Clinical trials: Night Work, active
Healthy Volunteers (HV)
Effects of a Sleep Education Program on the Health Status of Healthcare Workers Working 12-hour Alternating Day-night Shifts
In a context of seeking a better balance between personal and professional life and labor shortages, the use of 12-hour alternating day-night shifts has become more common in work organizations, particularly in healthcare…
- Trial name
- SLEEPMORE (NCT07326579)
- Testing
- Sleep educational
- Where
- 3 sites in France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Type 2 Diabetes, Shift-work Disorder
Effects of an Evening PROtein PrEload on Metabolic Health in Night ShIfT Workers (PROPENSITy)
This study will compare the effects of a whey protein supplement or a placebo consumed before the evening meal on health outcomes in night shift workers.
- Trial name
- PROPENSITy (NCT04869098)
- Testing
- whey protein
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Circadian Misalignment, Sex Differences
Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?
This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag).
- Trial name
- NCT07441265
- Testing
- Day shift, Night shift
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Night Shift Work, Sickness Absence
Night Work Hours Reduction Trial
The primary aim of this study is to investigate the effects of reducing weekly working hours among employees working night shifts regularly from 38 hours 15 minutes to 36 hours on payroll-based, objective working-hour…
- Trial name
- WHRedu (NCT07848607)
- Testing
- Reduced Working Hours (from 38h15minutes to 36h)
- Where
- 3 sites in Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Finnish Institute of Occupational Health
Breast Neoplasms Diagnosis
Breast Cancer Risk Assessment in Night Shift Workers - Implementation of a Personalized Consultation
This study evaluates adherence to a personalized prevention plan in female night shift workers at increased risk of breast cancer.
- Trial name
- NIGHT-SCAN (NCT07630935)
- Testing
- Personalized Prevention Plan
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nocturia
How Well and Safely Does Lemborexant Work for People Who Wake up at Night to Urinate (LENS)
Nocturia is defined by doctors as getting up one or more times a night to use the bathroom, where you were asleep before going to use the washroom and then going back to sleep afterward.
- Trial name
- LENS (NCT07840638)
- Testing
- Lemborexant tablets
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University of Alberta
Shift Work Sleep Disorder
A Pilot of a Personalized Circadian mHealth to Improve Sleep in Night Shift Workers
The goal of this project is to establish the evidence base for equitable accessibility and implementation of the precision sleep medicine mobile application, SHIFT.
- Trial name
- SAIL (NCT06809335)
- Testing
- Personalized circadian mHealth
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Henry Ford Health System
Night Work
Apples in Night Shift
Background: Emergency doctors face a highly stressful work environment during night shifts. Long-term night shift work can lead to sleep deprivation, fatigue accumulation, and disruption of the biological clock, which may affect…
- Trial name
- NCT06714422
- Testing
- apple group, no apple group
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Night Shift Work, Time Restricted Eating
Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers
In this randomized controlled trial, the investigators will assess the health impacts of optimizing the timing of dietary consumption in nurses and nursing assistants who work night shifts, have a habitual eating window of 14…
- Conditions
- Night Shift Work, Time Restricted Eating, Overweight, Obesity
- Trial name
- SHIFT (NCT06891352)
- Testing
- Dietary Monitoring, Time-Restricted Eating (TRE), Time-Restricted Eating with a Low-Glycemic Snack (TRE-LGS)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Salk Institute for Biological Studies
Breast Cancer Risk Factors
Night-shift Work and Breast Cancer
Scientific evidence established about the effects of night work on health both in the short term (insomnia, excessive sleepiness, difficulty concentrating or lack of energy) and in the long term (moderately high risk of…
- Trial name
- BC-NSW-02/2023 (NCT06786949)
- Testing
- Questionnaire, Blood samples for biomarker measurement
- Where
- 2 sites in Italy
- Volunteers
- 6,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease
Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers
People who experience repeated bouts of circadian misalignment, such as shift workers, are at higher risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D) compared to daytime workers.
