Clinical trials: Non Organic Psychosis
Schizophrenia, Prodrome
Indicated Prevention With Omega-3 Fatty Acids in Adolescents With 'At-Risk-Mental-State' for Psychosis
Early intervention in psychosis might be associated with better outcomes. However, intervention in the pre-psychotic phase has been questioned as, using current criteria, only 20-50% of individuals classified as prodromal develop…
- Trial name
- NCT00396643
- Testing
- Omega 3 fatty acids
- Where
- Austria
- Volunteers
- 81 people
- Sponsor
- Medical University of Vienna
Psychosis, Psychotic Disorders
Acceptability, Feasibility and Preliminary Outcomes of the Kiso Mind App for Outpatients With Schizophrenia Spectrum Disorders
The Kiso pilot study is a randomized controlled trial to test the acceptability and feasibility of a novel digital intervention, namely the Kiso Mind smartphone app. A parallel-group design is utilized.
- Conditions
- Psychosis, Psychotic Disorders, Primary Psychotic Disorders, Schizophrenia Spectrum Disorders
- Trial name
- KISO (NCT07395206)
- Testing
- Digital: Kiso Mind App
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Schizophrenia
Tracking Outcomes in Psychosis
The investigators propose to study the brain processes that result in thought and language disorder and influence outcomes seen in patients with schizophrenia using a combination of brain scans and clinical assessments.
- Trial name
- TOPSY (NCT02882204)
- Where
- Canada
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Schizophrenia, Schizoaffective Disorder
Effect of Neuroplasticity Modulation in tDCS Treatment Response Among Schizophrenia Patients With Auditory Hallucination
Schizophrenia is a severe neuropsychiatric disorder of the brain and is also one of the top ten disabling diseases. A common symptom of schizophrenia (SCZ) is hearing voices inside one's heads which others do not.
- Trial name
- NCT04629352
- Testing
- Verum Accelerated Transcranial Direct Current Stimulation (acctDCS)
- Where
- India
- Volunteers
- 72 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Schizophrenia Spectrum Disorders, Social Cognition
Using Illusions to Boost Social Cognition
This study aims to explore whether the observation of complex visual objects can help improve social cognition in people living with psychotic disorders.
- Trial name
- SOLLUSIONS (NCT07602712)
- Testing
- Visual-illusion social cognition session (immediate), Visual-illusion social cognition session (delayed)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hôpital le Vinatier
Schizophrenia
Effectiveness of Neuroadaptive Cognitive Training in Adolescents at Risk for Psychosis
This study will evaluate the effectiveness of intensive computerized cognitive training in preventing the onset of psychotic disorder and improving adaptive functioning in adolescents at high risk of schizophrenia.
- Trial name
- NCT00655239
- Testing
- Neuroadaptive cognitive training, Computer games
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Clinical High Risk for Psychosis (CHR)
Interventions for Clinical High Risk Youth in Tunisia
Study participants will take part in one of the two types of treatments aimed at improving daily functioning as follows: either a Cognitive Training (CT) Program or an Enhanced - Treatment as Usual (E-TAU) Group.
- Trial name
- CHRTUNISIA (NCT06582901)
- Testing
- Cognitive training (CT) plus the neuropsychological educational approach to cognitive remediation (NEAR) model and an Enhanced - Treatment as Usual (E-TAU), Enhanced - Treatment as Usual
- Where
- Tunisia
- Volunteers
- 54 people
- Sponsor
- University of California, Los Angeles
Psychotic Episode, Psychological Trauma
A Rater-blinded RCT to Compare Effectiveness of EMDR vs TAU in Patients With First Episode Psychosis and History of Psychological Trauma
The main objective of this project is to analyze whether EMDR therapy, as an adjuvant to usual treatment, is effective in reducing post-traumatic stress and psychotic/affective symptoms in patients with a FEP and comorbid…
- Trial name
- NCT03991377
- Testing
- Eye movement desensitization and reprocessing therapy, Treatment as usual
- Where
- Spain
- Volunteers
- 71 people
- Sponsor
- Parc de Salut Mar
Schizophrenia and Disorders With Psychotic Features, Psychotic Episode
Effectiveness of a Mindfulness-based Group Training Addressing Social Cognition in First Episode Psychosis (AGES-Mind)
The current investigation aims to compare two group intervention in patients with a first episode of psychosis, that is, people who have suffered their first psychotic episode within 5 years prior to their inclusion in the study.
- Trial name
- AGES-Mind (NCT03309475)
- Testing
- SocialMIND, Psychoeducational multicomponent intervention, Psychosocial treatment
- Where
- Spain
- Volunteers
- 59 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Cannabis Use Disorder, Psychosis
rTMS Treatment for Cannabis Use Disorders in Psychosis
Cannabis use during adolescence represents a significant risk factor for the development of psychosis including schizophrenia. Moreover, cannabis is the most commonly used drug among patients with an existing psychotic disorder.
- Trial name
- NCT03069612
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Centre for Addiction and Mental Health
Neurodegenerative Diseases, Parkinson Disease
Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerative Diseases
It is hypothesize that patients with clinically diagnosed neurodegenerative diseases will have significantly different receptor occupancy of 5HT2A receptors compared to a healthy age/sex-matched control group.
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Parkinson Disease Psychosis
- Trial name
- NCT05357612
- Testing
- Pimavanserin
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity, Vitamin D Deficiency
Vitamin D Supplementation in Psychiatric Illnesses
Children and adolescents with psychiatric illnesses who are treated with medications called second generation antipsychotic agents (SGA) often gain excessive weight during their treatment with these medications.
- Conditions
- Obesity, Vitamin D Deficiency, Psychosis, Schizophrenia
- Trial name
- VDSS (NCT01004354)
- Testing
- Ergocalciferols
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Massachusetts, Worcester
Psychosis; Acute
Cerebellum-based Imaging Neural Markers for Antipsychotic Response
This study plans to collect 120 patients with first-episode psychosis. Participants will receive multimodal MRI scans (naturalistic fMRI, structural, diffusional) and comprehensive clinical assessments at baseline, and…
- Trial name
- CINEMA (NCT07483294)
- Testing
- risperidone, aripiprazole
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwell Health
Schizophrenia Spectrum
Target Engagement for Oxytocin: Dose Ranging Study
This study will evaluate the effect of 8 doses of intranasal oxytocin or placebo on two proposed measures of target engagement in brain.
- Trial name
- R21Dose (NCT02498236)
- Testing
- Intranasal Oxytocin
- Volunteers
- 51 people
- Sponsor
- University of California, Los Angeles
Psychosis
Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia
The purpose of this study is to reveal the specific effects of computer-aided cognitive training on course and rehabilitation in early onset schizophrenia
- Trial name
- NCT01781364
- Testing
- Brain Fitness Training, Posit Science SF
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Konstanz
22q11 Deletion Syndrome
Indicated Prevention With Long-chain Polyunsaturated Omega-3 Fatty Acids in Patients With 22q11 Microdeletion Syndrome.
The purpose of the present trial is to investigate the effects of omega-3 PUFAs in individuals aged 12-26 years with 22q11DS at ultra-high risk for developing a first episode of psychosis.
- Trial name
- NCT02070211
- Testing
- omega-3 PUFAs, Standard care
- Where
- Holy See
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Mental Health, Oral Health Care
The Mouth Matters in Mental Health Trial -2
This clinical trial will evaluate the effectiveness and cost-effectiveness of a link work intervention for supporting people with severe mental health difficulties to attend a routine dental appointment.
- Conditions
- Mental Health, Oral Health Care, Psychosis
- Trial name
- NCT07470437
- Testing
- Link work intervention
- Where
- 5 sites in United Kingdom
- Volunteers
- 480 people
- Sponsor
- Lancashire and South Cumbria NHS Foundation Trust
At Risk Mental State (ARMS), Psychosis
Minocycline and/or Omega-3 Fatty Acids Added to Treatment as Usual for At Risk Mental States
This is a randomized double-blind placebo controlled trial which aims to evaluate the efficacy and tolerability of minocycline and Omega-3 fatty acids for patients with ARMS.
- Trial name
- NAYAB (NCT02569307)
- Testing
- Minocycline, Omega-3 fatty acids, Minocycline Plus Omega-3 fatty acids
- Where
- 7 sites in Pakistan
- Volunteers
- 326 people
- Sponsor
- Pakistan Institute of Living and Learning
Psychosis, Schizophrenia and Other Psychotic Disorders
What is the Feasibility of Narrative Exposure Therapy (NET) for People Experiencing Psychosis?
The goal of this interventional study is to evaluate the feasibility of Narrative Exposure Therapy (NET) for people experiencing psychosis.
- Trial name
- NCT07237529
- Testing
- Narrative Exposure Therapy (NET)
- Volunteers
- 1 people
- Sponsor
- University of Nottingham
Schizophrenia, Psychosis
Cognitive Remediation in Schizophrenia
The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with chronic schizophrenia or…
- Trial name
- NCT01903707
- Testing
- Cognitive Remediation Therapy
- Where
- Ireland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
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