Clinical trials: Non-invasive
Glomerulonephritis Acute
Urinary T Cell Biomarker for Prediction in ANCA Glomerulonephritis
Urinary T lymphocytes may be predictive for clinical outcome in patients with ANCA associated glomerulonephritis (ANCA GN). The investigators hypothesize that the amount of CD4+ effector/memory T cells in urine at time of…
- Trial name
- NCT04320667
- Testing
- Flow cytometry analysis of urine samples
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 79 people
- Sponsor
- Charite University, Berlin, Germany
Stress, Physiological, Sport Injury
Immediate Effect of Non-invasive Auricular Acupoint Stimulation for the Performance and the Meridian Activities of Archery Athletes
In our hypothesis, auricular acupoint stimulation might improve the attention and heart rate variability in archery athletes. The meridian activities regarding the attention and action in Chinese medicine systems might be…
- Trial name
- NCT04637607
- Testing
- Auricular acupoints stimulation
- Where
- Taiwan
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Biomarker
Validation Study of a Serum-miRNA Signature in Glioma Patients.
Prospective, multicenter, noninterventional, nonprofit study of a cohort of patients with glioma, aimed at validating miRNA-serum signatures associated with IDH1 status and prognosis, as reliable, specific and sensitive…
- Trial name
- NCT06178692
- Testing
- Validation of miRNA-serum signatures associated with IDH1 status
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Regina Elena Cancer Institute
Healthy Volunteer
TVNS and Upper GI Motility
To study the impact of tVNS on gut motor function, with regards to its potential to induce phase III contractions in the upper GI tract, in healthy subjects.
- Trial name
- NCT06700200
- Testing
- taVNS
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Surgery, Trauma to the Abdomen
Non Invasive Ventilation in Abdominal Postoperative Period
Acute respiratory failure may occur early in the postoperative course, requiring endotracheal intubation and mechanical ventilation in selected patients, thus increasing morbidity and mortality and prolonging intensive care unit…
- Conditions
- Surgery, Trauma to the Abdomen, Acute Respiratory Failure
- Trial name
- NIVAS (NCT01971892)
- Testing
- Non Invasive ventilation (facial mask and NIV ventilator), Standard oxygen therapy with facial mask
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
High Risk Non-Muscle Invasive Bladder Urothelial Carcinoma, Stage 0a Bladder Cancer AJCC v8
IDO and PD-L1 Peptide Based Immune-Modulatory Therapeutic (IO102-IO103) in Combination With Pembrolizumab for BCG-Unresponsive or Intolerant, Non-Muscle Invasive Bladder Cancer
This phase I trial tests the safety and side effects of a PD-L1/IDO peptide vaccine (IO102-IO103) in combination with pembrolizumab in treating patients with non-muscle invasive bladder cancer.
- Conditions
- High Risk Non-Muscle Invasive Bladder Urothelial Carcinoma, Stage 0a Bladder Cancer AJCC v8, Stage 0is Bladder Cancer AJCC v8, Stage I Bladder Cancer AJCC v8
- Trial name
- NCT05843448
- Testing
- PD-L1/IDO Peptide Vaccine, Pembrolizumab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, Davis
Burn Injury
Effect of Non-Invasive Vagus Nerve Stimulation in Burn Patients
This study will evaluate the effects of non-invasive vagus nerve stimulation (nVNS) in adults with burn injuries. Burn patients may experience anxiety, poor sleep quality, pain, itching, and changes in autonomic nervous system…
- Trial name
- NCT07566871
- Testing
- Non-Invasive Vagus Nerve Stimulation, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fenerbahce University
Respiratory Distress Syndrome
Is Synchronization More Effective During Noninvasive Ventilation in Immediately Extubated Preterm Infants?
