Clinical trials: Nicotine Use, open to volunteers
Substance Use Disorder, Alcohol Use Disorder
Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
Background: People who will participate in research studies need to undergo proper screening, evaluation, and assessment (SEA). SEA helps keep those who participate in studies safe. It also helps ensure accurate study results.
- Trial name
- NCT06552741
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Diabetes Mellitus, Type 2, Nicotine Dependence, Cigarettes
Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients
Diabetes has become an increasingly serious global health issue. In 2024, approximately 537 million adults were living with diabetes, and this number is projected to rise to 783 million by 2045, representing a 46% increase.
- Trial name
- NCT06924697
- Testing
- Application of GLP-1RAs drugs, DPP-4i group
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai East Hospital
Tobacco Use
Cardiovascular Effects of Very Low Nicotine Content Cigarettes
The study is measuring Cardiovascular effects of very low nicotine content cigarettes on daily and non-daily smokers
- Trial name
- CEV (NCT05707871)
- Testing
- SPECTRUM cigarettes, usual brand of Cigarettes
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Tobacco Use Disorder, Addiction Nicotine
Accelerated dTMS Smoking Cessation
The goal of this clinical trial is to examine whether a 5-day course of bilateral accelerated deep transcranial magnetic stimulation (aTMS) is a feasible treatment to help adults (18-65) with Tobacco Use Disorder to quit smoking.
- Trial name
- NCT07292883
- Testing
- Bilateral deep accelerated repetitive transcranial magnetic stimulation
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Waypoint Centre for Mental Health Care
E Cigarette Use, Cessation, Tobacco
Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use
This study aims to improve understanding of how people who use electronic cigarettes (ECIGs or e-cigarettes) respond when they try to stop using them and whether nicotine replacement therapy (NRT) can make that process easier.
- Conditions
- E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
- Trial name
- NCT07786896
- Testing
- Nicotine Replacement Therapies, Brief Behavioral Counseling
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- West Virginia University
Nicotine Dependence, Tobacco-Related Carcinoma
A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users
This clinical trial evaluates a smartphone application (app) called Acceptance and Commitment Therapy (ACT) on Vaping for helping young adults quit using electronic cigarettes (e-cigarettes).
- Trial name
- NCT06909500
- Testing
- Smartphone app, Text Message, Survey Administration
- Where
- United States
- Volunteers
- 1,178 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Nicotine Dependence, Cigarettes
AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation
The goal of this quasi-experimental study is to test if a smartphone app can help adolescents aged 14-20 quit e-cigarettes. The main questions it aims to answer are: Can the app help adolescents manage cravings and increase their…
- Trial name
- NCT06965296
- Testing
- AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- State University of New York at Buffalo
E-cigarette Use, Vaping
A Trial of Varenicline for E-cigarette Cessation
This is randomized, placebo-controlled clinical trial in treatment-seeking adults who report regular e-cigarette use to test the hypothesis that varenicline is efficacious for quitting e-cigarettes.
- Conditions
- E-cigarette Use, Vaping, Nicotine Dependence
- Trial name
- NCT07040566
- Testing
- Varenicline 1mg BID
- Where
- 2 sites in United States
- Volunteers
- 326 people
- Sponsor
- Yale University
Major Depressive Disorder, Bipolar Disorder
Neurostructural and Biochemical Signatures of Tobacco Smoking in Mood Disorders
Tobacco smoking is significantly more common among individuals with mood disorders, such as major depressive disorder (MDD) and bipolar disorder, compared to the general population.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Tobacco Use Disorder, Mood Disorders
- Trial name
- NCT07910318
- Volunteers
- 240 people
- Sponsor
- Assiut University
Neuropathic Pain, Anxiety Disorder/Anxiety State
Predictive and Impact of Pain After 6 Months of Radiotherapy, in Head and Neck Cancer
Head and neck cancers are a source of complications and after-effects related to the disease and treatment. These cancers and their treatment alter the quality of life of patients and generate pain with physical and psychological…
- Conditions
- Neuropathic Pain, Anxiety Disorder/Anxiety State, Pain, Chronic, Alcohol Use Disorder
- Trial name
- DIP-CAOS (NCT05505188)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Caen
Smoking, Smoking Behaviors
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products.
- Conditions
- Smoking, Smoking Behaviors, Nicotine Dependence
- Trial name
- NCT06077240
- Testing
- E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Yale University
Nicotine Use Disorder
Real-time eCounselling for Nicotine Addiction
The goal of this clinical trial is to pilot an eHealth intervention (real-time telecounselling) in nicotine addiction. The main questions it aims to answer are: Is the intervention likely to be efficacious in preventing an…
- Trial name
- NCT06544057
- Testing
- CBT-MI
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Overcome
Smoking, Smoking Behaviors
Abuse Liability of Two Modern Oral Nicotine Pouched Products
This is a single-site, open-label, randomized, 4-way cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]) and plasma nicotine…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT07595055
- Testing
- Usual Brand (UB) filtered, menthol or non-menthol combustible cigarette, Modern Oral Pouch Wintergreen-A 9 mg Nicotine, Modern Oral Pouch Wintergreen-B 9 mg Nicotine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
HIV, Smoking
Reduce Tobacco Use in People Living With HIV in Switzerland
The purpose of this trial is to test the effectiveness of offering a menu of different tobacco smoking substitutional products (e-cigarettes, nicotine pouches, nicotine patches in addition to usual of care) for smokers in the…
- Trial name
- RETUNE (NCT06789692)
- Testing
- tobacco smoking substitution products
- Where
- 7 sites in Switzerland
- Volunteers
- 972 people
- Sponsor
- University Hospital, Basel, Switzerland
Tobacco Cessation, Smoking Cessation
Effectiveness of Oral Nicotine Pouches as a Cessation Tool Among Adult Tobacco Users in Pakistan
Smoking remains a major public health challenge in Pakistan, where many adult smokers have limited access to effective smoking cessation support.
- Trial name
- NCT07785479
- Testing
- Velo 6 mg Oral Nicotine Pouches, Motivational Counselling
- Where
- Pakistan
- Volunteers
- 148 people
- Sponsor
- Cyntax Health Projects PVT LTD
Nicotine Addiction, Craving
Advancing VR-based Attentional Bias as a Biomarker for Tobacco Use Disorder
The proposed project will include enrollment of 200 daily tobacco cigarette users, ages 22+, from the San Diego community. Participants will be assessed on the VR Nicotine Cue Exposure paradigm then randomized (stratified on age…
- Trial name
- VR (NCT06582888)
- Testing
- Varenicline Tartrate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Diego
Smoking
Using Smartwatches to Monitor Smoking in Real-life Situations
Background: It is important to quickly identify when people are at risk of smoking. Most current methods rely on people reporting when they smoke or what makes them want to smoke.
- Trial name
- NCT07067151
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute on Minority Health and Health Disparities (NIMHD)
THC, Cannabis
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco.
- Conditions
- THC, Cannabis, Cannabis Use, Cannabis Smoking
- Trial name
- CANNIC (NCT05999383)
- Testing
- Cannabis, Nicotine, Pax Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Veterans, Tobacco Use Disorder
Varenicline for Smoking Reduction in Veterans Not Ready To Quit
In order to reduce the prevalence of cigarette smoking among Veterans, it is vital that healthcare providers offer effective tobacco treatment to all Veterans who smoke, including those not ready to make a quit attempt.
- Conditions
- Veterans, Tobacco Use Disorder, Cigarette Smoking, Tobacco Dependence
- Trial name
- NCT06966362
- Testing
- Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT)
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- VA Office of Research and Development
Tobacco Cessation, Electronic Nicotine Delivery Systems
Flavored Electronic Nicotine Delivery Systems to Lower Smoking and Exposure to Tobacco Toxicants Among Cigarette Smokers Interested in Quitting, REFLECT Trial
This clinical trial studies whether different flavored electronic nicotine delivery systems (ENDS) help lower smoking and exposure to tobacco toxicants among cigarette smokers interested in reducing their smoking.
- Trial name
- REFLECT (NCT07896330)
- Testing
- Vaping - Fruit flavored ENDS, Biospecimen Collection, Vaping - tobacco flavored ENDS
- Where
- United States
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute