Clinical trials: Non-Insulin Dependent
Cardiovascular Diseases, Heart Diseases
VLDL and LDL Particle Types as Coronary Heart Disease Risk Factors
To evaluate very low density lipoprotein (VLDL) and low density lipoprotein (LDL) particle types as predictors of initial coronary events.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Infarction
- Trial name
- NCT00065793
- Volunteers
- 1,478 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Non-Insulin Dependent, Non-Insulin Dependent
Study of the Effects of Vitamin C on Patients With Type 2 Diabetes
Diabetes is a disease characterized by decreased sensitivity to the action on insulin to promote sugar (glucose) use and blood vessel relaxation (vasodilation) in muscle.
- Trial name
- NCT00001870
- Testing
- Acetylcholine
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Diabetes Mellitus, Non-Insulin-Dependent
Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus
This is a multicenter, randomized, blinded, placebo-controlled study to assess the effects on glucose control of AC2993 as compared to placebo in patients with type 2 diabetes.
- Trial name
- NCT00035984
- Testing
- AC2993
- Where
- 100 sites in United States
- Volunteers
- 734 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Non-Insulin-Dependent, High Risk for Cardiovascular Event
Multicenter Trial to Evaluate the Effect of Dapagliflozin on the Incidence of Cardiovascular Events
This study is being carried out to determine the effect of dapagliflozin on cardiovacular outcomes when added to current background therapy in patients with type 2 diabetes with either established cardiovacular disease or…
- Trial name
- DECLARE-TIMI58 (NCT01730534)
- Testing
- Dapagliflozin 10 mg
- Where
- 805 sites in United States, Argentina and 32 more
- Volunteers
- 17,190 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus
Effect of Gelofusine on GLP1-receptor Imaging
The highly promising and innovative tracer on 111In-DTPA-AHX-Lys40-Exendin 4 has been applied to determine beta cell mass in healthy volunteers and patients with type 1 diabetes.
- Trial name
- GLP1-EX-GELO (NCT02541734)
- Testing
- Gelofusine, 111In-exendin 4 SPECT/CT
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes Mellitus, NIDDM
Comparison Study of Usual Care vs. Usual Care Plus Community Intervention to Manage Type 2 Diabetes
The overall purpose of this research is to examine and compare the effectiveness and costs of a community-based intervention to support self-management with usual primary care for older adults with Type 2 Diabetes Mellitus and…
- Conditions
- Type 2 Diabetes Mellitus, NIDDM, Non-insulin Dependent Diabetes Mellitus
- Trial name
- NCT02158741
- Testing
- Home Visits and Lifestyle Education Support
- Where
- 8 sites in Canada
- Volunteers
- 291 people
- Sponsor
- McMaster University
Heart Diseases, Myocardial Infarction
Biomarkers of Oxidative Stress in LOOK AHEAD - Ancillary to LOOK AHEAD
To determine how weight loss achieved by intensive lifestyle intervention including diet and exercise alters lipoprotein oxidation/oxidative stress and antioxidant status in overweight diabetic individuals.
- Conditions
- Heart Diseases, Myocardial Infarction, Obesity, Diabetes Mellitus, Non-insulin Dependent
- Trial name
- NCT00031226
- Sponsor
- Arizona State University
Diabetes Mellitus, Non-Insulin-Dependent
Evaluation of an Orally Administered Medication When Taken in Conjunction With Pramlintide
This is a randomized, single-blind, placebo-controlled, crossover study to examine the effect of pramlintide on the pharmacokinetics of an orally administered medication
- Trial name
- NCT00044707
- Testing
- Pramlintide acetate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- AstraZeneca
Cardiovascular Diseases, Heart Diseases
Heritage Study--Genetics, Exercise and Risk Factors
To document the role of the genotype in the cardiovascular and metabolic responses to aerobic exercise-training and the contribution of inherited factors in the changes brought about by regular exercise for several cardiovascular…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Diabetes Mellitus, Non-insulin Dependent, Diabetes Mellitus
- Trial name
- HERITAGE (NCT00005137)
- Testing
- exercise program
- Sponsor
- Washington University School of Medicine
Hyperlipidemia, Diabetes Mellitus, Type 2
Atorvastatin and LDL Profile in Non-Insulin Dependent Diabetes Mellitus
The study will investigate the effects of atorvastatin on the concentrations of small, dense LDL and HDL subfractions in patients with diabetes and the underlying mechanisms of these effects.
