Clinical trials: Non-ST-Elevation Myocardial Infarction
Coronary Artery Disease
Intravascular Identification and Drug-Eluting Balloon Treatment of Vulnerable Lipid-Rich Plaques
Rationale: Two-thirds of intracoronary thrombi causing acute coronary syndrome (ACS) result from rupture of lipid-rich plaques (LRP).
- Trial name
- DEBuT-LRP (NCT04765956)
- Testing
- Drug-eluting balloon treatment
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Coronary Syndrome
Protective Effect of Early High Dose stATins On Cardiovascular and Renal Events in Acute Coronary Syndrome
Registration of all ACS patients (STEMI and NSTEMI) admitted to the cardiology ward and scheduled for early invasive strategy. The aim is to evaluate the protective effects of early (on admission) high-dose high-potency statin…
- Trial name
- PRATO-ACS (NCT04087200)
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Centro Cardiopatici Toscani
Myocardial Infarction
Comparison of Ticagrelor Pharmacokinetics and Pharmacodynamics in STEMI and NSTEMI Patients
The purpose of the PINPOINT study is to compare pharmacokinetics (PK) and pharmacodynamics (PD) of ticagrelor in ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) patients designated…
- Trial name
- PINPOINT (NCT02602444)
- Testing
- ticagrelor
- Where
- Poland
- Volunteers
- 73 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Myocardial Infarction
Utility of Residual Syntax Score to Predict Outcome After Acute Myocardial Infarction
The aim of this study is to evaluate the utility of residual syntax score after PCI of the culprit vessel for patients with AMI (STEMI or NSTEMI) to predict 6-months clinical outcomes.
- Trial name
- NCT05392777
- Testing
- Residual syntax score
- Where
- Egypt
- Volunteers
- 490 people
- Sponsor
- Cairo University
Acute Coronary Syndrome
Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronary Syndromes
The purpose of this trial is to learn about the effects of inclisiran in people with serious heart conditions (acute coronary syndromes), when this treatment is started early after hospital admission.
- Trial name
- ACS (NCT07102628)
- Testing
- Inclisiran
- Where
- 69 sites in Argentina, Australia and 12 more
- Volunteers
- 300 people
- Sponsor
- Novartis Pharmaceuticals
Non-ST-elevation Myocardial Infarction
Thrombus Aspiration in ThrOmbus Containing culpRiT Lesions in Non-ST-Elevation Myocardial Infarction (TATORT-NSTEMI)
Whereas thrombus aspiration in patients with ST-elevation myocardial infarction (STEMI) is recommended by current guidelines, there are insufficient data to unequivocally support thrombectomy in patients with non-STEMI (NSTEMI).
- Trial name
- NCT01612312
- Testing
- Thrombectomy, Standard percutaneous coronary intervention
- Where
- 7 sites in Germany
- Volunteers
- 400 people
- Sponsor
- University of Leipzig
Percutaneous Coronary Intervention
Comparison of Anticoagulation for All-comers Undergoing Percutaneous Coronary Revascularization Trial
The purpose of this trial is to determine whether bivalirudin is non-inferior to unfractionated heparin in patients with stable angina, unstable angina, or non-ST segment elevation myocardial infarction undergoing percutaneous…
- Trial name
- CALIFORNIA (NCT02448550)
- Testing
- Bivalirudin, Unfractionated heparin
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Kaiser Permanente
Non ST Segment Elevation MI and Unstable Angina
Impact of Different Treatment in Multivessel Non ST Elevation Myocardial Infarction (NSTEMI) Patients: One Stage Versus Multistaged Percutaneous Coronary Intervention (PCI)
Patients with NSTEMI and multivessel disease will be scheduled to undergo early invasive strategy (PCI within 72 hours) of de novo native coronary artery lesions were considered for recruitment into the study.
- Trial name
- SMILE (NCT01478984)
- Testing
- One-Stage group, Multi-Staged group
- Where
- Italy
- Volunteers
- 247 people
- Sponsor
- Gennaro Sardella
Non-ST-Elevation Myocardial Infarction
Thrombus Aspiration During Percutaneous Coronary Intervention in Acute Non-ST-elevation Myocardial Infarction Study
In this trial, the investigators will evaluate the effect of thrombus aspiration followed by stent implantation in improving myocardial blush grade in patients with acute non-ST-elevation myocardial infarction compared to…
- Trial name
- TAPAS II (NCT01013038)
- Testing
- Thrombus aspiration followed by stent implantation, conventional PCI
- Where
- Netherlands
- Volunteers
- 540 people
- Sponsor
- University Medical Center Groningen
Myocardial Infarction
Acute Versus Subacute Angioplasty in Patients With NON-ST-Elevation Myocardial Infarction
Patients with acute myocardial infarction (AMI) are categorized according to the electrocardiogram (ECG) findings into: 1) patients with ST-Elevation Myocardial Infarction (STEMI), 2) patients with Bundle Branch Block Myocardial…
- Trial name
- NONSTEMI (NCT01638806)
- Testing
- Group I: Primary PCI
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aarhus University Hospital Skejby
Myocardial Infarction, Angioplasty
Intracoronary Bolus Only Compared With Intravenous Bolus and 12-hours Infusion of Abciximab in Non-ST Elevation Myocardial Infarction.
Intracoronary bolus Abciximab single is non-inferior to intravenous and continuous 12- hours infusion in the size reduction of infarction on cardiac magnetic resonance in Non-ST elevation Myocardial infarction.
- Trial name
- NCT01080638
- Testing
- glycoprotein IIb/IIIa inhibitor (abciximab)
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Acute Coronary Syndrome
A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects
This study will evaluate the relative efficacy and safety of prasugrel and clopidogrel in a medically managed Unstable Angina/Non-ST-Elevation Myocardial Infarction (UA/NSTEMI) acute coronary syndrome (ACS) population (that is…
- Trial name
- TRILOGY ACS (NCT00699998)
- Testing
- Clopidogrel, Prasugrel, Commercially-available Aspirin
- Where
- 688 sites in United States, Argentina and 51 more
- Volunteers
- 9,326 people
- Sponsor
- Eli Lilly and Company
Myocardial Infarction
Is the Current Threshold for Diagnosis of "Abnormality", Including Non ST Elevation Myocardial Infarction, Using Raised Highly Sensitive Troponin Appropriate for a Hospital Population? The CHARIOT Study
Currently when defining the upper limit of normal (ULN) or 99th percentile of a troponin assay manufacturer's use a healthy population traditionally aged 18-40.
- Trial name
- CHARIOT (NCT03047785)
- Where
- United Kingdom
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Acute Coronary Syndromes (ACS), Ventricular Tachycardia (VT)
Analysis of Life-threatening ARrhythMias After Acute Coronary Syndrome
Patients admitted with an acute coronary syndrome (ACS) are at increased risk of malignant cardiac arrhythmias (MA), such as sustained ventricular tachycardia and ventricular fibrillation.
- Conditions
- Acute Coronary Syndromes (ACS), Ventricular Tachycardia (VT), Ventricular Fibrillation, Pulseless Electrical Activity
- Trial name
- ALARM-ACS (NCT07824050)
- Where
- Netherlands
- Volunteers
- 2,775 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Acute Coronary Syndrome (ACS)
Prasugrel Switching Study in Patients With Acute Coronary Syndrome (ACS) Who Underwent Percutaneous Coronary Intervention (PCI)
This Phase IV, multicenter trial is designed to assess the efficacy of prasugrel in preventing the formation of blood clots in Taiwanese patients with ACS who have been treated with PCI.
- Trial name
- NCT03672097
- Testing
- Prasugrel
- Where
- 10 sites in Taiwan
- Volunteers
- 204 people
- Sponsor
- Daiichi Sankyo Taiwan Ltd., a Daiichi Sankyo Company
Acute Coronary Syndromes (ACS), Troponin I
Effect of Point-of-care Analysis of Ultrasensitive Troponin I on Length of Hospital Stay in Patients With Cardiac Chest Pain (POC Troponina)
This clinical study aims to compare two different methods for measuring high-sensitivity troponin I, a key biomarker used to diagnose heart attacks.
- Conditions
- Acute Coronary Syndromes (ACS), Troponin I, Point-of-Care Testing
- Trial name
- POC Troponina (NCT06861582)
- Testing
- Point-of-care ultrasensitive troponin testing, Laboratory-based ultrasensitive troponin testing
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
ST-Elevation Myocardial Infarction
Colchicine's Efficacy in MI Patients: Comparing PCI and Non-Reperfusion Approaches
This study investigates the effect of Colchicine in preventing heart structure changes following ST-segment elevation myocardial infarction.
- Trial name
- NCT06426537
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- Indonesia
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Brawijaya
NonST Elevation Myocardial Infarction, Myocardial Infarction
Fractional Flow Reserve Versus Angiographically Guided Management to Optimise Outcomes in Unstable Coronary Syndromes
Background: In patients with acute non-ST elevation myocardial infarction (NSTEMI) coronary arteriography is usually recommended however visual interpretation of the coronary angiogram is subjective.
- Trial name
- FAMOUS NSTEMI (NCT01764334)
- Testing
- Fractional flow reserve
- Where
- 6 sites in United Kingdom
- Volunteers
- 350 people
- Sponsor
- NHS National Waiting Times Centre Board
Stable Angina (SA), NSTE-ACS (NSTEMI and UA)
Utilisation of Angiox® in European Practice
The objective of this study is to determine utilisation patterns in patients receiving Angiox® in participating European centres.
- Conditions
- Stable Angina (SA), NSTE-ACS (NSTEMI and UA), STEMI (STE-ACS)
- Trial name
- EURO-vision (NCT01011504)
- Where
- 2 sites in France, Germany
- Volunteers
- 2,019 people
- Sponsor
- The Medicines Company
ST Elevation Myocardial Infarction (STEMI)
Effects of Early Vagus Nerve Stimulation on Infarct Damage and Functioning After Acute STEMI
The goal of this clinical trial is to investigate whether early non-invasive vagus nerve stimulation (nVNS) can reduce infarct damage and improve functioning after acute ST-elevation myocardial infarction (STEMI).
- Trial name
- NCT06865716
- Testing
- Active noninvasive vagus nerve stimulation, Chum electrode attached to patient's lower ear lobe
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Bnai Zion Medical Center