Clinical trials: Nociplastic Pain
Chronic Low Back Pain (CLBP), Nociplastic Pain
PRT for Chronic Low Back Pain
The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) is a feasible and acceptable treatment to complete for working-age adults (ages 18-65) with chronic low back pain.
- Trial name
- NCT07696741
- Testing
- Pain Reprocessing Therapy, Monitoring and Education
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Chronic Low-back Pain
The METRIC Study Protocol
The goal of this clinical trial is to test the effects of spinal manipulative therapy in individuals with chronic primary low back pain and determine the neurophysiological mechanisms underlying pain relief.
- Trial name
- METRIC (NCT05986370)
- Testing
- lumbar spinal manipulative therapy, full spine spinal manipulative therapy
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Université du Québec à Trois-Rivières
Subacromial Pain Syndrome, Rotator Cuff Related Shoulder Pain
Pain Phenotype and Response to Corticosteroid Injection in Patients With Subacromial Pain Syndrome (SAPS)
The goal of this prospective cohort study is to investigate whether pain phenotype is associated with subsequent change in pain intensity after corticosteroid injection given as part of routine care in patients diagnosed with…
- Conditions
- Subacromial Pain Syndrome, Rotator Cuff Related Shoulder Pain, Shoulder Pain, Shoulder Impingement Syndrome
- Trial name
- NAP SAPS CSI (NCT07792421)
- Testing
- Clinical evaluation
- Where
- Denmark
- Volunteers
- 134 people
- Sponsor
- Vejle Hospital
Fibromyalgia (FM)
Investigating the Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on the Brain in People With Fibromyalgia
The first goal of this study is to see how brain activity changes in people with fibromyalgia after they get a treatment called rTMS (repetitive transcranial magnetic stimulation).
- Trial name
- rTMS (NCT07260864)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
PARKINSON DISEASE (Disorder)
EFficacy and safEty of cRisugabalin on nocipLastic paIn in Patients With Parkinson's Disease (RELIEF-PD): a Multicentre, Double-blind, Randomised Controlled Trial
The goal of this clinical trial is to evaluate the efficacy and safety of Crisugabalin in adult participants with Parkinson's disease suffering from nociceptive pain. The main question it aims to answer is: 1.
- Trial name
- RELIEF-PD (NCT07483398)
- Testing
- Crisugabalin
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Guangdong Provincial People's Hospital
Sensory Profiles, Central Sensitisation
Prognostic Factor Research of Sensory Profiles in Development of Central Sensitization
A longitudinal observational cohort study to investigate the value of prognostic factors, here sensory profiles , and others, in the development of central sensitization in the low back pain population.
- Conditions
- Sensory Profiles, Central Sensitisation, Low Back Pain, Nociplastic Pain
- Trial name
- NCT04974229
- Testing
- In line with the Dutch guideline for non-specific low back pain, Standard usual care for non-specific low back pain was applied.
- Where
- Belgium
- Volunteers
- 102 people
- Sponsor
- Vrije Universiteit Brussel
Carpal Tunnel Syndrome, Pain, Chronic
Combined Physical and Psychological Intervention in Carpal Tunnel Syndrome Patients With Nociplastic Pain
This randomized, assessor-blinded, parallel-group trial evaluated the effectiveness of adding a psychologically informed pain-management intervention to standardized physical rehabilitation in adults with electrodiagnostically…
- Trial name
- NCT05915611
- Testing
- Standardized Carpal Tunnel Syndrome Rehabilitation, Psychologically Informed Pain-Management Program, Attention-Matched Health Education
- Where
- Egypt
- Volunteers
- 178 people
- Sponsor
- Ahram Canadian University
Temporomandibular Disorders (TMD), Nociplastic Pain
Effects of Aerobic and Strength Exercice on Nociplastic Pain in Temporomandibular Disorders
Chronic temporomandibular disorders are common in the general population. Nociplastic pain seems to be present in this pathology, with an hypersensitivity to touch, pressure and movement observed in both local and remote areas…
- Conditions
- Temporomandibular Disorders (TMD), Nociplastic Pain, Aerobic Exercise, Strengthening Exercises
- Trial name
- NCT06584526
- Testing
- Physical Therapy, Physical Therapy and Aerobic Exercise, Physical Therapy and Strength Exercise
- Where
- Spain
- Volunteers
- 51 people
- Sponsor
- Universitat Internacional de Catalunya
Chronic Pain, Nociplastic Pain
Multimodal Lifestyle Approach for Chronic Pain With Nociplastic Pain Features
This single-center, single-arm pilot feasibility study aims to examine the feasibility and preliminary effectiveness of an intervention program using a pain education booklet based on a multimodal lifestyle approach for patients…
- Trial name
- MLA-MM (NCT07693062)
- Testing
- Multimodal Lifestyle Approach Using a Pain Education Booklet
- Where
- 2 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Prefectural University of Hiroshima
Carpal Tunnel Syndrome
Predicting Nociplastic Pain in Carpal Tunnel Syndrome Through Quantitative Sensory Testing
This study aims to investigate the predictive value of quantitative sensory testing (QST) in identifying patients with carpal tunnel syndrome (CTS) who are at risk of developing nociplastic pain.
