Clinical trials: Nicotine Vaping
Nicotine Dependence, E-Cig Use
Research and Innovation to Stop E-cigarette/Vaping in Young Adults
The aim of this study is to test intervention components to help young adults quit vaping. A 2x2 factorial design will be used where all participants receive quitline-delivered behavioral phone counseling, and components to be…
- Trial name
- (RISE) (NCT04974580)
- Testing
- Nicotine patch, Phone Counseling, Digital Coaching
- Where
- United States
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Cigarette Smoking Behavior
Effects of Cigarette and E-cigarette Flavors on Substitutability in the ETM
In 2009, the FDA banned all flavored conventional cigarettes except menthol. While no such ban exists for e-cigarettes, proposals have emerged in several regions.
- Trial name
- NCT06910202
- Testing
- Manipulation of nicotine/tobacco product price and availability
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Virginia Polytechnic Institute and State University
Marijuana Dependence
Vaping THC From Electronic Cigarettes
This study aims to understand THC pharmacology and the safety of cannabis vaping, including the pharmacology and safety of co-administration of nicotine and THC.
- Trial name
- V-PAX (NCT02955329)
- Testing
- Nicotine, Cannabis, PAX Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Addiction, E-Cig Use
Sex Differences in E-cig Perception: Study 1
The primary objective is to examine the influence of sex on sensory effects, appeal, and reinforcing value of nicotine containing e-cigs in popular flavor components; sweet and cooling.
- Conditions
- Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
- Trial name
- NCT05432830
- Testing
- E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yale University
Cancer, Vaping
Study of Vaping Use Among Adolescent and Young Adult Patients With Cancer
The purpose of this study is to learn more about how adolescent and young adult (AYA) cancer patients, their parents and caregivers (referred to as a carebuddy in this study), and their healthcare providers think about and…
- Trial name
- NCT07860801
- Testing
- Study assessments
- Where
- 7 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Smoking Cessation
The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette
This three-group randomized double-blind placebo-controlled trial (N=180) will evaluate the impact of combination zonisamide and bupropion on the process of switching from combustible cigarettes (CCs) to an e-cigarette.
- Trial name
- NCT05205811
- Testing
- Bupropion, Zonisamide, E-cigarette
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Smoking Cessation, Electronic Cigarette Use
The Avenues Study: Dual Use Cessation
The overarching goal of this research is to determine the most effective approach for helping dual users of cigarettes and electronic nicotine delivery systems (ENDS) quit smoking.
- Trial name
- NCT06474299
- Testing
- Varenicline, Nicotine patch, Dual Focused Cessation Counseling
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Wisconsin, Madison
Cannabis, Vaping
A Virtual Reality Game to Prevent E-cigarette and Cannabis Vaping
The goal of this study is to develop and test an adapted version of our virtual reality videogame intervention prototype, Invite Only VR, developed for middle school students, which focuses on e-cigarette and marijuana vaping…
- Conditions
- Cannabis, Vaping, Emotion Regulation
- Trial name
- NCT07413432
- Testing
- Virtual reality videogame intervention for vaping prevention
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Yale University
Smoking, Healthy
In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense
While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use.
- Trial name
- Cinimic (NCT03700892)
- Testing
- Cinnamaldehyde e-liquid, PG/VG e-liquid
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Electronic Cigarette Use
Assessing the Effect of Flavor on ENDS Users' Experiences and Exposures
Recently, Maziak established a clinical lab at FIU to test the potential of waterpipe tobacco flavor regulation by the FDA. Given the importance of flavors on adolescent ENDS uptake and use, this lab is equipped to study the…
- Trial name
- NCT04192032
- Testing
- Preferred Juul pod flavor (5% nicotine), Classic Tobacco Juul pod flavor (5% nicotine), Preferred flavor with HWL
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Florida International University
Tobacco Dependence
Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers
The overall goal of this project is to understand the likely health effects of cigarette smokers switching to a Standardized Research Electronic Cigarette (SREC) and to assess the role of nicotine delivery on switching and…
- Trial name
- NCT03625986
- Testing
- Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Tobacco Use
Baby Albert: Electronic Cigarette Pharmacokinetics (PK) and Abuse Liability
The overall aim of the current research is to understand purchasing and product choice behaviors of tobacco/nicotine users if banning the sale of fully nicotinized cigarettes were to go into effect.
- Trial name
- NCT03637452
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Tobacco Use, Smoking
Effectiveness of Tobacco Cessation Interventions in Sweden
Smoking is still one of the most important risk factors causing morbidity and mortality in Sweden. Every year, 12,000 Swedish citizens die prematurely from smoking, and smoking is responsible for up to 60% of the inequity in…
- Conditions
- Tobacco Use, Smoking, Cigarette Use, Electronic
- Trial name
- RSP (NCT04819152)
- Testing
- Tobacco cessation intervention
- Where
- 8 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Lund University
Alcohol Use, E-cigarette Use
Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol Use
A high priority research area for the Food and Drug Administration Center for Tobacco Products (FDA CTP) is determining who will start using tobacco products and who will stop using tobacco products.
- Conditions
- Alcohol Use, E-cigarette Use, Cigarette Use
- Trial name
- NCT07010601
- Testing
- Experimental Tobacco Marketplace, Hypothetical Novel Nicotine Product Purchase Tasks
- Where
- United States
- Volunteers
- 737 people, healthy volunteers welcome
- Sponsor
- Mark J Rzeszutek, PhD
Healthy, Nicotine Addiction
Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids
The goal of this clinical trial is to learn if low nicotine eliquids work to reduce exposure to nicotine, in addicted ecig users, without increasing consumption of other harmful constituents.
- Conditions
- Healthy, Nicotine Addiction, Electronic Cigarette Use
- Trial name
- NCT06602492
- Testing
- Lower nicotine e-liquid, Higher nicotine eliquid
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Rochester Institute of Technology
Nicotine Dependence
Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment
The purpose of this research study is to determine whether combining electronic nicotine delivery systems (ENDS) with nicotine patch treatment will augment abstinence rates compared to either treatment alone.
- Trial name
- ENDS-P50 (NCT02487953)
- Testing
- Nicotine patch, ENDS
- Where
- United States
- Sponsor
- Duke University
Obesity, Smoking Cessation
Trial for Harm Reduction With Incentives & Vaping E-cigarettes
The purpose of this study is to provide preliminary information on the effect of electronic nicotine delivery systems (ENDS) provisions and contingent incentives (CI) on smoking in individuals with overweight/obesity who smoke…
- Trial name
- THRIVE (NCT06111053)
- Testing
- ENDS, CI, No ENDS
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Brown University
Healthy Smokers, Smoking Cessation
Efficacy and Safety of an Electronic Nicotine Delivery Device (E-Cigarette)
The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (E-Cigarette) to induce long-term smoking reduction/abstinence in smokers unwilling to quit.
- Trial name
- NCT01164072
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Catania
Nicotine Addiction
Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids
The goal of this observational study is to learn if electronic cigarette users who currently choose to use lower nicotine eliquids have reduced harm compared those who choose higher nicotine eliquids.
- Trial name
- NCT06619964
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rochester Institute of Technology
Vascular Reactivity, Serum Biomarkers
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
To examine vascular reactivity and inflammatory biomarkers via quantitative magnetic resonance imaging (MRI) and blood serum, respectively, in a crossover study where active vapers (electronic cigarette users) and smokers will…
- Trial name
- AeCE (NCT05271578)
- Testing
- Standardized Electronic Research Cigarette, Nicotine Research Cigarette
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania