Clinical trials: Non-invasive
Prostate Cancer Aggressiveness
Active Surveillance SNEP Assay Registry Trial for Prostate Cancer
A multi-center, prospective active surveillance registry trial assessing the performance of a non-invasive blood test for indolent prostate cancer disease management.
- Trial name
- NCT04052048
- Testing
- Subtraction Normalized Expression of Phagocytes Blood Test
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Immunis.AI
Myeloproliferative Disorder, Essential Thrombocythemia
Pilot Study for the Development of a Diagnostic Score to Differentiate Myeloproliferative Neoplasms.
Prospective study for the development of a non-invasive score for differentiating prefibrotic myelofibrosis from essential thrombocytosis and overt myelofibrosis.
- Conditions
- Myeloproliferative Disorder, Essential Thrombocythemia, Primary Myelofibrosis, Prefibrotic Stage, Primary Myelofibrosis, Fibrotic Stage
- Trial name
- BioScoreSMP (NCT03869476)
- Testing
- Non-invasive diagnosis score
- Where
- 2 sites in France
- Volunteers
- 133 people
- Sponsor
- University Hospital, Angers
Motor Neuron Disease
EncoreAnywhere Use in Motor Neurone Disease
Motor neurone disease is a progressive incurable disease causing weakness and paralysis of muscles. Respiratory failure is the most common cause of death in motor neurone disease.
- Trial name
- NCT03154450
- Testing
- EncoreAnywhere with data available to review, EncoreAnywhere with no data available to review
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Myocardial Ischemia
Assessment of Coronary Stenoses Using Coronary CT-angiography and Non-invasive Fractional Flow Reserve Measurement.
The purpose of this study is to determine whether a novel non-invasive method to estimate coronary blood flow (FFRct) is applicable to evaluate the functional significance of coronary stenoses in non-culprit vessels in a…
- Trial name
- NCT01739075
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Aarhus
Pulmonary Embolism
High-Flow Nasal Cannula Versus Non-Invasive Ventilation for Acute Respiratory Failure in Pulmonary Embolism.
Acute pulmonary embolism (PE) often causes hypoxemic respiratory failure through ventilation-perfusion mismatch and right-ventricular (RV) strain; supportive oxygenation plus prompt anticoagulation are crucial to care .
- Trial name
- NCT07381712
- Testing
- High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Urinary Bladder Neoplasms, Sexual Dysfunction, Physiological
Sexual Function in Patients Suspected of Non-muscle Invasive Bladder Cancer
The purpose of the study is to investigate sexual function in patients suspected of non muscle invasive bladder cancer (NMIBC). The investigators hypothesis is that reduced sexual function is underdiagnosed in patients with…
- Conditions
- Urinary Bladder Neoplasms, Sexual Dysfunction, Physiological, Sexual Dysfunctions, Psychological, Erectile Dysfunction
- Trial name
- NCT02381912
- Testing
- EORTC QLQ-C30 and EORTC BLS-24 questionnaire
- Where
- Denmark
- Volunteers
- 210 people
- Sponsor
- Herlev Hospital
Acute Coronary Syndrome, Myocardial Ischemia
Non Invasive Extra-corporeal ECG Signal Analysis Algorithm( NID Algorithm) for Myocardial Ischemia
The NIA algorithm is similar to the traditional 12-lead ECG equipment. By analyzing patient data, NIA algorithm provides more detailed results compared to traditional 12-lead ECG.
- Trial name
- NCT02579512
- Testing
- Extra-corporeal ECG signal analysis
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Taichung Veterans General Hospital
Dysphagia, Stroke
Fostering Eating After Stroke With Transcranial Direct Current Stimulation
Swallowing difficulties are common after a stroke and can lead to serious complications like pneumonia and malnutrition. Unfortunately, there are no effective treatment for improving swallowing in stroke patients.
- Trial name
- FEASt (NCT01919112)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Reduction of Unwanted Fat
Non-Invasive Cooling of Fat Cells
The purpose of this study is to evaluate a non-invasive cooling device to determine if cold exposure will consistently result in a reduction of subcutaneous fat.
- Trial name
- NCT00762437
- Testing
- Zeltiq Dermal Cooling Device
- Where
- 11 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Pain, Anesthesia
Impact of Intraoperative Non-invasive Analgesia Monitoring Using Nociception Level Index on Patient Management
This prospective randomised clinical trial aims to assess the impact of intraoperative nociception monitoring using NOL on anesthetic management during major abdominal surgery.
