Clinical trials: Nitrous Oxide
Shoulder Dislocation
Virtual Reality Hypnosis Versus Inhaled Nitrous Oxide in Anterior Shoulder Dislocation Reduction: an Open Multicenter Randomized Controlled Trial
Anterior shoulder dislocation (ASD) is a common situation in the emergency department (ED). Quick reductions lead to reduced mid and long term complications. No technique is superior to one another.
- Trial name
- NCT05388942
- Testing
- Virtual reality hypnosis, Nitrous oxide
- Where
- France
- Volunteers
- 126 people
- Sponsor
- CHU de Reims
Contraceptive Devices, Long-Acting Reversible Contraception
Nitrous Oxide for Pain Management During IUD Insertion in Nulliparous Adolescent Women
This pilot study aims to assess the feasibility, acceptability, and effectiveness of using nitrous oxide (N2O) sedation for intrauterine device (IUD) insertions for nulliparous adolescent and young adult women in a primary care…
- Conditions
- Contraceptive Devices, Long-Acting Reversible Contraception, Analgesia, Adolescent Health
- Trial name
- NCT04089852
- Testing
- Nitrous oxide gas for inhalation, Oxygen Gas for Inhalation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Colorectal Cancer
Nitrous Oxide and Risk of Cancer Recurrence After Colorectal Surgery: A Randomized, Blinded Study
This study was developed to test the hypothesis that the risk of colorectal cancer recurrence was similar in patients who were randomly assigned to 65% nitrous oxide or nitrogen during colorectal surgery.
- Trial name
- NCT00781352
- Testing
- nitrous oxide, nitrogen
- Where
- Austria
- Volunteers
- 408 people
- Sponsor
- The Cleveland Clinic
Major Depressive Disorder
SMILE Trial - Imaging Sub-Study
This is a pilot sub-study of an ongoing trial comparing N2O to midazolam in MDD and will examine neuroimaging correlates of treatment response.
- Trial name
- NCT05528718
- Testing
- Nitrous oxide gas for inhalation, Midazolam injection
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Unity Health Toronto
Chronic Leg Ulcer
Efficacy of 50% Nitrous Oxide/50% Oxygen Gas Premix in Chronic Leg Ulcer Debridement
Adequate analgesia in serial chronic leg ulcer debridement can be difficult to achieve. A common analgesia method is the topical administration of local anesthetics directly onto the wound.
- Trial name
- NCT02696460
- Testing
- N2O/O2 analgesia, Lidocaine/Prilocaine analgesia
- Volunteers
- 21 people
- Sponsor
- Venenklinik Bellevue
Depression
Nitrous Oxide and EMOtional Cognition
The goal of this study is to uncover the underlying neuropsychological mechanisms of nitrous oxide, which may be relevant to its reported antidepressant effects.
- Trial name
- NEMO (NCT06557642)
- Testing
- Entonox, Medical Air
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Colonoscopy Procedure
Safety Study of Colonoscopy Under Sedation
The aim of this study was to compare the analgesia provided by nitrous oxide/oxygen sedation or general anesthesia for colonoscopy
- Trial name
- KALINAG (NCT00930358)
- Testing
- MEOPA, general anaesthesia
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Low Back Pain, Anxiety
Efficacy on Anxiety of the Digital Music Application Versus Equimolar Mixture of Oxygen and Nitrous Oxide in Patients Receiving CT-guided Lumbar Infiltration
Since the Covid-19 crisis, patients appear more stressed, with increasing fear of exams and the hospital environment, in particular for CT scan teams, which require injections.
- Trial name
- MKI-TDM (NCT06928740)
- Testing
- Music Care® device, EMONO
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pregnancy
Nitrous Oxide and Neuraxial Labor Analgesia Use on Maternal Fetal Outcomes
The purpose of this study is to evaluate maternal and neonatal outcomes in parturients who used nitrous oxide and neuraxial labor analgesia during labor.
- Trial name
- NOLA (NCT04813874)
- Testing
- Nitrous Oxide, Neuraxial analgesia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pain, Anxiety
Lumbar Puncture in Emergency Under Nitrous OXide
Lumbar puncture (LP) is a frequent exam that can cause pain and anxiety. In a scheduled setting, it has been shown that nitrous oxide use during the procedure was able to reduce both pain and anxiety.
