Clinical trials: Non-ST-segment Elevation Myocardial Infarction
ST-segment Elevation Myocardial Infarction (STEMI)
Intracoronary rhTNK-tPA Versus Tirofiban in Patients With STEMI and High Thrombus Burden
The goal of this clinical trial is to compare the efficacy and safety of intracoronary rhTNK-tPA or Tirofiban in patients with ST-segment elevation myocardial infarction and high thrombus burden.
- Trial name
- H2-THROMBUS (NCT06769256)
- Testing
- rhTNK-tPA, 4-8 mg, Tirofiban
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
NSTEMI
A Pilot Proof of Concept, Randomized Controlled, Single-Center Study of a Decision Aid Tool for Older Patients Considering LHC as Treatment for NSTEMI
This study will be a single-center, prospective, un-blinded, randomized controlled trial evaluating a decision aid tool for older patients considering left heart catheterization (LHC) as treatment for non-ST elevation myocardial…
- Trial name
- NCT04270630
- Testing
- Shared Decision Aid
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Acute Coronary Syndrome, STEMI
Platelet Inhibition With Ticagrelor 60 mg Versus Ticagrelor 90 mg in Elderly Patients With ACS
Elderly individuals are increasingly represented among patients with acute coronary syndrome (ACS). Dual antiplatelet therapy (DAPT) with aspirin and an oral P2Y12 receptor inhibitor has an established role in the prevention of…
- Conditions
- Acute Coronary Syndrome, STEMI, NSTEMI, Coronary Artery Disease
- Trial name
- PlinytheElder (NCT04739384)
- Testing
- Ticagrelor 90mg, Ticagrelor 60 mg
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Federico II University
Non-ST Elevation Myocardial Infarction (NSTEMI), Acute Coronary Syndrome
Left Atrial Strain for Predicting MACE in NSTEMI
This prospective observational study aims to evaluate whether left atrial reservoir strain, measured by two-dimensional speckle tracking echocardiography, independently predicts 6-month major adverse cardiovascular events (MACE)…
- Conditions
- Non-ST Elevation Myocardial Infarction (NSTEMI), Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- NCT07797634
- Volunteers
- 150 people
- Sponsor
- Assiut University
Unstable Angina, Coronary Atherosclerosis
Serp-1 for the Treatment of Acute Coronary Syndrome
Males and females aged 18-80 years who present with ACS (unstable angina and non ST-elevation MI) defined as one or more episodes of angina lasting at least 5 minutes in the last 24 hours before admission and greater than 0.05 mV…
- Conditions
- Unstable Angina, Coronary Atherosclerosis, Coronary Restenosis
- Trial name
- NCT00243308
- Testing
- Serine proteinase-1 (Serp-1)
- Where
- 8 sites in United States, Canada
- Volunteers
- 72 people
- Sponsor
- Viron Therapeutics Inc
Non ST Segment Elevation Myocardial Infarction
One-hour Diagnostic Algorithm for NSTEMI
Predictable values of the 1-hour algorithm for estimating the concentration of troponin using highly sensitive reagents are 98-100% for excluding myocardial infarction (MI) and 75-80% for identifying this pathology.
- Trial name
- NCT03507270
- Testing
- FABP
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
ST Elevation Myocardial Infarction, Non ST Elevation Myocardial Infarction
Colchicine and Spironolactone in Patients with MI / SYNERGY Stent Registry
The CLEAR SYNERGY trial will study the long term effects of treatments following PCI to treat myocardial infarction. These treatments address both the culprit artery (PCI with SYNERGY stent) as well as the non-culprit arteries…
- Trial name
- CLEAR SYNERGY (NCT03048825)
- Testing
- Colchicine, Spironolactone, SYNERGY Bioabsorbable Polymer Drug-Eluting Stent
- Where
- 109 sites in United States, Australia and 12 more
- Volunteers
- 7,264 people
- Sponsor
- Population Health Research Institute
Coronary Heart Disease, NSTEMI
Bare Metal Stent Versus Drug Coated Balloon With Provisional Stenting in Non-ST-Elevation Myocardial Infarction
The aim of the present trial is to assess the efficacy of the standalone use of SeQuent(R) Please coated balloon compared to a bare metal stent (BMS) in patients with NSTEMI.
- Trial name
- PEPCADNSTEMI (NCT01489449)
- Testing
- Stent, SeQuent(R) Please coated balloon
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- University Hospital, Saarland
Coronary Artery Disease, Angina, Unstable
Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease
The goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, ST-elevation myocardial infarction and unstable angina/NSTEMI, assess the risk factors…
- Conditions
- Coronary Artery Disease, Angina, Unstable, Angina, Stable, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT04163484
- Testing
- Iodinated contrast
- Where
- Russia
- Volunteers
- 156 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Tomography, Optical Coherence, Myocardial Revascularization
The FAST OCT Study
This trial is designed to associate angiography-based fractional flow reserve (3D-angio-based FFR) values with optical coherence tomography findings in pre- and post-percutaneous coronary intervention in patients with non-ST…
- Conditions
- Tomography, Optical Coherence, Myocardial Revascularization, NSTEMI - Non-ST Segment Elevation MI, Unstable Angina
- Trial name
- NCT04683133
- Testing
- Optical coherence tomography assessment
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Cardiac Rehabilitation
The Use of Contextualised Body Data in Cardiac Rehabilitation (CR)
KiCS1 study : Digital health for current hospital- based Cardiac rehabilitation programmes to increase effectiveness and patient outcomes.
