Clinical trials: Non Union Fracture
Nonunion of Fracture
Platelet-rich Plasma Combined With Conventional Surgery in the Treatment of Atrophic Nonunion of Femoral Shaft Fractures
To objectively analyze the effectiveness of platelet-rich plasma (PRP) combined with conventional surgery in the treatment of atrophic nonunion of femoral shaft fractures.
- Trial name
- NCT03129971
- Testing
- conventional surgery, autologous platelet-rich plasma
- Volunteers
- 92 people
- Sponsor
- Qinghai University
Non Union/Delayed Fractures
Mononucleotide Autologous Stem Cells and Demineralized Bone Matrix in the Treatment of Non Union/Delayed Fractures
The study is a prospective, trial to test the safety and feasibility of injecting autologous, isolated, sterile centrifuged NBMC, and Ignite® DBM in the treatment of high risk non union/delayed fractures.
- Trial name
- NCT01435434
- Testing
- the Sepax is a tool to standardize adult stem cell. Ignite ®ICS injectable scaffold manufactured by Wright Medical Technology.
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Nonunion of Bone Graft, Fractures Non Union
Reamer Irrigator Aspirator (RIA) vs Autogenous Iliac Crest Bone Graft (AICBG) for the Treatment of Non-unions
The specific question the investigators will seek to answer is: can the Reamer Irrigator Aspirator (RIA) provide a bone graft source for the treatment of nonunions that is equally effective to Autogenous Iliac Crest Bone Graft…
- Trial name
- NCT01382485
- Testing
- RIA harvesting group, AICBG harvesting group
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Nonunion of Fracture of Fifth Metatarsal
A Double-Blind Study on Adjunctive Use of PEMF in the Treatment of 5th Metatarsal Non-Union Fractures
The purpose of this study is to analyze the effect of PEMF in surgical reconstruction of 5th metatarsal non-union fractures.
- Trial name
- NCT00586170
- Testing
- EBI Bone Healing System, Surgery
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Zimmer Biomet
Bone Metastases, Fracture Nonunion
Ankle Arthrodesis Nail for 2-level Pathologic Tibial Fracture
Tibial pseudarthrosis in 83 year old patient suffering from pathologic fractures
- Conditions
- Bone Metastases, Fracture Nonunion, Bone Lesion
- Trial name
- NCT04940754
- Testing
- osteosynthesis
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Orthopaedie Zentrum Zuerich
Scaphoid Fracture, Scaphoid Nonunion
Arthroscopic vs. Open Bone Grafting for Scaphoid Delayed/Nonunion
Single site, prospective, observer-blinded randomized controlled trial. Eighty-eight patients aged 18-68 years with scaphoid delayed/non-union, will be randomized, 1:1, to either open iliac crest cancellous graft reconstruction…
- Trial name
- NCT05574582
- Testing
- Graft reconstruction and internal fixation with compression screw
- Where
- Denmark
- Volunteers
- 88 people
- Sponsor
- Herlev and Gentofte Hospital
Nonunion Fracture
Treatment of Atrophic Nonunion Fractures by Autologous Mesenchymal Stem Cell Percutaneous Grafting
Bone fractures heal most of the time particularly well and without complications. The solidification takes rarely more than two to three months. The wound healing depends greatly on a good blood supply and needs several steps.
- Trial name
- NCT01429012
- Testing
- Mesenchymal Stem Cells, Culture medium without MSC.
- Where
- Belgium
- Sponsor
- University of Liege
Osteomyelitis, Bone Infection
Clinical Effectiveness of S53P4 Bioactive Glass in Treatment of Long-bone Chronic Osteomyelitis
This clinical trial studies the clinical effectiveness of S53P4 bioactive glass (BAG) as a bacterial growth inhibiting bone graft substitute in a one-stage or two-stage surgical procedure for treatment of chronic long bone…
- Conditions
- Osteomyelitis, Bone Infection, Non-Union Fracture, Bone Infection of Lower Leg
- Trial name
- NCT04945434
- Testing
- S53P4 bioactive glass (BonAlive)
- Volunteers
- 78 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Femur Distal Fracture, Nonunion of Fracture
Distal Femur Fracture Nonunion - Statistical Analysis Plan
Here the investigators describe the statistical analysis plan for the study assessing the prediction of fracture nonunion leading to secondary surgery in patients with distal femur fractures.
- Trial name
- NCT05163795
- Testing
- Lateral locking plate
- Where
- Finland
- Volunteers
- 299 people
- Sponsor
- Töölö Hospital
Wound Infection, Fractures, Open
Tobramycin Injection to Prevent Infection in Open Fractures
The goal of open extremity fracture (OEF) treatment is to promote fracture healing and restore function while preventing the development of infection.
