Clinical trials: Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
Myocardial Infarction
A Study of RO4905417 in Patients With Non ST-Elevation Myocardial Infarction (Non-STEMI) Undergoing Percutaneous Coronary Intervention
This randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of RO4905417 in patients with non ST-elevation myocardial infarction (Non-STEMI) undergoing percutaneous coronary intervention (PCI).
- Trial name
- NCT01327183
- Testing
- Percutaneous Coronary Intervention (PCI), RO4905417
- Where
- 66 sites in United States, Canada and 2 more
- Volunteers
- 532 people
- Sponsor
- Hoffmann-La Roche
Acute Coronary Syndrome, Non ST Elevation Myocardial Infarction
Assessment of Coronary Flow Reserve by Doppler Flow WIre in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Differences Between the Loading Dose of Prasugrel and Ticagrelor .
Study design Investigators aim to perform a prospective, single-center, investigator-initiated, randomized study to compare the Adenosine-induced coronary vasodilatation after the loading dose of Ticagrelor either Prasugrel…
- Conditions
- Acute Coronary Syndrome, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- NCT02032303
- Testing
- Assessment of coronary flow reserve, Percutaneous Coronary Intervention, Ticagrelor loading
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Azienda Policlinico Umberto I
Left Ventricular Dysfunction, Coronary Artery Disease
Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function
The purpose of this study is to assess if using the Impella® CP (or Impella® 2.5) device during high-risk PCI in patients with reduced left-sided heart function will result in an improvement in symptoms, heart function and health…
- Trial name
- PROTECT IV (NCT04763200)
- Testing
- Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump
- Where
- 110 sites in United States, Canada and 5 more
- Volunteers
- 1,252 people
- Sponsor
- Abiomed Inc.
ST Elevation Myocardial Infarction, Non ST Elevation Myocardial Infarction
Colchicine and Spironolactone in Patients with MI / SYNERGY Stent Registry
The CLEAR SYNERGY trial will study the long term effects of treatments following PCI to treat myocardial infarction. These treatments address both the culprit artery (PCI with SYNERGY stent) as well as the non-culprit arteries…
- Trial name
- CLEAR SYNERGY (NCT03048825)
- Testing
- Colchicine, Spironolactone, SYNERGY Bioabsorbable Polymer Drug-Eluting Stent
- Where
- 109 sites in United States, Australia and 12 more
- Volunteers
- 7,264 people
- Sponsor
- Population Health Research Institute
STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
Dutch Cangrelor Registry
Cangrelor is a fast and directly acting platelet aggregation inhibitor. It is potentially indicated for several types of patients who are undergoing PCI.
- Conditions
- STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI, Coronary Artery Disease
- Trial name
- NCT04138641
- Testing
- Cangrelor
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Isala
Acute Coronary Syndrome, Depression
MBCT Delivered Via Group Videoconferencing for ACS Patients With Elevated Depression Symptoms
The objective of this study is to identify Acute Coronary Syndromes (ACS) patients' specific needs and preferences for depression treatment via in-person or virtual individual interviews to (a) guide MBCT adaptation; and identify…
- Conditions
- Acute Coronary Syndrome, Depression, Myocardial Infarction, Unstable Angina
- Trial name
- NCT03878160
- Testing
- Individual Interview
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Acute Coronary Syndrome, STEMI - ST Elevation Myocardial Infarction
Optical Coherence Tomography in Acute Coronary Syndrome
The OPTICO-ACS- study program - combining for the first time in vivo characterization of the ACS-causing "culprit lesion" by intracoronary imaging technique with optical coherence tomography (OCT) and molecular analysis of…
- Conditions
- Acute Coronary Syndrome, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI, Atherosclerosis, Coronary
- Trial name
- OPTICO-ACS (NCT03129503)
- Where
- 3 sites in Germany
- Volunteers
- 414 people
- Sponsor
- Charite University, Berlin, Germany
Stable Angina, Ischemic Heart Disease Silent
A Randomized Clinical Evaluation of the BioFreedom™ Stent
The purpose of this study is to demonstrate that a BioFreedom™ Drug Coated Stent is non-inferior to a bare metal stent at one year as measured by the composite safety endpoint of cardiovascular death, myocardial infarction and…
- Conditions
- Stable Angina, Ischemic Heart Disease Silent, ST Elevation (STEMI) and Non-ST Elevation (NSTEMI) Myocardial Infarction, In-stent Coronary Artery Restenosis
- Trial name
- Leaders Free (NCT01623180)
- Testing
- Biofreedom™ Drug Coated Stent (DCS), Gazelle™ Bare Metal Coronary Stent (BMS)
- Where
- Switzerland
- Volunteers
- 2,456 people
- Sponsor
- Biosensors Europe SA
Non-ST Elevated Myocardial Infarction
Coronary CT Angiography in Non ST-elevation Myocardial Infarction
Non ST-elevation myocardial infarction (NSTEMI) represents 70-75% of all myocardial infarctions. Current guidelines recommend invasive angiography and this patient group represents a major burden on the invasive catheterization…
- Trial name
- CT-NSTEMI (NCT04537741)
- Testing
- Coronary CT angiography, Invasive coronary angiography
- Where
- 8 sites in Norway
- Volunteers
- 300 people
- Sponsor
- St. Olavs Hospital
Non-ST-elevation Myocardial Infarction
ImmeDiate Versus EArLy Invasive Approach in Non-ST-Elevation Myocardial Infarction (IDEAL NSTEMI)
Of estimated 140,000 cases of acute myocardial infarction admitted to hospitals in Germany per year, approximately 50% present with Non-ST-elevation myocardial infarction (NSTEMI).
