Clinical trials: Nicotine Replacement Therapy
Smoking Cessation
Project Quit: Positive vs. Negative Offers of an Online Stop Smoking Program
This project is designed to test the effects of affirmation and positive/negative imagery on individuals' thoughts about quitting smoking and willingness to join a stop smoking program.
- Trial name
- NCT01923467
- Testing
- Project Quit stop smoking program, Nicotine patches 21 mg
- Where
- United States
- Volunteers
- 767 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Mental Health, Stress Disorders, Post-Traumatic
Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder
The primary study objective is to conduct a prospective, randomized controlled clinical trial that compares the effectiveness of two approaches for delivering smoking cessation treatment for veterans with posttraumatic stress…
- Conditions
- Mental Health, Stress Disorders, Post-Traumatic, Substance-Related Disorders, Tobacco Use Disorder
- Trial name
- NCT00118534
- Testing
- Integrated Care for Smoking Cessation in PTSD patients, Standard of Care
- Where
- 11 sites in United States
- Volunteers
- 943 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Smoking Cessation, Electronic Cigarette Use
Comparison of Nicotine Replacement Therapy and Electronic Cigarettes for Smoking Cessation in Pakistan
Smoking is prevalent in Pakistan, and a large proportion of the adult population smokes cigarettes or uses other forms of tobacco.
- Trial name
- NCT06063421
- Testing
- Electronic Cigarette (EC), Nicotine Replacement Therapy
- Where
- Pakistan
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- Strategic Health Research Limited
Tobacco Use Cessation
Reward Sensitivity and Pharmacotherapy for Smoking Cessation
The goal of this clinical research study is learn if varenicline or the nicotine patch can help people with different types of emotion and attention levels to quit smoking.
- Trial name
- NCT02162849
- Testing
- Varenicline, Nicotine Patch, Questionnaires
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Smoking Cessation
PMCAN for Smokers at Smoking Hotspots
Background: Many smokers cannot quit due to nicotine withdrawal symptoms, which peak at the first week of abstinence. Proactive recruitment of smokers is needed as most smokers do not seek smoking cessation (SC) services.
- Trial name
- NCT02935231
- Testing
- Nicotine Replacement Therapy (NRT), Minimal Cessation Advice (MCA), Health warning leaflet
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Tobacco Dependence, COPD Asthma
Cytisine vs Nicotine Replacement Therapy
Tobacco is the most preventable cause of disease and death in Canada. Although the tobacco use rate has substantially gone down in the general population, significant differences exist between sub-populations in Canada, for…
- Conditions
- Tobacco Dependence, COPD Asthma, Mental Illness, Substance Use
- Trial name
- NCT03249428
- Testing
- Cytisine, Nicotine replacement therapy (NRT)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Tobacco Dependence
Nicotine Pharmacodynamics With a New Oral Nicotine Replacement Therapy and Nicotine Gum
A comparison of two products for oral nicotine replacement with respect to relief of urges to smoke after single doses of nicotine.
- Trial name
- NCT01368016
- Testing
- Nicotine
- Where
- 2 sites in Sweden
- Volunteers
- 346 people
- Sponsor
- McNeil AB
Smoking Cessation
Safety and Efficacy Study of the NRT CQSS2 System for Smoking Cessation in Treatment-Seeking Subjects
Transdermal nicotine delivery systems are a cigarette smoking cessation aid designed to deliver nicotine into the systemic circulation via the skin.
- Trial name
- NCT03178422
- Testing
- CQSS2, NicoDerm CQ Patch
- Where
- 5 sites in United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Chrono Therapeutics, Inc.
Cigarette Smoking, Tobacco Use
Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
This study aims to investigate harm-reduction sampling in a choice format versus medicinal nicotine sampling on smoking behavior, identify mechanisms of sampling's effects, and explore moderators of these effects among a national…
- Conditions
- Cigarette Smoking, Tobacco Use, Cigarette Smoking Behavior
- Trial name
- NCT07199517
- Testing
- HRP Sampling period, NPL Sampling period
- Where
- United States
- Volunteers
- 472 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Smoking Cessation
Smoking Cessation Intervention During Low Dose CT (LDCT) Screening for Lung Cancer
The goal of this clinical research study is to offer lung cancer screenings to smokers who want to change their smoking behaviors.
- Trial name
- NCT03059940
- Testing
- Questionnaires, Low Dose Computed Tomography Scan, Shared Decision Making + Video
- Where
- United States
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Smoking Cessation
Interventions for Smoking Among Persons in Recovery
Examine the efficacy of a stepped-care smoking cessation intervention for current and former smokers in chemical dependency treatment programs.