- Conditions
- Wound Infection, Fractures, Open, Surgical Site Infection
- Trial name
- NCT04964947
- Testing
- Tobramycin Injection
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- Massachusetts General Hospital
Pseudarthrosis, Fractures, Ununited
Treatment of Atrophic Nonunion by Preosteoblast Cells
Treatment of nonunion, delayed union and malunion fractures of long bones remains problematic. The definition of nonunion is a failure of the fracture to heal in six months in a patient in whom progressive repair had not been…
- Trial name
- NCT00916981
- Testing
- percutaneous autologous preosteoblast cells implantation
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Jean-Philippe Hauzeur
Tibia Distal Fracture, Nonunion of Fracture of Tibia
Is Far Cortical Locking More Effective Than Bicortical Locking in Treating AO 43A1-3 Fractures?
Delayed union or nonunion, which is a common complication of periarticular fractures repaired with angled locking plate systems, may be due to the unintentionally rigid formation of this system.
- Trial name
- NCT06005090
- Testing
- Far Cortical Locking Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Saglik Bilimleri Universitesi
Pseudoarthrosis of Bone, Implant Breakage
Corticalisation After Femoral Nail Dynamization in Hypertrophic Non-unions
In 12 patients with corticalization and hypertrophic pseudarthrosis were present after dynamization, the old nail was removed and nail exchange was performed with a longer and larger diameter nail to pass the region formed in the…
- Trial name
- NCT05423561
- Testing
- exchange nailing with larger, thicker nail crossing corticalization
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Scaphoid Non-union Advanced Collapse (SNAC Wrist)
The Use of Adaptive Proximal Scaphoid Implant (APSI): Long Term Follow-up
Scaphoid proximal pole fracture with avascular necrosis is a complex surgical problem. In some cases, it's possible to perform a scaphoid hemiarthroplasty with an adaptative proximal scaphoid implant (APSI), made of pyrocarbon…
- Trial name
- NCT06808594
- Testing
- APSI prosthesis implant
- Volunteers
- 36 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Forearm Injuries, Radius Fractures
Time to Healing in Displaced Pediatric Diaphyseal Forearm Fractures Treated With Bioabsorbable Compared to Titanium Intramedullary Nails
This study looks at children with forearm fractures that need surgery. The standard treatment uses titanium nails, which usually need to be removed in a second operation later.
- Conditions
- Forearm Injuries, Radius Fractures, Ulna Fractures, Fractures, Bone
- Trial name
- FOREST (NCT07536581)
- Testing
- Bioabsorbable intramedullary nail, Titanium elastic intramedullary nail
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Children's Fractures Interest Group, Denmark
Nonunion Fracture
The Efficacy of Mesenchymal Stem Cells for Stimulate the Union in Treatment of Non-united Tibial and Femoral Fractures in Shahid Kamyab Hospital
Because the rate of non union of long bone in lower extremities specially in tibia in this two last decade due to malnutrition and smoking and other risk factors was increased, so many patient in our country suffer from non union…
- Trial name
- NCT01788059
- Testing
- injection the mesenchymal stem cell in non union site
- Where
- Iran
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Emdadi Kamyab Hospital
Nonunion Fracture
Allograft vs. Autograft Nonunion
The purpose of this research study is to find out if patients treated for nonunion fracture with autograft or allograft return to activity faster.
- Trial name
- NCT07310082
- Testing
- Autograft, Allograft
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Wake Forest University Health Sciences
Fracture, Healed, Fibrous Union
Mid-term Outcome Following Revision Surgery of Clavicular Non- and Malunion
Background Treatment of clavicular non- and malunion is still challenging. Current surgical procedures often result in partially frustrating functional outcome along with high-grade subjective impairment and increased rates of…
- Trial name
- Nonunion (NCT02951468)
- Testing
- LCP plus iliac crest autograft
- Volunteers
- 14 people
- Sponsor
- Technical University of Munich
Non Union Diaphyseal Fractures
A Randomized Controlled Cost Study of Infuse BMP 2 vs Iliac Crest Autograft for Non Union of Long Bone Fractures
We are inviting individuals such as yourself, who have diaphyseal fracture (broken bone) with a non union to participate in this research study.
- Trial name
- Infuse (NCT00856479)
- Testing
- Infuse Bone Morphogenic Protein (BMP) 2, iliac crest autograft
- Where
- Canada
- Sponsor
- Ross Leighton
Nonunion Fracture
Treatment of Nonunion of Limb Fracture With Human Amniotic Epithelial Cells（hAECs）
The purpose of this study is to evaluate the efficacy and safety of human amniotic epithelial cells transplant in nonunion of limb fracture patients.
- Trial name
- NCT03031509
- Testing
- Human Amniotic Epithelial Cells, debridement
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai East Hospital