Clinical trials: Nicotine
Smoking, Nicotine Dependence
A Brief Dental Office Intervention With Tobacco Quitline
The novel and exploratory nature of this intervention relates to the concept of incorporating patient-specific oral health information obtained during a dental hygiene visit into the tobacco quitline counseling.
- Trial name
- NCT00273156
- Testing
- Telephone quitline
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Dependence
Clinical Study to Assess Bioequivalence Between Nicorette Extra Mint Gum and Nicorette® Mint Gum in Healthy Smokers
This is a research study to verify the same effectiveness and safety profile for the test products, nicotine 2 mg gum and nicotine 4 mg gum, as for the already approved products, Nicorette Mint 2 mg gum and Nicorette Mint 4 mg…
- Trial name
- NCT03259607
- Testing
- Nicorette Extra Mint 2 mg Gum, Nicorette Mint 2 mg Gum, Nicorette Extra Mint 4mg Gum
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- McNeil AB
Smoking, Tobacco Product
Japanese Post-Market Cohort Study
The objectives and endpoints of this study were analyzed in the study population of adults eligible to purchase tobacco products.
- Trial name
- NCT03020667
- Where
- Japan
- Volunteers
- 1,124 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Tobacco Addiction, Dual Tobacco Use
Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors
The main focus of this study is to determine the use of nicotine-containing products across the three experimental conditions. Subjects will be monitored to determine their continued use of assigned cigarettes, switching to other…
- Trial name
- NCT02000921
- Testing
- VLNC cigarettes, Combusted Products, Non-combusted products
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
HIV Associated Cognitive Motor Complex
Effect of Galantamine on Inflammation and Cognition
This study tests whether galantamine (GAL) reduces HIV-related inflammation and cognitive deficits. In this double-blind placebo-controlled crossover study, HIV-infected individuals (N=120; 60 smokers and 60 non-smokers) will be…
- Trial name
- CHI (NCT03384784)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Pennsylvania
Cigarette Smoking
Mechanisms of the Nicotine Metabolism Effect on Tobacco Dependence
The purpose of the study is to learn more about tobacco dependence and nicotine metabolism in African-Americans and whites, by studying to see if how fast a person metabolizes nicotine (how the body breaks down nicotine into…
- Trial name
- NMR (NCT01627392)
- Testing
- Smoking abstinence
- Where
- United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Dependence
Nicotine Withdrawal Symptoms and Smoking Relapse
Background: Smoking is thought to cause changes in the brain that lead to addiction and craving. Smokers who try to quit experience nicotine withdrawal symptoms that include irritability, anxiety, and difficulty concentrating.
- Trial name
- NCT01511614
- Testing
- Transcranial Direct Current Stimulation, Nicotine patch, Varenicline Pill
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Nicotine Replacement Therapy in Nicotine-dependent Arrestees
Tobacco use affects more than 50% of adult arrestees, of which 70% are dependent on nicotine. However, they have no access to tobacco during detention in police cells.
- Trial name
- SUBNIGAV (NCT02905734)
- Testing
- Nicotine patch
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tobacco Cessation, Dental Practice
To Promote Tobacco Free Life in the Dental Practice in France
In France, 34% of the adult population is smoking every day. The links between smoking and the development of several chronic disorders is well established and smoking is directly implicated in most of the oral diseases such as…
- Trial name
- TOBAFREE-DP (NCT04498858)
- Testing
- Patient interview
- Where
- France
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Substance Dependence
Relapse Prevention Study in Newly Abstinent Smokers
The purpose of this study is to determine the effect of GSK598809 as compared to placebo in preventing recently-quit smokers from going back to smoking.
- Trial name
- NCT00793468
- Testing
- GSK598809, Nicotine Replacement Transdermal Patch
- Where
- 10 sites in United States
- Sponsor
- GlaxoSmithKline
Cerebral Palsy
Home-Based Training With Feedback to Improve Outcomes in Adolescents and Young Adults With Cerebral Palsy..
