Clinical trials: Non-ST-elevation Myocardial Infarction, open to volunteers
Acute Coronary Syndromes
Impact of Non-medicalized ECG Practices Initiated by SAMU in Dispatch Strategies
The performance of an ECG by non-medicalized prehospital teams (firefighters, first responders, paramedic ambulances) is developing across the territory to cope with the increasing demand (SAMU calls) for a service that cannot…
- Trial name
- ECG-PHNM (NCT07144059)
- Testing
- ECG by the SMUR after medical interrogation by the SAMU, ECG performed by a non-medical vector
- Volunteers
- 350 people
- Sponsor
- Centre Hospitalier Sud Francilien
ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
Intensive Lipid-lowering in Patients With STEMI and NSTEMI (Germany on Target)
Intensive Lipid-Lowering Therapy guided by a cloud-based Software System (CLIMEDO GmbH) improves (European Society of Cardiolofgy/European Atherosclerosis Society) ESC/EAS-guideline recommended LDL-cholesterol target attainment…
- Conditions
- ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction, LDL-cholesterol
- Trial name
- GoT (NCT05587621)
- Testing
- statins, ezetimibe, bempedoic acid, evolocumab, alirocumab, inclisiran
- Where
- 10 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Jena University Hospital
Coronary Artery Ectasia, Acute Coronary Syndromes (ACS)
Multicenter Trial of Antithrombotic Strategies in Acute Coronary Syndrome With Coronary Artery Ectasia
Coronary artery ectasia (CAE) is a condition in which a coronary artery becomes abnormally dilated, measuring at least 50% larger than the adjacent normal segment.
- Conditions
- Coronary Artery Ectasia, Acute Coronary Syndromes (ACS), STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI)
- Trial name
- OVER-TIME II (NCT07511257)
- Testing
- Aspirin 100 mg, Clopidogrel 75 mg, Rivaroxaban 15 mg
- Where
- Mexico
- Volunteers
- 326 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Acute Coronary Syndromes, STEMI
Early Single Antiplatelet Therapy After IVUS-Guided PCI in Acute Coronary Syndrome
This is a prospective, open-label, multicenter, randomized, phase IV clinical trial designed to evaluate the safety and efficacy of early aspirin discontinuation followed by potent P2Y12 inhibitor monotherapy after intravascular…
- Conditions
- Acute Coronary Syndromes, STEMI, NSTEMI, Unstable Angina
- Trial name
- SAPT-ACS (NCT07684742)
- Testing
- Early P2Y12 Inhibitor Monotherapy, Standard Dual Antiplatelet Therapy
- Where
- South Korea
- Volunteers
- 1,900 people
- Sponsor
- Gyeongsang National University Hospital
Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction
PRospective Evaluation of Complete Revascularization in Patients With multiveSsel Disease Excluding chroNic Total Occlusions
This prospective, multicenter, non-randomized, single arm, objective performance goal (OPG) study is designed to evaluate clinical outcomes after complete revascularization by PCI and imaging guidance (OCT) in patients with…
- Conditions
- Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction, Unstable Angina, Stable Angina
- Trial name
- PRESENT (NCT05230446)
- Testing
- PCI with OCT guidance
- Where
- Netherlands
- Volunteers
- 609 people
- Sponsor
- Erasmus Medical Center
NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI), Acute Myocardial Infarction (AMI)
Treatment With Aspirin Alone Versus Aspirin in Combination With Fondaparinux Before Early Coronary Assessment in Patients With Non-ST-Elevation Myocardial Infarction
The main goal of this study is to compare two treatments in patients with a specific type of heart attack called Non-ST-elevation Myocardial Infarction (NSTEMI).
- Trial name
- FOXY (NCT06710184)
- Testing
- Aspirin, Fondaparinux Sodium
- Where
- 10 sites in Denmark
- Volunteers
- 5,076 people
- Sponsor
- University of Aarhus
Acute Myocardial Infarction, Cardiogenic Shock
Assessment of ECMO in Acute Myocardial Infarction Cardiogenic Shock
Data from case series and large retrospective trials suggest that the early treatment of cardiogenic shock AMI patients with the association of VA-ECMO and IABP may significantly decrease mortality, which is still unacceptably…
- Trial name
- ANCHOR (NCT04184635)
- Testing
- VA-ECMO
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Infarction (MI), Heart Failure
Timing of Coronary Angiography in NSTEMI Complicated by Acute HF
Study objectives: To determine the optimal timing of coronary angiography (CAG) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) complicated by acute decompensated heart failure (AHF).