- Conditions
- Pain, Anesthesia, Perioperative Care
- Trial name
- NCT06804434
- Testing
- Lidocaine Intravenous Infusion, NOL
- Where
- Romania
- Volunteers
- 160 people
- Sponsor
- Osoian Cristiana
Prematurity; Extreme, Feeding Patterns
To Determine the Best Feeding Practice in Preterm Infants on Non-invasive Ventilation.
To evaluate the duration to reach full feeds by comparing continuous gavage feeds versus bolus feeds in preterm infants who are on non-invasive respiratory support (RAM cannula - short binasal prongs).
- Conditions
- Prematurity; Extreme, Feeding Patterns, Ventilator Lung; Newborn
- Trial name
- NCT05824377
- Testing
- Continuous Feeds, Intermittent Bolus Feeds
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Rajeev Kumar
Respiratory Failure, Re-intubation Rate
High Flow Nasal Cannula Versus Non Invasive Positive Pressure Ventilation in Reducing The Rate of Reintubation
This is study aim to compare between high flow nasal canula (HFNC) and non invasive positive pressure ventilation (NIPPV) in reducing the rate of reintubation in mechanically ventilated patient with successful weaning
- Trial name
- NCT06029699
- Testing
- high flow nasal cannula, non invasive positive pressure ventilation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Light Sedation, Mechanical Ventilation
Long-term Sedation With Remimazolam Besylate in Critically Ill Patients
A randomized non-inferior trial comparing remimazolam besylate with propofol for long-term sedation during invasive mechanical ventilation in critically ill patients
- Trial name
- LOSREB (NCT05555667)
- Testing
- Remimazolam besylate, Propofol
- Where
- China
- Volunteers
- 728 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Alzheimer Disease
Non-invasive Blood-brain Barrier Opening in Alzheimer's Disease Patients Using Focused Ultrasound
The purpose of this study is to test a new technique that may, in the future, help deliver medications to the brain of people with Alzheimer's disease.
- Trial name
- NCT04118764
- Testing
- Neuronavigation-guided single-element focused ultrasound transducer, Definity, Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Columbia University
Ischemic Heart Disease
Evaluation of Integrated Cardiac Imaging in Ischemic Heart Disease
Main purpose of the study: To comparatively assess the diagnostic performance of non invasive anatomical and functional imaging modalities to detect significant obstructive coronary artery disease as demonstrated at invasive…
- Trial name
- EVINCI (NCT00979199)
- Testing
- Non invasive cardiac imaging
- Where
- 16 sites in Finland, France and 7 more
- Volunteers
- 697 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
Pulmonary Hypertension
Acute Exposure of Simulated Hypoxia on Cardiac Output
Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to simulated altitude (FIO2: 15.1% = equivalent to 2500m above sea level) on non-invasive cardiac output assessments by…
- Trial name
- NCT03574675
- Testing
- Simulated Altitude (FiO2: 15.1)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Non-invasive Mechanical Ventilation as a Rescue Therapy to Relieve Dyspnea in Patients With Stable Severe COPD
The purpose of this study is to determine whether non-invasive mechanical ventilation(NIV), playing the role as a rescue therapy , are effective in relieving exertional dyspnea in stable severe COPD patients.
- Trial name
- NCT02012101
- Testing
- niv plus oxygen therapy, oxygen therapy
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Non-melanoma Skin Cancer
Imaging Methods for the Diagnosis of Non-melanoma Skin Cancer and Its Precursors
Prospective, unicentric study that examines if imaging devices like total body photography, dermoscopy, optical coherence tomography and in vivo reflectance confocal microscopy as an addition to clinical examination lead to a…
- Trial name
- NCT05842421
- Testing
- optical coherence tomography, in vivo reflectance confocal microscopy, 3D total body photography
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Technische Universität Dresden
Healthy
Non-invasive Measurement of Glucose with Advanced Spectroscopy Techniques and Machine Learning Models
Primary aim of this pilot study is to provide evidence for a non-invasive, continuous, and transcutaneous measurement method to determine blood glucose levels robustly and accurately.
- Trial name
- NCT06406075
- Testing
- Lab demo 1.0
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Liom Health AG
Prostatic Neoplasms, Esophageal Neoplasms
Tumor Hypoxia With HX4 PET in Several Diseases
Regulation of tissue oxygen homeostasis is critical for cell function, proliferation and survival. Evidence for this continues to accumulate along with our understanding of the complex oxygen-sensing pathways present within…
- Conditions
- Prostatic Neoplasms, Esophageal Neoplasms, Neoplasm Metastases, Brain, Rectal Neoplasms
- Trial name
- HX4 SD (NCT02584400)
- Testing
- Injection with the hypoxia tracer [18F]HX4,
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- Maastricht Radiation Oncology
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