Clinical trials: Non Organic Psychosis
Schizophrenia, Cognition
Promoting Cognitive Health in Schizophrenia
The goal of this clinical trial is to effectively implement virtually-delivered interventions in mental health institutions nationwide to improve the cognitive health of individuals living with schizophrenia.
- Trial name
- iCogCA (NCT05661448)
- Testing
- Cognitive remediation, MetaCognitive Training
- Where
- 5 sites in Canada
- Volunteers
- 192 people
- Sponsor
- Douglas Mental Health University Institute
Schizophrenia, Schizoaffective Disorder
Assessment of Efficacy of a Psychological Therapy in Inpatients With a Schizophrenic Psychosis
This randomised three-arm study aims to evaluate the efficacy and feasibility of a cognitive behavioral therapy (INT-Integrated Neurocognitive Therapy for Schizophrenia Patients) in the treatment of schizophrenia patients in an…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychotic Disorders
- Trial name
- CBTSZ (NCT03316664)
- Testing
- Integrated Neurocognitive Therapy (INT), Integrated Psychological Therapy (IPT), COGPACK
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- Psychiatric University Hospital, Zurich
Schizophrenia, Psychotic Disorders
Efficacy and Mechanisms of Change of an Emotion-oriented Version of Cognitive-behavioral Therapy for Psychosis
The aim of the present single-blind randomized-controlled therapy study is to assess the efficacy of a new form of Cognitive Behavioral Therapy for delusions with a focus on emotion regulation, improvement of self-esteem and…
- Conditions
- Schizophrenia, Psychotic Disorders, Delusions, Emotions
- Trial name
- CBTd-E (NCT02787135)
- Testing
- emotion-oriented Cognitive Behavior Therapy
- Where
- 2 sites in Germany
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Psychosis
The Relationship Between Autobiographical Memory and Motivation
People with a diagnosis of psychosis often experience low motivation and pleasure when thinking about doing future activities. This leads, quite understandably, to doing fewer activities they used to enjoy and not taking up…
- Trial name
- NCT03677635
- Testing
- Guided Autobiographical Memory Recall
- Where
- 2 sites in United Kingdom
- Volunteers
- 31 people
- Sponsor
- King's College London
Schizophrenia Spectrum and Other Psychotic Disorders
Feasibility and Outcomes of a Digital Health Support for the Schizophrenia Spectrum
This protocol describes an attempt to capture the development phase of a mobile support for individuals with schizophrenia. The intent is to describe and account for a rigorous development process that will result in the creation…
- Trial name
- NCT03649815
- Testing
- App4Independence
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- Centre for Addiction and Mental Health
Psychotic Disorders, Prodromal Symptoms
Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial
The present study is a confirmatory efficacy trial of Family Focused Therapy for youth at clinical high risk for psychosis (FFT-CHR).
- Conditions
- Psychotic Disorders, Prodromal Symptoms, Prodromal Schizophrenia, Psychosis
- Trial name
- NCT04338152
- Testing
- Family Focused Therapy for Clinical High Risk Youth (FFT-CHR), Enhanced Care (EC)
- Where
- 7 sites in United States, Canada
- Volunteers
- 220 people
- Sponsor
- University of California, Los Angeles
Prodromal Schizophrenia
Evaluation of Step-Based Care for Individuals at Clinical High Risk for Psychosis
The Ohio State University Early Psychosis Intervention Center is implementing a specialized clinical program to serve individuals who meet clinical high risk criteria for a psychosis.
- Trial name
- NCT03970005
- Testing
- Step-Based Care Model
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Psychosis
A Large Pragmatic Cluster Randomized Controlled Trial of a Multi-element Psychosocial Intervention for Early Psychosis
Multi-element interventions for first-episode psychosis (FEP) are promising but have mostly been conducted on non epidemiologically representative samples in experimental settings, raising the risk thereby of underestimating the…
- Trial name
- GETUP-PIANO (NCT01436331)
- Testing
- Treatment As Usual (TAU), TAU+CBT for pts+Family Intervention+CM.
- Where
- Italy
- Volunteers
- 626 people
- Sponsor
- Universita di Verona
Healthy, Modeling Psychosis
Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids
The study evaluates the gene-environment interaction of the COMT-genotype on the effects of the phytocannabinoids delta-9-tetrahydrocannabinol, cannabidiol or a combination of both on induction of psychotic symptoms…
- Trial name
- NCT02487381
- Testing
- delta-9-tetrahydrocannabinol, Cannabidiol
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Schizophrenia, Psychosis
The Sub-Sero Study
Schizophrenia is a severe, often chronic mental disorder, characterized by positive and negative symptoms and cognitive deficits.
