Clinical trials: Nitric Oxide
High Altitude Pulmonary Hypertension
Inhaled Nitric Oxide for High Amplitude Pulmonary Edema (HAPE)
High Altitude Pulmonary Edema (HAPE) is a critical, non-cardiogenic pulmonary edema that manifests in high-altitude conditions, marked by the rapid onset of symptoms such as dyspnea, cough, frothy sputum, and cyanosis.
- Trial name
- HAPE (NCT06852924)
- Testing
- Nitric Oxide Generation and Delivery System
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Novlead Inc.
Asthma
The Use of Fractional Exhaled Nitric Oxide in the Identification of Non-adherence in Difficult Asthma
Asthma usually responds to standard doses of inhaled steroids with or without additional therapies to control their symptoms. However, approximately 5-10% do not respond to this treatment strategy and are referred to as having…
- Trial name
- NCT01219036
- Testing
- Budesonide (directly observed)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Liam Heaney
Diabetic Foot Ulcer
A Feasibility Study of Advance Plasma Therapy001 Plasma/Nitric Oxide Therapy for the Treatment of Diabetic Foot Ulcers
The clinical trial will assess the delivery of Nitric Oxide topically to the diabetic foot ulcer wound and the surrounding wound area as it related to wound healing.
- Trial name
- NCT03078933
- Testing
- Standard of Care, Nitric Oxide Therapy 2x week 6 min. plus standard of care, Nitric Oxide Therapy 2x week 12 min. plus standard of care
- Where
- 15 sites in United States
- Volunteers
- 100 people
- Sponsor
- Origin Inc.
COPD
Exhaled NO Based Treatment of Chronic Obstructive Pulmonary Disease (COPD), ICS/LABA Versus LAMA
It is recognized that eosinophilic airway inflammation is more likely respond to steroid treatment. However, in real-world practice, it is difficult to routinely assess airway inflammation using sputum induction because of…
- Trial name
- NCT02546349
- Testing
- fluticasone/salmeterol, tiotropium
- Where
- Taiwan
- Volunteers
- 143 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cardiovascular Diseases, Metabolic Syndrome X
Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome
The purpose of the study is to test higher versus lower doses of aspirin on markers of atherosclerosis in patients at risk of a first heart attack.
- Conditions
- Cardiovascular Diseases, Metabolic Syndrome X, Atherosclerosis
- Trial name
- PAD (NCT00272311)
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Gastrointestinal Motility Disorder, Disturbance of Salivary Secretion
Nitric Oxide Control of Migrating Motor Complex: L-NMMA Effects in Relation to Receptor Blockades
The aim is to elucidate how NO works in conjunction with other neurotransmitters to regulate the migrating motility complex (MMC).
- Trial name
- LNMMA (NCT02245165)
- Testing
- L-Nitro-Monomethyl-Arginine (LNMMA) 10 mg/kg IV, saline
- Where
- Sweden
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Cardiovascular Diseases, Nephropathy
Effect of the Aquaretic Tolvaptan on Nitric Oxide System (TORA)
The purpose of this study is to investigate the effect of tolvaptan on renal water, sodium and potassium excretion, plasma concentration of vasoactive hormones,central blood pressure, pulse wave velocity (PWV) and augmentation…
- Trial name
- NCT01638663
- Testing
- Tolvaptan
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Sickle Cell Disease
Blood Flow and Pain Crises in People With Sickle Cell Disease
Background: Many people with sickle cell disease have repeated episodes of severe pain that lasts for days, requiring hospital care. These episodes, called pain crises, may be caused by changes in blood flow.
