Clinical trials: Non Organic Psychosis
Clinical High Risk for Psychosis (CHR)
A Multimodal Imaging Study of Dopamine in Early Psychosis
The development of new treatments for psychosis, a psychiatric condition that is prevalent and highly disabling despite antipsychotic medications, has been limited, in part, by a lack of information from brain imaging studies…
- Trial name
- MISDEP (NCT06977308)
- Testing
- Methylphenidate (MPH), [11C]raclopride
- Volunteers
- 115 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Schizoaffective Disorder
Horyzons: Implementation in Clinical Practice
A clinical trial investigating the feasibility and acceptability of implementing a moderated online social media platform with therapeutic content, Horyzons, as a part of care received at first-episode psychosis (FEP) clinics…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorders, Unspecified Schizophrenia Spectrum and Other Psychotic Disorder
- Trial name
- NCT04673851
- Testing
- Horyzons USA
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of North Carolina, Chapel Hill
Schizophrenia, Schizoaffective Disorder
SUCCEED Africa: Support, Comprehensive Care and Empowerment of People With Psychosocial Disabilities
Although psychotic disorders typically affect less than 1% of the population, they are a significant cause of disability worldwide.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizotypal Disorder, Acute and Transient Psychotic Disorder
- Trial name
- SUCCEED (NCT06007105)
- Testing
- SUCCEED Community-Based Intervention
- Where
- 4 sites in Malawi, Nigeria and 2 more
- Volunteers
- 425 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Schizophrenic Disorders
Interest of EMDR Schizophrenic Disorders
The purpose of this study is to determine the interest of the use of EMDR (Eye Movement Desensitization and Reprocessing) psychotherapy in the management of psychotic disorders, in particular schizophrenic disorders.
- Trial name
- EMDRpsychose (NCT05164289)
- Testing
- Control group, EMDR group
- Where
- 2 sites in France
- Volunteers
- 6 people
- Sponsor
- Hôpital NOVO
First Episode Psychosis (FEP), Metabolic Syndrome X
Nursing Intervention in Weight and Metabolic Syndrome Management in First-episode Psychosis (MetaKOP)
The goal of this clinical trial is to evaluate if a nursing intervention based on the carbohydrate-insulin model can effectively reduce weight and manage the risk of metabolic syndrome (MetS) in individuals with first-episode…
- Trial name
- MetaKOP (NCT06650943)
- Testing
- Nursing Consultation in Weight Management and Metabolic syndrome
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Hospital de Basurto
DiGeorge Syndrome, Velocardiofacial Syndrome
Velocardiofacial (VCFS; 22q11.2; DiGeorge) Syndrome Study
Velocardiofacial syndrome, also known as 22q11.2 syndrome or DiGeorge syndrome, has been associated with many features such as a cleft palate, heart defects, and learning, speech and feeding problems.
- Conditions
- DiGeorge Syndrome, Velocardiofacial Syndrome, 22q11.2 Syndrome
- Trial name
- NCT00105274
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Schizophenia Disorder, Severe Mental Illness
Effect of Occupational Therapy on Psychosocial Parameters and Functioning in Individuals With Severe Mental Illness
Severe mental illness (SMI), including schizophrenia spectrum disorders and bipolar disorder, is associated with significant impairments in psychosocial functioning, daily life participation, self-efficacy, and social…
- Conditions
- Schizophenia Disorder, Severe Mental Illness, Bipolar Disorder, Nonorganic Psychosis
- Trial name
- OT-SMI (NCT07879118)
- Testing
- Occupational Therapy Group Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Biruni University
Psychosis; Episode
A Mobile Application to Improve Case-management and Patient's Functioning in First Episode Psychosis
First Episode Psychosis (FEP) includes perceptual distortions, delusions and cognitive impairment with severe consequences, such as suicidal behaviour.
- Trial name
- PLAN-e-PSY (NCT04657380)
- Testing
- PLAN-e-PSY mobile application, Control Group
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Hôpital le Vinatier
Cannabis Use, SCHIZOPHRENIA
Precision Brain Stimulation to Reduce Cannabis Craving in Schizophrenia
The central hypothesis is this: Brain circuits most relevant to cannabis use in schizophrenia are distinct from pathways identified in healthy controls who use cannabis.
- Conditions
- Cannabis Use, SCHIZOPHRENIA, Psychosis, rTMS
- Trial name
- NCT07196462
- Testing
- 3 Minute iTBS to the L DLPFC, One-Minute, Personalized, DMN Targeted CTBS
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Post Traumatic Stress Disorder, Psychotic Disorders
Effectiveness of Trauma Therapy in Patients With PTSD and Comorbid Psychotic Disorder
Effectiveness of trauma therapy using prolonged exposure for the treatment of post-traumatic stress disorder (PTSD) in patients with comorbid psychotic disorder
- Conditions
- Post Traumatic Stress Disorder, Psychotic Disorders, Psychosis, Schizophrenia
- Trial name
- PEPSY (NCT04911010)
- Testing
- Prolonged Exposure
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Hamburg-Eppendorf
Psychosis, Schizophrenia
Contrasting Group Therapy Methods for Psychosis
Current Canadian Clinical Practice guidelines emphasize the need for effective psychosocial adjuncts to pharmacotherapy for schizophrenia (Canadian Psychiatric Association 2005).
- Conditions
- Psychosis, Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- MCT (NCT01764568)
- Testing
- Metacognitive Training (MCT), Cognitive Remediation (CR)
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- University of British Columbia
Psychosis
The Clinical and Socio-demographic Characteristics of Young People Aged 12 to 25 Consulting on Ambulatory Structures in the Seine Saint-Denis
A prospective study of the clinical and socio-demographic characteristics of young people aged 12 to 25 consulting on ambulatory structures in the Seine Saint-Denis.
- Trial name
- EPS-12-25 (NCT04365621)
- Testing
- we enrolled ultra-high risk of psychosis (UHR) patient to describe
- Where
- 5 sites in France
- Volunteers
- 900 people
- Sponsor
- Januel
First-Episode Psychosis, Bipolar Disorder
Comparison of Aripiprazole Versus Risperidone on Brain Morphology Using MRI
Significant changes in brain morphology are observed in people with first-episode psychosis. Studies have shown that total brain volume and particular brain structures are decreased in people with psychosis disorders.
- Trial name
- CARB (NCT02334904)
- Testing
- Aripiprazole, Risperidone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Schizophrenia; Psychosis, Remission
Effects of an Interpersonal Communication Skills Training Program on Medication Adherence of Schizophrenic Patients
This quasi-experimental two-group pretest-posttest study examined the effects of an interpersonal communication skills training program on medication adherence in patients with schizophrenia, measured at pre-intervention…
- Conditions
- Schizophrenia; Psychosis, Remission, Non-Adherence, Medication
- Trial name
- NCT07165821
- Testing
- Interpersonal Communication Skills Training Program, Usual care
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Suranaree University of Technology
Psychotic Disorders, Schizophrenia
Mindfulness Group-based Intervention for Early Psychosis: A Pilot Study
Recent research has suggested that mindfulness-based interventions for psychosis may be effective in reducing the negative symptoms of schizophrenia (e.g., social withdrawal, lack of motivation) and the distress associated with…
- Trial name
- NCT02342210
- Testing
- Mindfulness Ambassador Council for Early Psychosis (MAC-EP)
- Volunteers
- 21 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Schizophrenia
A Trial of 10 and 30 mg Doses of CVL-231 (Emraclidine) in Participants With Schizophrenia
This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-group, 6-week trial to evaluate the efficacy, safety, and tolerability of 2 fixed doses of CVL-231 (Emraclidine) (10 mg QD and 30 mg QD) in…
- Trial name
- NCT05227690
- Testing
- Emraclidine 10 mg, Emraclidine 30 mg
- Where
- 25 sites in United States, Bulgaria
- Volunteers
- 385 people
- Sponsor
- AbbVie
Schizophrenia, Schizoaffective Disorder
Cognitive Remediation and Functional Skills Training in Schizophrenia
This randomized trial is examining whether a treatment called cognitive remediation is more effective when it is paired with a social and functional skills training component.
- Trial name
- NCT01175642
- Testing
- Cognitive Remediation, FAST
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- National Alliance for Research on Schizophrenia and Depression
Mental Health Promotion
Designing and Evaluating a Classroom-Based Mental Health Programme for Adolescents.
This study is a mixed-methods feasibility trial designed to examine whether a universal classroom-based psychoeducational programme which covers unusual sensory experiences, psychosis, mental health stigma, and coping strategies…
- Trial name
- NCT07660874
- Testing
- School-Based Mental Health Programme
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Schizophrenia, Psychotic Disorders
Efficacy and Mechanisms of Change of an Emotion-oriented Version of Cognitive-behavioral Therapy for Psychosis
The aim of the present single-blind randomized-controlled therapy study is to assess the efficacy of a new form of Cognitive Behavioral Therapy for delusions with a focus on emotion regulation, improvement of self-esteem and…
- Conditions
- Schizophrenia, Psychotic Disorders, Delusions, Emotions
- Trial name
- CBTd-E (NCT02787135)
- Testing
- emotion-oriented Cognitive Behavior Therapy
- Where
- 2 sites in Germany
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Schizophrenia
Omega-3 Fatty Acids Efficacy in First-episode of Schizophrenia
There is accumulating experimental evidence to suggest the role of essential fatty acids (EFA) in neuronal migration, pruning and synaptic plasticity.
- Trial name
- OFFER (NCT02210962)
- Testing
- essential fatty acids, olive oil
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Lodz
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