Clinical trials: Non-Diabetic, open to volunteers
Class V Dental Caries, Type 2 Diabetes Mellitus, Giomer Technology; Injectable Resin Composite; Zirconia-Modified Glass Ionomer
Zirconia-Reinforced Glass Ionomer Versus Injectable Giomer in Class V Restorations
This randomized controlled clinical trial aims to compare the clinical performance of zirconia-reinforced glass ionomer and injectable giomer restorations in Class V carious lesions among controlled type II diabetic against…
- Trial name
- NCT07731308
- Testing
- Zirconomer, Beautifil Flow Plus X
- Volunteers
- 100 people
- Sponsor
- Cairo University
Healthy Volunteers, Non Diabetic Hyperglycemia
Safety of Mulberry Leaf Extract Capsule on Blood Glucose Control in Healthy Volunteer
Volunteers were divided into 2 groups: mulberry leaf extract capsule (DNJ 12mg) group and placebo group. They took the sample 3 times/day for 8 weeks.
- Trial name
- NCT07532135
- Testing
- Mulberry Leaf Extract
- Where
- Thailand
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Preterm Birth, Hyperglycemia
Blood Glucose in Pregnant Non-diabetic Women During Treatment With Betamethasone for Fetal Lung Maturation
In case of threatening preterm birth, it is standard to recommend treatment with betamethasone to accelerate fetal lung maturation.
- Conditions
- Preterm Birth, Hyperglycemia, Neonatal Hypoglycemia, Threatened Preterm Labor
- Trial name
- NCT06794307
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- University of Aarhus
Diabetes Mellitus, Diabetic Neuropathies
Integrated Oral Care Intervention for Xerostomia in Diabetes Patients
Diabetes patients commonly experience dry mouth also known as xerostomia which can affect eating speaking oral health and overall quality of life.
- Trial name
- IOCID (NCT07425275)
- Testing
- Integrated Oral Care Intervention
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Khyber Medical University Peshawar
Kidney Diseases
China Kidney Patient Trials Network
This is a prospective multi-centre, observational cohort study of incident and prevalent patients diagnosed with a kidney disease in China.
- Trial name
- CKPTN (NCT05036850)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- George (Beijing) Clinical Research Co. Ltd.
Overweight , Obesity
Phase 3 Study of MWN109 Injection in Participants With Overweight or Obesity
This is a phase 3, multicenter, randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of MWN109 injection in non-diabetic participants with overweight or obesity.
- Trial name
- NCT07778693
- Testing
- MWN109 1, MWN109 2, MWN109 3
- Where
- China
- Volunteers
- 760 people
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Diabetic Neuropathy, Neuropathic Pain
Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic Neuralgia
Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic Neuralgia
- Conditions
- Diabetic Neuropathy, Neuropathic Pain, Neuralgia, Postherpetic
- Trial name
- PRISE (NCT07712913)
- Testing
- Experimental: Pregabalin XR, Comparator: Dorene Tabs
- Where
- 15 sites in Brazil
- Volunteers
- 348 people
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Non-Proliferative Diabetic Retinopathy
A Study to Evaluate the Efficacy and Safety of OTX-TKI (Axitinib Implant) in Participants With Non-Proliferative Diabetic Retinopathy
The purpose of this trial is to study the safety and effectiveness of OTX-TKI (axitinib intravitreal hydrogel) for the treatment of Non-Proliferative Diabetic Retinopathy.
- Trial name
- HELIOS-3 (NCT07235085)
- Testing
- Intravitreal injection of axitinib hydrogel implant followed by a second intravitreal injection of the axitinib implant at Week 24
- Where
- United States
- Volunteers
- 930 people
- Sponsor
- Ocular Therapeutix, Inc.
Chronic Kidney Disease
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort
This study will evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single ascending doses (SAD) and multiple ascending doses (MAD) of AZD4248 administered as an oral solution and intravenous (IV)…
- Trial name
- NCT07024823
- Testing
- AZD4248
- Where
- 5 sites in United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Triglycerides Glucose Index, Angiographic Profiling
Triglycerides Glucose Index on Angiographic Profiling of Non-Diabetic Premature Coronary Artery Disease Patients
This study aims to evaluate the impact of the triglyceride-glucose (TyG) index on the angiographic profiling of non-diabetic patients with premature coronary artery disease (CAD).
- Conditions
- Triglycerides Glucose Index, Angiographic Profiling, Non-Diabetic, Premature
- Trial name
- NCT07154186
- Testing
- Coronary Angiographic Assessment
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Sohag University
Diabetes Mellitus, Diabetic Neuropathy
Effects of Ankle Block on Postoperative Analgesia in Diabetic and Non-Diabetic Patients
This prospective observational study aims to evaluate the effects of ultrasound-guided ankle block on sensory and motor block characteristics and postoperative analgesic outcomes in patients undergoing lower extremity surgery.