- Trial name
- NCT03994965
- Testing
- Pimavanserin 34 milligrams (MG) [Nuplazid]
- Sponsor
- Bjorn H. Ebdrup
Delusions, Depression
Effect of 4-session Metacognitive Training in Chinese Adult Outpatients With Schizophrenia Spectrum Disorders and Major Depressive Disorder
Psychological studies have shown that individuals tend to attribute causes of positive and negative events differently. Specifically, individuals hold an internalising or externalising bias of attribution which, in the case of…
- Trial name
- NCT03449394
- Testing
- Metacognitive Training
- Where
- Hong Kong
- Volunteers
- 113 people
- Sponsor
- Chinese University of Hong Kong
First Episode Psychosis (FEP), Psychosis
Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis
Psychotic disorders affect approximately 4% of Canadians and have a significant impact on individuals' well-being, their families and social networks, and healthcare systems.
- Conditions
- First Episode Psychosis (FEP), Psychosis, Schizophreni-form Disorder, Dependence Addictive
- Trial name
- Mobile Health (NCT07811466)
- Testing
- CHAMPS, I Can Change
- Volunteers
- 550 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Psychosis
Mindfulness, Group Therapy and Psychosis; Training Decreases Anxiety and Depression
The objective of this non-randomized, within-group comparison was to evaluate the addition of mindfulness as a new technique in an outpatient group therapy program for participants diagnosed with a psychotic spectrum disorder…
- Trial name
- NCT04711460
- Testing
- Younger participants, Older participants, TAU
- Volunteers
- 116 people
- Sponsor
- University of Minnesota
Mental Health Symptoms, Wearables
My Experiences: Leveraging Digital Technologies to Better Understand Mental Health
Mental health disorders are one of the most challenging chronic conditions to identify, treat and manage. This is largely due to the fact that diagnoses are almost entirely based on the patient's recall of current and past…
- Trial name
- NCT05753605
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- 4YouandMe
Schizophrenia
The Effects of Prebiotics on Cognitive Functioning and Weight Gain in Psychosis
The investigators propose a maltodextrin-controlled cross over experimental medicine study that aims to examine the role of the immune system in cognitive processes and weight gain in 40 adult patients with psychosis, stable on…
- Trial name
- Prepsy (NCT03153046)
- Testing
- prebiotics, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- University of Oxford
Psychotic Disorders
Epidemiology Study of Psychosis
Purpose Psychotic disorders (including schizophrenia) are complex neurobehaviour disorders influenced by genetic, neurodevelopmental, neurochemical, as well as psychosocial factors.
- Trial name
- NCT01423669
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
First Episode Psychosis
Role of Minocycline in First Episode Psychosis
The purpose of this study is to determine whether the addition of minocycline or placebo to treatment as usual (TAU): 1. prevents the accumulation of negative symptoms and intellectual decline following a first episode of…
- Trial name
- NCT00916461
- Testing
- Minocycline
- Where
- 4 sites in Brazil, Pakistan
- Volunteers
- 52 people
- Sponsor
- Stanley Medical Research Institute
Psychotic Disorders
Hormonal and Inflammatory Biomarkers and Response to Cognitive Remediation in Recent-onset Psychosis
This study aims to explore whether hormones or inflammatory markers are associated with cognitive changes following cognitive remediation therapy (CRT) in people with a recent-onset psychotic disorder.
- Trial name
- NCT04418570
- Testing
- cognitive remediation, attendance to an Early Intervention Service for Psychosis
- Volunteers
- 28 people
- Sponsor
- Corporacion Parc Tauli
Psychotic Disorders, Schizophreniform Disorders
Clinical Trial of Integrated Treatment Versus Standard Treatment in First Episode Psychosis
The purpose of the study was to evaluate the effects of integrated treatment for patients with a first episode of psychotic illness.
- Conditions
- Psychotic Disorders, Schizophreniform Disorders, Schizoaffective Disorder, Psychosis, Brief Reactive
- Trial name
- NCT00157313
- Testing
- Integrated treatment, family involvement, Social skills training
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Bispebjerg Hospital
Schizophrenia, Schizoaffective Disorder
Prospective Cytochrome P450 Genotyping and Clinical Outcomes in Patients With Psychosis
The aim of the study is to examine whether determining treatment strategies based upon Cytochrome P450 2D6 (CYP2D6) genotype will improve drug response rates and clinical outcome in patients with psychosis.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychotic Disorder Not Otherwise Specified, Severe Bipolar Disorder With Psychotic Features
- Trial name
- NCT01878513
- Testing
- risperidone
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Northwell Health
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