- Trial name
- INSPIRE (NCT00714896)
- Testing
- Stepped-Care, Control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use, Tobacco Use Cessation
Metabolism-informed Care for Smoking Cessation
Nicotine mediates smoking's addictive effects in the brain. The ratio of 3-hydroxycotinine to cotinine, known as the nicotine metabolite ratio, or NMR, is a genetically- informed biomarker reflecting hepatic CYP2A6 activity and…
- Trial name
- NCT03227679
- Testing
- Nicotine Metabolite Ratio, Varenicline, Bupropion
- Volunteers
- 82 people
- Sponsor
- Vanderbilt University Medical Center
Bladder Cancer, Cervical Cancer
Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking
RATIONALE: Stop-smoking plans, including counseling and nicotine replacement therapy, may help smokers quit smoking. It is not yet known whether counseling and the nicotine lozenge is more effective than counseling and the…
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00365508
- Testing
- nicotine lozenge, nicotine patch
- Where
- 10 sites in United States
- Volunteers
- 642 people
- Sponsor
- Fox Chase Cancer Center
Tobacco Use Cessation
Improving Varenicline Adherence and Outcomes in Homeless Smokers
the purpose of the study is to see if varenicline in combination with motivational counseling helps homeless cigarette smokers quit smoking.
- Trial name
- NCT00786149
- Testing
- Varenicline plus Motivational Interviewing counseling, Varenicline without counseling
- Where
- United States
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Growth Hormone Deficiency, Endocrine System Diseases
A Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product in Adults With Growth Hormone Deficiency
A 38-week dosing trial of lonapegsomatropin, a long-acting growth hormone product, administered once-a-week versus placebo-control.
- Conditions
- Growth Hormone Deficiency, Endocrine System Diseases, Hormone Deficiency
- Trial name
- foresiGHt (NCT04615273)
- Testing
- Lonapegsomatropin, Somatropin
- Where
- 113 sites in United States, Armenia and 22 more
- Volunteers
- 264 people
- Sponsor
- Ascendis Pharma Endocrinology Division A/S
Smoking Cessation
Phase II Study to Evaluate the Effectiveness of EVT 302 in Smoking Cessation.
This study will investigate the efficacy of EVT 302, a potent and selective inhibitor of Monoamine Oxidase - B, in improving quit rates in chronic cigarette smokers who are motivated to quit smoking.
- Trial name
- NCT00738595
- Testing
- EVT 302, EVT 302 plus open label Nicotine replacement
- Where
- 9 sites in Germany
- Volunteers
- 400 people
- Sponsor
- Evotec Neurosciences GmbH
Smoking Cessation
Smoking Cessation and Sexual Health in Men
This is a 12-week clinical trial investigating the effects of smoking cessation on sexual functioning in men. This study consists of 3 sessions and provides 8 weeks of free nicotine transdermal patches.
- Trial name
- NCT00833404
- Testing
- Nicotine transdermal patch
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Texas at Austin
Tobacco Use Disorder, Nicotine Dependence
Personalized Dosing of Nicotine Replacement (NRT to Effect)
Medications for smoking cessation are currently only effective in helping a minority of smokers quit. Drug development is slow and expensive, so there is much interest in optimizing the effectiveness of existing treatments and…
- Trial name
- NCT03000387
- Testing
- Nicotine Patch
- Where
- 2 sites in Canada
- Volunteers
- 211 people
- Sponsor
- Centre for Addiction and Mental Health
Healthy
A Study to Assess the Nicotine Pharmacokinetics, Tolerability and Safety With a New Oral Nicotine Replacement Product in Healthy Japanese Smokers
In Part 1, the purpose of this study is to elucidate the single-dose pharmacokinetic profiles of 1 spray and 2 consecutive sprays of oromucosal nicotine spray (ONS) in comparison with those of nicotine gum and cigarette smoking…
- Trial name
- NCT03398876
- Testing
- Oromucosal Nicotine Spray (ONS), Nicotine Gum, Cigarette
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Janssen Pharmaceutical K.K.
Smoking Cessation, Cardiovascular Disease
What Are the Effects of Varenicline Compared With Nicotine Replacement Therapy on Long Term Smoking Cessation and Clinically Important Outcomes?
Introduction: Smoking is a major avoidable cause of ill-health and premature death. Treatments that help patients successfully quit smoking have an important effect on health and life expectancy.
- Conditions
- Smoking Cessation, Cardiovascular Disease, Respiratory Disease, Myocardial Infarction
- Trial name
- NCT02681848
- Testing
- Varenicline, Nicotine replacement therapy
- Volunteers
- 180,000 people
- Sponsor
- University of Bristol