Clinical trials: No Condition, open to volunteers
Newborn, Infant, Disease, Neurodevelopmental Disorders
Perinatal Covid-19 Infection, NO Pathway, and Minipuberty
Some evidence exists that SARS-COV-2 may infect pituitary axis, and therefore may alter hypothalamic function. Whether perinatal COVID-19 is associated with alterations in the maturation of the Hypothalamic-Pituitary-Gonadal…
- Trial name
- miniNO-COVID (NCT04952870)
- Testing
- Inhaled NO, routine care
- Where
- 2 sites in France, Greece
- Volunteers
- 180 people
- Sponsor
- University Hospital, Lille
Healthy
The Healthy Elderly Longevity Cohort
With the completion of the human genome project, investigators can now explore new questions in human biology. Previously human genetics focused on highly penetrant, Mendelian traits; however, now rare and common variants can be…
- Trial name
- Wellderly (NCT01004133)
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Endometriosis (Diagnosis), Endometriosis
Combining Ultrasound and Biomarkers to Diagnose Superficial Endometriosis
Endometriosis is a benign gynecological disease characterized by uterine-like cells growing outside the uterus, leading to pain, infertility, and inflammation.
- Trial name
- SPGENDO (NCT05523284)
- Testing
- SonoPODography
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cognitive Dysfunction, Cognitive Disorder, Dietary Supplements
INSIDE: Intervention in Nutritional Supplementation to Improve Cognitive Decline in Elderly.
This study investigates the effect of nutritional supplementation on cognitive performance in older adults over a 90-day period using a double-blind randomized controlled design.
- Trial name
- INSIDE (NCT07000500)
- Testing
- Nutritional Supplement
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Maria Paço
Kidney Cancer, Renal Cell Carcinoma Metastatic
Deferred Cytoreductive Nephrectomy in Synchronous Metastatic Renal Cell Carcinoma: The NORDIC-SUN-Trial
BACKGROUND: For synchronous metastatic renal cell carcinoma (RCC), surgical resection of the primary tumor in the presence of distant metastases has been the standard of therapy for select patients followed by systemic therapy.
- Conditions
- Kidney Cancer, Renal Cell Carcinoma Metastatic, Synchronous Neoplasm
- Trial name
- NORDIC-SUN (NCT03977571)
- Testing
- Cytoreductive nephrectomy, Tissue sampling
- Where
- 11 sites in Denmark, Finland and 2 more
- Volunteers
- 400 people
- Sponsor
- Niels Fristrup
Urolithiasis, Stones, Kidney
Trial of Ureteroscopy vs Steerable Continuous Flow Aspiration Technology
The goal of this clinical trial is to compare Steerable Ureteroscopic Renal Evacuation (SURE) using the CVAC System and standard ureteroscopy (URS) with laser lithotripsy for the treatment of urolithiasis.
- Conditions
- Urolithiasis, Stones, Kidney, Renal Stones, Kidney Stones
- Trial name
- TRUST (NCT07101809)
- Testing
- Steerable Ureteroscopic Renal Evacuation (SURE) using the CVAC System, Standard Ureteroscopy (URS)
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Calyxo, Inc.
Restless Leg Syndrome (RLS), Spinal Cord Stimulation (SCS)
Neuromodulation to Overcome Severe Restless Legs Syndrome
This prospective, single-center, first-in-indication feasibility study will evaluate the safety and preliminary effectiveness of spinal cord stimulation (SCS) for the treatment of severe, treatment-refractory primary Restless…
- Trial name
- NO RLS (NCT07780032)
- Testing
- Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Marshall Holland
No Conditions, Improving Referrals Into NHS CAMHS
Enhancing Child and Adolescent Mental Health Service Referrals 2
Background Increasing numbers of children and young people are being referred to Child and Adolescent Mental Health Services (CAMHS). However, a quarter are 'rejected' for treatment. This can happen for simple reasons like: 1.
- Trial name
- EN-CAMHS 2 (NCT07399106)
- Testing
- Work Package 1, Work Package 2, Work Package 3
- Where
- United Kingdom
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Greater Manchester Mental Health NHS Foundation Trust
Macular Hole, Macular Hole Surgery
No Endotamponade for Macular Hole Repair: the NEMAR Study
Full-thickness macular hole (MH) is a common sight threatening macular condition with a prevalence of 3.3 per 1000 individuals. Prompt surgical repair of MH is imperative in preventing irreversible vision loss from MH as the…
- Trial name
- NEMAR (NCT06908824)
- Testing
- Conventional surgery, ILM flap with no gas tamponade
- Where
- 3 sites in Hong Kong, Poland and 1 more
- Volunteers
- 180 people
- Sponsor
- Chinese University of Hong Kong
Insomnia, Menopause
No More Sleepless Nights in Perimenopause
The goal of the clinical trial is to learn if Hormone Replacement Therapy (HRT) and Cognitive Behavioral Therapy (CBT-I) can treat insomnia in menopausal women.
