Clinical trials: Non Organic Psychosis
Schizophrenia; Psychosis
Feasibility Trial of a Parent Peer-Co-Led Caregiver Group for Pediatric Early Onset Schizophrenia Spectrum Disorders
While early onset schizophrenia spectrum disorders are among the most debilitating psychiatric illnesses, evidence-based treatment for this population is limited.
- Trial name
- NCT07867964
- Testing
- Group Therapy, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston Children's Hospital
Psychotic Disorders, Personality Disorders
The Staged Treatment in Early Psychosis Study
A sequential multistage randomised clinical trial (SMART) to produce evidence to guide a step-wise clinical approach for the treatment of ultra high risk patients and reduction of risk for psychosis and other deleterious clinical…
- Conditions
- Psychotic Disorders, Personality Disorders, Clinical High Risk
- Trial name
- STEP (NCT02751632)
- Testing
- Support and Problem Solving Therapy, Cognitive Behavioural Case Management, Fluoxetine
- Where
- 5 sites in Australia
- Volunteers
- 342 people
- Sponsor
- Orygen
Psychotic Disorders
A Novel Treatment Approach for Self-Stigma in First Episode Psychosis
Stigma towards mental illness is one of the greatest barriers to functional recovery that people with psychotic disorders face. Internalization of stigma (self-stigma) is associated with increased depressive symptoms, treatment…
- Trial name
- BOOST (NCT03491852)
- Testing
- BOOST Intervention, Waitlist Control
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Queen's University
First Episode Psychosis (FEP), At Risk Mental State (ARMS)
Reducing the Duration of Untreated Psychosis in the United States
The goal of this project is to investigate whether a systematic screening approach for individuals with first episode psychosis (FEP) can substantially reduce Duration of Untreated Psychosis (DUP).
- Trial name
- NCT03369730
- Where
- 3 sites in United States
- Volunteers
- 94 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
First Episode Psychosis
OnTrackNY's Learning Healthcare System
This application proposes OnTrackNY as a regional scientific hub for the Early Psychosis Intervention Network (EPINET) program as part of the National Institute of Mental Health (NIMH)'s creation of a national learning health…
- Trial name
- NCT04021719
- Testing
- Stakeholder feedback, Data infrastructure
- Where
- United States
- Volunteers
- 2,100 people
- Sponsor
- New York State Psychiatric Institute
Alzheimer Disease
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
The purpose of this study is to evaluate the safety and efficacy of KarXT in adult participants with mild to severe Alzheimer's Disease (AD) with moderate to severe psychosis related to AD.
- Trial name
- NCT06585787
- Testing
- KarXT
- Where
- 296 sites in United States, Argentina and 23 more
- Volunteers
- 406 people
- Sponsor
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Parkinson's Disease Psychosis
A Study of the Safety and Efficacy of Pimavanserin in Patients With Parkinson's Disease Psychosis
The purpose of this study is to evaluate the safety and efficacy of 40 mg pimavanserin compared to placebo in patients with Parkinson's disease psychosis (PDP).
- Trial name
- NCT01174004
- Testing
- pimavanserin tartrate
- Where
- 63 sites in United States, Canada
- Volunteers
- 199 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Schizophrenia, Schizoaffective Disorder
Tetrabenazine for Partial Responders
Purpose of Study: A) To improve outcome in large population of antipsychotic patients with schizophrenia or schizoaffective who are only partial responders B) To increase understanding of pharmacology and mechanisms of action…
- Trial name
- NCT00362804
- Testing
- Tetrabenazine
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Centre for Addiction and Mental Health
Attention Deficit Disorder With Hyperactivity
A Study on Suicidality, Psychosis or Substance Abuse With Methylphenidate, Atomoxetine, Amphetamine/Dextroamphetamine or Lisdexamfetamine
The purpose of this study is to estimate the observed incidence of the health outcomes (suicide attempt or ideation, suicide ideation, suicide attempt, psychosis, and substance abuse) in a cohort of participants diagnosed with…
- Trial name
- NCT04132557
- Testing
- Methylphenidate, Lisdexamfetamine, Atomoxetine
- Where
- United States
- Volunteers
- 430,000 people
- Sponsor
- Janssen Research & Development, LLC
Prodromal Schizophrenia
Early Detection and Intervention for Women At-risk of Psychosis
This study aims to examine the effectiveness of the cognitive behavioral therapy in preventing the conversion of psychosis in a sample of individuals at-risk for psychosis.
