Clinical trials: Non-invasive
Breast Cancer, Neuroendocrine Tumors
Simultaneous Hyperpolarized [1-13C]Pyruvate and 18F-FDG PET/MRS in Cancer Patients
Prospective phase 2a clinical trial to demonstrate proof-of-concept for simultaneous hyperpolarized [1-13C]pyruvate and 18F-FDG for positron emission tomography (PET) and MRS (magnetic resonance spectroscopy) in a PET/MR scanner…
- Conditions
- Breast Cancer, Neuroendocrine Tumors, Neuroendocrine Carcinoma, Neuroendocrine Carcinoma Metastatic
- Trial name
- NCT05396118
- Testing
- 18F-FDG, Injection of hyperpolarized [1-13C]Pyruvate, PET/MR/MRS/MRSI scanning
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Osteopenia
Study of the Effect of Once a Week Risedronate on the Microstructure of Tibia and Radius Using a New Scanning Method
The primary purpose of the protocol is to evaluate the sensitivity of 3D-pQCT (3D-Peripheral Quantitative Computed Tomography) technology to detect minute changes in bone microarchitecture.
- Trial name
- NCT00386360
- Testing
- risedronate
- Where
- 9 sites in Argentina, Australia and 5 more
- Volunteers
- 161 people
- Sponsor
- Warner Chilcott
Infectious Keratitis
Non-invasive Diagnostics of Microbial Keratitis
Infectious keratitis is a significant cause of partial vision loss and blindness and places a large burden on eye care professionals.
- Trial name
- NCT06364878
- Testing
- In vivo confocal microscopy, Tear film sampling
- Where
- Norway
- Volunteers
- 125 people
- Sponsor
- Sorlandet Hospital HF
Chronic Pain, Osteoarthritis
Effects of tDCS and tUS on Pain Perception in OA of the Knee
The purpose of this study is to investigate the effects of transcranial direct current stimulation (tDCS) in conjunction with transcranial ultrasound (TUS) on pain perception and functional limitations in people with…
- Trial name
- NCT02330315
- Testing
- transcranial direct current stimulation (tDCS), transcranial ultrasound (TUS)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Spaulding Rehabilitation Hospital
Atherosclerosis
Non-Invasive Imaging of Atherosclerosis
The purpose of this study is to develop and validate novel magnetic resonance imaging (MRI), dynamic contrast enhanced (DCE)-MRI and positron emission tomography (PET)/MR techniques for the detection and risk stratification of…
- Trial name
- NCT01418313
- Where
- United States
- Volunteers
- 886 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Respiratory Distress Syndrome, Newborn, Infant, Premature
Neural Control of Non-invasive Ventilation in the Preterm
The present study will use a new type of respirator in premature babies who need help with their breathing. This new respirator uses signals from the baby's diaphragm - the most important breathing muscle - to control the timing…
- Trial name
- NCT00368485
- Testing
- Neurally Controlled Mechanical Ventilation
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Liver Failure, Liver Transplantation
Autoregulation Assessment During Liver Transplantation
Patients with liver failure undergoing liver transplantation often have clinical or sub-clinical encephalopathy that may lead to increased intracranial pressure.
- Conditions
- Liver Failure, Liver Transplantation, Encephalopathy
- Trial name
- NCT01425385
- Testing
- Near infrared spectroscopy monitoring, Autoregulation monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Neuromuscular Diseases, Kyphoscoliosis
Installation of Non-invasive Ventilation at Home Using Telemedicine : a Pilot Study on Feasibility and Impact on Ventilation Compliance
Neuromuscular diseases are frequently associated with respiratory failure, which requires Non Invasive Ventilation (NIV). Currently, the NIV installation is done during an hospitalization of several days.
- Conditions
- Neuromuscular Diseases, Kyphoscoliosis, Non Invasive Ventilation
- Trial name
- Tele-VAD (NCT02103790)
- Testing
- Home NIV installation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Complications; Cesarean Section, Anesthesia; Adverse Effect, Spinal and Epidural
Non-invasive Cardiac Output Monitoring in Obstetric Patients
The investigators hypothesize that continuously measuring stroke volume (SV) and cardiac output (CO) will 1) reveal hemodynamic instability in a timely manner and alert the physician promptly, 2) provide information for the…
- Trial name
- NCT01516697
- Testing
- experimental, Control
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Respiratory Failure, Hypoxemia
NIV-FOB, HFNC-FOB- Comparison of Methods
The aim of the study is to asses safety and indications and contraindications for performing bronchofiberocopy (FB) with respiratory support methods, i.e. non-invasive ventilation (NIV) and high flow nasal oxygen therapy (HFNO).
