Clinical trials: No Evidence of Disease
Head and Neck Cancer
Neck Surgery in Treating Patients With Early-Stage Oral Cancer
RATIONALE: Surgery may be an effective treatment for oral cancer. It is not yet known whether surgery to remove the tumor and lymph nodes in the neck is more effective than surgery to remove the tumor alone in treating patients…
- Trial name
- NCT00571883
- Testing
- questionnaire administration, psychosocial assessment and care, quality-of-life assessment
- Where
- 27 sites in United Kingdom
- Volunteers
- 652 people
- Sponsor
- The Facial Surgery Research Foundation
Healthy
Topical Myristyl Nicotinate Cream on the Skin of Healthy Volunteers
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of topical myristyl nicotinate cream may stop skin cancer from forming.
- Trial name
- NCT00619060
- Testing
- Topical Myristyl Nicotinate Cream
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Healthy, no Evidence of Disease
Diindolylmethane in Healthy Volunteers
This randomized phase I trial is studying the side effects and best dose of diindolylmethane in healthy volunteers. Chemoprevention is the use of certain drugs or substances to keep cancer from forming, growing, or coming back.
- Trial name
- NCT00392652
- Testing
- oral microencapsulated diindolylmethane
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Survivorship, Recurrent
Association Between Exercise, Patient-Reported Outcomes, and Clinical Events in Adult Cancer Survivors
This protocol is a retrospective study using observational data to conduct a target trial emulation to examine the association of exercise on cancer specific endpoints and other clinical outcomes in cancer survivors.
- Conditions
- Survivorship, Recurrent, Recurrence, Cancer
- Trial name
- NCT07030686
- Testing
- Exercise
- Where
- 3 sites in United States
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer, Healthy, no Evidence of Disease
Exercise Programs in Healthy Young Women at Increased Risk of Developing Breast Cancer
RATIONALE: Exercise may change the risk of developing breast cancer. It is not yet known whether low-intensity exercise or high-intensity exercise is more effective in lowering the risk of breast cancer.
- Trial name
- NCT00892515
- Testing
- exercise intervention, counseling intervention, gas chromatography
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Knee Osteoarthritis
The McKenzie System With Arthritic Knees: Do Some Knees Respond to Specific Exercise More Than General or no Exercise
The purpose of the study is to explore if a subgroup of people with osteoarthritic knees can be identified using the McKenzie System of Mechanical Diagnosis and Therapy.
- Trial name
- NCT01641874
- Testing
- Exercise, Evidence based exercise
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Squamous Cell Carcinoma
Comparing Two Surveillance Approaches for People Who Have Received Treatment for HPV-associated Head and Neck Cancer and Show No Signs of Disease
The purpose of this study is to compare standard surveillance with telemedicine surveillance (tele-surveillance) and find out which surveillance approach is best for people with HPV-associated head and neck cancer who have no…
- Trial name
- NCT05048459
- Testing
- Standard surveillance, Telemedicine surveillance (tele-surveillance), Questionnaires
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Healthy, no Evidence of Disease
Dose-Finding of Retinoid 9cUAB30 in Healthy Volunteers
This randomized phase I trial studies the side effects and the best dose of retinoid 9cUAB30 in healthy volunteers. Chemoprevention is the use of certain drugs to keep cancer from forming.
- Trial name
- NCT01336387
- Testing
- retinoid 9cUAB30, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Patients With Pace Makers But no Evidence of Ischemic Heart Disease
A Methodological Open Label Cross-Over Controlled Study To Assess The Effect Of Drugs On Ventricular Repolarization and QT Interval At Fixed Heart Rate Under Autonomic Blockade
To assess the effects of GTN on QT and QTc in subjects with And without atrial pacing. This will be done with and without autonomic blockade at two different pacing rates.
- Trial name
- NCT00174512
- Testing
- GTN, Moxifloxacin
- Where
- 6 sites in Belgium, United Kingdom
- Volunteers
- 36 people
- Sponsor
- Pfizer
Breast Cancer, Healthy, no Evidence of Disease
Study of Breast Tissue in Women Not Previously Diagnosed With Breast Cancer Who Are Undergoing Fine Needle Aspiration
RATIONALE: Studying samples of blood and breast tissue from healthy women in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to breast cancer risk.
- Trial name
- NCT00896636
- Testing
- Random fine need aspiration (rFNA), Mammogram
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Healthy, no Evidence of Disease, Tobacco Use Disorder
Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci)
Chemoprevention is the use of certain substances to keep cancer from forming, growing, or coming back. Curcumin is a compound found in plants that may prevent colon cancer from forming.
- Trial name
- NCT00365209
- Testing
- laboratory biomarker analysis, pharmacological study, curcumin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Fallopian Tube Cancer, Ovarian Cancer
Erlotinib or Observation in Treating Patients Who Have Undergone First-Line Chemotherapy for Ovarian Cancer, Peritoneal Cancer, or Fallopian Tube Cancer
RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Sometimes after treatment, the tumor may not need additional treatment until it progresses.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00263822
- Testing
- erlotinib hydrochloride
- Where
- 92 sites in Australia, Austria and 6 more
- Volunteers
- 835 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Relapsing-Remitting Multiple Sclerosis
Ocrelizumab or Alemtuzumab Compared With Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis - a Phase-2 Randomised Controlled Trial
A multicentre controlled phase II trial to compare the efficacy and safety of ocrelizumab or alemtuzumab and autologous Hematopoietic Stem Cell Transplantation (aHSCT).
- Trial name
- COAST (NCT04971005)
- Testing
- Autologous Hematopoietic Stem Cell Transplantation, Ocrelizumab, Alemtuzumab
- Where
- 2 sites in Germany
- Volunteers
- 1 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Healthy
Flaxseed Intervention Study to Assess Sex Hormone Levels Among Post-Menopausal Women
The purpose of this study is to understand whether consuming flaxseed for approximately 50 days may beneficially affect the level of certain hormones in the blood thought to be involved in the development of breast cancer.
- Trial name
- NCT02501031
- Testing
- Ground flaxseed
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Cancer Care Ontario
Thoracic Sarcomas, Thorasic Cancers
Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum
Background: During recent years, cancer-testis (CT) antigens (CTA), particularly those encoded by genes on the X chromosome (CT-X genes), have emerged as attractive targets for cancer immunotherapy.
- Conditions
- Thoracic Sarcomas, Thorasic Cancers, Cancers of Non-thoracic Origin With Metastases to the Lungs or Pleura, Sarcoma
- Trial name
- NCT02054104
- Testing
- H1299 cell lysates, Cyclophosphamide, Celecoxib
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Anxiety, No Evidence of Disease
Video-Based Intervention in Reducing Anxiety in Patients Undergoing Lung Cancer Screening
This pilot trial studies a video-based intervention in reducing anxiety in patients undergoing lung cancer screening. Giving a video-based intervention to patients prior to lung cancer screening may reduce anxiety and improve the…
- Conditions
- Anxiety, No Evidence of Disease, Lung Carcinoma
- Trial name
- NCT02288416
- Testing
- educational intervention, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
No Evidence of Disease, Prostate Carcinoma
Se-Methyl-Seleno-L-Cysteine or Selenomethionine in Preventing Prostate Cancer in Healthy Participants
This randomized phase I trial studies the side effects and the best dose of Se-methyl-seleno-L-cysteine or selenomethionine in preventing prostate cancer in healthy participants.
- Trial name
- NCT01497431
- Testing
- Selenium, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 3 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
No Evidence of Disease
Celecoxib in Decreasing the Damaging Effects of Sunburn in Healthy Volunteers
This clinical trial studies celecoxib in decreasing the damaging effects of sunburn in healthy volunteers. Celecoxib may reduce skin damage by blocking enzymes associated with sunburn in healthy volunteers.
- Trial name
- NCT02090933
- Testing
- Celecoxib, Laboratory Biomarker Analysis, UV Light Therapy
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Dysplastic Nevus, Health Status Unknown
Internet-based Intervention for Skin Self-Examination in Participants With Increased Risk for Melanoma
This trial studies an internet-based intervention for skin self-examination (SSE) in participants at increased risk for melanoma. Early detection of suspicious growths on the skin can be done by performing regular SSE checks.
- Conditions
- Dysplastic Nevus, Health Status Unknown, Melanoma, No Evidence of Disease
- Trial name
- NCT03725449
- Testing
- Best Practice, mySmartCheck, Survey Administration
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Breast Cancer, Early Breast Cancer
An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard adjuvant endocrine therapy for patients with ER+/HER2- early breast cancer with intermediate-high or high risk for disease…
- Trial name
- CAMBRIA-2 (NCT05952557)
- Testing
- Camizestrant, Tamoxifen, Anastrozole
- Where
- 661 sites in United States, Argentina and 42 more
- Volunteers
- 5,511 people
- Sponsor
- AstraZeneca