Clinical trials: Nicotine Replacement Therapy
Smoking
Study of Nicotine Patch in Pregnancy (SNIPP)
There are no established evidences as to the effectiveness in smoking pregnant women of nicotine patches in increasing birth weight, smoking abstinence during pregnancy and concerning the safety their for the fetus/newborn.
- Trial name
- SNIPP (NCT00507975)
- Where
- 2 sites in France
- Volunteers
- 404 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nicotine Dependence
Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers
The proposed study will assess the efficacy of moclobemide, a selective, reversible MAO-A inhibitor, in facilitating smoking cessation in treatment-seeking female smokers.
- Trial name
- RIMA (NCT01926626)
- Testing
- Nicotine Patch, Moclobemide
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Jed E. Rose
Second Hand Tobacco Smoke, Nicotine Dependence
Kids Safe and Smokefree (KiSS)
The study's primary aim is to test the hypothesis that an intervention integrating pediatric clinic-level quality improvement with home-level behavioral counseling (CQI+BC) will result in greater reductions in child cotinine (a…
- Trial name
- KiSS (NCT01745393)
- Testing
- Clinic Quality Improvement + Behavioral Counseling, Clinic Quality Improvement + Attention Control
- Where
- 4 sites in United States
- Volunteers
- 327 people
- Sponsor
- Temple University
Tobacco Use Cessation
Improving Quitline Support Study
This study seeks to evaluate ways to improve outcomes for low-education, uninsured or Medicaid-eligible smokers who do not successfully quit with standard telephone quit line treatment.
- Trial name
- IQS (NCT03538938)
- Testing
- 1-Call Quitline Counseling, 4-Call Quitline Counseling, Nicotine patch
- Where
- United States
- Volunteers
- 1,316 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Schizophrenia, Schizoaffective Disorder
Smoking Relapse Prevention in Schizophrenia
This study seeks to determine if continued treatment with bupropion and nicotine replacement therapy (NRT) can reduce the smoking relapse rate in patients with schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Smokers
- Trial name
- NCT00320697
- Testing
- bupropion + nicotine patch + nicotine gum or lozenges
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- North Suffolk Mental Health Association
Smoking Cessation
Gen AI Powered Behavioral Support Plus Chewing Gum Intervention for Construction Workers Who Smoke
The goal of this pilot trial is to learn if 1-week NRT sampling, 3-week chewing gum, and 12-week chatbot-delivered instant messaging support works to help smoking cessation in construction workers who smoke.
- Trial name
- NCT07649018
- Testing
- AWARD advice, Brief leaflet on health warning and smoking cessation, Referral card
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Smoking Cessation
In-patient Smoking Cessation Intervention Using Counseling, Spirometry and Nicotine Replacement Therapy
The objective of the study is to assess the effect of in-hospital intensive counseling and NRT (nicotine replacement therapy) vs. usual care, on smoking cessation or enrollment to smoking cessation behavioral intervention.
- Trial name
- NCT02470923
- Testing
- Nicotine replacement therapy, Intensive counseling, Medical advice
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Soroka University Medical Center
Alcohol Drinking
Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 1: Nicotine Replacement Therapy
This study examines the effect of combined nicotine replacement therapy (transdermal patch + nasal spray vs. transdermal patch + placebo nasal spray) on reactivity to alcohol and self-administration behavior.
- Trial name
- NCT00699556
- Testing
- 21mg transdermal nicotine patch (Nicoderm CQ), 1mg nicotine nasal spray
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Yale University
Cigarette Smoking-Related Carcinoma
Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia
This clinical trial compares the use of oral nicotine pouches to nicotine replacement therapy, consisting of nicotine patches and lozenges, to reduce cigarette use in smokers living in rural Appalachia.
- Trial name
- ARISE (NCT06763536)
- Testing
- Carbon Monoxide Measurement, Nicotine Lozenge, Oral Nicotine Pouch
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Smoking
Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 (THS 2.2)
The primary objective of this clinical study is to evaluate the pharmacokinetic (PK) profile (rate and amount of nicotine absorbed) following a single use of the THS 2.2 compared to the PK profiles from a single use of a…
- Trial name
- NCT01967732
- Testing
- THS 2.2, CC, NNS
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking, Tobacco Use
Effect of a Perioperative Smoking Cessation Program on Smoking Cessation/Reduction and Perioperative Complications
The purpose of this study is to determine whether a perioperative smoking cessation program, implemented at least 3 weeks prior to elective surgery, is effective in increasing rates of smoking cessation or reduction.
