Clinical trials: Noise
Normal Eyes
Evaluation of Heidelberg Engineering SPECTRALIS OCT Signal to Noise Ratio Effect on Parameter Measurements
Evaluation of effect of various OCT scan speeds and filters on parameter measurements.
- Trial name
- NCT04961398
- Testing
- OCT imaging
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Sensorineural Hearing Loss
Phase I/IIa Study Evaluating Safety and Efficacy of an Intratympanic Dose of PIPE-505 in Subjects With Hearing Loss
This is a randomized, double-blind study of PIPE-505, or placebo, in subjects with hearing loss associated with speech-in-noise impairment.
- Trial name
- NCT04462198
- Testing
- PIPE-505
- Where
- 8 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
Noise-induced Hearing Loss
Protective Effects of EPI-743 on Noise-Induced Hearing Loss
If effective, administration of EPI-743 should have protective effects against temporary noise-induced hearing loss.
- Trial name
- NCT02257983
- Testing
- EPI-743
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Edison Pharmaceuticals Inc
Hearing Loss, Cochlear
Improved Speech Recognition Performance in Noise by Encoding Binaural Spatial Cues to the Cochlear Implant User.
The aim of the study is to evaluate the interaural time difference (ITD) benefit in patients with bilateral cochlear implants and to assess speech performance in noisy conditions compared to normal hearing listeners.
- Trial name
- APPIC (NCT04357704)
- Testing
- S0N0, S0N500, S-500N500
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oticon Medical
Hearing Impairment
Wide-Bandwidth Open Canal Hearing Aid For Better Multitalker Speech Understanding
Our goal is to design and build a new hearing aid system, which mitigates the most common complaints that hearing aid users have.
- Trial name
- NCT00582946
- Testing
- Hearing Aid
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- EarLens Corporation
Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD)
Early Stage of Alzheimer's and Parkinson's Diseases, HearIng Relevance (SAPHIR)
The study aims to phenotype hearing in patients with early stage of neurodegenerative disorders to explore the prevalence of various hearing disorders in comparison to a control population.
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD), Healthy Participants
- Trial name
- SAPHIR (NCT07083089)
- Testing
- Thorough Hearing assessment
- Where
- 4 sites in France
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Cilcare SAS
Hearing Loss, Sensorineural Hearing Loss
Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC
This study is a single-center, randomized, placebo-controlled, double-blind, single ascending dose escalation study to determine the safety, tolerability, and PK profile of oral administration of HPN-07 in single doses to…
- Conditions
- Hearing Loss, Sensorineural Hearing Loss, Noise-Induced Hearing Loss
- Trial name
- NCT02259595
- Testing
- HPN-07, NAC
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Otologic Pharmaceutics, Inc.
Healthy Eyes
Evaluation of the Signal to Noise Ratio at Various Retinal Layers
Compare the signal to noise ratio of each device at various retinal layers.
- Trial name
- NCT02982174
- Testing
- 3D OCT-1 Maestro, DRI OCT Triton
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Topcon Medical Systems, Inc.
Hearing Loss, Sensorineural, Hearing Loss
Speech Intelligibility in Quiet and Noise for New vs. Legacy Hearing Aids
This clinical investigation is designed to compare audiological performance (i.e., measurements of sound quality and speech understanding) between Starkey's new receiver-in-canal device and a commercially available legacy…
- Trial name
- NCT05101083
- Testing
- New Receiver-in-Canal Device, Legacy Receiver-in-Canal Device
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Starkey Laboratories, Inc
Noise Exposure, Noise-induced Hearing Loss
Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss
The goal of this interventional clinical study is to investigate the use of mild therapeutic hypothermia devices for preservation of sensory structures in the cochlea after noise exposure. The main aims of the study are: 1.
- Conditions
- Noise Exposure, Noise-induced Hearing Loss, Noise; Adverse Effect, Mild Therapeutic Hypothermia
- Trial name
- NCT06729632
- Testing
- Cold pack-delivered mild therapeutic hypothermia
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Restorear Devices LLC
Hearing Loss
Noise Reduction Preferences in Teenagers and Pre-teens
Noise reduction preferences and blue tooth access to hearing aid streaming features will be evaluated in experienced hearing aid users age 10-17.
- Trial name
- NCT05372094
- Testing
- Phonak Hearing Aid
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sonova AG
Speech Intelligibility in Noise
Study of a Signal-processing Algorithm Aiming at Improving Speech-in-noise Intelligibility in Normal-hearing and Hearing-impaired Persons
Nearly half a billion people suffer from disabling hearing loss. The most common form of hearing loss in adults is age-related hearing loss (ARHL), which causes a reduced ability to understand speech in noisy environments.
- Trial name
- AUDIOCAP 1 (NCT04775810)
- Testing
- The device is an algorithm designed to enhance speech intelligibility of speech-in-noise signals
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Archean Technologies
Hearing Loss
The Effects of Ultrasonic Noise Exposure on Human Hearing
The aim of this research is to investigate the effects of ultrasonic noise exposure on the human auditory system (how it effects hearing).
- Trial name
- NCT03515928
- Testing
- Ultrasonic noise exposure, Pure Tone Audiometry
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ultrahaptics Ltd
Speech Perception
Improving Perception of Speech in Noise in Children With Communication Disorders
Smarty Ears has developed a prototype of an innovative therapeutic training system to improve speech perception in noise by training children on interrupted noise (which has silent intervals that allow for fragments of the target…
- Trial name
- L2F (NCT04473729)
- Testing
- Audiovisual speech training in noise for children
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Smarty Ears
Sleep Initiation and Maintenance Disorders
Disturbed Sleep Model Study.
Subjects will be screened within 28 days. Each treatment session will consist of 2 PSG nights, study drug administration and noise model is conducted on second night.
- Trial name
- NCT00440323
- Testing
- SB-649868, Zolpidem
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
A Study of the Effect of Daridorexant on Nighttime Body Posture, the Noise Level Required to Wake up, and the Ability to Remember Words Previously Presented
A Study of the Effect of Daridorexant on Nighttime Body Posture, the Noise Level Required to Wake up, and the Ability to Remember Words Previously Presented
- Trial name
- NCT05702177
- Testing
- Daridorexant 25 mg, Daridorexant 50 mg
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Noise Induced Hearing Loss
A Phase 2b Study of SPI-1005 to Prevent Acute Noise Induced Hearing Loss
SPI-1005 is a novel oral drug that contains a glutathione peroxidase mimetic (ebselen) that will be tested in subjects with a history of NIHL at risk for additional NIHL.
- Trial name
- PANIHL (NCT02779192)
- Testing
- SPI-1005 200mg, SPI-1005 400mg
- Where
- 5 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sound Pharmaceuticals, Incorporated
Hearing Loss
Physiological, Behavioural and Subjective Measures of Listening Effort
Participants will perform two different listening tasks: (1) listening to, and repeating back, sentence lists presented in noise, and (2) listening to short radio excerpts and answering subsequent comprehension questions.
- Trial name
- NCT03761927
- Testing
- Hearing Aid without NR enabled, Hearing Aid with NR(1), Hearing Aid with NR(2)
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Sonova AG
Hearing Loss, Noise-Induced, Hearing Loss
Apple Hearing Study
The Apple Hearing Study is a partnership between the University of Michigan and Apple to study sound exposure and its impact on hearing health.
- Conditions
- Hearing Loss, Noise-Induced, Hearing Loss, Tinnitus
- Trial name
- AHS (NCT04172766)
- Where
- United States
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- Apple Inc.
Hearing Loss
Evaluation of Nucleus 6 Sound Coding Algorithms
The purpose of the study was to evaluate the features of the Nucleus 6 Sound Processor (CP900 series) on existing Nucleus recipients who currently use the previous generation sound processor, the Cochlear Nucleus CP810 (also…
- Trial name
- NCT01854879
- Testing
- Nucleus 6 sound processor
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Cochlear