Clinical trials: Non-infectious Uveitis
Uveitis
Multicenter Uveitis Steroid Treatment (MUST) Trial
The purpose of this study is to compare the effectiveness of standardized systemic therapy versus fluocinolone acetonide implant therapy for the treatment of severe cases of non-infectious intermediate uveitis, posterior uveitis…
- Trial name
- MUST (NCT00132691)
- Testing
- fluocinolone acetonide intraocular implant, oral corticosteroid with immunosuppressive agents as needed
- Where
- 23 sites in United States, Australia and 1 more
- Volunteers
- 255 people
- Sponsor
- JHSPH Center for Clinical Trials
Non-infectious Anterior Uveitis
Evaluation of DEXTENZA in the Management of Pain and Inflammation in Patients With Anterior Uveitis Compared to Standard of Care Topical Corticosteroids
This a prospective study review of the clinical efficacy of DEXTENZA for the treatment of anterior uveitis compared to the standard of care topical corticosteroid treatment
- Trial name
- DiverT (NCT04426734)
- Testing
- Dextenza Dexamethasone Implant, Topical Prednisolone Acetate 1%
- Volunteers
- 30 people
- Sponsor
- New England Retina Associates
Non-infectious Intermediate, Posterior and Panuveitis
Post-marketing Surveillance Study of Adalimumab (Humira®) for Non-infectious Intermediate, Posterior, or Panuveitis Patients
The objective of this study is to evaluate the safety and effectiveness of Humira® (Adalimumab) for the treatment of non-infectious intermediate, posterior, or panuveitis patients under a routine treatment practice.
- Trial name
- NCT03339102
- Where
- 17 sites in South Korea
- Volunteers
- 158 people
- Sponsor
- AbbVie
Uveitis
PANDA-ASOCT: Paediatric Anterior Uveitis Detection With Automated Image Analysis Using ASOCT
Uveitis is an inflammation inside the eye. Although rare, it is an important auto-inflammatory eye condition that affect children and young people (CYP).
- Trial name
- PANDA (NCT07813598)
- Testing
- Slit Lamp Examination, Anterior segment ocular coherence tomography (ASOCT)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Non-Infectious Anterior Uveitis
Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis
The purpose of this study is to determine the efficacy, safety, and tolerability of dexamethasone sodium phosphate Visulex (DSP-Visulex) after repeated-dose administration in patients with acute anterior uveitis.
- Trial name
- NCT02309385
- Testing
- 8% Dexamethasone Sodium Phosphate - Visulex, 15% Dexamethasone Sodium Phosphate - Visulex, Prednisolone Acetate (1%) Eye Drops
- Where
- 6 sites in United States
- Volunteers
- 44 people
- Sponsor
- Aciont Inc
Uveitis Posterior Non-Infectious, Uveitis, Intermediate
POC Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Active Intermediate, Posterior, or Pan NIU
This is a multi-center, randomized, double-masked, proof-of-concept study in patients with Active Noninfectious Intermediate, Posterior, or Panuveitis.
- Conditions
- Uveitis Posterior Non-Infectious, Uveitis, Intermediate, Noninfectious Panuveitis
- Trial name
- OPTYK-1 (NCT05953688)
- Testing
- ESK-001
- Where
- 17 sites in United States
- Volunteers
- 36 people
- Sponsor
- Alumis Inc
Non Infectious Uveitis
Treatment FOr Corticosteroid Dependent UveitiS
FOCUS is the first prospective randomized study comparing standard of care (mycophenolate mofetil) to adalimumab in recently active non infectious uveitis (NIU) with steroid dependency.
- Trial name
- FOCUS (NCT06258915)
- Testing
- Adalimumab, Mycophenolate Mofetil
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Uveitis Posterior Non-Infectious, Inflammation Eye
Targeting Immunosuppressive Treatment for Non-infectious Uveitis Using Aqueous Humor Cytokine Profiles
This multicenter, prospective, interventional, non-pharmacological study aims to investigate whether the intraocular cytokine profile is associated with the therapeutic response to immunosuppressive drugs in patients with…
- Conditions
- Uveitis Posterior Non-Infectious, Inflammation Eye, Uveitis, Uveitis, Anterior
- Trial name
- PRIN_NIU (NCT07262437)
- Testing
- to improve clinical practice in treatment of non-infective uveitis
- Where
- 3 sites in Italy
- Volunteers
- 220 people
- Sponsor
- University of Milan
Uveitis, Posterior, Uveitis, Intermediate
A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis
The objective of this study is to evaluate the safety and efficacy of LX211 as therapy in subjects with active non-infectious uveitis
- Conditions
- Uveitis, Posterior, Uveitis, Intermediate, Panuveitis
- Trial name
- LUMINATE (NCT00404612)
- Testing
- LX211
- Where
- 41 sites in United States, Austria and 5 more
- Volunteers
- 218 people
- Sponsor
- Lux Biosciences, Inc.