- Conditions
- Diabetes Mellitus, Diabetic Neuropathy, Postoperative Pain Management
- Trial name
- ANKLE-DM (NCT07404124)
- Testing
- Ultrasound-Guided Ankle Block
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Acute Ischemic Stroke
Acute Subcutaneous SemaglutidE in Acute Ischemic sTroke
Can Semaglutide help reduce the damage caused by a stroke? ASSET trial is a national, multicenter, clinical trial, investigating the safety and efficacy of Semaglutide in non-diabetic patients with acute ischemic stroke.
- Trial name
- ASSET (NCT05630586)
- Testing
- Semaglutide, Standard care
- Where
- Denmark
- Volunteers
- 380 people
- Sponsor
- Aarhus University Hospital
Effect of SGLT2 Inhibitors NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy
Effect of SGLT2 Inhibitors on NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy
To rule out the beneficial effect of SGLT2-I to reduce liver fat, and change in inflammatory markers (ALT, AST) in type 2 diabetic patients with non-alcoholic fatty liver disease.
- Trial name
- NCT06668753
- Testing
- Dapagliflozin 10mg Tab or Empagliflozin 10 mg Tab
- Volunteers
- 114 people
- Sponsor
- Assiut University
Diabetic Foot Ulcer
A Study to Evaluate the Efficacy of a Purified Native Type 1 Collagen Extracellular Matrix With Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers
This prospective, multi-center, randomized, controlled modified platform Trial compares Purified Native Type 1 Collagen Extracellular Matrix with Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care versus…
- Trial name
- PREPARE (NCT06618612)
- Testing
- Standard of Care, PuraPly AM, PuraPly XT
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Organogenesis
Diabetic Nepheopathy
Role of Renal Duplex Resistive Index (RRI) and Pulsatility Index (PI) in Assessment of Early Renal Microvascular Changes in Diabetic Patient
Diabetes mellitus (DM) is a globally prevalent metabolic disorder with an escalating burden on renal health. Diabetic kidney disease (DKD) represents the leading cause of end-stage renal disease (ESRD) worldwide, affecting…
- Trial name
- NCT07864740
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetic Foot Ulcer, Venous Leg Ulcer
Post-Marketing Surveillance of Dehydrated Human Amnion/Chorion Membrane (DHACM) in Non-Ischemic Chronic Wounds
The purpose of this survey is to observe the efficacy and safety of EPIFIX® dehydrated human amnion/chorion membrane (DHACM) for the treatment of intractable diabetic foot ulcers or venous leg ulcers.
- Trial name
- NCT06236750
- Testing
- EPIFIX
- Where
- 5 sites in Japan
- Volunteers
- 75 people
- Sponsor
- MiMedx Group, Inc.
Diabetic Foot Ulcer (DFU)
A Prospective Clinical Study to Evaluate the Effectiveness and Safety of Xcell Amnio MatrixTM (XAM) in the Management of Chronic Non-healing DFUs
The goal of this clinical trial is to evaluate the clinical outcomes of Diabetic Foot Ulcers (DFUs) treated with a weekly application of Xcell Amnio MatrixTM (XAM) as adjunct to standard of care (SOC) compared to SOC alone in…
- Trial name
- NCT07116174
- Testing
- Xcell Amnio Matrix, Standard of Care (SOC)
- Where
- 3 sites in United States
- Volunteers
- 135 people
- Sponsor
- New Horizon Medical Solutions
Diabetic Retinopathy, Vitreous Hemorrhage Due to Diabetes Mellitus
Pre-operative Vabysmo in Patients With Non-clearing Vitreous Hemorrhage Secondary to Proliferative Diabetic Retinopathy
In this phase IV, randomized, double-masked, sham-controlled study the investigators hope to determine the efficacy in peri-operative faricimab (Vabysmo) compared to sham in limiting complications from pars plana vitrectomy for…
- Trial name
- NCT06191094
- Testing
- Faricimab Injection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Diabetic Retinopathy
A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy
This study is open to adults with diabetic retinopathy. People who have non-proliferative diabetic retinopathy of moderate or high severity can join the study.
- Trial name
- NCT06321302
- Testing
- BI 764524, Aflibercept (Eylea®) - US only
- Where
- 90 sites in United States, Germany and 7 more
- Volunteers
- 175 people
- Sponsor
- Boehringer Ingelheim
Pre Diabetic, Hyperglycaemia (Non Diabetic)
Diabetes Prevention by Group Intervention and CGM Use in Pre-diabetic Adults
This study is being done to find better ways to help people with prediabetes prevent or delay the development of type 2 diabetes.
- Trial name
- CGM (NCT07543068)
- Testing
- Combines group sessions and CGM-based behavioral feedback
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sam Houston State University