This clinical trial aims to determine whether extrinsic feedback through music enhances the effects of home-based motor training for adolescents and young adults with cerebral palsy (CP) and whether feedback improves adherence to…
- Trial name
- THRIVE-CP (NCT06962618)
- Testing
- Music Motion Group, Control
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- University of Copenhagen
Smoking Cessation
Feasibility Study of Smoking Cessation for the Staff of a Hospital Center
The recorded prevalence of daily smoking among health professionals (doctors, nurses, midwives, etc.), regardless of their mode of practice (salaried or self-employed, etc.) varies between 14 and 23%.
- Trial name
- Je_Respire (NCT04635358)
- Testing
- Hypnosis, Psychological support, Nutrional support
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Smoking, Smoking, Cigarette
Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2
The purpose of the study is to evaluate how limiting the nicotine content in regular cigarettes affects choices for regular cigarette and e-cigarette products.
- Conditions
- Smoking, Smoking, Cigarette, E-Cig Use, Nicotine Dependence
- Trial name
- NCT05473585
- Testing
- very low nicotine content cigarettes, normal nicotine content cigarettes, Study e-cigarette
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Duke University
Nicotine
Nicotine and Brain Imaging Research Study
The aim of this study is to assess the impact of smoking on cortical GABA levels in males and females. Using magnetic resonance spectroscopy (MRS), we will examine the impact of sex and menstrual cycle phase on brain…
- Trial name
- NCT01227343
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Vascular Reactivity, Serum Biomarkers
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
To examine vascular reactivity and inflammatory biomarkers via quantitative magnetic resonance imaging (MRI) and blood serum, respectively, in a crossover study where active vapers (electronic cigarette users) and smokers will…
- Trial name
- AeCE (NCT05271578)
- Testing
- Standardized Electronic Research Cigarette, Nicotine Research Cigarette
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Prematurity; Extreme, Failure to Thrive in Newborn
Targeted Fortification of Donor Breast Milk in Preterm Infants
This study is a randomized controlled trial comparing standard fortification of donor breast milk to targeted fortification of donor breast milk in preterm infants.
- Conditions
- Prematurity; Extreme, Failure to Thrive in Newborn, Growth Retardation, Growth Failure
- Trial name
- NCT04294368
- Testing
- Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid, Similac Liquid Protein Fortifier, Nestle Microlipid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Pulmonary Disease, Autonomic Dysfunction
Meditative Movement for COPD Symptoms in Non-Smoking Flight Attendants
This study will explore the a Qigong based exercise intervention, here referred to as Meditative Movement (MM), to ameliorate the symptoms associated with chronic obstructive pulmonary disease (COPD) and its co-morbidities.
- Conditions
- Pulmonary Disease, Autonomic Dysfunction, COPD
- Trial name
- MMforFA (NCT02612389)
- Testing
- Meditative Movement taught via DVD
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Schizophrenia, Psychopathology
fMRI Study of Nicotinic Effect on Neurophysiology of Schizophrenia
Background: Individuals who have schizophrenia are significantly more likely to smoke than the general population, which leads to increased smoking-related illnesses and high rates of nicotine dependence.
- Conditions
- Schizophrenia, Psychopathology, Nicotine Dependence
- Trial name
- NCT01046526
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Electronic Nicotine Delivery Systems, Tobacco Products
Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults
Electronic Nicotine Delivery Systems (ENDS) use remains prevalent among young adults, and many have high interest in quitting, yet research on effective intervention is lacking.
- Conditions
- Electronic Nicotine Delivery Systems, Tobacco Products, Cigarette Smoking
- Trial name
- EQUIP (NCT06395415)
- Testing
- EQUIP, Standard Care
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Nicotine Dependence
Effects of Psilocybin on Craving in Nicotine Dependence
This pilot study will examine how a single 25 mg dose of psilocybin affects nicotine craving in people with nicotine dependence.
- Trial name
- SCANS-PSIL (NCT07852832)
- Testing
- Psilocybin (drug)
- Volunteers
- 3 people
- Sponsor
- University of British Columbia