- Trial name
- TIMING-AHF (NCT07002164)
- Testing
- Immediate coronary angiography, Delayed coronary angiography
- Where
- 20 sites in South Korea
- Volunteers
- 780 people
- Sponsor
- Chonnam National University Hospital
Myocardial Infarction (MI), Cardiogenic Shock
Optimal Timing of Microaxial Flow Pump(Impella CP) in AMI-related Cardiogenic Shock
PRIME-SHOCK is a prospective, single-center, open-label, randomized, superiority trial. Eligible participants with AMICS and a clinical decision to use Impella CP will be randomized in a 1:1 ratio before culprit-lesion PCI.
- Conditions
- Myocardial Infarction (MI), Cardiogenic Shock, ST-Segment Elevation Myocardial Infarction(STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- PRIME-SHOCK (NCT07817472)
- Testing
- Routine pre-PCI Impella CP, Selective post-PCI Impella CP
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Chonnam National University Hospital
Angina (Stable), CAD - Coronary Artery Disease
Advanced NanoTherapies Dual-API DCB to Treat De-Novo and ISR Lesions in Patients With Symptomatic Coronary Artery Disease
The study objectives are: 1. To evaluate the safety and performance of the SirPlux Duo PTCA to treat coronary ISR lesions 2.00-4.00 mm (inclusive) in diameter in patients with symptomatic coronary artery disease. 2.
- Conditions
- Angina (Stable), CAD - Coronary Artery Disease, Unstable Angina, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- ADVANCE-DUO (NCT07368933)
- Testing
- SirPlux Duo™ Dual API-Coated PTCA Balloon Catheter
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Advanced NanoTherapies
ST Elevation Myocardial Infarction
Risk Characterization of Non-culprit Vessels in Patients Undergoing Primary PCI for ST-elevation MI in Multivessel Disease
Most heart attacks occur because a clot forms in a coronary artery blocking blood flow. Without blood heart muscle dies. Untreated, clots can cause a specific type of heart attack -ST-elevation myocardial infarction (STEMI).
- Trial name
- PICNIC (NCT06506448)
- Testing
- CT Coronary Angiography
- Where
- 3 sites in United Kingdom
- Volunteers
- 320 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Myocardial Infarction, Myocardial Ischemia
OPTIMISER Registry - A Prospective Cohort Study to Describe the OPTIMal Management and Outcomes of PatIents PreSEnting With Acute MyocaRdial Infarction
The purpose of the OPTIMISER Registry is to prospectively and retrospectively collect baseline, clinical and procedural data in patients who present with AMI and are treated with PCI as well as prospectively collect the clinical…
- Conditions
- Myocardial Infarction, Myocardial Ischemia, STEMI, NSTEMI
- Trial name
- OPTIMISER (NCT04988672)
- Where
- Switzerland
- Volunteers
- 4,000 people
- Sponsor
- Luzerner Kantonsspital
Acute Coronary Syndrome
Protective Effect of Early High Dose stATins On Cardiovascular and Renal Events in Acute Coronary Syndrome
Registration of all ACS patients (STEMI and NSTEMI) admitted to the cardiology ward and scheduled for early invasive strategy. The aim is to evaluate the protective effects of early (on admission) high-dose high-potency statin…
- Trial name
- PRATO-ACS (NCT04087200)
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Centro Cardiopatici Toscani
Acute Coronary Syndromes (ACS), Troponin I
Effect of Point-of-care Analysis of Ultrasensitive Troponin I on Length of Hospital Stay in Patients With Cardiac Chest Pain (POC Troponina)
This clinical study aims to compare two different methods for measuring high-sensitivity troponin I, a key biomarker used to diagnose heart attacks.
- Conditions
- Acute Coronary Syndromes (ACS), Troponin I, Point-of-Care Testing
- Trial name
- POC Troponina (NCT06861582)
- Testing
- Point-of-care ultrasensitive troponin testing, Laboratory-based ultrasensitive troponin testing
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
Acute Coronary Syndromes, ST Elevation Myocardial Infarction
Smartphone AI Assistance for Prehospital ECG Interpretation
Prehospital providers interpret 12-lead electrocardiograms (ECGs) under time pressure and without immediate expert support. Missed acute coronary occlusion - occlusion myocardial infarction (OMI) - delays reperfusion, while false…
- Conditions
- Acute Coronary Syndromes, ST Elevation Myocardial Infarction, Non-ST Elevated Myocardial Infarction, Myocardial Infarction (MI)
- Trial name
- ECG-IA (NCT07810686)
- Testing
- Smartphone large language model assistance (GPT-4o, version-locked)
- Where
- Switzerland
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- École Supérieure de Soins Ambulanciers - College of Higher Education in Prehospital Care
Myocardial Infarction, Acute
Korea Acute Myocardial Infarction Registry
This multicentre observational registry study, the Korea Acute Myocardial Infarction Registry (KAMIR-7), aims to improve long-term prognosis in Korean patients with acute myocardial infarction (AMI) by establishing and operating…
- Trial name
- KAMIR-7 (NCT07409441)
- Where
- 2 sites in South Korea
- Volunteers
- 20,000 people
- Sponsor
- Samsung Medical Center
Stable Angina (SA), Unstable Angina (UA)
Breaking Fasts Ahead of Cardiac Caths
The goal of this clinical trial is to find out whether fasting is necessary before urgent inpatient cardiac catheterizations. For patients presenting with urgent heart-related pain or even mild heart attacks, researchers want to…
- Conditions
- Stable Angina (SA), Unstable Angina (UA), NSTEMI - Non-ST Segment Elevation MI
- Trial name
- BACON-RCT (NCT06996639)
- Testing
- Non-Fasting, Fasting
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of South Florida
Acute Coronary Syndromes (ACS), Coronary Artery Disease (CAD)
"Discovery2" Study of Using MCG at Emergency Departments
The purpose of this research is to collect the magnetic signals from the heart to identify features that may help Emergency Department (ED) doctors differentiate high and low risk patients for heart related chest pain.
- Conditions
- Acute Coronary Syndromes (ACS), Coronary Artery Disease (CAD), Chest Pain, NSTE-ACS (NSTEMI and UA)
- Trial name
- Discovery2 (NCT07822581)
- Testing
- Magnetocardiography
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- SB Technology, Inc.
NSTEMI, NSTEMI - Non-ST Segment Elevation MI
Efficacy of Immediate Versus Staged Complete Revascularization in Patients With NSTE-ACS and Multivessel Disease (FUTURE II)
This is a prospective, multi-center, randomized controlled, open-label, blinded endpoint assessment study. The objective is to compare the 1-year incidence of major adverse cardiovascular and cerebrovascular events (MACCE)…
- Conditions
- NSTEMI, NSTEMI - Non-ST Segment Elevation MI, Non-ST-elevation Acute Coronary Syndrome, NSTE-ACS (NSTEMI and UA)
- Trial name
- NCT07343076
- Testing
- Immediate Complete Revascularization, Staged Complete Revascularization
- Volunteers
- 1,904 people
- Sponsor
- RenJi Hospital
Coronary Arterial Disease (CAD), NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI)
Safety and Effectiveness of the Crystalline Sirolimus-Eluting Device in Patients With Coronary Artery Disease
This prospective, multicenter, post-market observational study aims to evaluate the safety and effectiveness of the crystalline sirolimus-coated balloon (SeQuent® Sirolimus-Coated Balloon) for the treatment of coronary artery…
- Conditions
- Coronary Arterial Disease (CAD), NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI), Stable Angina, Unstable Angina, NSTEMI, Drug Coated Balloon
- Trial name
- SECuRE (NCT07444957)
- Where
- Spain
- Volunteers
- 1,118 people
- Sponsor
- Fundación Interhospitalaria para la Investigación Cardiovascular FIC