Clinical trials: Non-Diabetic, open to volunteers
Eye Diseases, Retinitis Pigmentosa
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAION
This trial will study the safety and efficacy of intranasal delivery of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of non-arteritic ischemic optic neuropathy
- Conditions
- Eye Diseases, Retinitis Pigmentosa, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT05147701
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Diabetic Foot Ulcer (DFU), Chronic Foot Ulcers
Rising Tide - Amniotic Tissue(s) Treatments for Chronic Diabetic Foot Ulcers
The purpose of this clinical investigation is to evaluate the safety and efficacy of Amnion/Chorion/Amnion allograft , Amnion/Chorion allograft, and/or Amnion/Amnion allograft, plus Standard of Care (SOC) each versus SOC alone in…
- Trial name
- NCT06681428
- Testing
- Allograft
- Where
- 9 sites in United States
- Volunteers
- 240 people
- Sponsor
- Tides Medical
Pre Diabetic, Hyperglycaemia (Non Diabetic)
Diabetes Prevention by Group Intervention and CGM Use in Pre-diabetic Adults
This study is being done to find better ways to help people with prediabetes prevent or delay the development of type 2 diabetes.
- Trial name
- CGM (NCT07543068)
- Testing
- Combines group sessions and CGM-based behavioral feedback
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sam Houston State University
Diabetic Foot Ulcer, Diabetic Foot Ulcer (DFU)
Study to Assess Remote Imaging System to Monitor Diabetic Foot Ulcers
The goal of this observational pilot study is to evaluate whether a new remote monitoring platform (TASHA) can support accurate and reliable assessment of diabetic foot ulcers in adult patients receiving care in a UK NHS clinic.
- Trial name
- NCT07013448
- Testing
- Foot scan
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Medical Intelligence Group
Diabetes Mellitus, Ulcer Foot
Examining the Effectiveness of DermGEN™ in the Treatment of Diabetic Foot Ulcers in First Nations People
The study will examine the effectiveness of a decellularized dermal matrix (i.e., DermGEN™) in improving wound healing, quality of life and associated costs of treatment of DFUs in First Nations people living in the Northwestern…
- Conditions
- Diabetes Mellitus, Ulcer Foot, Ulcer Healing, Diabetic Foot Ulcer
- Trial name
- NCT05251480
- Testing
- Standard of Care, DermGEN™
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- DeCell Technologies Inc.
Type 1 Diabetes
The Effect of Improved Glycemic Control on the Composition and Function of High-Density Lipoproteins (HDL) in Patients With Type 1 Diabetes
The HAGI-T1D study aims to determine the effect of improved glycemic control on the composition and function of high-density lipoproteins (HDL) in patients with type 1 diabetes (T1D).
- Trial name
- HAGI-T1D (NCT07564752)
- Testing
- Blood test, Urine sample
- Where
- France
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Healthy Volunteers, Erythritol
SUVY VerSus SAccharose (SUVISA)
Sugar substitutes are increasingly used to reduce sugar intake. SÜVY is a food ingredient combining erythritol and polydextrose.
- Trial name
- SUVISA (NCT07901491)
- Testing
- SÜVY, Sucrose
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Minerais SAS
Lower Limb Amputation Above Knee
Microenvironment in Patients Undergoing Non-traumatic Amputation
The microenvironment of the amputation stump in patients undergoing non-traumatic transfemoral amputation will be investigated with a combination of microdialysis and tissue sampling.
- Trial name
- MiAMII (NCT07384689)
- Testing
- ciNPWT, SSD
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Diabetic Foot Ulcer
Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.
The goal of this clinical trial is to learn if using perinatal tissue allografts improves healing of chronic, non-healing foot ulcers in diabetic patients.
- Trial name
- NCT06437028
- Testing
- Dual-layer perinatal tissue allograft, Three-layer fenestrated perinatal tissue allograft, Standard of care
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Samaritan Biologics
Painful Diabetic Peripheral Neuropathy
Efficacy and Safety of Low-Dose Duloxetine Plus Alpha-Lipoic Acid Versus Standard-Dose Duloxetine in Painful Diabetic Peripheral Neuropathy
This study will evaluate the efficacy and safety of low-dose duloxetine combined with alpha-lipoic acid compared with standard-dose duloxetine in adults with painful diabetic peripheral neuropathy.
