Clinical trials: Nicotine Use Disorder
Nicotine Dependence
Study Two on the Effectiveness of Mindfulness Training for Smokers
The MTS2 study enrollment goal is N=240 adult smokers randomized to study treatments. The study design includes two randomized arms to compare matched intensive interventions and a third non-randomized option for participants who…
- Trial name
- MTS2 (NCT01299909)
- Testing
- Integrated Training for Smokers, Mindfulness Training for Smokers, Quitline
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Wisconsin, Madison
Tobacco Dependence
UW Quitting Using Intensive Treatment Study (QUITS)
This research will determine whether two highly promising modifications to varenicline treatment (i.e. use of a nicotine patch adjuvant and extended 24-week duration) produce superior smoking outcomes when they are either used…
- Trial name
- QUITS (NCT03176784)
- Testing
- Varenicline, Nicotine patch
- Where
- 2 sites in United States
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Nicotine Use Disorder
Effects of E-Cigarette Flavors on Adults TCORS 2.0
This study looks at the effects of flavors when administered with nicotine in e-cigarettes in younger and older adult cigarette smokers.
- Trial name
- NCT03635333
- Testing
- Nicotine, Flavor
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Yale University
Healthy, Nicotine Addiction
Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids
The goal of this clinical trial is to learn if low nicotine eliquids work to reduce exposure to nicotine, in addicted ecig users, without increasing consumption of other harmful constituents.
- Conditions
- Healthy, Nicotine Addiction, Electronic Cigarette Use
- Trial name
- NCT06602492
- Testing
- Lower nicotine e-liquid, Higher nicotine eliquid
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Rochester Institute of Technology
Nicotine Dependence
Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment
The purpose of this research study is to determine whether combining electronic nicotine delivery systems (ENDS) with nicotine patch treatment will augment abstinence rates compared to either treatment alone.
- Trial name
- ENDS-P50 (NCT02487953)
- Testing
- Nicotine patch, ENDS
- Where
- United States
- Sponsor
- Duke University
Nicotine Dependence
Varenicline for Nicotine Dependence Among Those With HIV/AIDS
Among people diagnosed with HIV/AIDS, the widespread use of highly active antiretroviral therapy (HAART) has greatly improved survival rates and changed the leading causes of death, from AIDS-related diseases to cardiovascular…
- Trial name
- NCT01710137
- Testing
- Varenicline, Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- University of Pennsylvania
Nicotine Dependence
Prize Reinforcement for Smoking Cessation
Nicotine dependence is prevalent in society, cigarette smoking is associated with several known health risks, and most dependent individuals find it very difficult to stop smoking cigarettes.
- Trial name
- NCT00865254
- Testing
- Standard Treatment, Traditional Contingency Management, Early Enhanced Contingency Management
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Nicotine Dependence
An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence
The transdermal nicotine patch is the most widely used form of tobacco dependence treatment in the US and Europe, but most smokers are unable to successfully quit with this form of treatment.
- Trial name
- NCT01047527
- Testing
- Transdermal nicotine patch
- Where
- 2 sites in United States
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence
IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate
This project will examine the impact of the nicotine dose and delivery rate on nicotine's abuse potential, versus its potentially beneficial effects on smoking urges and withdrawal.
- Trial name
- NCT05176418
- Testing
- low dose Nicotine, high dose Nicotine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Nicotine Dependence
Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction
The purpose of this study is to investigate the effect of gemfibrozil on nicotine reinforcement and cue-elicited craving. Other objectives of this study include screening for the ability of gemfibrozil to aid smoking abstinence…
- Trial name
- NCT01876810
- Testing
- Gemfibrozil
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Centre for Addiction and Mental Health
Depression, Smoking
Fluoxetine as a Quit Smoking Aid for Depression-Prone Smokers
This project is a treatment-matching study to test whether adding antidepressant pharmacotherapy to behavioral cessation treatment improves the depression-prone smoker's ability to quit, while not undermining cessation goals for…
- Trial name
- NCT00018174
- Testing
- Fluoxetine, Behavioral group smoking cessation treatment
- Where
- United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Tobacco-Use Disorder, Schizophrenia
Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke
Many individuals with schizophrenia smoke cigarettes. Individuals in the schizophrenic population often find it difficult to quit smoking.
