Clinical trials: Nicotine Dependence Tobacco Product
Tobacco Use Cessation, Alcohol-related Disorders
Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk
The majority of individuals with alcohol problems remain current smokers, and the negative health consequences of smoking among these individuals are substantial.
- Trial name
- NCT00861146
- Testing
- behavioral counseling plus contingency management
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Yale University
Second Hand Tobacco Smoke, Nicotine Dependence
Babies Living Safe and Smokefree
The purpose of this randomized controlled trial is to develop and test the efficacy of a multilevel, multimodal intervention designed to modify maternal smoking behavior to reduce children's exposure to secondhand tobacco smoke…
- Trial name
- BLiSS (NCT02602288)
- Testing
- Ask, Advise, Refer, Telebased tobacco counseling, Telebased nutrition counseling
- Where
- 2 sites in United States
- Volunteers
- 396 people
- Sponsor
- Temple University
Tobacco Use Disorder
Persistence-Targeted Smoking Cessation
The investigators propose to develop a theory-based smoking cessation intervention (called Persistence-targeted smoking cessation; PTSC).
- Trial name
- PTSC (NCT01654107)
- Testing
- Persistence Targeted Smoking Cessation, Clearing The Air, Nicotine lozenge
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Nicotine Dependence, Nicotine Addiction
A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults
Almost one in ten young adults report current e-cigarette use, putting them at risk of developing nicotine addiction and long-term health effects of exposure to inhaled toxicants.
- Conditions
- Nicotine Dependence, Nicotine Addiction, Nicotine Use Disorder, Nicotine Vaping
- Trial name
- NCT05897242
- Testing
- Smartphone app, Text Message, Survey Administration
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Smoking, Nicotine Dependence
Placebo-controlled Trial of Bupropion for Smoking Cessation in Pregnant Women
Smoking during pregnancy adversely affects the health of the mother and her developing baby. Maternal smoking approximately doubles the risk of miscarriage, placental complications, preterm delivery, low birth weight and fetal…
- Trial name
- BIBS (NCT02188459)
- Testing
- Bupropion
- Where
- 3 sites in United States
- Volunteers
- 129 people
- Sponsor
- Henry Kranzler
Tobacco Use Disorder, Nicotine Addiction
Cognitive Training for Nicotine Dependence
This randomized clinical trial tested the effects of a computerized (web-based) cognitive training intervention on smoking cessation.
- Trial name
- NCT01252966
- Testing
- Cognitive Training, Control training
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- University of Pennsylvania
Nicotine Dependence
Smoking While on Transdermal Nicotine Replacement Therapy: Effects on Craving and Cessation
Smoking while on nicotine patches will help subjects to reduce their expired carbon monoxide levels from the levels they were before they started using the patch. Subjects will also decrease their daily consumption of cigarettes.
- Trial name
- NCT00289653
- Testing
- Nicoderm
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation, Nicotine Dependence
Varenicline and Motivational Advice for Smokers With Substance Use Disorders
The purpose of this study is to evaluate the effects of 12 weeks of varenicline as compared to nicotine replacement therapy for smoking cessation among outpatients in treatment for substance use disorders.
- Trial name
- VARSUD (NCT00756275)
- Testing
- Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Brown University
Tobacco Dependence
Low Nicotine Cigarettes Plus Electronic Cigarettes
This study aims to determine the health effects of very low nicotine content in cigarettes, in conjunction with the availability of nicotine-containing electronic cigarettes (e-cigs) among smokers with mental health conditions…
- Trial name
- NCT04058717
- Testing
- Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Insomnia, Nicotine Dependence
Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
Objectives: The primary objective of this study is to determine the efficacy of eszopiclone at treating sleep problems related to withdrawal from nicotine in healthy smokers attempting smoking cessation.
- Trial name
- NCT00511134
- Testing
- Eszopiclone, Bupropion
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Yale University
Smoking Cessation
Treatment of Smoking Lapses and Relapses
Many smokers who try to stop smoking with nicotine medications (NM) such as gum, lozenge and patch, go back to smoking (i.e., a slip or lapse).
- Trial name
- NCT01807871
- Testing
- nicotine patch, experimental use, nicotine patch, labeled use
- Where
- United States
- Volunteers
- 701 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Nicotine Dependence, Cigarettes
Penn State TXT2Quit Study
This study is evaluating the feasibility and short term smoking cessation outcomes of an automated smoking cessation intervention delivered via mobile phone text messaging as an adjunct to Varenicline in a primary care setting.
- Trial name
- NCT02367391
- Testing
- Motivational Text Messages, Control
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Nicotine Dependence
Imaging Extrastriatal Dopamine Release in Tobacco Smokers and Nonsmokers
The goal is to examine sex differences in amphetamine-induced dopamine release in tobacco smokers and nonsmokers.
- Trial name
- NCT02348385
- Testing
- Amphetamine
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Dependence, Alcohol Drinking
Role of Proinflammatory Signaling in Alcohol Craving
Background: Drinking too much alcohol can injure cells in the body. Inflammation is the body s reaction to injured cells. Studies show that inflammation can cause cravings for alcohol.
- Conditions
- Alcohol Dependence, Alcohol Drinking, Stress, Alcohol-Related Disorders
- Trial name
- NCT01631630
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Nicotine Dependence, Cigarette Smoking
Smoking Cessation for Smokers With Sleep Problems
This is a pilot research study examining two types of behavioral counseling along with the nicotine patch for smoking cessation.
- Conditions
- Nicotine Dependence, Cigarette Smoking, Insomnia
- Trial name
- NCT01277887
- Testing
- Cognitive-Behavioral Counseling, Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Yale University
Nicotine Dependence
Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation
The purpose of this study is to look at brain function in order to understand how different treatments work to help people quit smoking.
- Trial name
- ConNicBrain (NCT01406223)
- Testing
- Varenicline, Bupropion, Nicotine patches
- Where
- 2 sites in United States
- Volunteers
- 282 people
- Sponsor
- Duke University
Nicotine Dependence, E-Cig Use
Research and Innovation to Stop E-cigarette/Vaping in Young Adults
The aim of this study is to test intervention components to help young adults quit vaping. A 2x2 factorial design will be used where all participants receive quitline-delivered behavioral phone counseling, and components to be…
- Trial name
- (RISE) (NCT04974580)
- Testing
- Nicotine patch, Phone Counseling, Digital Coaching
- Where
- United States
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Nicotine Dependence
Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study
One of the most promising lines of investigation for the therapeutic use of hallucinogens in the 1960s and 1970s was in the treatment of drug dependence.
- Trial name
- NCT01943994
- Testing
- Psilocybin-assisted treatment, Nicotine Replacement Therapy (NRT)
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alcohol Dependence, Nicotine Dependence
New Treatment for Alcohol and Nicotine Dependence
This research study aims to test whether topiramate (a drug that is being used for seizure) will help individuals who have problems with both alcohol and nicotine.
- Trial name
- NCT01182766
- Testing
- Low-Dose Topiramate, High-Dose Topiramate
- Where
- 4 sites in United States
- Volunteers
- 236 people
- Sponsor
- University of Virginia
Nicotine Dependence
Testing Financial Incentive Interventions in Dyadic-Smoker Couples
The proposed study investigates the feasibility and efficacy of FITs in dual-smoker couples [DSCs]. The core design is a three-group mixed repeated measures design, in which participants are randomized into one of three…
- Trial name
- NCT04832360
- Testing
- Financial Incentives
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Georgia