- Trial name
- NCT01568710
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Patients With End Stage Renal Disease on Hemodialysis
Effect of Plasma Sodium Concentration on Blood Pressure Regulators During Hemodialysis
Intradialytic hypotension (IDH) is a frequent and serious complication that may occur during hemodialysis treatment. The investigators and others have shown that the Hemocontrol biofeedback system is associated with improved…
- Trial name
- NCT03578510
- Testing
- Hemocontrol hemodialysis, Standard hemodialysis
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- University Medical Center Groningen
Induction of Labor Affected Fetus / Newborn, Rupture of Membranes Prior to Onset of Labor
Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of Membranes
The study aims to evaluate and assess the effectiveness and safety of vaginal administration of isosorbide mono nitrate (IMN) to induce cervical ripening and shorten the interval time between induction and delivery in women…
- Trial name
- NCT03665779
- Testing
- isosorbide mononitrate
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- ahmed nagy shaker ramadan
Stroke
The Efficacy of Nitric Oxide in Stroke (ENOS) Trial
Nitric oxide is a multimodal candidate treatment for acute stroke having a number of properties which may be beneficial in acute stroke, including lowering blood pressure, causing cerebral vasodilation, and improving central and…
- Trial name
- ENOS (NCT00989716)
- Testing
- Transdermal glyceryl trinitrate patch, Pre-stroke antihypertensives
- Where
- United Kingdom
- Volunteers
- 3,500 people
- Sponsor
- University of Nottingham
Healthy
Nitric Oxide, LPS and the Pathogenesis of Asthma Phase II
The purpose of the study is to determine the role of nitric oxide (NO) in asthma and to characterize the symptoms associated with inhaled endotoxin (lipopolysaccharide [LPS]) in normal subjects.
- Trial name
- NCT00643058
- Testing
- LPS endotoxin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- John Sundy
Idiopathic Pulmonary Arterial Hypertension, Primary Pulmonary Hypertension
Efficacy Study of Cardizem in Pulmonary Arterial Hypertension
The purpose of this study is to determine if cardizem is effective in the treatment of nitric oxide non-responder pulmonary arterial hypertension.
- Conditions
- Idiopathic Pulmonary Arterial Hypertension, Primary Pulmonary Hypertension, Pulmonary Arterial Hypertension, Familial Primary Pulmonary Hypertension
- Trial name
- NCT01645826
- Testing
- Diltiazem Hydrochloride, Sugar Pill
- Where
- United States
- Sponsor
- University of South Florida
Mycobacterium Abscessus Infection
Inhaled Nitric Oxide for Patients With MABSC
A Prospective, Open labeled, multi-Center, Evaluation of the Efficacy Safety and Tolerability of Nitric Oxide Given Intermittently via Inhalation to Subjects with NTM (specifically MABSC) Nitric Oxide (NO) has been shown to play…
- Trial name
- NCT03208764
- Testing
- Nitric Oxide
- Where
- Israel
- Volunteers
- 9 people
- Sponsor
- Beyond Air Inc.
Pulmonary Hypertension
Comparison of Vasodilator Response of Inhaled Epoprostenol and Inhaled Nitric Oxide
The overarching goal of this study is to examine the acute vasoreactive response to both inhaled nitric oxide and inhaled epoprostenol across both traditionally and non-traditionally interrogated phenotypes in PH, and to further…
- Trial name
- NCT04231084
- Testing
- Vasodilator testing (Inhaled Nitric Oxide), Vasodilator testing (Inhaled Epoprostenol)
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Brigham and Women's Hospital
Healthy Subjects With Low Energy Levels
A Trial to Study the Effects of Ginseng and Cordyceps on Aerobic Capacity, Lactate Kinetics, and Nitric Oxide
This study is a double-blind, randomized, parallel group, three-arm, placebo-controlled trial of seventy-five (75) apparently healthy male and female participants to be recruited at a single investigational center in Northeast…
- Trial name
- NCT07729943
- Testing
- Panax ginseng, Cordycep Militaris
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Applied Food Sciences Inc.
Hypertension, Hypertension (HTN)
Effects of Beetroot Extract on Blood Pressure and Exercise in Hypertensive Older Women
The goal of this clinical trial is to learn about the acute effects of beetroot extract in older women with high blood pressure.
- Trial name
- NCT07444138
- Testing
- Beetroot Extract (Nitrate-rich), Exercise, Rest (Control Condition)
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- São Paulo State University