Clinical trials: No Disease, active
Healthy Volunteers (no Disease Condition Under Study)
A Phase 1, First-in-Human Trial of BLN-481in Healthy Adult Participants
This Phase 1 first-in-human study will evaluate BLN-481 in healthy adults. Participants will receive BLN-481 or placebo. Part 1 evaluates single ascending intravenous (IV) doses (SAD) and optional subcutaneous (SC) doses.
- Trial name
- NCT07903064
- Testing
- BLN-481
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Beeline Medicines Corporation
No Reflow Phenomenon, Reperfusion Injuries, Myocardial
Evaluating SGLT2 Inhibitors for the Reduction of No-Reflow Phenomenon in Patients Undergoing PCI
Study Background \& Purpose: The no-reflow phenomenon is a significant complication occurring in patients with acute myocardial infarction who undergo percutaneous coronary intervention (PCI).
- Conditions
- No Reflow Phenomenon, Reperfusion Injuries, Myocardial, Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT07898709
- Testing
- Empagliflozin (SGLT2i), dapagliflozin, Standard medical treatment
- Where
- 4 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
No Evidence of Disease, BRCA1 Syndrome
Culturally-Informed Counseling in Latinas at High Risk for Hereditary Breast or Ovarian Cancer
This pilot clinical trial studies a culturally-informed counseling intervention in Latinas at high risk for hereditary breast or ovarian cancer.
- Conditions
- No Evidence of Disease, BRCA1 Syndrome, BRCA2 Syndrome, Hereditary Female Breast Carcinoma
- Trial name
- NCT01230346
- Testing
- questionnaire administration, survey administration, counseling intervention
- Where
- 3 sites in United States
- Volunteers
- 493 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction
The DISCOVER INOCA Prospective Multi-center Registry
The overall objective of this multi-center registry is to identify specific phenotypes of INOCA with both an anatomic evaluation (coronary angiography and intravascular imaging) and physiologic assessment with the Abbott…
- Conditions
- Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction, Coronary Vasospasm, Endothelial Dysfunction
- Trial name
- DISCOVER INOCA (NCT05288361)
- Testing
- Coroventis Coroflow Cardiovascular System and PressureWire™ X Guidewire
- Where
- 9 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yale University
Patients Must Have Histologically or Cytologically Confirmed Locally Advanced or Metastatic NSCLC, EGFR Mutation-negative and ALK Rearrangement-negative
Efficacy and Safety of Ivonescimab Monotherapy as First-Line Treatment for PD-L1-Positive, Driver Gene-Negative, Locally Advanced or Metastatic NSCLC: A Multicenter, Prospective, Real-World Cohort Study
The treatment decisions, assessment schedule, and study procedures in this research will adhere to the routine clinical practice of each participating center.
- Conditions
- Patients Must Have Histologically or Cytologically Confirmed Locally Advanced or Metastatic NSCLC, EGFR Mutation-negative and ALK Rearrangement-negative, Eastern Cooperative Oncology Group Performance Status (ECOG PS) Score of 0 to 2, No Prior Systemic Therapy Received for the Advanced or Metastatic Disease
- Trial name
- PROMISE (NCT07696832)
- Testing
- Ivonescimab Injection
- Where
- China
- Volunteers
- 265 people
- Sponsor
- Guangdong Association of Clinical Trials
No Disease or Condition is Being Studied
French Contrast Versus Oregon Circuit Training in Competitive Football Players
This randomized, two-arm, parallel-group clinical trial is designed to compare French Contrast Training (FCT) with Oregon Circuit Training (OCT) for improving explosive strength, lower-limb power, and agility in competitive…
- Trial name
- FCT-OCT (NCT07865702)
- Testing
- French Contrast Training, Oregon Circuit Training
- Where
- Pakistan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Superior University
No Disease
A Study to Test the Repeatability and Reproducibility in Rod Intercept Time Within the AdaptDx Pro in Healthy Subjects With Normal Vision (FlashForward)
The purpose of this study is to test the repeatability and reproducibility in Rod Intercept (RI) time with two AdaptDx Pro devices in healthy subjects with normal vision.
- Trial name
- FlashForward (NCT07860905)
- Testing
- AdaptDx Pro
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AdaptDx, Inc.
No Disease or Condition is Being Directly Studied, The Focus of the Study in Healthy Volunteers
Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations
The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with…
- Trial name
- NCT07786467
- Testing
- Osteopathic Manipulation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lake Erie College of Osteopathic Medicine
No Specific Medical Conditions or Disease States
Dozee Validation for Contactless Heart Rate and Respiration Monitoring in Clinical Settings
The Dozee VS system (K221555) is a contactless device that tracks heart rate and breathing rate using a sensor sheet placed under the mattress.
- Trial name
- NCT07735403
- Testing
- Telemetry monitoring
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Turtle Shell Technologies Pvt. Ltd.
