Clinical trials: Non ST Elevation Myocardial Infarction (NSTEMI)
Acute Coronary Syndrome, Non-ST Elevation (NSTEMI) Myocardial Infarction
An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction
The use of supplemental oxygen in the setting of suspected acute myocardial infarction (AMI) is manifested in international treatment guidelines and established in prehospital and hospital clinical routine throughout the world.
- Conditions
- Acute Coronary Syndrome, Non-ST Elevation (NSTEMI) Myocardial Infarction, Acute ST Segment Elevation Myocardial Infarction, Angina, Unstable
- Trial name
- DETO2X-AMI (NCT01787110)
- Testing
- Oxygen
- Where
- 34 sites in Sweden
- Volunteers
- 6,629 people
- Sponsor
- Karolinska Institutet
Non-ST-Elevation Myocardial Infarction
Thrombus Aspiration During Percutaneous Coronary Intervention in Acute Non-ST-elevation Myocardial Infarction Study
In this trial, the investigators will evaluate the effect of thrombus aspiration followed by stent implantation in improving myocardial blush grade in patients with acute non-ST-elevation myocardial infarction compared to…
- Trial name
- TAPAS II (NCT01013038)
- Testing
- Thrombus aspiration followed by stent implantation, conventional PCI
- Where
- Netherlands
- Volunteers
- 540 people
- Sponsor
- University Medical Center Groningen
Acute Coronary Syndromes
Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry
The primary objective of the UPSTREAM Registry is to address the data gap regarding the course of NSTEMI (Non-ST-Elevation Myocardial Infarction)between ED (Emergency Department) arrival and diagnostic angiography in detail, by…
- Trial name
- NCT02271022
- Testing
- Non-Interventional Study
- Where
- 55 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- AstraZeneca
Obesity /Overweight, Acute Myocardial Infarction (STEMI/ NSTEMI)
Diet Therapy Versus Prescriptive Educational Group Intervention in Overweight / Obese Patients at First Episode of AMI: a Randomized Controlled Trial
Results after interventions on lifestyle in the secondary prevention of ischemic heart disease are not always consistent, and the Guidelines multidisciplinary measures aren't easily achievable.
- Trial name
- NCT02323802
- Testing
- educational group intervention, prescriptive diet
- Where
- 2 sites in Italy
- Volunteers
- 90 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Myocardial Infarction, Myocardial Ischemia
Time for a Paradigm Shift: STEMI/NSTEMI to OMI/NOMI ?
The current ST-segment elevation (STEMI)/non-STEMI treatment paradigm misses nearly one fourth of acute coronary occlusions (ACO) that needs immediately reperfusion.
- Trial name
- DIFOCCULT-2 (NCT05705102)
- Testing
- Coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 2,500 people
- Sponsor
- Marmara University
Coronary Artery Disease, Coronary Stenosis
ILUMIEN IV: OPTIMAL Percutaneous Coronary Intervention (PCI)
The objective of this prospective, single-blind clinical investigation is to demonstrate the superiority of an Optical Coherence Tomography (OCT)-guided stent implantation strategy as compared to an angiography-guided stent…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Atherosclerosis, STEMI
- Trial name
- NCT03507777
- Testing
- Coronary PCI guided by OCT, Coronary PCI guided by Angiography
- Where
- 90 sites in United States, Australia and 18 more
- Volunteers
- 2,487 people
- Sponsor
- Abbott Medical Devices
STEMI, NSTEMI
Assessment of Individual Risk of Cardiovascular Events by Platelet FcGammaRIIa
This is a Prospective, Observational Multicenter Non-Interventional Cohort Study. The primary objective is to determine whether platelet expression of FcγRIIa is associated with risk of myocardial infarction (MI), stroke and…
- Trial name
- NCT05175261
- Testing
- Prolocor pFCG test
- Where
- United States
- Volunteers
- 764 people
- Sponsor
- Prolocor, Inc
Tomography, Optical Coherence, Myocardial Revascularization
The FAST OCT Study
This trial is designed to associate angiography-based fractional flow reserve (3D-angio-based FFR) values with optical coherence tomography findings in pre- and post-percutaneous coronary intervention in patients with non-ST…
- Conditions
- Tomography, Optical Coherence, Myocardial Revascularization, NSTEMI - Non-ST Segment Elevation MI, Unstable Angina
- Trial name
- NCT04683133
- Testing
- Optical coherence tomography assessment
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
NSTEMI - Non-ST Segment Elevation MI, STEMI (ST Elevation MI)
Aspirin-free Strategy With Ticagrelor in Patients With a Myocardial Infarction Treated Medically Alone
In patients with a myocardial infarction (MI) treated medically alone, the objective of the PANTHEON trial is to evaluate if ticagrelor monotherapy reduces bleeding events, without an increase in patient-oriented ischemic events…
- Conditions
- NSTEMI - Non-ST Segment Elevation MI, STEMI (ST Elevation MI), Myocardial Infarction
- Trial name
- PANTHEON (NCT07257198)
- Testing
- Ticagrelor + aspirin
- Where
- Canada
- Volunteers
- 2,570 people
- Sponsor
- Montreal Heart Institute
Myocardial Infarction
Utility of Residual Syntax Score to Predict Outcome After Acute Myocardial Infarction
The aim of this study is to evaluate the utility of residual syntax score after PCI of the culprit vessel for patients with AMI (STEMI or NSTEMI) to predict 6-months clinical outcomes.
- Trial name
- NCT05392777
- Testing
- Residual syntax score
- Where
- Egypt
- Volunteers
- 490 people
- Sponsor
- Cairo University
Ischemic Heart Disease (IHD)
XTR003 PET Radiotracer for the Detection of Viable Myocardium
The study was designed to explore the clinical feasibility of XTR003, a PET myocardial fatty-acid tracer, for the detection of viable myocardium in patients with ischemic heart disease (IHD).
- Trial name
- NCT05885854
- Testing
- XTR003
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Sinotau Pharmaceutical Group
Acute Coronary Syndrome, Unstable Angina
Acute Coronary Syndrome Sri Lanka Audit Project
ACSSLAP is the first island wide audit project in Sri Lanka on ACS.
- Conditions
- Acute Coronary Syndrome, Unstable Angina, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction
- Trial name
- ACSSLAP (NCT02893280)
- Testing
- aspirin, clopidogrel, statin, enoxaparin, streptokinase
- Where
- Sri Lanka
- Sponsor
- University of Colombo
Acute Coronary Syndromes (ACS), Ventricular Tachycardia (VT)
Analysis of Life-threatening ARrhythMias After Acute Coronary Syndrome
Patients admitted with an acute coronary syndrome (ACS) are at increased risk of malignant cardiac arrhythmias (MA), such as sustained ventricular tachycardia and ventricular fibrillation.
- Conditions
- Acute Coronary Syndromes (ACS), Ventricular Tachycardia (VT), Ventricular Fibrillation, Pulseless Electrical Activity
- Trial name
- ALARM-ACS (NCT07824050)
- Where
- Netherlands
- Volunteers
- 2,775 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
EARLY-MYO-CMR-II Registry
The purpose of this registry is to depict the myocardial tissue characteristics in NSTEMI patients by CMR and other cardiac imaging modalities and to assess the prognostic value of imaging-derived indices.
- Trial name
- NCT03995433
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- RenJi Hospital
Acute Coronary Syndrome (ACS)
Lp(a) Lowering Study of Pelacarsen (TQJ230) in Patients in the US With Elevated Lp(a) and Recent ACS (STEMI/NSTEMI) - Lp(a)FRONTIERS PEARL
CTQJ230A1US13 is a randomized, double-blind, placebo-controlled, multicenter phase IIIb study designed to evaluate the efficacy, safety, tolerability, and coronary plaque effects of early pelacarsen (TQJ230) initiation in…
- Trial name
- NCT07625306
- Testing
- Pelacarsen
- Sponsor
- Novartis Pharmaceuticals
Coronary Artery Diseases
BIOFLOW-III UK Satellite Registry Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). 500 subjects will be enrolled in this registry.
- Trial name
- NCT02257710
- Testing
- Orsiro
- Where
- 4 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Biotronik UK Ltd.
Myocardial Infarction, Myocardial Ischemia
Time for a Diagnostic Paradigm Shift From STEMI/NSTEMI to OMI/NOMI
The investigators hypothesize that occlusion myocardial infarction(MI)/non-occlusion MI approach to MI treatment will better predict acute coronary occlusion on coronary angiography, better limit infarct size, better preserve…
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Acute Coronary Syndrome, Diagnosis
- Trial name
- DIFOCCULT-3 (NCT06570759)
- Testing
- Early intervention for OMI, Standard early intervention for STEMI, Standard delayed intervention for NSTEMI
- Where
- 18 sites in Turkey (Türkiye)
- Volunteers
- 6,000 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Effect of Diabetes on Long Term Excess Mortality Following Acute Myocardial Infarction
Long Term Excess Mortality of Acute Myocardial Infarction in Patients With and Without Diabetes: A Population-based Cohort Study
Diabetes is key risk factor for death following acute myocardial infarction. However, the long-term excess risk of death associated with diabetes following acute myocardial infarction not known.
- Trial name
- NCT02591576
- Volunteers
- 700,000 people
- Sponsor
- University of Leeds
Atrial Fibrillation
Artificial Intelligence Models to Predict Clinically Relevant Cardiovascular Outcomes
Atrial fibrillation (AF) is a frequent and clinically relevant problem among the events that may occur during the hospitalization period in patients with cardiovascular disease.
- Trial name
- PERCARD (NCT06847100)
- Testing
- Blood withdrawal
- Where
- 4 sites in Finland, Germany and 1 more
- Volunteers
- 273 people
- Sponsor
- Centro Cardiologico Monzino
STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI)
Intensive Cholesterol-Lowering Within 24 Hours of PCI Perioperative Period
This project team is conducting a multicenter randomized controlled study, aiming to administer PCSK9 inhibitors subcutaneously as early as possible within 24 hours during the perioperative period of AMI (included <24h STEMI and…
- Trial name
- INCLINE-AMI (NCT07290699)
- Testing
- Recaticimab
- Volunteers
- 2,442 people
- Sponsor
- Second Affiliated Hospital of Nanchang University