- Trial name
- NCT03751865
- Testing
- CBT, Psychoeducation
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- The University of Hong Kong
Intensive Care Psychosis
Follow-up in Pediatric Intensive Care Unit
Background In developed countries, mortality rates in pediatric intensive care units (PICUs) are around 4% and thus, most children admitted to these units survive.
- Trial name
- APRELAREA (NCT06363344)
- Testing
- Questionnaires : PHQ-9 (Kroenke, 2001), the PSC (Sheldrick, 2012), the ASQ-SE (Squires, 2015), the PedsQL (Varni, 1999)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Schizophrenia, Alzheimer's Disease Psychosis
A Food Effect Study of LY03020 in Healthy Subjects
This is a randomized, open-label, single-dose, two-period, crossover study to assess the food effect on pharmacokinetics (PK) and safety of LY03020 in healthy subjects.
- Trial name
- NCT07292233
- Testing
- LY03020
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Schizophrenia, Psychotic Disorders
Problem-solving-based Bibliotherapy Program for Family Caregivers
This proposed randomized controlled trial will test the effectiveness of a problem-solving based bibliotherapy program (PSBBP) for Chinese family caregivers in psychotic disorders (not more than 5 years onset).
- Trial name
- PSBBP (NCT02391649)
- Testing
- Self-learning program, Psycho-education program (in Phase 2)
- Where
- 2 sites in Hong Kong
- Volunteers
- 422 people
- Sponsor
- Chinese University of Hong Kong
Bipolar Disorder, Mood Disorders
A Study to Evaluate the Efficacy and Safety of Flexible Doses of Extended-release (ER) Paliperidone Compared With Flexible Doses of Quetiapine and Placebo in Patients With Bipolar I Disorder
The purpose of this study is to evaluate the effectiveness and safety of flexible-doses paliperidone ER (3 to 12 mg as needed) compared with placebo over 3 weeks in patients with Bipolar I Disorder who are experiencing an acute…
- Trial name
- NCT00309699
- Testing
- Quetiapine, Paliperidone ER
- Where
- 47 sites in United States, Greece and 6 more
- Volunteers
- 493 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Schizophrenia
Comparison of Aripiprazole and Risperidone for the Treatment of People With First-Episode Psychosis
This 52 week long study evaluates the effectiveness of aripiprazole versus risperidone in treating people with first-episode schizophrenia.
- Trial name
- NCT00320671
- Testing
- Aripiprazole, Risperidone
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Northwell Health
Violence Risk, Early Psychosis
BRAVE Program to Improve Safety and Reduce Violence Risk in Early Psychosis
This study evaluates the feasibility and acceptability of BRAVE, a manualized cognitive behavioral therapy (CBT)-based intervention designed to address dynamic risk factors for violence among young adults with early psychosis.
- Trial name
- BRAVE (NCT07417904)
- Testing
- BRAVE (Behavioral Response Against Violence Engagement), Treatment As Usual (TAU)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Howard University
Psychosis
Improving Psychological Therapy for Psychosis: A Case Series
Standard psychological therapy for psychosis (Cognitive Behavioural Therapy) is made up of different 'ingredients', also called treatment components.
- Trial name
- NCT03920384
- Testing
- Experimental intervention arm, Active control arm
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Edinburgh
Clinical High-risk Syndrome of Psychosis
RTMS for CHR Based on Personalized Targets Using Magnetoencephalography
This study is an before-after study in the same subject, which enrolled 26 individuals with high-risk psychiatric syndrome (CHR). The target of subjects intervention relies on the results of magnetoencephalography localization.
- Trial name
- NCT06802952
- Testing
- rTMS
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Shanghai Mental Health Center
Depression - Major Depressive Disorder, Bipolar
Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health Trajectories
Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health (BLOOM) is a project that aims to overcome age and diagnostic boundaries to generate person-specific longitudinal profiles of mental…
- Conditions
- Depression - Major Depressive Disorder, Bipolar, Psychosis, Eating Disorder NOS
- Trial name
- BLOOM (NCT06978452)
- Where
- Canada
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Schizophrenia, Psychosis
Non-Invasive Direct Current Stimulation for Cognition in Schizophrenia
This study proposes to assess the effect of trans-cranial direct current stimulation (tDCS) on cognitive control, working memory, functional, clinical, and cognitive outcomes in schizophrenia patients.
- Trial name
- NCT02739347
- Testing
- Active Trans-cranial direct-current stimulation
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.