No-Reflow Phenomenon, Coronary Artery Disease
A Study to Evaluate the Impact of Pre-procedural Intracoronary Nicorandil Injection to PREVENT reductioN Of decREased TIMI FLOW in Patients Who Undergoing Percutaneous Coronary Intervention for the Coronary Artery Disease
The aim of this study was to determine the effect of intra-coronary administration of nicorandil on the prevention of lowering of coronary blood flow for high-risk plaque lesions defined as the high value of lipid core burden…
- Conditions
- No-Reflow Phenomenon, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT05427786
- Testing
- Nicorandil
- Where
- South Korea
- Volunteers
- 458 people
- Sponsor
- Korea University Anam Hospital
Angina With No Obstructive Coronary Artery Disease
Diagnosis of Women With ANOCA
Angina is a feeling of chest pain or discomfort which can happen if there is reduced blood flow to the heart. Patients can experience angina with no obstructive coronary arteries (ANOCA) which is a difficult condition to treat…
- Trial name
- NCT07802457
- Where
- 11 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- NHS Greater Glasgow and Clyde
No Disease or Condition is Being Directly Studied, The Focus of the Study in Healthy Volunteers
The Effect of Osteopathic Manipulative Techniques on Human Tear Composition
This is a pilot study to determine if osteopathic manipulation can alter the concentration of proteins and lipids in human tears.
- Trial name
- NCT07633496
- Testing
- Osteopathic Manipulative Treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lake Erie College of Osteopathic Medicine
No Disease or Condition is Being Studied, Stress (Psychology)
Caring for Dementia Caregivers in Ethnic Immigrant Communities
Many caregivers of people with Alzheimer's disease or other dementias-especially those in immigrant communities who don't speak English well-don't get access to helpful, proven support programs.
- Trial name
- NCT07550075
- Testing
- K-Savvy, Healthy Living
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Southern California
No Specific Diseases or Conditions Are Being Studied
THE EFFECT OF SIMULATION-BASED INTERPROFESSIONAL EDUCATION ON ATTITUDES TOWARD TEAMWORK
Our study aims to evaluate the effect of interprofessional simulation-based learning on teamwork attitudes among nursing and paramedic students during the patient handover process.
- Trial name
- NCT07655752
- Testing
- Simulation-Based Interprofessional Education Program
- Volunteers
- 56 people
- Sponsor
- Saglik Bilimleri Universitesi
General Population (no Specific Condition or Disease)
SAPHIR2 : Simplification of PHysical Activity Assessment by Rapid Interrogation
A multicentric, non-interventional study using a clinical questionnaire (SAPHIR) and activity monitor (Activ-PAL) to estimate the level of physical activity in the general population.
- Trial name
- SAPHIR2 (NCT07147608)
- Testing
- actimeter wearing, physical activities questionnaires
- Where
- 3 sites in France
- Volunteers
- 118 people
- Sponsor
- University Hospital, Angers
No Disease
Fibrescope vs Videolaryngoscope for Nasotracheal Intubation
Patients having surgery under general anaesthesia require insertion of a breathing tube to keep the airway open. The technique of inserting a breathing tube through the nose into the trachea (airway) is known as nasotracheal…
- Trial name
- NCT07353255
- Testing
- Nasotracheal Intubation with Fibrescope, Nasotracheal Intubation with Video laryngoscope
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
No Restriction on Disease
The Purpose of This Clinical Trial is to Evaluate the Accuracy of Blood Pressure Measurement of HiCardi M350 Compared to Blood Pressure Measured by Auscultatory Sphygmomanometer in Adult Volunteers (Including Those Meeting Blood Pressure Distribution Requirements) in Accordance With ISO 81060-2:2018
This prospective, single-center, single-arm pivotal clinical trial is designed to evaluate the accuracy of blood pressure measurements obtained using the HiCardi M350 patient monitor compared with measurements obtained using an…
- Trial name
- NCT07622498
- Testing
- HiCardi M350
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yonsei University
No Disease or Condition is Being Studied, Surgical Procedures, Minimally Invasive
Hand Versus Foot Controls for Robotic Surgery Simulation
Why is the study being done? Robotic-assisted surgery offers high precision and ergonomic benefits, but it requires specialized console skills that differ significantly from traditional open or laparoscopic surgery.
- Trial name
- CLUTCH WAR (NCT07618429)
- Testing
- Hand Clutch, Foot Clutch
- Where
- Thailand
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Microvascular Angina, Angina, Stable
iCorMicA - Stratified Medicine in Angina
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry.
- Conditions
- Microvascular Angina, Angina, Stable, Ischemia With No Obstructive Coronary Arteries (INOCA), Coronary Microvascular Dysfunction (CMD)
- Trial name
- iCorMicA (NCT04674449)
- Testing
- Disclosure of IDP results, IDP performed but results not disclosed
- Where
- 39 sites in Ireland, Netherlands and 2 more
- Volunteers
- 1,500 people
- Sponsor
- NHS Greater Glasgow and Clyde
General Population (no Specific Condition or Disease)
Brain Function Messures of a Psychological Flexibility Skills Training Based on ACT Over Disordered Eating Behaviors
Overweight and obesity are an increasing tendencies worldwide. Disordered Eating Behaviors (DEBs) are feeding dynamics commonly present on them, as in Feeding Disorders (FD).
- Trial name
- FLEXEAT (NCT07492056)
- Testing
- A Psychological Flexibility Skills Training based on ACT.
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California