Clinical trials: Non-invasive
Resistance Exercise, Physical Inactivity
Modified Breath Test to Determine Anabolic Sensitivity Across Physical Activity States
Developing tools to detect when our bodies are more resistant towards protein synthesis is valuable for identification of when someone may be at risk of losing body or muscle mass such as with aging or certain diseases.
- Conditions
- Resistance Exercise, Physical Inactivity, Amino Acids, Dietary Protein
- Trial name
- BTLP (NCT06209424)
- Testing
- Habitual Activity, Step-Reduction, Resistance Exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Non-Invasive Blood Pressure
SuperSTAT Noninvasive Blood Pressure Monitor Evaluation
The accuracy and/or performance of the GE DINAMAP noninvasive blood pressure (NIBP) monitors may be improved with modifications in software and/or hardware monitoring techniques and/or accessories.
- Trial name
- NCT00603486
- Testing
- GE DINAMAP with SuperSTAT algorithm monitor
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Bladder (Urothelial, Transitional Cell) Cancer, NMIBC
DV+BCG in HER2-Expressing, BCG-Naïve High-Risk NMIBC
The purpose of this study is to learn about the safety and effects of the study medicine (Disitamab Vedotin) in people with non-muscle invasive bladder cancer.
- Trial name
- HERO (NCT07207824)
- Testing
- Active Comparator: BCG induction and maintenance, DV + BCG induction and maintenance
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Fudan University
Bladder Cancer
Assessement of the Concordance of Genomic Alterations Between Urine and Tissue in High-Risk NMIBC Patients
The analysis of cell-free tumor DNA (cfDNA) in plasma has emerged as a clinically relevant predictive and prognostic biomarker in several metastatic solid malignancies, and even now represents standard-of-care for prescription of…
- Trial name
- ALU (NCT04412070)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hopital Foch
COPD, Non-invasive Ventilation
Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving Carbon Dioxide Clearance in AECOPD Patients
High-frequency oscillatory ventilation (HFOV), as an ideal lung-protecting ventilation method, has been gradually used in neonatal critical care treatment, and is currently recommended as a rescue method for neonatal acute…
- Trial name
- NCT05435183
- Testing
- Non-invasive high-frequency oscillatory ventilation, Noninvasive Bilevel Positive Pressure Ventilation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Baseline, Hemodilution
Performance of Non-Invasive Monitors During ANH
The aim of this study is to assess the responsiveness of the standard minimally invasive hemodynamic monitors used in the operating room to known changes in the intravascular volume status that occur during blood removal and…
- Trial name
- NCT02179827
- Where
- United States
- Sponsor
- University of California, Davis
Children With Heart Transplants
Tissue Doppler Echo Imaging of Heart Function After Transplant
There are many children born with Congenital Heart Disease. Many of these children have to undergo surgical procedures to correct the problem. Some patients must eventually get a new heart.
- Trial name
- NCT00208650
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Emory University
Acute Respiratory Failure, Acute-on-chronic Respiratory Failure
VICOR Study-High Frequency Chest Wall Oscillations (HFCWO) in Patients With Acute Respiratory Failure and Hypersecretion
The study aims to evaluates if the treatment with HFCWO Via The Vest® Airway Clearance System, in addition to standard care in critically ill patients admitted in the Respiratory Intensive Care Unit for acute respiratory failure…
- Conditions
- Acute Respiratory Failure, Acute-on-chronic Respiratory Failure, Airway Clearance Impairment
- Trial name
- VICOR2 (NCT05751707)
- Testing
- High Frequency Chest Wall Oscillations via The Vest® Airway Clearance System
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Raffaele Scala
Primary Open Angle Glaucoma, Open Angle Glaucoma
Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy
The goal of this clinical trial is to show non-inferiority of the MIMS® device/procedure with Mitomycin-C, in terms of its surgical success rate, compared to trabeculectomy with Mitomycin-C in subjects diagnosed with primary open…
- Trial name
- NCT06313749
- Testing
- Minimally Invasive Micro Sclerostomy Device
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Sanoculis Ltd
Non-Small Cell Lung Cancer
Noninvasive vs. Invasive Lung Evaluation
Tumor derived cell free DNA (cfDNA) is increasingly used in the clinic to obtain genotype information about lung cancer, but its concordance with concurrent tumor-derived sequenced data is not known.