- Trial name
- NCT05959954
- Testing
- Quantitative Sensory Testing (QST)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ahram Canadian University
Chronic Pain, Central Sensitisation
Brain MRI for Knee OA
It has been estimated that 300 million people worldwide have osteoarthritis (OA), and this has increased by 97% over the past 25 years.
- Conditions
- Chronic Pain, Central Sensitisation, Knee Osteoarthritis
- Trial name
- NCT05986513
- Testing
- Cold Pressor Gel Test
- Where
- 2 sites in Canada
- Volunteers
- 66 people
- Sponsor
- Toronto Rehabilitation Institute
Fibromyalgia, Nociplastic Pain
Vestibular Innovation in Pain 2
Fibromyalgia is the most common centralized pain disorder, affecting up to 3% of the population. Current treatments are incompletely effective, often poorly tolerated, and costly: there remains an urgent need for novel…
- Trial name
- VIPR (NCT07423377)
- Testing
- Vestibulocortical Stimulation
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Sensory Profiles, Nociplastic Pain, Low Back Pain
Type 3 Predictive Observational Study for Sensory Profiles in Central Sensitization in Low Back Pain Population.
This study conducts prognostic research to develop, validate, and evaluate the predictive role of sensory profiles in the development of sensory profiles over time.
- Trial name
- T3PredCohSt (NCT05097235)
- Where
- Netherlands
- Volunteers
- 114 people
- Sponsor
- Vrije Universiteit Brussel
Chronic Pain, Cancer Pain
Clinical Classification of Pain in Breast Cancer Survivors
Breast cancer is the most common malignancy in women worldwide according to International Agency for Research on Cancer. Unfortunately, cancer survivors often face long-term symptoms that occur or persist after completion of…
- Conditions
- Chronic Pain, Cancer Pain, Breast Cancer
- Trial name
- NCT04219072
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Kutahya Health Sciences University
Chronic Low-back Pain
Effects of Therapeutic Neuroscience Education in Patients With Chronic Low Back Pain
The study will be Randomized controlled trail, Subject diagnosed with low back pain meeting predetermined inclusion and exclusion criteria will be divided into two groups.
- Trial name
- NCT05848076
- Testing
- TNE, core stability
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Chronic Pain (Back / Neck)
Effectiveness of a Pain Neuroscience Education and Therapeutic Exercise Program Delivered by Primary Care Physiotherapists to Patients With Chronic Nociplastic Spinal Pain
The main objective of the project is to evaluate the effectiveness, in terms of quality of life, of a therapy based on an Active Coping Protocol for Non-Cancer Chronic Pain in the Primary Care setting.
- Trial name
- AP-AADC (NCT07133607)
- Testing
- education about pain and physical excersice, education about pain and physical excersice with somatosensorial treatment, Classic physiotherapy treatment with physical exercise, analgesic electrotherapy and thermotherapy
- Volunteers
- 135 people
- Sponsor
- Distrito de Atención Primaria Sevilla
Fibromyalgia, Chronic Migraine, Headache
Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia
Chronic pain (CP) is a substantial healthcare challenge with considerable economic costs. Recently, the term Nociplastic Pain (NP) has been introduced as a third descriptor of mechanisms related to CP.
- Conditions
- Fibromyalgia, Chronic Migraine, Headache, Vulvodynia
- Trial name
- PSYCHOFIBRO (NCT06138171)
- Testing
- Psychological self-reported measures assesment (questionnaire)
- Where
- Italy
- Volunteers
- 1,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Chronic Low Back Pain (CLBP), Acute Low Back Pain
Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)
This prospective cohort study investigates the neurobiological, genetic, and psychosocial mechanisms underlying acute and chronic low back pain (LBP).
- Conditions
- Chronic Low Back Pain (CLBP), Acute Low Back Pain, Low Back Pain, Chronic Pain
- Trial name
- LBPB (NCT06967363)
- Testing
- Nerve Block, endoscopic spinal disecetomy, Medication
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Peking University Third Hospital
Subacromial Pain Syndrome, Rotator Cuff Related Shoulder Pain
Nociplastic Pain in Patients Diagnosed With Subacromial Pain Syndrome (SAPS)
The goal of this cross-sectional study is to estimate the prevalence of the nociplastic pain phenotype, according to the IASP clinical criteria, among patients diagnosed with SubAcromial Pain Syndrome (SAPS).
- Conditions
- Subacromial Pain Syndrome, Rotator Cuff Related Shoulder Pain, Shoulder Pain, Shoulder Impingement Syndrome
- Trial name
- The NAP SAPS (NCT07792434)
- Testing
- Clinical evaluation
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Vejle Hospital
Myofascial Pain, Physical Therapy
Myofascial Pain and Central Sensitization
This prospective, observational cohort pilot study compared pain phenotyping and functional measures in 30 participants with non-acute neck and/or shoulder girdle pain consistent with primary myofascial pain at 3-months following…
- Trial name
- NCT04929171
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan