Clinical trials: Non Variceal Bleed
Upper Gastrointestinal Bleeding
Hemostatic Powder Following Injection Therapy Versus Conventional Dual Therapy for Endoscopic Hemostasis for Non-variceal Upper Gastrointestinal Bleeding
Acute upper gastrointestinal hemorrhage (UGIH) is a common condition that leads to hospital admission, and has significant associated morbidity and mortality, especially in the elderly.
- Trial name
- NCT02717416
- Testing
- Endo-Clot, hemoclip or electrical coagulation
- Where
- South Korea
- Volunteers
- 226 people
- Sponsor
- Yonsei University
Upper Gastrointestinal Bleeding
PuraStat® Combined With Adrenaline Versus Standard of Care in Upper Gastrointestinal Bleeding
PuraStat® is a novel gel that offers several advantages over traditional hemostatic powders. Its transparency allows for continuous visualization of the bleeding site, and it can be applied in narrow spaces or in combination with…
- Trial name
- NCT06896409
- Testing
- PuraStat® combined with Adrenaline, Standard of Care
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Tallaght University Hospital
Liver Cirrhosis, Portal Hypertension
Continuous Versus Bolus Infusion of Terlipressin for Portal Hypertension Related Bleeding in Liver Cirrhosis
Terlipressin is the mainstay drug for the treatment of acute variceal bleeding in liver cirrhosis. According to the drug instructions, intravenous bolus infusion is the standard approach of terlipressin.
- Conditions
- Liver Cirrhosis, Portal Hypertension, Variceal Hemorrhage, Bleeding
- Trial name
- NCT03130127
- Testing
- Terlipressin
- Volunteers
- 40 people
- Sponsor
- General Hospital of Shenyang Military Region
Gastrointestinal Hemorrhage
Bipolar Hemostatic Forceps Versus Standard Therapy in Acute Non-variceal Upper GI Bleeding
Bipolar hemostatic forceps will be tested against standard therapy in active, non-variceal, upper gastrointestinal bleeding by a prospective, randomized trial
- Trial name
- BeBop (NCT05353062)
- Testing
- Hemostatic therapy, Endoscopic therapy with hemoclip +/- injection of epinephrine solution
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Cirrhosis, Esophageal and Gastric Varices
Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis
The APIXABAN-PK trial is a prospective, randomized, single-blind, placebo-controlled study designed to evaluate the efficacy and safety of apixaban in combination with carvedilol versus placebo with carvedilol in preventing…
- Conditions
- Cirrhosis, Esophageal and Gastric Varices, Ascites, Hepatic Encephalopathy
- Trial name
- APIXABAN-PK (NCT07521332)
- Testing
- Apixaban, Carvedilol
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Asian Institute Of Medical Sciences
Non-variceal Upper Gastrointestinal Bleeding, Gastrointestinal Ulcer
European Survey of Non-Variceal Upper Gastro Intestinal Bleeding (NVUGIB)
The aim of this study is to assess the current management strategies in a pan-European "real-life" setting to uncover the unmet need in this area: non-variceal gastrointestinal bleedings.
- Conditions
- Non-variceal Upper Gastrointestinal Bleeding, Gastrointestinal Ulcer, Gastrointestinal Hemorrhage
- Trial name
- ENERGIB (NCT00797641)
- Where
- 97 sites in Belgium, Greece and 5 more
- Volunteers
- 2,500 people
- Sponsor
- AstraZeneca
Gastrointestinal Bleeding
Computed Tomography in Gastrointestinal Bleeding
Gastrointestinal bleeding represents a serious clinical problem and a common cause of hospitalisation with a mortality rate of 6-10% for upper Gastrointestinal bleeding and of 4% for lower Gastrointestinal bleeding requires a…
- Trial name
- NCT03243240
- Testing
- mutlidetector computed tomography
- Volunteers
- 30 people
- Sponsor
- Assiut University
GastroIntestinal Bleeding, Anemia
Iron Supplementation in Upper Non-variceal Gastrointestinal Bleeding
Anemia is a frequent complication of gastrointestinal bleeding, affecting 61% of the patients. Currently, anemia caused by gastrointestinal bleeding can be treated with iron supplementation.
- Trial name
- FIERCE (NCT05060731)
- Testing
- Oral iron supplementation, Intravenous iron supplementation
- Where
- Hungary
- Volunteers
- 570 people
- Sponsor
- University of Pecs
Gastrointestinal Hemorrhage, Hematemesis; With Ulcer
Efficacy and Safety of Nexpowder™ for Non-variceal, Upper Gastrointestinal Bleeding
The purpose of this pilot clinical trial is to confirm the efficacy and safety of Nexpowder™ for hemostasis in pilot cohort of patients with NVUGIB in Singapore
- Conditions
- Gastrointestinal Hemorrhage, Hematemesis; With Ulcer, Endoscopy
- Trial name
- NCT06269588
- Testing
- Nexpowder
- Where
- Singapore
- Volunteers
- 24 people
- Sponsor
- Changi General Hospital
Actual or Potential Nonvariceal Bleeding in the Upper Gastrointestinal (GI) Tract
Clinical Evaluation of the Safety and Performance of Microwave Coagulation Using the HS1 Instrument
Clinical evaluation of the safety and performance of microwave coagulation using the HS1 Instrument for actual or potential non-variceal bleeding in the upper Gastrointestinal (GI) tract
- Trial name
- NCT04406116
- Testing
- Microwave coagulation using HS1 Instrument
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Creo Medical Limited
Gastroesophageal Varices Hemorrhage, Hepatocellular Carcinoma
A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol (S-HCC)
Patients with hepatocellular carcinoma and esophageal varices bleeding were randomized to undergo endoscopic ligation alone (group A) and additive propranolol treatment (group B) after stabilization of their first acute bleeding.
- Trial name
- NCT01451658
- Testing
- propranolol
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Upper Gastrointestinal Bleeding
OTSC vs. Angiographic Embolization in Patients With Refractory Non-variceal Upper Gastrointestinal Bleeding
In the management of patients with acute upper non-variceal upper gastrointestinal bleeding, further bleeding is the most important adverse factor predictive of mortality.
- Trial name
- NCT04902248
- Testing
- The OTSC® System Set, angiographic embolization
- Where
- 5 sites in China, Hong Kong and 1 more
- Volunteers
- 236 people
- Sponsor
- Chinese University of Hong Kong
Liver Cirrhosis, Hepatoma
A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol
New strategy to improve the outcomes in patients with HCC and acute variceal bleeding. NSBB added to endoscopic ligation may further reduce rebleeding in cirrhotic patients.
- Trial name
- NCT01298284
- Testing
- propranolol
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Portal Hypertension
Risk Factors for Variceal Bleeding in Egyptian Patients With Non-Cirrhotic Portal Hypertension
Background \& Aims: Non-cirrhotic portal hypertension (NCPH) represents a relatively infrequent group of conditions. This work aimed at determining causes of NCPH and evaluating the role of some clinical, laboratory, imaging and…
- Trial name
- NCT02635815
- Testing
- Upper gastrointestinal endoscopy
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Esophageal Varices Bleeding
The Compliance and Prognosis of NSBB Secondary Prevention of Cirrhosis With Gastroesophageal Varices Bleeding
Non-selective beta blockers are commonly used drugs for primary prevention and secondary prevention in patients with cirrhotic decompensated esophageal varices bleeding，the basic heart rate, blood pressure and condition of…
- Trial name
- NCT03683121
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Renmin Hospital of Wuhan University
Non-variceal Upper Gastrointestinal Bleeding
Surgicel® (Fibrillar) in Non-variceal UGI Bleeding
The aim of this study is to assess of effect of Surgicel® (Fibrillar) for preventing delayed bleeding after endoscopic hemostasis in non-variceal upper gastrointestinal bleeding
- Trial name
- NCT02054260
- Testing
- Surgicel
- Where
- South Korea
- Sponsor
- Soonchunhyang University Hospital