Clinical trials: Non Organic Psychosis
Dissociative Disorder
Prevalence of Dissociative Identity Disorder in At-risk Outpatient Groups Reporting Childhood Trauma.
The investigators will study the prevalence of dissociative identity disorder (DID) in three populations at risk in cases of childhood psychotrauma : patients with a diagnosis of borderline personality, patients with a diagnosis…
- Trial name
- IDENTITY (NCT06330467)
- Testing
- psychometric assessment, semi-structured clinical interview
- Where
- 3 sites in France
- Volunteers
- 350 people
- Sponsor
- Centre Psychothérapique de Nancy
Psychosis
Source-monitoring & Psychosis
Source-monitoring is a cognitive process that refers to the ability to remember the source of an information. Some studies have showed source-monitoring deficits in patients with schizophrenia as well as in individuals at…
- Trial name
- SOURIPSY (NCT04236531)
- Testing
- Cognitive tests and neuroimaging
- Where
- 2 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Psychosis, Schizophrenia
State Representation in Early Psychosis
The purpose of this study is to examine state representation in individuals aged 15-45 who have been diagnosed with a psychotic illness, as well as young adults who do not have a psychiatric diagnosis.
- Conditions
- Psychosis, Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Schizoaffective Disorder
- Trial name
- STEP (NCT05273164)
- Where
- United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Schizophrenias, Psychoses
Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia
The purpose of this study is to determine whether preventative treatment with sarcosine can reduce symptoms and delay/avoid disease progression in individuals defined as being in a prodromal stage of schizophrenia.
- Conditions
- Schizophrenias, Psychoses, Psychotic Disorders, Schizophrenic Disorders
- Trial name
- NCT00276263
- Testing
- Sarcosine (N-methylglycine)
- Where
- 2 sites in Israel
- Sponsor
- Herzog Hospital
Psychosis, Schizophrenia
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental…
- Trial name
- NCT04940663
- Testing
- EMA
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Psychosis, Mania
Combining mHealth and Nurse-delivered Care to Improve the Outcomes of People With Serious Mental Illness in West Africa
In West Africa, most people with serious mental illness receive care from traditional or faith healers at prayer camps. The stepped-wedge cluster randomized trial aims to evaluate the effectiveness of a dual-pronged intervention…
- Conditions
- Psychosis, Mania, Depression
- Trial name
- NCT05703711
- Testing
- mHealer
- Where
- Ghana
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Washington
Psychotic Disorder
Mindfulness-Based Family Psychoeducation Intervention for Early Psychosis
A brief Mindfulness-Based Family Psychoeducation programme is developed to reduce the caregiver's stress and to promote young people's recovery.
- Trial name
- NCT03688009
- Testing
- Mindfulness-Based Family Psycho-Education (MBFBE), Family Psycho-Education (FPE)
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Schizophrenia
Efficacy and Safety of Iloperidone Compared With Placebo and Active Control in Subjects With Acute Schizophrenia
The purpose of this study is to determine the safety and efficacy of iloperidone compared to placebo and an active comparator in the treatment of patients with schizophrenia in acute exacerbation.
- Trial name
- NCT00254202
- Testing
- Iloperidone, Ziprasidone
- Where
- 42 sites in United States, India
- Volunteers
- 593 people
- Sponsor
- Vanda Pharmaceuticals
Psychotic Disorders
Fitforlife- Exercise in Care of Psychosis
Persons affected by psychosis have a shorter life expectancy mainly due to metabolic disorders. This is partly due to the drugs but also to a sedentary life style.
- Trial name
- NCT04239612
- Testing
- Physical exercise
- Where
- Sweden
- Volunteers
- 156 people
- Sponsor
- Karolinska Institutet
Psychosis
From Prevention to Community Integration: IPCST for Severe Mental Illness in Chinese Communities (Hong Kong and Beijing)
This research project aims at early detection, early intervention, and recovery of individuals with psychosis and prevention of their family members who are at high risk of having developmental problems and developing psychosis…
- Trial name
- NCT03565055
- Testing
- IPCST, E.A.S.Y
- Volunteers
- 100 people
- Sponsor
- The Hong Kong Polytechnic University
Psychosis, Medication Adherence
Piloting MOL Intervention for Neuroleptic Decision Making
The aim of the current study is to pilot a novel intervention to help people explore their decision making around the use of neuroleptic medication.
- Trial name
- NCT03537040
- Testing
- Method of Levels
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Manchester
Psychosis
Narrative Identity and Its Relationship to Subjective Multidimensional Well-being in First Episode Psychosis
The transition between adolescence and adulthood (generally defined as ages 18 to 25) is a key developmental window for narrative identity and psychotic disorders. Narrative identity is positively associated with mental health.
- Trial name
- PEPsy-Identity (NCT06464848)
- Testing
- Narrative identity task
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Psychosis, First Episode Psychosis
Stratification and Treatment in Early Psychosis Study - ENHANCE
The purpose of this study is: To investigate whether the response to antipsychotic treatment can be enhanced by adding cannabidiol (CBD) to the existing treatment, compared to placebo, in participants with a first episode of…
- Conditions
- Psychosis, First Episode Psychosis, Psychotic Disorders, Psychotic Episode
- Trial name
- STEP-ENHANCE (NCT06778564)
- Testing
- CBD 100 mg/mL Oral Solution
- Where
- 17 sites in Austria, Germany and 7 more
- Volunteers
- 250 people
- Sponsor
- University of Oxford
Clinical High Risk for Psychosis, Ultra High Risk for Psychosis
Endocannabinoid Activity Remodulation for Psychosis Liability in Youth
Clinical High-Risk (CHR) for Psychosis is characterized by the occurrence of unusual stressful experiences (attenuated psychotic symptoms, APS), anxious symptoms, psychological distress, and substantial impairment of the…
- Conditions
- Clinical High Risk for Psychosis, Ultra High Risk for Psychosis, Attenuated Psychotic Symptoms
- Trial name
- EARLY (NCT06037993)
- Testing
- Ultra-micronized Palmitoylethanolamide (PEA)
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- University of Udine
Psychotic Disorders
Culturally Responsive Person-Centered Care for Psychosis
This study will compare standard individualized care to person-centered care and community-integrating care for treating psychosis in adults of Hispanic or African descent.
- Trial name
- NCT00231933
- Testing
- Person-centered planning (PCP), Community integration (CI), Illness management recovery (IMR)
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- Yale University
Psychosis
Improving Access to Early Psychosis Coordinated Specialty Care
The aim of this study is to evaluate the feasibility of developing an Early Psychosis CSC service delivery model suitable for rural settings in NC.
- Trial name
- NCT04277585
- Testing
- Telehealth
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of North Carolina, Chapel Hill
Psychotic Disorders, Schizophrenia
FAST-A Study to Evaluate the Efficacy and Safety of Quetiapin IR in Patients With Acute Psychosis
The purpose of this study is to compare the efficacy of quetiapine IR, following rapid titration versus conventional titration in patients with acute psychosis
- Conditions
- Psychotic Disorders, Schizophrenia, Bipolar Disorder
- Trial name
- FAST (NCT00486798)
- Testing
- Quetiapine, Rating Scales, Self Assessment Form
- Where
- 13 sites in Sweden
- Sponsor
- AstraZeneca
Delusional Disorder, Brief Psychotic Disorder
FEEL-GOOD: A Multicenter Trial of a Mindfulness-Based Group Therapy in Young Adults With Early Psychosis
FEEL-GOOD is a prospective multi-site single-blinded randomized controlled trial in young inpatients with acute early psychosis. Participants are randomized 1:1 to FEEL-GOOD plus treatment as usual (TAU) or TAU alone.
- Conditions
- Delusional Disorder, Brief Psychotic Disorder, Schizophreniform Disorder, Schizophrenia / Schizoaffective Disorder
- Trial name
- FEEL-GOOD (NCT07645443)
- Testing
- FEEL GOOD, Treatment as Usual (TAU)
- Where
- 8 sites in Germany
- Volunteers
- 252 people
- Sponsor
- Stephanie Mehl
Schizophrenia, Schizoaffective Disorder
Assessment of Efficacy of a Psychological Therapy in Inpatients With a Schizophrenic Psychosis
This randomised three-arm study aims to evaluate the efficacy and feasibility of a cognitive behavioral therapy (INT-Integrated Neurocognitive Therapy for Schizophrenia Patients) in the treatment of schizophrenia patients in an…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychotic Disorders
- Trial name
- CBTSZ (NCT03316664)
- Testing
- Integrated Neurocognitive Therapy (INT), Integrated Psychological Therapy (IPT), COGPACK
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- Psychiatric University Hospital, Zurich
Psychosis, Schizophrenia
CARE Study: Improving Treatment for the Most Severely Ill With Schizophrenia
This is a 9 week, multicentre, randomized, double-blind, placebo-controlled trial with two parallel groups. There is also an open-label extension phase of 18 weeks.
- Trial name
- NCT00272584
- Testing
- Risperidone
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
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