- Trial name
- NCT06497894
- Testing
- Cognitive Behavioural Therapy for Insomnia (CBT-I), Hormone Replacement Therapy (HRT), Sleep Hygiene
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
No Conditions
Impact of an Intervention Education Program on the Knowledge, Attitudes, and Practices of Dietitians
This study aims to develop, implement, and evaluate an educational program-based intervention on the knowledge, attitude, and practice toward renal nutrition among dietitians working with chronic kidney disease (CKD) patients in…
- Trial name
- NCT06862466
- Testing
- Education intervention
- Where
- Malaysia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Coronary Microvascular Dysfunction, Ischaemia With Non Obstructed Coronary Arteries
Mechanisms Behind Microvascular Dysfunction in INOCA
The purpose of the study is to identify the causes of chest pain in patients experiencing chest pain with no signs of narrowing in the coronary arteries of the heart.
- Trial name
- ExINOCA-P1 (NCT06529861)
- Testing
- [15O]H2O-PET Imaging
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Plasmodium Falciparum Malaria
Mass Vaccine and Drug Administration, Bangladesh
This is an open i.e. not blinded, cluster-randomised, controlled intervention study. The study will use a factorial design to estimate the protective effectiveness of mass drug administrations, mass vaccinations, combined mass…
- Trial name
- MVDA (NCT06068530)
- Testing
- DHA/piperaquine and a SLD-PQ, Study vaccine R21/Matrix-M™
- Where
- 2 sites in Bangladesh
- Volunteers
- 10,000 people
- Sponsor
- University of Oxford
General Population (no Specific Condition or Disease)
Collection of Stool From Healthy Donors for the ex Vivo Study of Shifts of Microbiome Induced by Dairy Phages and Antibiotics: a Model of Bacteria/Host Interaction (DAIRY-SHAPE)
The gut microbiota plays a crucial role in health through its involvement in pathogen defense, immune regulation, and nutrient digestion.
- Trial name
- DAIRY-SHAPE (NCT07212400)
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Breast Cancer
Single Pre-Operative Radiation Therapy - With Delayed or No Surgery (SPORT-DNS)
Eligible women will receive neoadjuvant single fraction radiotherapy followed by surgery performed after one year
- Trial name
- SPORT-DNS (NCT05217966)
- Testing
- Radiation: Single Pre-Operative Radiation Therapy
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Coronary Arterial Disease (CAD)
Comparative of Plasma Proteomics & Metabolomics in Coronary Artery Disease: Obstructive,Non-Obstructive, & No Lesions
The presence and clinical evolution of coronary atherosclerosis depend on various classic risk factors and biomarkers. However, the search for more specific markers is necessary, especially for individuals with non-obstructive…
- Trial name
- PROTEODAC (NCT06900270)
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Membrane Stripping, Cervical Ripening
The SWEEP Trial: a Randomized Controlled Trial
The purpose of this clinical trial is to determine whether serial membrane sweeping at term is more effective than no membrane sweeping in promoting spontaneous onset of labor.
- Conditions
- Membrane Stripping, Cervical Ripening, Memrane Sweeping
- Trial name
- NCT07043088
- Testing
- Membrane sweeping
- Where
- 2 sites in Denmark
- Volunteers
- 1,536 people
- Sponsor
- University of Aarhus
Haemoglobinopathies
Observational Study for Patients With Hemoglobinopathies and Rare Inherited Anemia and Covid 19
The COVID-19 pandemic is causing many deaths around the world, putting a strain on health services. Patients with pre-existing chronic conditions are most affected by the SARS-COV2 infection.
- Trial name
- NCT04746066
- Where
- 2 sites in Italy
- Volunteers
- 10,000 people
- Sponsor
- Società Italiana Talassemie ed Emoglobinopatie
Lung Cancer
Multinational Observational Study to Describe Diagnostic Stage Shift in Patients With Lung Cancer Using Medical Records
Multinational observational study to describe diagnostic stage shift in patients with lung cancer using medical records. Increased lung cancer screening programs and increased utilization of other screening modalities such as…
- Trial name
- DIASTAG (NCT06842056)
- Volunteers
- 3,000 people
- Sponsor
- AstraZeneca
Non Small Cell Lung Carcinoma, c-MET
Study to Evaluate Adverse Events and Efficacy of Intravenous (IV) Telisotuzumab Adizutecan in Combination With a PD-1 Immune Checkpoint Inhibitor in Adult Participants With Advanced or Metastatic Non-Squamous NSCLC With No Prior Treatment for Advanced Disease, and No Actionable Genomic Alterations
Non small cell lung carcinoma (NSCLC) is the most frequently occurring histologic subtype of lung cancer and is the leading cause of cancer-related deaths worldwide.
- Trial name
- NCT06772623
- Testing
- Telisotuzumab Adizutecan, Budigalimab, Pembrolizumab
- Where
- 126 sites in United States, Argentina and 14 more
- Volunteers
- 252 people
- Sponsor
- AbbVie