Clinical trials: Non Obstructive Azoospermia
Non-obstructive Azoospermia
Anti-mullerian Hormone,Testesterone,Esrtadiol,Testesterone/Esrtadiol Ratio as Predictive Values for TESA and TESE Outcome in Non Obstructive Azoospermia
*Evaluate the predictive value of AMH, Testosterone,Estradiol,Testosterone Estradiol ratio for TESA and TESE outcome in non obstructive azoospermic patients.
- Trial name
- NCT04308486
- Volunteers
- 50 people
- Sponsor
- Assiut University
Non Obstructive Azoospermia
Standard IV Cannula Aspiration (SIVCA): A Novel, Efficient and Minimally Invasive Testicular Sperm Aspiration Technique
Study question: Can enough testicular tissue be aspirated for sperm retrieval in non-obstructive azoospermia (NOA), using a wide bore 14-G Standard IV cannula in comparison to micro-TESE? Summary answer: Standard IV cannula…
- Trial name
- NCT05247723
- Testing
- Standard IV Cannula for aspiration of testicular sperm, Micro-TESE
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Cairo University
Infertility, Non-obstructive Azoospermia
PET-MRI for Functional Imaging of the Testis: A Feasibility Study
The primary objective of this study is to explore feasibility of testis functionality assessment and testis imaging obtained from Positron Emissions Tomography (PET) /Magnetic Resonance Imagine (MRI).
- Conditions
- Infertility, Non-obstructive Azoospermia, Vasectomy
- Trial name
- NCT02669108
- Testing
- PET/ MRI of the Testis
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Non-obstructive Azoospermia
Gabapentin for Post-Operative Pain Control and Narcotic Reduction in Scrotal Surgery
The use of non-narcotic multi-modal analgesia to be used in the pre-operative, peri-operative and post-operative period to reduce or potentially eliminate narcotic usage following scrotal surgery.
- Trial name
- NCT04230980
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Weill Medical College of Cornell University
Azoospermia, Infertility
Microdissection Testicular Sperm Extraction (MicroTESE) and IVF-ICSI Outcome in Non-Obstructive Azoospermia (NOA)
We evaluated the application of surgical testicular exploration with the aid of a microscope (MictoTESE) to increase the chances of obtaining sperm in men with impaired sperm production, a condition known as non-obstructive…
- Trial name
- NCT00484081
- Testing
- Microdissection Testicular Sperm Extraction, ICSI
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Clinic and Research Center in Human Reproduction Roger Abdelmassih
Testicular Sperm Extraction in Azoospermic Patients
Laterality Success Determination of Microscopic Testicular Sperm Extraction in Non Obstructive Azoopsermia Patients
Determination of percentage of successful sperm retrieval in single testis in cases who will do bilateral TESE and identification factors mostly associated with successful sperm retrieval
- Trial name
- NCT07259967
- Testing
- Testicular sperm extraction
- Volunteers
- 80 people
- Sponsor
- Assiut University
Non Obstructive Azoospermia, Cryptozoospermia
Identifying Candidates for Limited Dissection at Microdissection TESE.
The goal of this retrospective observational study is to learn whether certain clinical characteristics can help predict which infertile men may successfully have sperm retrieved using a less-invasive "mini-incision" version of…
- Conditions
- Non Obstructive Azoospermia, Cryptozoospermia, Oligoasthenoteratozoospermia, Male Infertility
- Trial name
- NCT07286279
- Where
- Canada
- Volunteers
- 248 people
- Sponsor
- Clinique Ovo
Non-obstructive Azoospermia
Intra-Testicular Transplantation of Autologous Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility.
This is an open label, single arm, single center investigation to assess the safety and efficacy of purified adult autologous, bone marrow derived, highly specialized, differentiation specific into spermatogonial lineages, and…
- Trial name
- NCT02641769
- Testing
- Stem Cell Transplantation
- Where
- Jordan
- Volunteers
- 600 people
- Sponsor
- Stem Cells Arabia
Azoospermia, Nonobstructive, Oligozoospermia
Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia.
The investigators hope to learn if Letrozole is effective and safe in improving severe male infertility by increasing testosterone, decreasing oestradiol and stimulating sperm production thereby improving sperm motility…
- Trial name
- NCT02900105
- Testing
- Letrozole
- Where
- Singapore
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Azoospermia, Nonobstructive
TESE and Non Obstructive Azoospermia
Azoospermia is complete absence of sperm in the ejaculate. It accounts for 10-15% of male infertility cases. It is classified as obstructive and non-obstructive azoospermia (NOA). NOA constitutes 60% of all cases of azoospermia.
- Trial name
- NCT03146260
- Testing
- Conventional TESE, Microdissection TESE
- Volunteers
- 148 people
- Sponsor
- Assiut University
Azoospermia
GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia
Preliminary reports showed that hormonal treatment may improve the chance of retrieving viable testicular sperm from men with NOA.
- Trial name
- NCT02544191
- Testing
- GnRHa/ hCG/ hMG
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jinling Hospital, China
Non-obstructive Azoospermia
Use of Semen TEX101 to Improve Sperm Retrieval Rates for Men With Non-obstructive Azoospermia
The investigators hypothesize that sperm production varies with time in men with no sperm in semen (non-obstructive azoospermia, NOA) and that the semen protein, TEX101, is able to monitor these changes.
- Trial name
- NCT02851966
- Testing
- mTESE
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Mount Sinai Hospital, Canada
Cancer, Hematologic Diseases
Autologous Transplantation of Human Cryopreserved Testis Tissue
For pre-pubertal boys undergoing gonadotoxic therapies, freezing immature testicular tissue (ITT) containing spermatogonial stem cells (SSCs) is currently the only option to potentially preserve future fertility.
- Conditions
- Cancer, Hematologic Diseases, Infertility, Male, Azoospermia, Nonobstructive
- Trial name
- ReSTORE (NCT07364409)
- Testing
- Autologous Transplantation of Testis Tissue
- Where
- Denmark
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Azoospermia, Nonobstructive, Non-obstructive Azoospermia
Inhibin B/FSH Ratio as a Predictor of Testicular Pathology in NOA
This retrospective observational study evaluated the diagnostic and predictive value of serum Inhibin B (INHB), follicle-stimulating hormone (FSH), and the INHB/FSH ratio in differentiating histopathological subtypes of…
- Trial name
- NCT07415928
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Non-obstructive Azoospermia
Testicular Proteins for Sperm Retrieval Prediction Protein1, Testis-Expressed Gene 101, and Lectin Galactoside-binding Protein in Predicting Surgical Sperm Retrieval in Men With Non-Obstructive Azoospermia
Generally, azoospermia is characterized as obstructive (OA) or nonobstructive (NOA). Surgical spermatozoa retrieval results vary in success rates.
- Trial name
- Genomics (NCT06154954)
- Testing
- Semen analysis
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Azoospermia, Nonobstructive
2015-Metabolomics&Microbiome-infertility
The study aims to carry out a translational analysis of the microbiome and metabolomics in patients suffering from non-obstructive azoospermia, with the aim of investigating prognostic factors predictive of the possible finding…
- Trial name
- NCT06181851
- Testing
- Analysis of microbiome and metabolomics
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS San Raffaele