- Conditions
- Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity, Blood Pressure
- Trial name
- SHINE (NCT06550115)
- Testing
- Time-restricted eating, Control eating
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Gingivitis, Circadian Rhythm Disruption
Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption
This prospective cross-sectional clinical study aims to investigate the relationship between circadian rhythm disruption and periodontal inflammation by evaluating circadian clock protein levels, inflammatory (IL-1beta) and…
- Conditions
- Gingivitis, Circadian Rhythm Disruption, Periodontal Inflammation, Circadian Rhythm Sleep Disorder, Shift Work Type
- Trial name
- Nursma-CIRC-HG (NCT07592052)
- Testing
- Standard Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Inonu University
Sleep, Slow-wave Sleep, Sleep Enhancement, Sleep Optimization, Sleep Inertia
Association Between Slow Wave Activity and Sleep Inertia
Observational study: The goal of this observational study is to learn about the association between slow wave activity before awakening and post-awakening psychomotor vigilance task in time-fixed, 2-hour, simulated night naps in…
- Conditions
- Sleep, Slow-wave Sleep, Sleep Enhancement, Sleep Optimization, Sleep Inertia, Night Shift Work
- Trial name
- NCT07409883
- Testing
- Nap intervention
- Where
- Thailand
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Sleep Disorder
Impact of Relaxation Sessions Using a Virtual Reality Application on the Sleep Quality of Caregivers Working Night Shifts
This project aims to evaluate the impact of relaxation sessions conducted using a virtual reality device on the sleep quality of night-shift healthcare workers.
- Trial name
- Luciole (NCT07395323)
- Testing
- Arm 1: Experimental (VR) Intervention: Virtual reality sessions, Arm 2: Control (No VR / Standard Care)
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier St Anne
Obesity, Shift-work Disorder
Night Shift Work and Biomarkers of Obesity Risk in Hospital and Industry Workers
Shift work is a well-known risk factor for the development of overweight and obesity, which may lead to downstream effects such as increased risk of cardiometabolic diseases and cancer.
- Conditions
- Obesity, Shift-work Disorder, Circadian Rhythm Disorders
- Trial name
- Shift2Health (NCT06288568)
- Testing
- No intervention
- Where
- Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Shift-work Disorder
Impact of Night Shift Work on Dietary Habits Among Intensive Care and Emergency Healthcare Workers (NUTRINIGHT)
Night shift work is an essential component of healthcare systems, particularly in intensive care units and emergency departments, where continuous patient monitoring and rapid clinical decision-making are required.
- Trial name
- NCT07394283
- Testing
- Healthcare Night Shift Workers
- Where
- France
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Paroxysmal Nocturnal Hemoglobinuria
A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it Works
This study is researching an experimental treatment combination with two experimental drugs called pozelimab and cemdisiran. The study is focused on people with paroxysmal nocturnal hemoglobinuria (PNH).
- Trial name
- ACCESS-EXT (NCT05744921)
- Testing
- Pozelimab, Cemdisiran
- Where
- 50 sites in Brazil, Canada and 19 more
- Volunteers
- 202 people
- Sponsor
- Regeneron Pharmaceuticals
Airway Management, Tracheal Intubation
Effect of Night Shift Versus Daytime Duty on Tracheal Intubation Complications and Duration in Surgical Patients
Airway management is one of the most critical steps of anesthesia, and its complications can be life-threatening. Reduced staffing, differences in personnel experience, and physical and mental fatigue during off-hours (evenings…
- Conditions
- Airway Management, Tracheal Intubation, Intubation Complications, General Anesthesia
- Trial name
- NCT07823179
- Testing
- Tracheal Intubation
- Volunteers
- 1,000 people
- Sponsor
- Merve Yazici Kara
Paroxysmal Nocturnal Hemoglobinuria
A Study to Evaluate How Pozelimab + Cemdisiran Combination Therapy Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Whose Current Treatment is Not Working Efficiently
This study is researching a treatment combination with two experimental drugs called pozelimab and cemdisiran referred to as "study drugs".
- Trial name
- NCT07154745
- Testing
- Pozelimab, Cemdisiran
- Where
- 20 sites in Brazil, Canada and 5 more
- Volunteers
- 35 people
- Sponsor
- Regeneron Pharmaceuticals
Sleep Deprivation, Menstrual Cycle
The Effects of Night Shift Work on Health Across the Menstrual Cycle
The study aims to investigate the effects of sleep deprivation on women's health across different phases of the menstrual cycle.
- Conditions
- Sleep Deprivation, Menstrual Cycle, Brain Health, Metabolism
- Trial name
- MENSLEEP (NCT06683248)
- Testing
- Investigate sleep deprivation
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University