- Conditions
- Tobacco-Use Disorder, Schizophrenia, Psychotic Disorders
- Trial name
- NCT00307203
- Testing
- bupropion SR, Cognitive Behavioral Group Therapy, nicotine replacement therapy
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence, Tobacco Smoking
Effects of Intranasal Oxytocin on Cigarette Smoking
Socioemotional processing dysfunctions (i.e., disruptions in affective, cognitive, and neural processes that encode, interpret, and respond to socially and emotionally relevant stimuli) have been implicated in tobacco smoking and…
- Trial name
- NCT02595749
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Mental Health, Stress Disorders, Post-Traumatic
Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder
The primary study objective is to conduct a prospective, randomized controlled clinical trial that compares the effectiveness of two approaches for delivering smoking cessation treatment for veterans with posttraumatic stress…
- Conditions
- Mental Health, Stress Disorders, Post-Traumatic, Substance-Related Disorders, Tobacco Use Disorder
- Trial name
- NCT00118534
- Testing
- Integrated Care for Smoking Cessation in PTSD patients, Standard of Care
- Where
- 11 sites in United States
- Volunteers
- 943 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Nicotine Addiction
Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids
The goal of this observational study is to learn if electronic cigarette users who currently choose to use lower nicotine eliquids have reduced harm compared those who choose higher nicotine eliquids.
- Trial name
- NCT06619964
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rochester Institute of Technology
Tobacco Use Disorder
Smoking Cessation Treatment With Transdermal Nicotine Replacement Therapy - 1
The purpose of this study is to look at how feasible it is to incorporate a state-of-the-art smoking cessation treatment program into community substance abuse treatment programs and its impact on substance abuse and cigarette…
- Trial name
- NCT00067158
- Testing
- nicotine transdermal system
- Where
- 13 sites in United States
- Volunteers
- 585 people
- Sponsor
- New York University
Nicotine Dependence
Very Low-Nicotine Cigarettes in Smokers With SUD
The purpose of this study is to determine the efficacy, acceptability and unintended consequences of very low nicotine content cigarettes (VLNCC) in smokers with current or past year substance use disorders (SUD).
- Trial name
- VLNC (NCT01989507)
- Testing
- Nicotine, behavioral counseling for smoking cessation
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Brown University
Smoking Cessation, Nicotine Dependence
Study Assessing Efficacy and Safety of NFL-101 on Reduction of Reinforcing Properties of Cigarettes (PRECESTO)
PRECESTO is a randomized, double-blind, cross-over trial on 34 smokers who do not want to stop smoking and get high satisfaction from smoking.
- Trial name
- PRECESTO (NCT06091826)
- Testing
- NFL-101
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- NFL Biosciences SAS
Nicotine Dependence
Manipulating Tobacco Constituents in Female Menthol Smokers
This study examines the potential effect of reducing nicotine content or menthol or both in women of reproductive age, a vulnerable population identified by the FDA in need of further research.
- Trial name
- Menthol (NCT02048852)
- Testing
- Reduced Nicotine Content- Non Menthol, Reduced Nicotine Content- Menthol, Conventional Nicotine Content- Menthol
- Where
- 2 sites in United States
- Volunteers
- 381 people, healthy volunteers welcome
- Sponsor
- UConn Health
Tobacco Smoking, Nicotine Dependence
Effects of Intensive Behavioral Training Program on Impulsivity and Inhibitory Control in Smokers
Dependence on tobacco derived nicotine is a major public health problem. Substance users who complete training in mindfulness subjectively report increased patience and improved motor control over their impulses.
- Conditions
- Tobacco Smoking, Nicotine Dependence, Impulsivity, Addiction
- Trial name
- IBTP (NCT01314378)
- Testing
- Mindfulness Training, Cognitive-Behavioral Therapy
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital