Clinical trials: Non Cystic Fibrosis Bronchiectasis
Bronchiectasis
Exercise Training in Patients With Non-cystic Fibrosis (CF) Bronchiectasis
The aim of this project is to examine the short and long term effects of an 8 week, twice weekly, outpatient exercise training program for people with bronchiectasis.
- Trial name
- NCT00885521
- Testing
- Exercise
- Where
- 3 sites in Australia
- Volunteers
- 39 people
- Sponsor
- Bayside Health
Bronchiectasis
The Role of Viral Infection in Acute Exacerbations of Non-cystic Fibrosis Bronchiectasis in Adults
Bronchiectasis is clinically characterized by irreversible dilation of the bronchi and bronchioles leading to persistent cough, purulent sputum, and airway flow limitation, which may be accompanied by recurrent exacerbations.It…
- Trial name
- NCT01801657
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Bronchiectasis
Effects of Chest Physiotherapy (CPT) on Lung Clearance Index (LCI) in Non Cystic Fibrosis (CF) Bronchiectasis
This study will investigate the effects of on technique of chest physiotherapy on pulmonary function. Effects of pulmonary function will be measured by the spirometry, body plethysmography and by the multiple breath nitrogen…
- Trial name
- NCT02411981
- Testing
- Autogenic drainage
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Non-cystic Fibrosis Bronchiectasis
A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis
This study is a randomized, double-blind, placebo-controlled study designed to assess the efficacy and safety of ensifentrine inhalation suspension (3 mg) delivered twice daily via standard jet nebulizer up to 52 weeks, compared…
- Trial name
- NCT06559150
- Testing
- Nebulized Ensifentrine Suspension; 3 mg
- Where
- 51 sites in United States, Italy and 2 more
- Volunteers
- 284 people
- Sponsor
- Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA
Non-cystic Fibrosis Bronchiectasis, Healthy
The Sputum Colour Chart as a Predictor of Lung Inflammation and Proteolysis in Non-cystic Fibrosis Bronchiectasis
Non-cystic fibrosis bronchiectasis patients (and controls) were recruited for the study. The investigators' aim was to study the relevance of clinical parameters in terms of underlying disease severity, proteolysis and…
- Trial name
- NCT01792440
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bronchiectasis
Efficacy of Budesonide-Formoterol in Bronchiectasis
Some studies have concluded that high-dose inhaled steroids (IS) are effective in the clinical control of patients with bronchiectasis, however the high doses needed provokes some adverse effects and lower doses are not…
- Trial name
- NCT00728715
- Testing
- budesonide-formoterol single inhaler, High dose of budesonide, A
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital General de Requena
Non-Cystic Fibrosis Bronchiectasis
An Expanded Access Study to Assess Brensocatib for Participants With Non-Cystic Fibrosis Bronchiectasis
The purpose of this study is to allow early access to brensocatib for participants with non-cystic fibrosis bronchiectasis (NCFBE) who have successfully completed the INS1007301 ASPEN Clinical trial.
- Trial name
- NCT05344508
- Testing
- Brensocatib
- Sponsor
- Insmed Incorporated
BRONCHIECTASIS
Atorvastatin in Bronchiectasis in Patients With Pseudomonas Aeruginosa
Statins are a class of drug used to prevent heart attacks and strokes by lowering blood cholesterol levels. They have also been found to have a beneficial "side effect" of lowering the level of inflammation in the body.
- Trial name
- NCT01299194
- Testing
- ATORVASTATIN
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Edinburgh
Non-cystic Fibrosis Bronchiectasis
A Study to Assess the Safety of HSK31858 in Participants With Non-Cystic Fibrosis Bronchiectasis
This is a phase III, single-arm, open-label, multicenter study to assess the safety of HSK31858 in non-cystic fibrosis bronchiectasis (NCFBE) participants.
- Trial name
- NCT07616375
- Testing
- HSK31858, tablet
- Where
- China
- Volunteers
- 669 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Cystic Fibrosis and Non CF Bronchiectasis
The Role of Vitamin D3 in Pediatric Bronchiectasis Severity
Vitamin D3 therapy was effective in decreasing the frequency of pulmonary exacerbations and preserving lung functions , thereby improving the disease severity even more in non CF than CF bronchiectasis patients
- Trial name
- NCT04411901
- Testing
- Cholecalciferol (vitaminD3)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Heba Omara
Bronchiectasis
Long Term Nebulised Gentamicin in Patients With Bronchiectasis
The hypothesis of this randomized placebo controlled trial is that targeted nebulized gentamicin to the airways will reduce bacterial burden and limit neutrophil airways inflammation.
- Trial name
- NCT00749866
- Testing
- Gentamicin, Saline
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Edinburgh
Bronchiectasis, Non-Cystic Fibrosis, High Intensity Interval Exercise
High-Intensity Interval Exercise in Bronchiectasis Patients
The aim of our study is to investigate the effect of high-intensity interval exercise (HIIE) on the symptoms of bronchiectasis in patients with the disease. The main questions it aims to answer are: 1.
- Trial name
- NCT07805174
- Testing
- high-intensity interval exercise, Airway clearance tecniques
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Non-cystic Fibrosis Bronchiectasis
Breathing Training and Exercise Capacity in Non-CFB
The purpose of this research is to investigate whether a home-based and health coach supported specific breathing and respiratory muscle training program improves the ability to exercise, the function of the lungs and breathing…
- Trial name
- NCT05860803
- Testing
- LungTrainers, LungTrainers Pulmonary Rehabilitation regime
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Non-Cystic Fibrosis Bronchiectasis
Safety and Efficacy Study of Ciprofloxacin for Inhalation in Patients With Non-Cystic Fibrosis Bronchiectasis "ORBIT-1"
The purpose of this study is to evaluate the safety and efficacy of Ciprofloxacin for Inhalation in the treatment of patients with non-cystic fibrosis (CF) bronchiectasis.
- Trial name
- NCT00889967
- Testing
- Ciprofloxacin for Inhalation
- Where
- 37 sites in United States, Canada and 2 more
- Volunteers
- 95 people
- Sponsor
- Aradigm Corporation
Bronchiectasis
Salmeterol-Fluticasone Combined Inhaled Therapy for Non-cystic Fibrosis Bronchiectasis
The objective of this study is to assess the efficacy and safety of Salmeterol-Fluticasone （ICS and LABA）combined inhaled therapy for non-cystic fibrosis（non-CF）bronchiectasis patients with chronic airflow obstruction.
- Trial name
- NCT02782312
- Testing
- ICS+LABA, routine therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Non Cystic Fibrosis Bronchiectasis in Children
The Efficacy of Azithromycin in Treating Children With Non Cystic Fibrosis Bronchiectasis
Bronchiectasis is characterized by a permanent and abnormal dilatation of a part of the bronchial tree. An accumulation of mucus in the respiratory tract ensues, resulting in frequent bacterial infections and eventual destruction…
- Trial name
- AZI-STOP (NCT02531984)
- Testing
- Azithromycin
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Bronchiectasis
Comparison of Two Antibiotic Regimens for the Treatment of Early Airways Infection With PA in Adults With Bronchiectasis
Chronic airways infection with Pseudomonas aeruginosa (PA) is associated with increased frequency of exacerbations, deterioration in quality of life and increased mortality in adult patients with bronchiectasis.
- Trial name
- ANTEIPA (NCT06368804)
- Testing
- Antibiotic monotherapy treatment and follow-up, Antibiotic bitherapy treatment and follow-up
- Where
- 18 sites in France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Bronchiectasis
Assessment of Early Outcomes of Roflumilast in Patients With Non Cystic Fibrosis Bronchiectasis
Aim of the work Assessment of early outcome of using Roflumilast in patients with bronchiectasis regarding: Severity of symptoms Frequency of exacerbations Change in pulmonary function Systemic inflammation
- Trial name
- NCT04090294
- Testing
- Roflumilast
- Volunteers
- 35 people
- Sponsor
- Assiut University
Non-cystic Fibrosis Bronchiectasis
Mortality in Non-cystic Fibrosis Bronchiectasis
In this study we analyzed the overall survival for all newly diagnosed patients with non-cystic fibrosis bronchiectasis from June 2006 onwards.
- Trial name
- NCT01792427
- Where
- Belgium
- Volunteers
- 253 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bronchiectasis
Safety and Potential Efficacy of Human Mesenchymal Stem Cells in Non-Cystic Fibrosis Bronchiectasis
To demonstrate the safety of bone marrow-derived allogeneic human Mesenchymal Stem Cells (hMSCs) in patients with bronchiectasis receiving standard of care therapy, and to explore treatment efficacy
- Trial name
- CELEB (NCT02625246)
- Testing
- hMSCs
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Marilyn Glassberg