- Trial name
- KiCS1 (NCT05492526)
- Testing
- Ki Monitor without feedback, Ki monitor with contextualised data feedback
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Coronary Artery Disease, Unstable Angina
Restore EF Observational Study
A multi-center, prospective, observational, non-interventional single arm, study of the intermediate-term clinical outcomes collected from electronic health records of high-risk patients which have previously undergone standard…
- Conditions
- Coronary Artery Disease, Unstable Angina, Angina, Stable, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- NCT04648306
- Testing
- Prophylactic Impella support for a non-emergent PCI
- Where
- 21 sites in United States
- Volunteers
- 406 people
- Sponsor
- Abiomed Inc.
Non-ST-elevation Myocardial Infarction
ImmeDiate Versus EArLy Invasive Approach in Non-ST-Elevation Myocardial Infarction (IDEAL NSTEMI)
Of estimated 140,000 cases of acute myocardial infarction admitted to hospitals in Germany per year, approximately 50% present with Non-ST-elevation myocardial infarction (NSTEMI).
- Trial name
- IDEAL NSTEMI (NCT00954668)
- Testing
- immediate angiography and revascularization, early invasive angiography
- Where
- Germany
- Sponsor
- University of Leipzig
Cardiac Disease
Triple Antithrombotic Therapy in Cardiac Patients Requiring Revascularization
Aim(s)/Objective(s) To evaluate the safety and efficacy of triple antithrombotic therapy in patients taking DAPT of aspirin and a P2Y12 inhibitor in addition to either a NOAC or warfarin for the prevention of thromboembolic or…
- Trial name
- NCT03889574
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Methodist Health System
STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
Dutch Cangrelor Registry
Cangrelor is a fast and directly acting platelet aggregation inhibitor. It is potentially indicated for several types of patients who are undergoing PCI.
- Conditions
- STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI, Coronary Artery Disease
- Trial name
- NCT04138641
- Testing
- Cangrelor
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Isala
Coronary Artery Disease
SELUTION 4 De Novo Small Vessel IDE Trial
Prospective, randomized controlled, single-blind, multicenter, clinical trial to demonstrate the safety and efficacy of the SELUTION SLR 014 PTCA DEB for treatment of de novo lesions in small coronary vessels, defined as…
- Trial name
- NCT05946629
- Testing
- PCI with SELUTION SLR DCB, PCI with FDA approved "-limus" DES
- Where
- 70 sites in United States, Belgium and 1 more
- Volunteers
- 960 people
- Sponsor
- M.A. Med Alliance S.A.
Acute Coronary Syndrome
A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome
Ticagrelor is a new, reversible binding, anti-platelet medication. Anti-platelet medications work to prevent the formation of blood clots.
- Trial name
- PLATO (NCT00391872)
- Testing
- Ticagrelor, Clopidogrel
- Where
- 672 sites in United States, Argentina and 42 more
- Volunteers
- 18,624 people
- Sponsor
- AstraZeneca
Myocardial Infarction, Acute Coronary Syndrome
Identification of Risk Factors for Acute Coronary Events by OCT After STEMI and NSTEMI in Patients With Residual Non-flow Limiting Lesions
The objective of this study is to compare the clinical outcome of Non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) patients with non-obstructive, non-culprit coronary lesions and…
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- PECTUS-obs (NCT03857971)
- Testing
- Coronary Optical Coherence tomography
- Where
- Netherlands
- Volunteers
- 438 people
- Sponsor
- Radboud University Medical Center
Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI
Metabolomics and Microbiomics in Cardiovascular Diseases
"MEtabolomics and MicrObiomics in caRdIovAscular diseases Mannheim (MEMORIAM) " is a single-center, prospective and observational study investigating to identify disease-specific metabolic, respectively microbiomic, patterns of…
- Conditions
- Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI, STEMI - ST Elevation Myocardial Infarction, Myocardial Infarction, Acute
- Trial name
- MEMORIA (NCT04146701)
- Testing
- Blood draw
- Where
- Germany
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
NSTEMI
COlchicine Improve EnDothElial Function in Non ST Elevation Myocardial Infarction Patients
Colchicine has antiinflammatory properties. It has been shown to be effective in improving outcome in stable coronary disease. The exact mechanism is unclear.
- Trial name
- CODEN (NCT02095522)
- Testing
- Colchicine
- Where
- 2 sites in Israel
- Sponsor
- Tel-Aviv Sourasky Medical Center