- Trial name
- NILE (NCT03615443)
- Testing
- Guardant360
- Volunteers
- 306 people
- Sponsor
- Guardant Health, Inc.
Ventricular Tachycardia, Ventricular Arrhythmias
CARA-VT: a Dosimetric in Silico Study
Ventricular tachycardia (VT) is a potentially deadly condition, common in patients with structural heart disease or dilated cardiomyopathy.
- Trial name
- CARA-VT (NCT07590908)
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Non Muscle Invasive Bladder Cancer
Efficacy of Gemcitabine Submucosal Injection for Preventing Recurrence in Intermediate- and High-Risk Non-Muscle-Invasive Bladder Cancer: A Randomized Trial
Bladder cancer is the most common malignant tumor of the urinary system in China, and its incidence has been increasing year by year.
- Trial name
- GEM-IR-NMIBC (NCT07198451)
- Testing
- Gemcitabine Submucosal Injection, Gemcitabine Intravesical Instillation
- Volunteers
- 320 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Cardiac Disease
Evaluation of NICOM (Bioreactance) for the Non-invasive Determination of Cardiac Output
Cardiac output (CO) is an important parameter in the diagnosis and therapy of cardiac diseases. The current standard methods for the determination of CO, however, are either invasive (e.g.
- Trial name
- NCT02331329
- Testing
- NICOM cardiac output measurement, Cardiac MRT cardiac output measurement
- Volunteers
- 41 people
- Sponsor
- Universitätsmedizin Mannheim
Core Body Temperature in Healthy Subjects, Immune Response to mRNA COVID-19 Vaccination
Fever Tracking Study
The aim of this study is to investigate the feasibility of continuous fever tracking of participants having fever symptoms in a home setting, using a core body temperature (CBT) sensor.
- Trial name
- NCT05475067
- Where
- Switzerland
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Respiration Disorders
Multicenter Prospective Observational Study on Diaphragmatic Function Assessment by Ultrasound in Patients With Acute Respiratory Failure Receiving Non-invasive Mechanical Ventilation or High Flow Nasal Canula
The primary goal of this study is to assess diaphragm function in patients with acute respiratory failure before and during the use of high-flow oxygen and/or non-invasive breathing support.
- Trial name
- DIAFUSION (NCT06892912)
- Testing
- Diaphragmatic ultrasound
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Foro Internacional en Cuidado Crítico
Subcutaneous Fat
Clinical Investigation of Non Invasive Fat Reduction
The purpose of this study is to compare non invasive treatments using a YAG and Didode Laser to reduce the volume of fat.
- Trial name
- NCT01842802
- Testing
- Diode Laser, YAG laser
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Cynosure, Inc.
Respiratory Failure
Clinical Assessment Method in Patients Using Non-invasive Ventilation
This is an observational study of recording the respiratory parameters of patients when receiving non-invasive ventilation and analyze the relationship between those parameters and clinical outcomes.
- Trial name
- NCT04053777
- Testing
- non-invasive ventilation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Intra-amniotic Infection
Non-invasive Test to Detect Intra-amniotic Infection in Women With Preterm Labor and Intact Amniotic Membranes
The purpose of this study is to collect clinical specimens and corresponding clinical data to develop a non-invasive test for detection of intra-amniotic infection and prediction of preterm birth in women and intact amniotic…
- Trial name
- IAI (NCT00700219)
- Where
- 21 sites in United States
- Volunteers
- 900 people
- Sponsor
- ProteoGenix, Inc.
Nasolabial Fold Correction, Facial Aging
Bridging Technique Validation for Nasolabial Folds JN-BRIDGE-1
The goal of this clinical study is to learn whether the Bridging Technique can safely and effectively treat nasolabial folds (NLF, also known as smile lines) in adults.
- Conditions
- Nasolabial Fold Correction, Facial Aging, Skin Rejuvenation, Wrinkles Such as Nasolabial Folds
- Trial name
- BRIDGING (NCT07178119)
- Testing
- (Bridging) Horizontal Cannula Technique for Treatment of Nasolabial Folds using AILEENE Vol. 2
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr. Joseph M Novoa Libermann
Type 2 Diabetes
Evaluation of SCOUT DS in Subjects With Type 2 Diabetes
The primary objective of the trial is to collect SCOUT DS and Hemoglobin A1c measurements of subjects who have been diagnosed with Type 2 diabetes.
- Trial name
- TCOYD (NCT01346033)
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- VeraLight, Inc.
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