Clinical trials: Nicotine
Smoking Cessation
Use of Nicotine Replacement Therapy (NRT) Sample and Brief Smoking Cessation Advice for Recruiting Smokers
Background More than 60% of the daily smokers in Hong Kong have never tried and have no intention to quit smoking. About 30.8% of daily smokers attempted to quit but failed.
- Trial name
- NCT03717051
- Testing
- Nicotine replacement therapy (NRT) sampling, Medication counseling
- Where
- Hong Kong
- Volunteers
- 834 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Smoking Cessation
Cognition and Smoking Relapse (HCS)
This study tests whether withdrawal-related cognitive deficits increase smoking relapse among HIV-infected (HIV+) vs. HIV-uninfected smokers (HIV-).
- Trial name
- HCS (NCT03169101)
- Testing
- Nicotine patch, Behavioral counseling
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- University of Pennsylvania
Smoking
Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 (THS 2.2)
The primary objective of this clinical study is to evaluate the pharmacokinetic (PK) profile (rate and amount of nicotine absorbed) following a single use of the THS 2.2 compared to the PK profiles from a single use of a…
- Trial name
- NCT01967732
- Testing
- THS 2.2, CC, NNS
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Nicotine Dependence, Tobacco Smoking
Effects of Intranasal Oxytocin on Cigarette Smoking
Socioemotional processing dysfunctions (i.e., disruptions in affective, cognitive, and neural processes that encode, interpret, and respond to socially and emotionally relevant stimuli) have been implicated in tobacco smoking and…
- Trial name
- NCT02595749
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Smoking
Metabolism of NNK in Japanese Americans
The risk of lung cancer varies by individual and by ethnic/racial group. In this study the investigators will explore how individual differences in the metabolism of a tobacco-specific lung carcinogen may contribute to the…
- Trial name
- NCT04228952
- Testing
- Modified Natural American Spirit-Tan or Green cigarettes injected with labeled NNK
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Smoking, Smoking Cessation
Smartphone Intervention for Smoking Cessation and Improving Adherence to Treatment Among HIV Patients
The purpose of this study is to learn if a mindfulness-based smoking cessation smartphone app can help people quit smoking and stay on antiretroviral therapies.
- Conditions
- Smoking, Smoking Cessation, HIV
- Trial name
- NCT03999411
- Testing
- Nicoderm C-Q Transdermal Product, Adherence to Antiretroviral Therapy Counseling, Behavioral Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Miami
Smoking Cessation, Nicotine Dependence
Comparing NicoBloc to Nicotine Lozenges
To examine the feasibility, acceptability, and preliminary impact of using NicoBloc compared to nicotine lozenges
- Trial name
- NCT03720899
- Testing
- NicoBloc, Nicotine Lozenge
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Postoperative Pain
Anesthesia and Postoperative Pain
The purpose of this study is to compare post-operative pain after anesthesia with either isoflurane or propofol. Each group will be further randomized to receive intranasal nicotine or placebo in order to detect potential…
- Trial name
- NCT00232817
- Testing
- Nicotine (drug)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Columbia University
Nicotine Addiction, Panic Attack
Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine
The purpose of the current study is to evaluate the efficacy of d-cycloserine in augmenting treatment of smoking cessation for individuals with panic attacks.
- Trial name
- DCS/PSRT (NCT01944423)
- Testing
- d-cycloserine, Nicotine replacement therapy, Panic and Smoking Reduction Treatment
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Smoking, Tobacco
Nicotine Pharmacokinetics of THS Single Use of a Regular or a Menthol Stick Compared to CIG
The purpose of this study was to describe the nicotine pharmacokinetic (PK) profile during and after single use of THS (Induction heating technology, with either a regular or menthol stick) compared to singular CIG smoking in…
- Trial name
- NCT05789420
- Testing
- P1R stick, P1M stick, CIG
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking, Nicotine Dependence
Placebo-controlled Trial of Bupropion for Smoking Cessation in Pregnant Women
Smoking during pregnancy adversely affects the health of the mother and her developing baby. Maternal smoking approximately doubles the risk of miscarriage, placental complications, preterm delivery, low birth weight and fetal…
- Trial name
- BIBS (NCT02188459)
- Testing
- Bupropion
- Where
- 3 sites in United States
- Volunteers
- 129 people
- Sponsor
- Henry Kranzler
Tobacco Use Cessation
Improving Quitline Support Study
This study seeks to evaluate ways to improve outcomes for low-education, uninsured or Medicaid-eligible smokers who do not successfully quit with standard telephone quit line treatment.
- Trial name
- IQS (NCT03538938)
- Testing
- 1-Call Quitline Counseling, 4-Call Quitline Counseling, Nicotine patch
- Where
- United States
- Volunteers
- 1,316 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Nicotine Use Disorder
Effects of E-Cigarette Flavors on Adults TCORS 2.0
This study looks at the effects of flavors when administered with nicotine in e-cigarettes in younger and older adult cigarette smokers.
- Trial name
- NCT03635333
- Testing
- Nicotine, Flavor
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Yale University
Chemo Brain, Chemotherapy-related Cognitive Impairment
Nicotinic Treatment of Post-Chemotherapy Subjective Cognitive Impairment: A Pilot Study
The purpose of this study is to evaluate the use of a nicotine patch as a treatment for problems with attention, learning and memory in breast cancer patients who are 1-5 years post chemotherapy.
- Conditions
- Chemo Brain, Chemotherapy-related Cognitive Impairment, Chemo Fog, Breast Cancer
- Trial name
- NCT02312934
- Testing
- Transdermal nicotine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt University Medical Center
Tobacco Use Disorder
Varenicline-Aided Cigarette Reduction in Smokers Not Ready to Quit
The investigators will randomize smokers to receive 1) Varenicline + smoking cessation/reduction counseling or 2) Placebo pill + smoking cessation/reduction counseling.
- Trial name
- NCT01308736
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Nicotine Dependence
Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers
The proposed study will assess the efficacy of moclobemide, a selective, reversible MAO-A inhibitor, in facilitating smoking cessation in treatment-seeking female smokers.
- Trial name
- RIMA (NCT01926626)
- Testing
- Nicotine Patch, Moclobemide
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Jed E. Rose
Nicotine Dependence
A Study to Help People Quit Smoking.
You are invited to participate in a research study at the VA Connecticut Healthcare System (West Haven campus) that examines whether a medication called galantamine can improve your learning and memory, and also help you to quit…
- Trial name
- NCT01880099
- Testing
- Galantamine 8mg, Galantamine 16mg
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Cocaine Dependence, Nicotine Dependence
Efficacy of Varenicline in Methadone-Stabilized Cocaine Users
Cocaine addiction continues to be an important public health problem in the US with a significant cost to the individual and society.
- Trial name
- NCT00567320
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Electronic Cigarette Use
Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)
The purpose of this study is to determine if abuse liability indices will be impacted by varying flavors and e-cigarette (ECIG) nicotine delivery capability (i.e., nicotine flux) among current combustible cigarette users.
- Trial name
- NCT05971823
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence
A Smoking Cessation Treatment for Adult Women
The purpose of this study is to develop and pilot test a smoking cessation counseling that focuses on the perceived risks of quitting smoking (e.g., weight gain, managing cravings and negative affect, loss of enjoyment).
- Trial name
- NCT01422239
- Testing
- Tailored treatment, Standard Treatment
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University