- Trial name
- NCT07785544
- Testing
- Duloxetine, Alpha-Lipoic Acid
- Where
- Bangladesh
- Volunteers
- 170 people
- Sponsor
- Bangladesh Medical University
Insulin Resistance
Effects of Insulin Resistance in Non-diabetic Acute Coronary Syndrome Patients
Effects of insulin resistance in non-diabetic acute coronary syndrome patients by the homeostasis model assessment index (HOMA2-IR)
- Trial name
- NCT06163768
- Testing
- Insulin resistance
- Where
- Vietnam
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Diabetic Nepheopathy
Role of Renal Duplex Resistive Index (RRI) and Pulsatility Index (PI) in Assessment of Early Renal Microvascular Changes in Diabetic Patient
Diabetes mellitus (DM) is a globally prevalent metabolic disorder with an escalating burden on renal health. Diabetic kidney disease (DKD) represents the leading cause of end-stage renal disease (ESRD) worldwide, affecting…
- Trial name
- NCT07864740
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Assiut University
Non-diabetic Chronic Kidney Disease
Vascular Effects of SGLT2i in Non-diabetic CKD
Empagliflozin, a sodium-glucose co-transporter 2 inhibitor (SGLT2i), is a novel diabetic medication that reduces the risk of progression of chronic kidney disease (CKD) and heart failure and improves exercise tolerance regardless…
- Trial name
- EMPA-CKD (NCT07060417)
- Testing
- Empagliflozin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Office of Research and Development
Class V Dental Caries, Type 2 Diabetes Mellitus, Giomer Technology; Injectable Resin Composite; Zirconia-Modified Glass Ionomer
Zirconia-Reinforced Glass Ionomer Versus Injectable Giomer in Class V Restorations
This randomized controlled clinical trial aims to compare the clinical performance of zirconia-reinforced glass ionomer and injectable giomer restorations in Class V carious lesions among controlled type II diabetic against…
- Trial name
- NCT07731308
- Testing
- Zirconomer, Beautifil Flow Plus X
- Volunteers
- 100 people
- Sponsor
- Cairo University
Diabetic Macular Edema
Home- vs Hospital-based Care of Anti-VEGF Treatment for Diabetic Macular Edema: Non-inferiority RCT
Diabetic macular edema (DME) is a common cause of central visual loss in diabetic patients and a global public health burden around the world.
- Trial name
- DME HOME (NCT06610747)
- Testing
- Home-based Care Monitoring, Aflibercept 2Mg/0.05Ml Inj,Oph, Laser Treatment
- Where
- 4 sites in China
- Volunteers
- 308 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Diabetes Mellitus
Clinical Performance of Giomer-Based Composite Restorations in Class V Carious Lesions in Diabetic and Non-Diabetic Patients
Diabetes mellitus is associated with structural and biochemical alterations in dentin that may negatively affect the clinical performance and longevity of adhesive dental restorations, particularly in cervical carious lesions.
- Trial name
- NCT07407855
- Testing
- Giomer-based composite restoration
- Volunteers
- 56 people
- Sponsor
- Cairo University
Obesity; Chronic Kidney Disease; Albuminuria
Study on the Efficacy and Safety of Initial Combination of Finerenone and Semaglutide in Non-Diabetic Adult Patients With Obesity Complicated by Chronic Kidney Disease With Albuminuria
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate whether starting finerenone together with semaglutide provides an additional reduction in urinary albumin-to-creatinine ratio…
- Trial name
- NCT07849348
- Testing
- Finerenone, Semaglutide
- Volunteers
- 266 people
- Sponsor
- Peking University People's Hospital
Subjects With Diabetes and DFU With a Suspicion of DFO
Bedside Bone Biopsy in Diabetic Foot Osteomyelitis
During their lifetime, 15 to 25% of patients with diabetes mellitus will develop a Diabetic Foot Ulcer (DFU) related to neuropathy and/or peripheral arterial disease.
- Trial name
- BOLBOC (NCT06066801)
- Testing
- Bedside blind bone biopsy procedure
- Where
- France
- Volunteers
- 320 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Foot Ulcer
A Study to Evaluate the Efficacy of a Purified Native Type 1 Collagen Extracellular Matrix With Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers
This prospective, multi-center, randomized, controlled modified platform Trial compares Purified Native Type 1 Collagen Extracellular Matrix with Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care versus…
- Trial name
- PREPARE (NCT06618612)
- Testing
- Standard of Care, PuraPly AM, PuraPly XT
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Organogenesis
Non-diabetic Obesity
PEG-rhGH and Semaglutide Combination Therapy in Non-Diabetic Obese Adults
This study aims to evaluate the efficacy and safety of PEG-rhGH Injection combined with Semaglutide Injection versus Semaglutide Injection monotherapy in improving body composition (lean body mass, fat mass, etc.) in non-diabetic…
- Trial name
- NCT06863363
- Testing
- PEG-rhGH Injection + Semaglutide Injection, Semaglutide Injection
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Shanghai Zhongshan Hospital