Clinical trials: Nicotine Use Disorder
Tobacco Use Disorder
Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day
The FDA recently gained the authority to regulate the nicotine content of cigarettes. Prior research suggests that smokers who switch to very low nicotine content (VLNC) cigarettes experience reduced addiction to nicotine and are…
- Trial name
- NCT03060083
- Testing
- Very low nicotine content (VLNC) cigarettes and nicotine replacement therapy (NRT), Reduce cigarettes per day (CPD) with nicotine replacement therapy (NRT)
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Nicotine Dependence
Adaptive Pharmacotherapy for Smoking Cessation
The purpose of this study is to assess an "adaptive" approach to smoking cessation pharmacotherapy. The protocol is designed to compare adaptive vs.
- Trial name
- NCT02501265
- Testing
- Varenicline Standard Protocol, Nicotine Patch Standard Protocol, Varenicline Adaptive Protocol
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Duke University
Alcohol Use Disorder, Nicotine Use Disorder
Neurobiology of Alcohol and Nicotine Co-Addiction
This proposal addresses the critical absence of information about the neurobiology of recovery from Alcohol Use Disorder (AUD) in alcohol and nicotine users.
- Trial name
- NAUD (NCT03338933)
- Testing
- magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Nicotine Dependence
Health Effects of SLT, Cigarette Smoking, and New Tobacco Products
The use of smokeless tobacco (ST) as a substitute for cigarette smoking has been suggested since it is considered by some to be a less harmful tobacco product (Russell, Jarvis and Feyerabend, 1980; Russell et al, 1981; Rodu…
- Trial name
- ANTS3 (NCT00469079)
- Testing
- Nicotine gum and lozenge, Taboka, Camel Snus
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Opioid-use Disorder
Coordinating Opioid Use Treatment Through Medical Management With Infection Treatment (Project COMMIT)
This study seeks to test a new model of care (ID/LAB) in which opioid use disorder (OUD) is managed by infectious disease (ID) specialists and hospitalists concurrent with management of the OUD-related infections, using…
- Trial name
- COMMIT (NCT04180020)
- Testing
- ID/LAB, TAU
- Where
- 3 sites in United States
- Volunteers
- 171 people
- Sponsor
- Yale University
Tobacco Use Disorder, Nicotine Addiction
Cognitive Training for Nicotine Dependence
This randomized clinical trial tested the effects of a computerized (web-based) cognitive training intervention on smoking cessation.
- Trial name
- NCT01252966
- Testing
- Cognitive Training, Control training
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder, Nicotine Dependence
Treatment of Nicotine Dependence and Acute Depression
The purpose of this study is to assess the safety and feasibility of concurrent treatment of nicotine dependence (cigarette smoking) and acute depression.
- Trial name
- NCT00186446
- Testing
- bupropion and smoking cessation behavioral intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Smoking Cessation, Smoking
A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers
The overall purpose of this research is two-fold. First, the two smoking cessation medication treatments with the strongest evidence of effectiveness have never been directly compared.
- Conditions
- Smoking Cessation, Smoking, Nicotine Dependence
- Trial name
- NHLBI-RO1 (NCT01553084)
- Testing
- Varenicline, Nicotine lozenge, Nicotine Patch
- Where
- 2 sites in United States
- Volunteers
- 1,086 people
- Sponsor
- University of Wisconsin, Madison
Schizophrenia
Use of Galantamine and CDP-choline (Citicoline) to Treat Adults With Schizophrenia
This study will evaluate the effectiveness of galantamine and CDP-choline in improving symptoms associated with schizophrenia.
- Trial name
- STAR-1 (NCT00509067)
- Testing
- Galantamine, CDP-choline, risperidone, olanzapine, quetiapine, ziprasidone, and/or aripiprazole
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Georgetown University
Nicotine Dependence
Repetitive Transcranial Magnetic Stimulation (rTMS) for Nicotine Addiction
Cigarette smoking remains a significant public health concern. A magnetic field applied to the outside of the skull can produce electrical activity in the brain without significant pain or the need for anesthesia.
- Trial name
- rTMS (NCT02401672)
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking, Nicotine Dependence
St. John's Wort for Tobacco Cessation
After a steady decline for the last 50 years, the prevalence of tobacco use in the United States has reached a plateau of approximately 23%.
- Trial name
- NCT00405912
- Testing
- St. John's Wort-900 mg/day, St. John's Wort-1800mg/day
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Schizophrenia, Cigarette Smoking
Varenicline for Cognitive Deficits and Cigarette Smoking in Schizophrenia - Efficacy and Predictors
This is a 8-week double-blind placebo controlled parallel group study of the efficacy of varenicline (Chantix) for smoking cessation in schizophrenic patients, and its effect on cognitive function in patients with…
- Trial name
- NCT00802919
- Testing
- Varenicline
- Where
- 4 sites in United States, China and 1 more
- Volunteers
- 93 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Nicotine Addiction
tDCS Effects on Resisting Smoking: Dose Ranging Study
Behaviors such as tobacco use, unhealthy diet, and sedentary behavior have far-reaching health implications. These modifiable behaviors account for a substantial proportion of deaths from cancer, cardiovascular disease and…
- Trial name
- RDR (NCT02624284)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
SCHIZOPHRENIA 1 (Disorder), Nicotine Use
Behavioral Impact and Neural Correlates of Network-based Brain Stimulation in Schizophrenia
The primary aims of this study are to investigate the behavioral effects of applying targeted transcranial magnetic stimulation (TMS) to a node of the brain network subserving attention in schizophrenia and schizoaffective…
- Trial name
- NCT07190352
- Testing
- iTBS to the DMN, cTBS to the DMN
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Beth Israel Deaconess Medical Center
Smokeless Tobacco Use
Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction
This study will be a randomized, blinded, placebo-controlled two-group clinical trial. The independent variable is treatment assignment (active 4-mg nicotine lozenge vs.
- Trial name
- NCT00392379
- Testing
- Nicotine Lozenges
- Where
- 2 sites in United States
- Volunteers
- 270 people
- Sponsor
- Mayo Clinic
Tobacco Use Cessation
Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study
The goal of this research study is to learn about 2 different interactive methods that are designed to help people with HIV/AIDS stop smoking.
- Trial name
- NCT02302859
- Testing
- Nicotine Patch, Questionnaires, Pamphlet
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center