- Conditions
- Hyperlipidemia, Diabetes Mellitus, Type 2, Non-Insulin Dependent Diabetes Mellitus
- Trial name
- ALPIN (NCT00640549)
- Testing
- Atorvastatin
- Where
- 14 sites in Germany
- Volunteers
- 41 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Cardiovascular Diseases, Heart Diseases
Physical Activity, Hypertension, Diabetes, and Coronary Heart Disease
To study the influences of physical activity on the incidence of hypertension, non-insulin-dependent diabetes (NIDDM), and coronary heart disease (CHD), taking into account the influences of other life-style elements such as body…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Diabetes Mellitus, Coronary Disease
- Trial name
- NCT00005419
- Sponsor
- Stanford University
Diabetes Mellitus, Type 2, Obesity
NEW DAY: Nutrition, Exercise, Weight Loss, Diabetes And You
This clinical trial examines whether the addition of individual sessions of a motivational intervention to a state-of-the art behavioral group weight loss intervention for overweight women with Type 2 diabetes improves the weight…
- Trial name
- NCT00007800
- Testing
- Behavioral Group Weight Loss Intervention, Motivational Interviewing
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiovascular Diseases, Heart Diseases
Diet, Insulin Resistance, and Cardiovascular Risk
To elucidate dietary factors that elevate risk for cardiovascular disease (CVD) in conjunction with insulin resistance.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Insulin Resistance, Hyperinsulinism
- Trial name
- NCT00005530
- Sponsor
- University of South Carolina
Cardiovascular Diseases, Atherosclerosis
Serum Total Homocysteine and C-Reactive Protein - Ancillary to IDNT
To examine the independent association of serum total homocysteine and C-reactive protein with arteriosclerotic cardiovascular disease morbidity and mortality.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Heart Diseases, Diabetes Mellitus, Non-insulin Dependent
- Trial name
- NCT00021918
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Non-Insulin-Dependent Diabetes Mellitus
Study In Patients With Type 2 Diabetes Who Are Taking Metformin And Sulfonylurea, Metformin And Insulin, Or Insulin
This study will use Magnetic Resonance Imaging (MRI) techniques to evaluate changes in fluid volume in the lower legs of diabetic patients who add either pioglitazone or placebo to their current diabetic regimen.
- Trial name
- NCT00269061
- Testing
- pioglitazone
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Insulin-Dependent
Efficacy Safety and Tolerability of Multiple Doses of Oshadi Icp (Oshadi Oral Insulin) in Patients With Type 1 Diabetes Mellitus - Phase II Clinical Study
Diabetes mellitus (DM) is a chronic disease of carbohydrate, fat, and protein metabolism caused by an absolute or relative deficiency of insulin, an anabolic hormone.
- Conditions
- Diabetes Mellitus, Insulin-Dependent, Type 1
- Trial name
- NCT01973920
- Testing
- Oshadi Icp
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Oshadi Drug Administration
Diabetes Mellitus, Non-Insulin-Dependent
Single Ascending Dose Study of BMS-820132 in Patients With Type 2 Diabetes
BMS-820132 is an investigational new drug being developed by BMS for treating Type 2 diabetes. The purpose of this study is to test the safety/tolerability (potential side effects) of single doses of the investigational new drug…
- Trial name
- NCT01105429
- Testing
- BMS-820132
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Bristol-Myers Squibb
Sleep Apnea Syndromes, Diabetes Mellitus, Non-insulin Dependent
Sleep Apnea in Look AHEAD Participants - Ancillary to Look AHEAD
To assess the effects of weight loss on sleep disordered breathing in obese, Type 2 diabetics with obstructive sleep apnea.
- Conditions
- Sleep Apnea Syndromes, Diabetes Mellitus, Non-insulin Dependent, Obesity, Diabetes Mellitus
- Trial name
- NCT00031239
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Polycystic Ovarian Syndrome, Pelvic Endometriosis
Prevalence of HbA1C in Women With PCOS
Women with PCOS have been observed to be potential diabetics.Recently,American Diabetes Association has suggested screening of women with PCOS for HbA1C.
- Conditions
- Polycystic Ovarian Syndrome, Pelvic Endometriosis, Insulin Resistance, Non-insulin Dependent Diabetes Mellitus
- Trial name
- WHI (NCT01838122)
- Where
- India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Southern Cross Fertility Centre
Diabetes, Diabetes Mellitus, Non-Insulin-Dependent
Effects of Exercise Intervention and Rehabilitation Exercise Intervention in Patients With Type 2 Diabetes
The purposes of the study are to determine if a supervised exercise intervention is improving the metabolic parameters in type 2 diabetes patients to investigate what kind of intervention (strength endurance training versus…
- Trial name
- NCT01393275
- Testing
- rehabilitation exercise intervention
- Where
- 2 sites in Germany
- Volunteers
- 68 people
- Sponsor
- University of Giessen