The purpose of this study is the examination of the hypothesis that synchronized nasal IMV as compared to non-synchronized nasal IMV will decrease breathing effort in preterm infants immediately after extubation when recovering…
- Trial name
- N_SIMV (NCT01664832)
- Testing
- S-nIMV
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Prof. Dr. Helmut Hummler
Chronic Obstructive Pulmonary Disease
Initiation of Long-term Non-invasive Ventilation in COPD
Rationale: Application of long-term non-invasive ventilation (NIV) in stable chronic obstructive pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure (CHRF) has recently been shown to improve survival…
- Trial name
- RECONSIDER (NCT02652559)
- Testing
- Transcutaneous measurements of PCO2, Telemonitoring, EMG
- Where
- Netherlands
- Volunteers
- 67 people
- Sponsor
- University Medical Center Groningen
Blood Pressure, Cardiovascular Risk Factor
Non-Invasive Aortic Ambulatory Blood Pressure Monitoring for The Detection of Target Organ Damage in The Chinese Population
This study is a sub-investigation of SAFAR study. Consecutive patients with established hypertension (treated or untreated with antihypertensive drugs) or with suspected hypertension are recruited and their 24-hour brachial and…
- Conditions
- Blood Pressure, Cardiovascular Risk Factor, Target Organ Damage, Cardiovascular Events
- Trial name
- SAFAR-China (NCT03154203)
- Testing
- No intervention in this study
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Lung Cancer
Oral Microbiome Diagnostics of Lung Cancer
The study aims to develop a deep learning-based diagnostic method for lung cancer using the oral microbiome. This innovative approach involves establishing an observational cohort of 576 individuals, including lung cancer…
- Trial name
- NCT06270992
- Testing
- NCCN (National Comprehensive Cancer Network) diagnosis
- Where
- Turkey (Türkiye)
- Volunteers
- 676 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Brain Tumor
Non-invasive Brain Tumor Molecular Diagnostics and Monitoring
This prospective multicenter study aims to enroll GBM patients who will undergo repeated assessments (preoperatively and 3 months post-surgery) to detect circulating tumor cells and analyze the transcriptomic profiles of EVs in…
- Trial name
- NCT06501521
- Testing
- Diagnostic test
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Non-invasive Brain Stimulation, Methodologic Study
Closed-loop Non-invasive Brain Stiumlation
Transcranial magnetic stimulation (TMS) is a widely used tool for exploring brain function in humans (Siebner et al. et al., 2022), which has led to new therapeutics for various psychiatric and neurological disorders (Lefaucheur…
- Trial name
- CLOSEDLOOP (NCT06600217)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Blood Pressure Measurement, Blood Pressure
NIBP Accuracy Study for Adult Subject Populations
The purpose of this study is to collect NIBP and invasive aortic pressure data from the clinical setting.
- Trial name
- NCT07697950
- Testing
- NIBP Measurement
- Where
- Finland
- Volunteers
- 130 people
- Sponsor
- GE Healthcare
Cardiac Transplant Rejection
A Pilot Study Evaluating the Potential of 18F Fluorodeoxyglucose PET-CT Imaging in Diagnosing Cardiac Rejection.
This pilot study aims to assess whether 18F-FDG PET CT imaging has the potential in diagnosing cardiac rejection. The investigators aim to recruit 20 heart transplant subjects within two groups of 10 subjects each.
- Trial name
- NCT06519240
- Testing
- 18F-Fluorodeoxyglucose Positron Emission Tomography-computed Tomography (18F-FDG PET CT)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Healthy
Brain State-dependent Stimulation to Improve Movement
Repetitive transcranial magnetic stimulation (rTMS) is a powerful tool to non-invasively modulate brain circuits, brain plasticity, and behavior.
- Trial name
- BrainSTIM (NCT05103176)
- Testing
- TMS, Object directed grasping
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Bronchiolitis, Respiratory Distress
Interest of Non Invasive Ventilation Versus Oxygen During the Intial Managment of Infant With Bronchiolitis
The purpose of the study is to evaluate, in a prospective way, the clinical, the manometric an gazometric benefit of non-invasive ventilation (VNI), (INFANTFLOW [EME, Brighton, England]) during bronchiolitis of the infant…
- Trial name
- NCT00513890
- Testing
- Infantflow [EME, Brighton, England]
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Montpellier
Neonatal Pain, Retinopathy of Prematurity (ROP)
Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants
The goal of this clinical trial is to learn whether intranasal fentanyl (a pain medicine given as a nasal spray) can reduce pain and is safe to use during routine eye examinations for retinopathy of prematurity (ROP) in preterm…
- Conditions
- Neonatal Pain, Retinopathy of Prematurity (ROP), Pain Management, Infant, Premature
- Trial name
- FIREFLY (NCT07112430)
- Testing
- Fentanyl Citrate (Intranasal)
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Marsha Campbell-Yeo
Anterior Cruciate Ligament Reconstruction Rehabilitation, Quadriceps Muscle Function
Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction
After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles.
- Trial name
- NCT07128602
- Testing
- active transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Arcadia University
Ventricular Tachycardia, Cardiomyopathies
Radiotherapy vs Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease
The goal of this randomized clinical trial is to test the efficacy of stereotactic body radiation therapy (SBRT) in treating ventricular tachycardia (VT) in patients with advanced structural heart disease.
- Conditions
- Ventricular Tachycardia, Cardiomyopathies, Arrhythmias, Cardiac, Ventricular Arrythmia
- Trial name
- RadioAblate-VT (NCT06360939)
- Testing
- SBRT, CA
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
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