- Trial name
- NCT01260233
- Testing
- Smoking cessation program
- Where
- Canada
- Volunteers
- 168 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Smoking Cessation, Smoking
Smoking Habits and Smoking Cessation in Young Adults
The purpose of this study is to assess the efficacy and effectiveness of varenicline and nicotine patch combined with motivational interview technique in smoking cessation of young adults over 12 months follow-up.
- Conditions
- Smoking Cessation, Smoking, Habits
- Trial name
- NCT01531049
- Testing
- varenicline, Nicotine cutaneous patch 15mg/16h, Nicotine cutaneous patch 10mg/16h
- Where
- Finland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tuula Toljamo
Dual Use of Cigarettes and E-cigarettes
DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy
This randomized clinical trial evaluates the effectiveness of augmented-dose combination nicotine replacement therapy (NRT) versus standard-dose NRT and no-NRT control for cessation of dual combustible cigarette (CC) and…
- Trial name
- NCT07754578
- Testing
- Text- and web-based support, Nicotine Replacement Therapy (NRT, nicotine patch), Nicotine replacement therapy lozenge
- Where
- United States
- Volunteers
- 321 people
- Sponsor
- Medical University of South Carolina
Vaping Cessation
Nicotine Patch Plus Nicotine Mouth Spray Versus Nicotine Reduction for Vaping Cessation
This research focuses on maximizing the chances of successfully quitting vaping. A large, pragmatic community-based clinical trial is planned in New Zealand to build on existing evidence from previous vaping and smoking cessation…
- Trial name
- EQUIT3 (NCT06832098)
- Testing
- Nicotine patches plus nicotine mouth spray, Nicotine Tapering Plan
- Where
- New Zealand
- Volunteers
- 774 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Smoking, Acute Coronary Syndrome
Smoking Cessation for Patients With Acute Coronary Syndrome (ACS)
The aim of the present study is to assess if a personal care program of smokers hospitalised for acute coronary syndrome can change the smoking habits as compared with similar patients in conventional care program at 6 months.
- Trial name
- PATPAC (NCT00987597)
- Testing
- Technique of in-vivo exposure (cigarette) and mental image exposure (craving), conventional follow-up
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Smoking
Efficacy and Safety Study of Nicotine Mint Lozenge (2mg and 4mg) in Smoking Cessation
A multi-center, randomized, double-blind, placebo-controlled, 4-arm clinical study to evaluate efficacy and safety of nicotine lozenge (2mg and 4mg) in smoking cessation in adult cigarette smokers who are motivated to quit…
- Trial name
- NCT00985985
- Testing
- Nicotine
- Volunteers
- 723 people
- Sponsor
- GlaxoSmithKline
Tobacco Use Cessation
Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study
The goal of this research study is to learn about 2 different interactive methods that are designed to help people with HIV/AIDS stop smoking.
- Trial name
- NCT02302859
- Testing
- Nicotine Patch, Questionnaires, Pamphlet
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Smoking, Tobacco
Smoking Reduction Intervention for Smoking Parents of Paediatric Patients in Hong Kong
A randomized controlled trial to evaluate the effectiveness of smoking reduction interventions for smoking parents in paediatric hospital setting in Hong Kong.
- Trial name
- NCT03879889
- Testing
- Nicotine patch
- Where
- Hong Kong
- Volunteers
- 210 people
- Sponsor
- Chinese University of Hong Kong
Tobacco Use Disorder
Tobacco Cessation in Postmenopausal Women (Part II) - 2
The purpose of this study is to evaluate the effects of ERT on appetitive behavior and withdrawal in short-term smoking cessation in postmenopausal females on transdermal nicotine replacement
- Trial name
- NCT00061074
- Testing
- Nicotrol
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Minnesota
Smoking
Naltrexone and Patch for Smokers
The aim of this study is to investigate the effects of naltrexone, alone and combined with nicotine patch, on responses of smokers to smoking cues after 10 hours of tobacco deprivation.
- Trial name
- NCT00018213
- Testing
- Naltrexone Hydrochloride, Transdermal Nicotine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs