Clinical trials: Nitrite
Metabolic Syndrome, Hypertension
Oral Nitrite in Adults With Metabolic Syndrome and Hypertension
This research study is being conducted to examine the effects of daily inorganic nitrite treatment on the cardiometabolic and hormonal disturbances observed in overweight/obese adults with the metabolic syndrome and high blood…
- Trial name
- ONTX (NCT01681810)
- Testing
- 14Nitrogen Sodium Nitrite
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Gladwin, Mark, MD
Long COVID, Cardiorespiratory Fitness
Nitrite Supplementation in Long COVID Patients
Potential benefits of a nitrate-rich juice supplement to improve skeletal muscle function and associated physical capacity will be studied in patients with Long COVID.
- Trial name
- NCT05618574
- Testing
- 140 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Subarachnoid Hemorrhage
Intravenous Nitrite Infusion for Reversal of Cerebral Vasospasm After Subarachnoid Hemorrhage
The hypothesis is that intravenous infusion of sodium nitrite is safe and effective for the reversal of cerebral vasospasm after subarachnoid hemorrhage in patients with a cerebral aneurysm.
- Trial name
- NCT02176837
- Testing
- Sodium Nitrite
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Hope Pharmaceuticals
Sickle Cell Anemia
Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease
This study examines ways in which nitric oxide (NO), an important molecule that controls how blood flows through the body's vessels, might be restored with a compound called sodium nitrite.
- Trial name
- NCT00095472
- Testing
- L-NMMA, Sodium Nitrite
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure
Haemodynamic Effects of Dobutamine and Nitrite in LV Dysfunction
Patients with poor heart function can, in certain situations, have a further weakening of the heart muscle such that it becomes difficult to provide enough blood to the brain and other organs.
- Trial name
- NCT02888561
- Testing
- Dobutamine, Nitrite
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- King's College London
Nitric Oxide, Endothelium-Derived Relaxing Factor
Effects of Nitrite on Blood Vessel Dilation in Normal Volunteers
Nitric oxide gas is important in regulating blood vessel dilation, and consequently, blood flow. This gas is continuously produced by endothelial cells, which line the blood vessels.
- Conditions
- Nitric Oxide, Endothelium-Derived Relaxing Factor, Healthy
- Trial name
- NCT00048477
- Testing
- L-NMMA and Sodium Nitrite
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Kidney Disease
Nitrite-boosting Therapy for Improving Physiological Function in Patients With Chronic Kidney Disease
Nitric oxide (NO) is an essential molecule in the body that is decreased in patients with chronic kidney disease (CKD), leading to reductions in vascular, movement ("motor") and cognitive functions.
- Trial name
- NCT03826147
- Testing
- Nitrate-rich beetroot juice, Nitrate-depleted beetroot juice
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Colorado, Boulder
Sickle Cell Anemia
Study of Beet Juice for Patients With Sickle Cell Anemia
The investigators hypothesize that increasing plasma nitrite using dietary nitrate will improve platelet function and red cell deformability and decrease MCHC in patients with sickle cell disease.
- Trial name
- NCT02162225
- Testing
- beet juice (Unbeetable)
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Cardiac Diseases
MEOPA-coupled Hypnosis Versus MEOPA-standard Care in Transesophageal Echocardiography
The primary purpose is to evaluate the impact of hypnosis coupled with MEOPA (Equimolar Mix-ture of Nitrogen Protoxide and Oxygen) on patient comfort when performing transoesophageal echocardiographies.
