Clinical trials: Nocebo Effects
Nocebo Effects, Hyperalgesia
The Role of Learning in Nocebo Hyperalgesia
Nocebo effects are adverse effects induced by patients' expectations. Nocebo effects on pain may underlie several clinical conditions, such as chronic pain. These effects can be learned via classical conditioning mechanisms.
- Conditions
- Nocebo Effects, Hyperalgesia, Chronic Pain, Pain Syndrome
- Trial name
- NCT03793790
- Testing
- Conditioning with partial reinforcement, Conditioning with continuous reinforcement, Counterconditioning
- Where
- Netherlands
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Chronic Pain, Pain Syndrome
Pain, Learning, and Nocebo
Nocebo effects, negative responses to inert or active treatments which are putatively induced by negative outcome expectations, have been shown to play a significant role in pain perception.
- Trial name
- PIPLE (NCT04762836)
- Testing
- D-cycloserine, Conditioning, Extinction
- Where
- Netherlands
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Pain, Itch
Learning Mechanisms for Placebo and Nocebo Studies on Somatosensory Sensations: a Systematic Review and Meta-analysis.
Placebo and nocebo effects are defined as the positive and negative effects occurring after the (supposed) administration of an inert treatment, which, through a given learning process, is believed to have positive or negative…
- Trial name
- NCT04387851
- Testing
- Control, Nocebo
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Leiden University Medical Center
Pain
Off-set Analgesia Induced by Cold Temperature
In this study, it will be investigated if the phenomenon of offset analgesia, usually associated with painful heat stimulation, could also be induced using cold painful temperatures.
- Trial name
- NCT07395869
- Testing
- Heat off-set analgesia, Cold off-set analgesia
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Rheumatic Diseases
Effectiveness of a Combined e-Learning and Virtual Reality Training Program for Healthcare Providers in Rheumatology
The goal of this clinical trial is to evaluate the effectiveness of communication training on the communication skills of the healthcare provider in the rheumatology department during consults with patients.
- Trial name
- NCT07835256
- Testing
- Expectancy-based communication training for healthcare providers
- Where
- Netherlands
- Volunteers
- 936 people, healthy volunteers welcome
- Sponsor
- Leiden University