Clinical trials: Nociplastic Pain, active
Fibromyalgia, Chronic Pain
Emotional Allodynia Questionnaire (AEQ) in Fibromyalgia (PEARL)
The Emotional Allodynia Questionnaire (AEQ) is an 11-item self-report instrument that measures disproportionate emotional reactivity to low-intensity interpersonal cues(perceived unresponsiveness, exclusion, loss of reciprocity)…
- Conditions
- Fibromyalgia, Chronic Pain, Nociplastic Pain
- Trial name
- PEARL (NCT07677631)
- Where
- 5 sites in Italy
- Volunteers
- 425 people
- Sponsor
- University of Bari
Frozen Shoulder, Adhesive Capsulitis
USG-Guided Shoulder Injections in Frozen Shoulder
Frozen shoulder (adhesive capsulitis) is characterized by pain and a progressive restriction of both active and passive shoulder range of motion, significantly impairing daily activities and quality of life.
- Conditions
- Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain, Nociplastic Pain
- Trial name
- NCT07493213
- Testing
- USG-guided suprascapular nerve block, USG-Guided suprascapular nerve block plus subacromial injection.
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Osteoarthritis, Back Pain
Investigation of the Cultural Adaptation, Validity, and Reliability of the Turkish Version of the CAP Questionnaire
The "CAP questionnaire," developed by modifying the CAP-Knee questionnaire to assess potential nociplastic pain features in painful musculoskeletal disorders, has been described.
- Conditions
- Osteoarthritis, Back Pain, Fibromyalgia
- Trial name
- NCT06825650
- Testing
- Questionnaire study
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Hacettepe University
Chronic Low Back Pain (CLBP), Acute Low Back Pain
Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)
This prospective cohort study investigates the neurobiological, genetic, and psychosocial mechanisms underlying acute and chronic low back pain (LBP).
- Conditions
- Chronic Low Back Pain (CLBP), Acute Low Back Pain, Low Back Pain, Chronic Pain
- Trial name
- LBPB (NCT06967363)
- Testing
- Nerve Block, endoscopic spinal disecetomy, Medication
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Peking University Third Hospital
PARKINSON DISEASE (Disorder)
EFficacy and safEty of cRisugabalin on nocipLastic paIn in Patients With Parkinson's Disease (RELIEF-PD): a Multicentre, Double-blind, Randomised Controlled Trial
The goal of this clinical trial is to evaluate the efficacy and safety of Crisugabalin in adult participants with Parkinson's disease suffering from nociceptive pain. The main question it aims to answer is: 1.
- Trial name
- RELIEF-PD (NCT07483398)
- Testing
- Crisugabalin
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Guangdong Provincial People's Hospital
Central Sensitisation, Low Back Pain
Nociplastic Pain Symptoms and Sensory Profiles in Low Back Pain
Assessing associations between Sensory profiles and nociplastic pain symptoms, and assessing the prognostic value of sensory profiles in the development of nociplastic pain symptoms in a low back pain population.
- Trial name
- NCT05592405
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Vrije Universiteit Brussel
Multiple Sclerosis, Chronic Pain
Pain Phenotypes in Individuals With Multiple Sclerosis
This observational cross-sectional study aims to determine chronic pain phenotypes in individuals with multiple sclerosis (MS) and to investigate the clinical characteristics associated with different pain phenotypes.
- Trial name
- NCT07766213
- Testing
- Pain classification method
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kutahya Health Sciences University
Neuropathic Pain, Nociplastic Pain
Evolution of Different Sensitivity Levels in Patients With Chronic Neuropathic Pain in the Pelvi-perineal Region After Treatment With High-concentration Capsaicin Patches
The primary objective of this study will be to demonstrate a change in pain sensitization parameters before and after the application of the high-concentration capsaicin patch.
- Trial name
- CAPSASENS (NCT07660510)
- Testing
- Quantitative Sensory Testing and questionnaires
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Chronic Pain (Back / Neck)
Effectiveness of a Pain Neuroscience Education and Therapeutic Exercise Program Delivered by Primary Care Physiotherapists to Patients With Chronic Nociplastic Spinal Pain
The main objective of the project is to evaluate the effectiveness, in terms of quality of life, of a therapy based on an Active Coping Protocol for Non-Cancer Chronic Pain in the Primary Care setting.
- Trial name
- AP-AADC (NCT07133607)
- Testing
- education about pain and physical excersice, education about pain and physical excersice with somatosensorial treatment, Classic physiotherapy treatment with physical exercise, analgesic electrotherapy and thermotherapy
- Volunteers
- 135 people
- Sponsor
- Distrito de Atención Primaria Sevilla
Chronic Pain, Nociplastic Pain
Different Treatments in Chronic Pain Patients.
The goal of this observational study is to compare different treatment options in a chronic pain population. The main questions it aims to answer are: What is the effectiveness of the different therapy options in the pain center…
- Trial name
- EC_PC_AZSTL (NCT05768477)
- Testing
- Consultation, Interventions, Baxter therapy
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- University Ghent
Chronic Pain, Nociplastic Pain
Multimodal Lifestyle Approach for Chronic Pain With Nociplastic Pain Features
This single-center, single-arm pilot feasibility study aims to examine the feasibility and preliminary effectiveness of an intervention program using a pain education booklet based on a multimodal lifestyle approach for patients…
- Trial name
- MLA-MM (NCT07693062)
- Testing
- Multimodal Lifestyle Approach Using a Pain Education Booklet
- Where
- 2 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Prefectural University of Hiroshima
Chronic Low Back Pain (CLBP), Nociplastic Pain
PRT for Chronic Low Back Pain
The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) is a feasible and acceptable treatment to complete for working-age adults (ages 18-65) with chronic low back pain.
- Trial name
- NCT07696741
- Testing
- Pain Reprocessing Therapy, Monitoring and Education
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Myofascial Pain Syndrome - Neck
Agreement Between CSI and IASP Pain Classification in Chronic Cervical Myofascial Pain
This study aims to investigate how closely two approaches to assessing pain-related characteristics agree in adults with chronic cervical myofascial pain syndrome (chronic neck pain associated with painful muscle trigger points).
- Trial name
- NCT07904364
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Mardin Artuklu University
Rheumatoid Arthritis (RA, Chronic Pain
Integrative AI-Based Multiomic and Neurophysiological Profiling of Chronic Pain in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease in which pain remains the most prominent and burdensome symptom from the patient's perspective.
- Trial name
- RA-PAIN-AI (NCT07769619)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Chronic Primary Orofacial Pain (CPOP), Persistent Idiopathic Facial Pain (PIFP)
An Innovative Cognitive-Behavioral Treatment For Chronic Orofacial Pain
Use these resources to provide understandable information about this study to patients, families, and health care providers: The present randomized clinical trial (RCT), conducted at the IRCCS Carlo Besta Neurological Institute…
- Trial name
- FACE-PRT (NCT07123233)
- Testing
- Pain Reprocessing Therapy, Usual Therapy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Rheumatoid Arthritis, Chronic Widespread Pain
Neurofeedback for Nociplastic Pain in Rheumatoid Arthritis (NECTAR)
Rheumatoid arthritis is an autoimmune condition, causing inflammation and pain. Yet pain may persist even when inflammation has been treated.
- Trial name
- NECTAR (NCT06240299)
- Testing
- Neurofeedback
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- NHS Greater Glasgow and Clyde
Bladder Pain Syndrome, Chronic Pelvic Nociplastic Pain
Venlafaxine Combined With Education and Behavioral Intervention for Bladder Pain Syndrome
This study aims to compare two treatment plans for adults with bladder pain syndrome (also called interstitial cystitis), a disease that causes long-lasting bladder pain, frequent urination and urgent need to pee.
- Conditions
- Bladder Pain Syndrome, Chronic Pelvic Nociplastic Pain, Interstitial Cystitis
- Trial name
- VEN-BPS (NCT07698626)
- Testing
- Venlafaxine oral tablet combined with Education and Behavioral Modification Program (EBMP), Education and Behavioral Modification Program (EBMP) only
- Volunteers
- 140 people
- Sponsor
- Beijing Tiantan Hospital
Fibromyalgia
Fibromyalgia Sleep A to ZZZ Study
This research study is testing whether changes in sleep timing and morning light therapy may have an impact on symptoms related to fibromyalgia.
- Trial name
- NCT06567886
- Testing
- Light Therapy, Sleep Stabilization
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- University of Michigan
Fibromyalgia (FM)
Investigating the Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on the Brain in People With Fibromyalgia
The first goal of this study is to see how brain activity changes in people with fibromyalgia after they get a treatment called rTMS (repetitive transcranial magnetic stimulation).
- Trial name
- rTMS (NCT07260864)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Subacromial Pain Syndrome, Rotator Cuff Related Shoulder Pain
Nociplastic Pain in Patients Diagnosed With Subacromial Pain Syndrome (SAPS)
The goal of this cross-sectional study is to estimate the prevalence of the nociplastic pain phenotype, according to the IASP clinical criteria, among patients diagnosed with SubAcromial Pain Syndrome (SAPS).
- Conditions
- Subacromial Pain Syndrome, Rotator Cuff Related Shoulder Pain, Shoulder Pain, Shoulder Impingement Syndrome
- Trial name
- The NAP SAPS (NCT07792434)
- Testing
- Clinical evaluation
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Vejle Hospital