- Trial name
- HYPNETO (NCT04398017)
- Testing
- Transesophageal echography
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Healthy, Healthy Volunteer
Effect of Nitrite on Exercise Physiology and Metabolism
This study will examine how nitrite infusions affect exercise tolerance (how much a person can exercise before having to stop). Exercise ability is limited by how fast oxygen can be delivered to the body and how fast the body can…
- Conditions
- Healthy, Healthy Volunteer, HV
- Trial name
- NCT00105222
- Testing
- Sodium Nitrite
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Colon Cancer
Natural Compounds to Reduce Nitrite in Meat Products
The PHYTOME project (Phytochemicals to reduce nitrite in meat products) is a major European Union (EU) co-funded research project that aims to develop innovative meat products in which the food additive nitrite has been replaced…
- Trial name
- PHYTOME (NCT04138654)
- Testing
- Processed meat product, White meat wash-out, Processed meat products enriched with natural compounds
- Where
- Netherlands
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Metabolic Syndrome, Hypertension
Oral Nitrite Trial for Hypertension and Metabolic Syndrome
The objective of the study is to investigate effects of inorganic sodium nitrite on the cardiometabolic and hormonal disturbances observed in a targeted population of overweight/obese adults with metabolic syndrome and…
- Trial name
- ONPC (NCT02517697)
- Testing
- 14 Nitrogen (N) Sodium Nitrite
- Where
- United States
- Sponsor
- Gladwin, Mark, MD
Diabetes, Hypertension
The Effect of Dietary Nitrate on Blood Pressure, Insulin Sensitivity, and Vascular Function in Type 2 Diabetes
Dietary nitrate supplementation has previously been shown to reduce blood pressure in healthy volunteers. The investigators wished to see whether this would be replicated in subjects with type 2 diabetes and age matched healthy…
- Trial name
- NCT04076007
- Testing
- Beetroot juice, Nitrate depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Acute Myocardial Infarction
Sodium Nitrite in Acute Myocardial Infarction
The purpose of this study is to determine whether the intravenous infusion of sodium nitrite safely prevents ischemia-reperfusion injury in subjects with acute myocardial infarction resulting in improved left ventricular function.
- Trial name
- NCT00924118
- Testing
- Sodium Nitrite
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Cardiac Arrest
Pilot Study of Sodium Nitrite in Resuscitated Cardiac Arrest Patients
Despite advances in cardiac arrest resuscitation survival from cardiac arrest is less than 20-30% and new therapies are urgently needed.
- Trial name
- NCT01178359
- Testing
- nitrite
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
Vascular Aging
Sodium Nitrite to Treat Arterial Aging
The proposed research will determine the effectiveness of nitrite, a naturally occurring compound in the body, for improving the health and function of arteries in middle-aged and older adults.
- Trial name
- NCT02022670
- Testing
- Sodium Nitrite
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Elderly Women
Water Exercise and Vascular Function in Elderly
Objectives: The purpose of this research was to assess modifications caused by a concurrent water exercise program on plasma nitrite (NO3), cerebral vascular resistance and cholesterol in the elderly and analyze the correlations…
- Trial name
- NCT01642654
- Testing
- Exercise, Educational lectures
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
Out-Of-Hospital Cardiac Arrest
Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest
In this clinical study, a total of 1500 patients with out-of-hospital cardiac arrest in Seattle/King County will be enrolled. This will be a randomized clinical trial and patients will receive either two different doses of IV…
- Trial name
- SNOCAT (NCT03452917)
- Testing
- sodium nitrite 45 mg, sodium nitrite 60 mg
- Where
- United States
- Volunteers
- 1,502 people
- Sponsor
- University of Washington
Cyanide Poisoning
Study of SIAN Nasal Spray in Healthy Adults
This study is designed to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of Stabilized Isoamyl Nitrite (SIAN) nasal spray in healthy subjects.
- Trial name
- NCT05194358
- Testing
- Stabilized Isoamyl Nitrite (SIAN)
- Where
- 2 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Blood Pressure Regulation
The Effects of Nitrate-Rich Mouthwash on Vascular Tone
High blood pressure (hypertension) is a major risk factor for cardiovascular disease. One important contributing factor to high blood pressure is reduced availability of nitric oxide (NO).
- Trial name
- NITRATONE (NCT07602764)
- Testing
- Nitrate-rich mouth rinse, Nitrate-rich drink
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Göteborg University