- Trial name
- IDEAL NSTEMI (NCT00954668)
- Testing
- immediate angiography and revascularization, early invasive angiography
- Where
- Germany
- Sponsor
- University of Leipzig
Coronary Stenosis, Coronary Disease
IonMAN Trial- First in Human Study of the IoNIR Ridaforolimus-Eluting Coronary Stent System
This is a prospective, multi-center, single-arm, open-label, First in Human clinical trial to provide preliminary evidence for the safety and efficacy of the novel IoNIR stent system.
- Conditions
- Coronary Stenosis, Coronary Disease, Non-ST Elevated Myocardial Infarction, Cardiovascular Diseases
- Trial name
- IonMAN (NCT05364697)
- Testing
- IoNIR Ridaforolimus-Eluting Coronary Stent System
- Where
- 4 sites in Brazil, Israel
- Volunteers
- 60 people
- Sponsor
- Medinol Ltd.
Myocardial Infarction (MI), Dyslipidemias
Germany on Target Registry
Germany on Target Registry (DaZiR) is a prospective, Germany-wide patient registry designed to assess lipid management and low-density lipoprotein cholesterol ( LDL-C) target attainment in adults following acute myocardial…
- Trial name
- DaZiR (NCT07835282)
- Testing
- No study-assigned intervention
- Volunteers
- 10,000 people
- Sponsor
- Deutsche Gesellschaft für Lipidologie e. V. (DGFL) - Lipid-Liga
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Acute Coronary Syndromes
AI-Assisted Coronary Syndrome Subtyping From Admission History of Present Illness: A Clinician Reader Study
This study will evaluate whether an OCR-LLM-based clinical decision support framework improves clinicians' accuracy in classifying coronary syndrome subtypes from admission history of present illness.
- Conditions
- Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Acute Coronary Syndromes, ST-segment Elevation Myocardial Infarction (STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- OCR-LLM-CHD (NCT07449429)
- Testing
- OCR-Prompt-LLM Information Extraction and Classification Workflow (OCR-Prompt-LLM), Manual Clinical Data Review
- Where
- China
- Volunteers
- 10 people
- Sponsor
- China National Center for Cardiovascular Diseases
Diabetes, STEMI
Sweetheart-Register: Risk Management of Diabetics with Acute Myocardial Infarction
The Sweetheart register (Risk management of Diabetics with acute myocardial infarction) documents both the prevalence of pathologic glucose metabolism in consecutive high-risk patients with STEMI and NSTEMI in daily hospital…
- Conditions
- Diabetes, STEMI, NSTEMI, Myocardial Infarction
- Trial name
- Sweetheart (NCT01197742)
- Where
- 2 sites in Germany
- Volunteers
- 2,772 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
Coronary Artery Disease
ST Segment Detection Study
The purpose of ST Detect study is to evaluate whether naturally occurring spontaneous coronary events and exercise induced cardiac ischemia, give rise to detectable changes on intracardiac electrogram (EGM) signals in patients…
- Trial name
- ST Detect (NCT00930969)
- Testing
- ICD
- Where
- 25 sites in United States, Austria and 5 more
- Volunteers
- 175 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Non-ST-Elevation Myocardial Infarction
Contrast Echocardiography in Non-ST Elevation Myocardial Infarction
In patients with acute myocardial infarction, treatment logistics are primarily defined based upon ST segment shift in the electrocardiogram.
- Trial name
- NCT01122069
- Testing
- Perflutren Lipid Microsphere ultrasound contrast
- Where
- Norway
- Volunteers
- 110 people
- Sponsor
- University of Bergen
Acute Coronary Syndromes (ACS), Troponin I
Effect of Point-of-care Analysis of Ultrasensitive Troponin I on Length of Hospital Stay in Patients With Cardiac Chest Pain (POC Troponina)
This clinical study aims to compare two different methods for measuring high-sensitivity troponin I, a key biomarker used to diagnose heart attacks.
- Conditions
- Acute Coronary Syndromes (ACS), Troponin I, Point-of-Care Testing
- Trial name
- POC Troponina (NCT06861582)
- Testing
- Point-of-care ultrasensitive troponin testing, Laboratory-based ultrasensitive troponin testing
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
Coronary Disease, Acute Coronary Syndrome
European Survey of Cardiovascular Disease Prevention, Diabetes and Chronic Kidney Disease (EUROASPIRE VI)
The goal of this observational study is to provide a unique European picture of preventive action by cardiologists, other specialists and primary care physicians looking after patients with coronary heart disease (CHD)…
- Conditions
- Coronary Disease, Acute Coronary Syndrome, Unstable Angina, ST Elevation Myocardial Infarction
- Trial name
- EUROASPIRE VI (NCT06495177)
- Where
- Turkey (Türkiye)
- Volunteers
- 8,000 people
- Sponsor
- European Society of Cardiology
Non-ST Elevation Myocardial Infarction (NSTEMI)
Antiplatelet Effects of Tirofiban vs. Cangrelor N-STEMI Patients Undergoing Percutaneous Coronary Intervention
Immediate potent inhibition of platelet function is critical for the prevention of periprocedural ischemic event occurrences in high risk N-ST segment elevation myocardial infarction (NSTEMI) in patients undergoing percutaneous…
- Trial name
- NCT03048019
- Testing
- Tirofiban, Cangrelor
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Inova Health Care Services
Coronary Stenosis, Acute Coronary Syndrome
Systemic, Pancoronary and Local Coronary Vulnerability
The aim of the VIP study is to investigate the impact of vulnerability markers (inflammatory serum biomarkers for systemic vulnerability, coronary shear stress and vulnerability mapping for pancoronary vulnerability, and…
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atheromatous Plaques
- Trial name
- VIP (NCT03606330)
- Testing
- Cardiac imaging tests, Venous blood sample collection
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center