- Trial name
- LENOX (NCT03941990)
- Testing
- Fixed 50:50 mixture of nitrous oxide and oxygen
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Clermont-Ferrand
Post Traumatic Stress Disorder
Exploring Nitrous Oxide Effects for Post Traumatic Stress Disorder (PTSD)
The purpose of this study is to understand nitrous oxide effects in post traumatic stress disorder (PTSD)
- Trial name
- tN2O (NCT03375294)
- Testing
- Nitrous Oxide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Stanford University
Hysteroscopy
Pericervical Analgesia Versus Analesia With Nitrous Oxide (N2O) in Outpatien Operative Hysteroscopy With Miniresector
This research will have the aim of evaluating and comparing the effectiveness of two methods (analgesia with nitrous oxide and pericervical analgesia, excluding the use of paracervical block due to the increased risk of…
- Trial name
- NCT06092541
- Testing
- Intervention Group: pericervical anesthesia, Nitroux Oxide anesthesia
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ospedale degli Infermi di Biella
Dental Care
Effects of EMONO in Children During Dental Care
The main objective of this project is to evaluate the effects sought and the effects felt by children when EMONO is used in pediatric dental care.
- Trial name
- MEOPAeDent (NCT03453411)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 679 people
- Sponsor
- Nantes University Hospital
Cannulation, Sevoflurane Induction
Determination of Optimum Time for Intravenous Cannulation in Children With Dexmedetomidine Premedication
Inhalational induction with sevoflurane, nitrous oxide, and oxygen is accepted as a safe technique to avoid any movement during intravenous cannulation in children.
- Conditions
- Cannulation, Sevoflurane Induction, Dexmedetomidine
- Trial name
- NCT05139212
- Testing
- Optimum time for intravenous cannulation in children premedicated with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
Most clinical major depression responds to standard treatments (medication and psychotherapy); however, a significant subset of depressed patients (15-20%) do not respond to these treatments and are referred to as…
- Trial name
- NCT02994433
- Testing
- Nitrous Oxide, MRI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pain
ANI and NoL Index Variations After Standard Nociceptive Stimulus at 0, 50, 25 % of Inhaled N2O in the Anesthetic Mixture
N2O has been used during general anesthesia (GA) for more than 100 years. It is known to have anesthetic agents sparing effect. But small is know on his real analgesic effect during GA.
- Trial name
- NCT02701478
- Testing
- N2O exposure
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Depressive Disorder, Major Depressive Disorder
Nitrous Oxide for Major Depressive Disorder
This study aims at investigating the persistence of antidepressant effect of Nitrous Oxide (N2O) for Treatment-Resistant Depression(TRD).
- Conditions
- Depressive Disorder, Major Depressive Disorder, Treatment Resistant Depression, Depressive Disorder, Major
- Trial name
- NCT03932825
- Testing
- Nitrous Oxide
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Lingjiang Li
Opioid-Related Disorders, Substance-Related Disorders
Effects of Subanesthetic Concentrations of Nitrous Oxide - 1
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Trial name
- NCT00000249
- Testing
- 20% N2O, 30% N2O, 40% N2O
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
ASA Class I/II Patients Scheduled for Surgery Under General Anesthesia
Nitrous Oxide - Sevoflurane-Remifentanil Interaction
patients are allocated to one of the two study groups. In both groups a mixture of 60% nitrous oxide and 40% oxygen is administered through a face mask.
- Trial name
- NCT01103193
- Testing
- remifentanil injected, sevoflurane in step up concentration
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Ghent
Quality of Recovery From Anaesthesia, Effects of Nitrous Oxide Following Anaesthesia
ENIGMA - Evaluation of Nitrous Oxide In the Gas Mixture for Anaesthesia: a Randomised Controlled Trial
We aim to investigate the effectiveness and safety of nitrous oxide (N2O) in anaesthesia. Hypothesis In patients undergoing anaesthesia for major surgery, avoidance of N2O will reduce hospital length of stay when compared with…
- Conditions
- Quality of Recovery From Anaesthesia, Effects of Nitrous Oxide Following Anaesthesia, Induced Endothelial Dysfunction
- Trial name
- NCT00164047
- Testing
- Nitrous Oxide
- Where
- Australia
- Volunteers
- 2,070 people
- Sponsor
- Bayside Health