion SR
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- James Davis
Nicotine Dependence, Cigarettes
Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior
This is a 2-arm, randomized controlled, population based trial to test the impact of multiple exposures to brief nicotine corrective messages among adult tobacco cigarette smokers and non-smokers followed in waves over 12 weeks.
- Trial name
- NCT04805515
- Testing
- Nicotine Corrective Messages
- Where
- United States
- Volunteers
- 794 people
- Sponsor
- University of Vermont
Psychosis, Substance Use
Families With Substance Use and Psychosis: A Pilot Study
The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT04284813
- Testing
- CRAFT-FT
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Nicotine Dependence, Smoking Cessation
Accelerated iTBS in Smoking Cessation
Cigarette smoking is one of the foremost causes of preventable disease and premature death. In 2014, 68% of adult smokers wanted to quit smoking and in 2017, 55.1% of adult smokers had made a quit attempt.
- Trial name
- NCT05271175
- Testing
- Active intermittent theta burst stimulation
- Where
- Cyprus
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Cyprus rTMS Center
Nicotine Dependence, Cigarettes
Translational Neuropsychopharmacology Research of Nicotine Addiction
This study will examine the effects of combining Varenicline (VRN) and N-acetylcysteine (NAC) on neural circuitry function and treating nicotine addiction.
- Trial name
- NCT02723162
- Testing
- Varenicline (VRN), N-Acetylcysteine (NAC)
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Dependence
TMS-fMRI for Neural Pathway in Smokers
Cigarette smoking causes significant morbidity and mortality in the United States. Smoking cessation is difficult, with the average smoker attempting to quit five times before permanent success.
- Trial name
- NCT02665338
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Xingbao Li
Nicotine Dependence, Nicotine Withdrawal
Progesterone and Brain Imaging Study
Male and female smokers were recruited to undergo 2 phases of smoking cessation. Each phase was 4 days long and involved 3 brain-imaging scans, blood draws and an intervention involving progesterone or a matched placebo.
- Trial name
- NCT01954966
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence
Community Intervention to Reduce Tobacco Use in Pregnant Women
In the southwest region of Alaska where the project takes place, 79% of Alaska Native women smoke cigarettes or use smokeless tobacco (ST) during pregnancy.
- Trial name
- Sisters (NCT02083081)
- Testing
- Community level intervention
- Where
- United States
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking Cessation, Nicotine Addiction
Innovative Digital Therapeutic for Smoking Cessation
This study is comparing the efficacy of two smoking cessation apps.
- Conditions
- Smoking Cessation, Nicotine Addiction, Drug Addiction, Drug Dependence
- Trial name
- NCT03694327
- Testing
- CT-101-M, QuitGuide
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- My Digital Study
Cancer of Head and Neck, Breast Cancer
Brain Stimulation For Cancer Smokers
Smoking cessation and relapse prevention represent and important opportunity to improve cancer survival rates, reduce the risk of cancer treatment complication, and improve the quality of life of patients with and survivors of…
- Conditions
- Cancer of Head and Neck, Breast Cancer, Prostate Cancer, Nicotine Dependence
- Trial name
- NCT03419741
- Testing
- Transcranial Magnetic Stimulation Clinical Research System
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Insomnia, Nicotine Dependence
Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
Objectives: The primary objective of this study is to determine the efficacy of eszopiclone at treating sleep problems related to withdrawal from nicotine in healthy smokers attempting smoking cessation.
- Trial name
- NCT00511134
- Testing
- Eszopiclone, Bupropion
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Dependence
Evaluation of Learning-Theory-Based Smoking Cessation Strategies
This clinical trial tested whether a new treatment designed to help smokers prepare to quit smoking by practicing quitting several times helped more smokers quit and stay quit than standard treatment with nicotine patch and…
- Trial name
- NCT01368653
- Testing
- Standard treatment, Standard treatment+practice quitting, Very low nicotine cigarettes
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Rutgers University