Uveitis, Intermediate Uveitis
Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis
This study is designed to determine the safety and tolerability of a single microinjection of triamcinolone acetonide (TRIESENCE®) into the suprachoroidal space (SCS) of patients who have non-infectious uveitis.
- Conditions
- Uveitis, Intermediate Uveitis, Posterior Uveitis, Panuveitis
- Trial name
- NCT01789320
- Testing
- triamcinolone acetonide (Triesence®)
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Clearside Biomedical, Inc.
Non-infectious Intermediate Posterior- or Pan-uveitis
A Study to Assess Change in Disease Activity and Adverse Events of Adalimumab in Chinese Participants Requiring High Dose Corticosteroids for Active Non-Infectious Intermediate, Posterior, or Pan-Uveitis
Non-infectious intermediate-, posterior- and pan-uveitis (NIIPPU) are sight threatening diseases with a high patient burden and negative impact on quality of life.
- Trial name
- NCT05414201
- Testing
- Adalimumab
- Where
- 7 sites in China
- Volunteers
- 87 people
- Sponsor
- AbbVie
Uveitis, Intermediate Uveitis
Intravitreal Sirolimus as Therapeutic Approach to Uveitis
The purpose of this study is to find out about the safety and effectiveness of two different doses the study drug, sirolimus, administered intravitreally in patients with uveitis.
- Conditions
- Uveitis, Intermediate Uveitis, Posterior Uveitis, Panuveitis
- Trial name
- SAVE-2 (NCT01280669)
- Testing
- Intravitreal injection 440mcg, Intravitreal injection of sirolimus 880mcg
- Where
- United States
- Sponsor
- Stanford University
Uveitis, Intermediate
Myfortic for the Treatment of Non-infectious Intermediate Uveitis
The objective of this clinical trial is to evaluate the efficacy, safety and tolerability of enteric-coated mycophenolate sodium (Myfortic®) in combination with low-dose corticosteroids (Decortin H®) compared to a monotherapy…
- Trial name
- MYCUV-IIT02 (NCT01092533)
- Testing
- Myfortic, Decortin
- Where
- 5 sites in Germany
- Volunteers
- 44 people
- Sponsor
- STZ eyetrial
Pharmacokinetics, Safety Issues
A Clinical Study With Adalimumab Biosimilar
The study aims to evaluate the pharmacokinetic profile, safety profile, and immunogenic potential of adalimumab of a new citrate-free formulation of adalimumab (Adalimumab Richmond) [Test Product] vs.
- Trial name
- NCT06291948
- Testing
- Humira® (adalimumab) AC Pen [Reference Product], Adalimumab Richmond [Test Product]
- Where
- Argentina
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Laboratorios Richmond S.A.C.I.F.
Non-infectious Anterior Uveitis
A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis
This is a randomized, multi-center, investigator masked, comparator controlled study. The purpose of this study is to determine the efficacy and safety of NS2 in patients with non-infectious acute anterior uveitis.
- Trial name
- NCT02406209
- Testing
- NS2, Prednisolone acetate ophthalmic suspension (1%)
- Where
- 15 sites in United States
- Volunteers
- 45 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Non-infectious Intermediate Uveitis, Non-infectious Posterior Uveitis
A Study of Brepocitinib in Adults With Active Non-Infectious Non-Anterior Uveitis
This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with active intermediate, posterior, or pan non-infectious uveitis (NIU).
- Conditions
- Non-infectious Intermediate Uveitis, Non-infectious Posterior Uveitis, Non-infectious Pan Uveitis
- Trial name
- NEPTUNE (NCT05523765)
- Testing
- Brepocitinib
- Where
- 15 sites in United States
- Volunteers
- 26 people
- Sponsor
- Priovant Therapeutics, Inc.
Non-infectious Anterior Uveitis
A Study to Evaluate TRS01 Eye Drops in Participants With Active Non-infectious Anterior Uveitis
The objective of this study is to evaluate the safety of TRS01 eye drops in participants with active non-infectious anterior uveitis .
- Trial name
- NCT04222712
- Testing
- TRS01 eye drops
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Tarsier Pharma
Uveitis
Study to Evaluate the Long Term Use of Treatment With AIN457 for Uveitis
This study will provide patients who have completed the AIN457 Phase II and Phase III clinical trials in non-infectious uveitis continued access to treatment with AIN457 while collecting safety data and information on long term…
- Trial name
- SUPPORT (NCT01327664)
- Testing
- AIN457
- Sponsor
- Novartis Pharmaceuticals
Uveitis
Efficacy and Safety of Adalimumab in Patients With Active Uveitis
A study comparing the safety and efficacy of adalimumab compared with placebo in patients with active uveitis.
- Trial name
- VISUAL l (NCT01138657)
- Testing
- Adalimumab, Prednisone
- Volunteers
- 239 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Uveitis
ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study)
The study aims to evaluate the potential role of ACTH gel in the management of non-infectious uveitis.
- Trial name
- ACTHAR (NCT02931175)
- Testing
- ACTH gel
- Where
- 7 sites in United States
- Volunteers
- 28 people
- Sponsor
- Quan Dong Nguyen