- Conditions
- Respiratory Failure, Hypoxemia, Hypoxemic Respiratory Failure
- Trial name
- NIRA (NCT05655026)
- Testing
- NIV, HFNO
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Medical University of Silesia
Focus is on Healthy Subjects
Validation of Pulse Wave Doppler Demodulation Algorithm for the Continuous, Non-invasive Measurement of Blood Flow Velocity
The investigators hypothesize that performance of fast-Fourier transformation on the raw Doppler signals obtained from ascending aortic blood flow will recreate the pulse wave Doppler trace visualized on modern echocardiography…
- Trial name
- NCT01750125
- Testing
- measure ascending aortic blood flow with pulse wave Doppler
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Acute Respiratory Failure
Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure
This study aims at assessing the correlation between trans esophageal pressure and related respiratory mechanics (including, among others, nasal pressure-Pnose) and non-invasive respiratory support failure in patients with acute…
- Trial name
- TEMPO (NCT03826797)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Modena and Reggio Emilia
Eczema, Psoriasis
Non-invasive Photoacoustic Imaging of Skin Inflammatory Disorders With Machine Learning-assisted Scoring
Inflammatory skin disorders are usually assessed by disease scoring system such as Scoring AD (SCORAD)/Eczema Area and Severity Index (EASI) and Psoriasis Area and Severity Index (PASI) for atopic eczema and psoriasis…
- Trial name
- NCT04809571
- Testing
- Photoacoustic imaging and Confocal Raman spectroscopy measurement
- Where
- Singapore
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Institute of Bioengineering and Bioimaging (IBB)
Urinary Retention
First-in-man Safety and Efficacy Trial of a Novel Non-invasive Bladder Emptying Device: The NIBED Study
The non-invasive bladder emptying device (NIBED) is a handheld medical device that is applied to the penis during urinating to aid bladder emptying in urinary retention patients with increased residual urine volume.
- Trial name
- NIBED pilot (NCT04919798)
- Testing
- Non-invasive bladder emptying device
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
COVID-19, Hypoxemic Respiratory Failure
The Effect of Non-invasive Respiratory Support on Outcome and Its Risks in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2)-Related Hypoxemic Respiratory Failure
Coronavirus disease (COVID-19) can result in severe hypoxemic respiratory failure that ultimately may require invasive mechanical ventilation in the Intensive Care Unit (ICU).
- Trial name
- NORMO2 (NCT06033560)
- Testing
- High flow nasal oxygen (HFNO, more than 15 L/min)
- Where
- Netherlands
- Volunteers
- 6,000 people
- Sponsor
- Amsterdam UMC, location VUmc
Tracheobronchomalacia
PEEP Mask for Tracheobronchomalacia-Induced Cough
This study aims to determine if an expiratory resistance device that delivers non-invasive positive expiratory pressure (nPEP) will reduce or stop coughing, reduce airway resistance and improve quality of life in patients with…
- Trial name
- NCT04169282
- Testing
- nPEP (non-invasive positive expiratory pressure) mask
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Respiratory Distress Syndrome, Ventilation Therapy; Complications
Changes in Lung Aeration and Inspiratory Effort With and Without Awake Prone
The investigators aimed to investigate the ventilation homogeneity and transpulmonary pressure during treatments of High-flow nasal cannula(HFNC) and (CPAP) on supine and prone position for COVID-19 or non-COVID-19 patients with…
- Trial name
- NCT05719103
- Testing
- With and Without Awake Prone Positioning
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai Zhongshan Hospital
Gastroparesis, Delayed Gastric Emptying
Gastric Focused Ultrasound Stimulation
This randomized, sham-controlled crossover pilot study will evaluate whether noninvasive gastric focused ultrasound stimulation is associated with changes in postprandial gastric electrical activity and gastrointestinal symptoms…
- Trial name
- NCT07851727
- Testing
- Gastric Focused Ultrasound Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Evan (Huiliang) Wang
COPD, Dyspnea
Deventilation Dyspnea in COPD Patients Using NIV
Non-invasive ventilation (NIV) has shown to be an effective therapy for patients with Chronic Obstructive Pulmonary Disease (COPD) with Chronic Hypercapnic Respiratory Failure (CHRF).
- Conditions
- COPD, Dyspnea, Mechanical Ventilation Complication
- Trial name
- NCT03503123
- Testing
- Monitoring physiology with Electrical Impedance Tomography, Electromyography and transcutaneous carbon dioxide measurements.
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Cerebrovascular Disorders, Cerebral Stroke
Using Repetitive Transcranial Magnetic Stimulation (rTMS) in the Rehabilitation of Chronic Spatial Neglect After Stroke
Visuospatial neglect is a common neurological symptom which appears following strokes on regions of the right hemisphere of the brain.
- Conditions
- Cerebrovascular Disorders, Cerebral Stroke, VISIO-spatial Neglect, VISUO-spatial Extinction
- Trial name
- NEGLECT (NCT01000103)
- Testing
- Real rTMS
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris